The Role of Serotonin in Early Cortical Development
Abstract
The cerebral cortex is widely innervated by serotonin (5-HT)-containing axons originating from neurons in the raphe nuclei. The early development of this monoamine system in the cortex prompted speculation long ago that it has important functions in cortical maturation and plasticity. Here we review evidence, derived from a plethora of studies and from our recent unpublished work, that supports an important role for 5-HT in a number of major events in the developing cortex, especially at the early stages. This evidence points to a regulatory role for 5-HT in neuronal proliferation, migration and differentiation, and in preventing apoptotic cell death.
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External neurotransmitter sources, such as the placenta, can play a role in the early shaping of cortical areas.
“External neurotransmitter sources, such as the placenta, can play a role in this early shaping of cortical areas [114, 118, 241, 242].”
From Development of prefrontal cortex (2022) · cites this paper as [242]
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- Authors
- Vitalis, T., & Parnavelas, J. G.
- Affiliations
- University College London (GB)
- ORCID
- Vitalis, Tania
- Venue
- Developmental Neuroscience
- Publisher
- S. Karger AG
- Published
- 2003
- Volume
- 25
- Issue
- 2-4
- Pages
- 245-256
- ISSN
- 0378-5866 (ISSN-L)
- 1421-9859
- OpenAlex
- W1967442405
- Cited by
- 171
- References
- 66
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 11 · 2020: 9 · 2019: 10 · 2018: 7 · 2017: 3 · 2016: 5 · 2015: 1 · 2014: 8 · 2013: 15 · 2012: 8
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- serotonin, cortical development, raphe nuclei, monoaminergic systems, cortical maturation, neuronal proliferation, neuronal migration, neuronal differentiation, apoptosis, cortical plasticity
- MeSH terms
- Animals, Cell Differentiation, Cell Movement, Cerebral Cortex, Humans, Neuronal Plasticity, Neurons, Serotonin, Apoptosis
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