Cited by 172Neurogenesis and neuroplasticity mechanismsNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

The Role of Serotonin in Early Cortical Development

Vitalis, Tania, Parnavelas, John G.·2003·Developmental Neuroscience

Abstract

The cerebral cortex is widely innervated by serotonin (5-HT)-containing axons originating from neurons in the raphe nuclei. The early development of this monoamine system in the cortex prompted speculation long ago that it has important functions in cortical maturation and plasticity. Here we review evidence, derived from a plethora of studies and from our recent unpublished work, that supports an important role for 5-HT in a number of major events in the developing cortex, especially at the early stages. This evidence points to a regulatory role for 5-HT in neuronal proliferation, migration and differentiation, and in preventing apoptotic cell death.

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Crossref · 10.1159/000072272

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66 of 66 references verified0 citation errors · 0 not checkable

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  • External neurotransmitter sources, such as the placenta, can play a role in the early shaping of cortical areas.

    “External neurotransmitter sources, such as the placenta, can play a role in this early shaping of cortical areas [114, 118, 241, 242].”

    From Development of prefrontal cortex (2022) · cites this paper as [242]

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Authors
Vitalis, T., & Parnavelas, J. G.
Affiliations
University College London (GB)
Venue
Developmental Neuroscience
Publisher
S. Karger AG
Published
2003
Volume
25
Issue
2-4
Pages
245-256
ISSN
  • 0378-5866 (ISSN-L)
  • 1421-9859
OpenAlex
W1967442405
Cited by
171
References
66
Citations by year
2026: 3 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 11 · 2020: 9 · 2019: 10 · 2018: 7 · 2017: 3 · 2016: 5 · 2015: 1 · 2014: 8 · 2013: 15 · 2012: 8
FWCI
1.38
Type
journal article
Language
en
Open access
closed
Locations
  • Developmental Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
Wellcome Trust
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
serotonin, cortical development, raphe nuclei, monoaminergic systems, cortical maturation, neuronal proliferation, neuronal migration, neuronal differentiation, apoptosis, cortical plasticity
MeSH terms
Animals, Cell Differentiation, Cell Movement, Cerebral Cortex, Humans, Neuronal Plasticity, Neurons, Serotonin, Apoptosis

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