Sleep, Microbes and Cytokines
Abstract
Dynamic changes in sleep in response to infectious challenge are a facet of the acute phase response. Changes in sleep induced by infection seem to be of recuperative value to the host. Furthermore, loss of sleep is associated with changes in immune function. Specific components of microbes such as muramyl peptides or endotoxin from bacteria or double-stranded RNA from virus induce sleep responses. These microbial-induced responses are mediated via enhanced cytokine and hormone production. Interleukin-1, tumor necrosis factor and interferon-Αare somnogenic. Interleukin-1-enhanced sleep involves growth hormone-releasing hormone. Microbial-cytokine-altered sleep results from an amplification of physiological sleep mechanisms.
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Mice infected with influenza virus display profound increases in NREM sleep and inhibition of REM sleep lasting 3 or more days.
“Mice infected with influenza virus display profound increase in NREM sleep and inhibition of REM sleep, which last 3 or more days (Krueger et al, 1994).”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Krueger et al, 1994
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- Authors
- Krueger, J. M., Toth, L. A., Floyd, R., Fang, J., Kapás, L., Bredow, S., & Obál, Jr.
- Affiliations
- University of Tennessee Health Science Center (US)
- Children's Research Hospital (JP)
- ORCID
- Kapás, Levente
- Venue
- Neuroimmunomodulation
- Publisher
- S. Karger AG
- Published
- 2010-05-21
- Volume
- 1
- Issue
- 2
- Pages
- 100-109
- ISSN
- 1021-7401 (ISSN-L)
- 1423-0216
- OpenAlex
- W2020131327
- Cited by
- 54
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 1 · 2020: 2 · 2017: 1 · 2016: 3 · 2014: 1 · 2013: 1
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImmunoModulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns026429-10)
- National Institute of Neurological Disorders and Stroke (NS-26429, NS-27250, NS-25378, R01NS027250, R01NS025378)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- sleep, infection, acute phase response, cytokines, interleukin-1, TNF-α, interferon-alpha, growth hormone-releasing hormone, muramyl peptides, endotoxin, double-stranded RNA, sleep-wake regulation, immune function
- MeSH terms
- Acetylmuramyl-Alanyl-Isoglutamine, Adult, Amino Acid Sequence, Animals, Bacterial Toxins, Homeostasis, Hormones, Humans, Infections, Molecular Sequence Data, Sleep, Sleep Wake Disorders, Growth Hormone-Releasing Hormone, Neuroimmunomodulation, Cytokines, Mice, Rats
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