Neural-immune interactions in the regulation of sleep
Open accessAbstract
Interactions between sleep and the immune system have been recognized for millennia. The lethargy and increased desire to sleep that accompany mild infections such as colds or "the flu" are common experiences. These experiences have fostered the belief that sleep promotes recovery from infectious challenge. Another common belief is that the lack of sleep increases susceptibility to infectious disease. However, despite these age-old and widespread beliefs, surprisingly little empirical evidence supports the hypotheses that increased sleep aids recovery from, and lack of sleep increases susceptibility to, infections. Although research conducted over the last 30 years has clearly demonstrated that sleep is altered during the course of infection, few experiments have directly tested the functional impact of sleep on responses to immune challenge. We will review relevant literature documenting that sleep patterns do indeed change during states of infectious disease, discuss potential mediators of these alterations in behavior, and finally address the issue of whether sleep or sleep loss impacts the ability of the host to mount an appropriate immune response.
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Gram-negative bacteria such as Escherichia coli or Pasteurella multocida induce biphasic NREM sleep responses and REM sleep inhibition, with timing and magnitude depending on route of administration.
“Gram-negative bacteria, such as Escherichia coli or Pasteurella multocida, also induce biphasic NREM sleep responses and REM sleep inhibition, although the timing and magnitude of these effects depend on route of administration (Opp and Toth, 2003).”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Opp and Toth, 2003
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Cites
Dunn, A. J., & Berridge, C. W. (1990) · Brain Research Reviews · doi:10.1016/0165-0173(90)90012-d · Cited by 1,352 · see citing works
Chronic stress alters the immune response to influenza virus vaccine in older adults.
Kiecolt-Glaser, J. K., Glaser, R., Gravenstein, S., Malarkey, W. B., & Sheridan, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.3043 · Cited by 789 · see citing works
Interleukin-1 Immunoreactive Innervation of the Human Hypothalamus
Breder, C. D., Dinarello, C. A., & Saper, C. B. (1988) · Science · doi:10.1126/science.3258444 · Cited by 759 · see citing works
Altered circadian activity rhythms and sleep in mice devoid of prion protein
Tobler, I., Gaus, S. E., Deboer, T., Achermann, P., Fischer, M. S., Rülicke, T., Moser, M., Oesch, B., McBride, P. A., & Manson, J. C. (1996) · Nature · doi:10.1038/380639a0 · Cited by 662 · see citing works
Physiological Correlates of Prolonged Sleep Deprivation in Rats
Rechtschaffen, A., Gilliland, M. A., Bergmann, B. M., & Winter, J. B. (1983) · Science · doi:10.1126/science.6857280 · Cited by 487 · see citing works
Stress response genes protect against lethal effects of sleep deprivation in Drosophila
Shaw, P. J., Tononi, G., Greenspan, R. J., & Robinson, D. F. (2002) · Nature · doi:10.1038/417287a · Cited by 479 · see citing works
Léger, D. (1994) · SLEEP · doi:10.1093/sleep/17.1.84 · Cited by 469 · see citing works
Shearer, W. T., Reuben, J. M., Mullington, J. M., Price, N. J., Lee, B.-N., Smith, E. O., Szuba, M. P., Van Dongen, H. P. A., & Dinges, D. F. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.112270 · Cited by 455 · see citing works
Interleukin 6 is involved in interleukin 1‐induced activities
Helle, M., Brakenhoff, J. P. J., de Groot, E. R., & Aarden, L. A. (1988) · European Journal of Immunology · doi:10.1002/eji.1830180619 · Cited by 409 · see citing works
Cytokine Actions in the Central Nervous System
Benveniste, E. N. (1998) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(98)00015-x · Cited by 383 · see citing works
Späth‐Schwalbe, E. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.5.1573 · Cited by 377 · see citing works
Mortality Risk Associated with Sleeping Patterns Among Adults
Wingard, D. L., & Berkman, L. F. (1983) · Sleep · doi:10.1093/sleep/6.2.102 · Cited by 371 · see citing works
Effects of sleep and sleep loss on immunity and cytokines
Irwin, M. R. (2002) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(02)00003-x · Cited by 366 · see citing works
Dinges, D. F., Douglas, S. D., Zaugg, L., Campbell, D. E., McMann, J. M., Whitehouse, W. G., Orne, E. C., Kapoor, S. C., Icaza, E., & Orne, M. T. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117184 · Cited by 361 · see citing works
Sleep problems in the community elderly as predictors of death and nursing home placement
Pollak, C. P., PERLICK, D. A., Linsner, J. P., Wenston, J., & Hsieh, F. (1990) · Journal of Community Health · doi:10.1007/bf01321316 · Cited by 350 · see citing works
Sleep Deprivation in the Rat: III. Total Sleep Deprivation
Everson, C. A., Bergmann, B. M., & Rechtschaffen, A. (1989) · SLEEP · doi:10.1093/sleep/12.1.13 · Cited by 341 · see citing works
Sleep Loss and “Divergent” Thinking Ability
Horne, J. A. (1988) · Sleep · doi:10.1093/sleep/11.6.528 · Cited by 311 · see citing works
Sleep and Sleep Regulation in Normal and Prion Protein-Deficient Mice
Tobler, I., Deboer, T., & Fischer, M. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-05-01869.1997 · Cited by 296 · see citing works
Recombinant tumor necrosis factor and interleukin 1 enhance slow-wave sleep
Shoham, S., Davenne, D., Cady, A. B., Dinarello, C. A., & Krueger, J. M. (1987) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1987.253.1.r142 · Cited by 290 · see citing works
Dhabhar, F. S., McEwen, B. S., & Spencer, R. L. (2008) · Neuroendocrinology · doi:10.1159/000127196 · Cited by 259 · see citing works
Sustained sleep deprivation impairs host defense
Everson, C. A. (1993) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1993.265.5.r1148 · Cited by 251 · see citing works
Partial sleep deprivation reduces natural killer cell activity in humans.
Irwin, M., Mascovich, A., Gillin, J. C., Willoughby, R., Pike, J., & Smith, T. L. (1994) · Psychosomatic Medicine · doi:10.1097/00006842-199411000-00004 · Cited by 249 · see citing works
Vgontzas, A. N., Mastorakos, G., Bixler, E. O., Kales, A., Gold, P. W., & Chrousos, G. P. (1999) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1999.00763.x · Cited by 249 · see citing works
Systemic bacterial invasion induced by sleep deprivation
Everson, C. A., & Toth, L. A. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.4.r905 · Cited by 248 · see citing works
Role of IL-6 in cytokine-induced sickness behavior: a study with IL-6 deficient mice.
Bluthé, R., Michaud, B., Poli, V., & Dantzer, R. (2000) · Physiology and Behavior · doi:10.1016/s0031-9384(00)00269-9 · Cited by 239 · see citing works
Sleep deprivation and human immune function
Dinges, D. F., Douglas, S. D., Hamarman, S., Zaugg, L., & Kapoor, S. C. (1995) · Advances in Neuroimmunology · doi:10.1016/0960-5428(95)00002-j · Cited by 234 · see citing works
Interleukin 1 receptors in the brain and endocrine tissues
Cunningham, E. T., & Souza, E. B. D. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90281-o · Cited by 230 · see citing works
The relationship of interleukin-1 and immune functions to sleep in humans.
Moldofsky, H., Lue, F. A., Eisen, J. S., Keystone, E., & Gorczynski, R. M. (1986) · Psychosomatic Medicine · doi:10.1097/00006842-198605000-00001 · Cited by 229 · see citing works
Lymphocyte and Granulocyte Reactions during Sleep Deprivation
Palmblad, J. E. W., Petrini, B., Wasserman, J., & Åkerstedt, T. (1979) · Psychosomatic Medicine · doi:10.1097/00006842-197906000-00001 · Cited by 208 · see citing works
Low levels of circulating inflammatory cytokines—Do they affect human brain functions?
Pollmächer, T., Haack, M., Schuld, A., Reichenberg, A., & Yirmiya, R. (2002) · Brain, Behavior, and Immunity · doi:10.1016/s0889-1591(02)00004-1 · Cited by 202 · see citing works
Suchecki, D., Lobo, L. L., Hipólide, D. C., & Tufik, S. (1998) · Journal of Sleep Research · doi:10.1046/j.1365-2869.1998.00122.x · Cited by 180 · see citing works
Handbook of Behavioral State Control: Cellular and Molecular Mechanisms
Brudzyński, S. M. (2000) · Europe PMC (PubMed Central) · Cited by 177 · see citing works
Mice Lacking the TNF 55 kDa Receptor Fail to Sleep More After TNFα Treatment
Fang, J., Wang, Y., & Krueger, J. M. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-15-05949.1997 · Cited by 167 · see citing works
Nilsson, P. M., Nilsson, J. ‐., Hedblad, B., & Berglund, G. (2001) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2001.00913.x · Cited by 161 · see citing works
Sleep as a Prognostic Indicator During Infectious Disease in Rabbits
Toth, L. A., Tolley, E. A., & Krueger, J. M. (1993) · Experimental Biology and Medicine · doi:10.3181/00379727-203-43590 · Cited by 153 · see citing works
Interleukin 1-receptor antagonist blocks interleukin 1-induced sleep and fever
Opp, M. R., & Krueger, J. M. (1991) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1991.260.2.r453 · Cited by 152 · see citing works
Self-citationA review of the biological effects of total sleep deprivation in man
Horne, J. A. (1978) · Biological Psychology · doi:10.1016/0301-0511(78)90042-x · Cited by 151 · see citing works
Nocturnal plasma levels of cytokines in healthy men
Gudewill, S., Pollmächer, T., Vedder, H., Schreiber, W., Fassbender, K. C., & Holsboer, F. (1992) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02190343 · Cited by 145 · see citing works
Sleep Patterns and Mortality among Elderly Patients in a Geriatric Hospital
Manabe, K., Matsui, T., Yamaya, M., Sato-Nakagawa, T., Okamura, N., Arai, H., & Sasaki, H. (2000) · Gerontology · doi:10.1159/000022184 · Cited by 138 · see citing works
Diurnal variation of TNFα in the rat brain
Floyd, R. A., & Krueger, J. M. (1997) · Neuroreport · doi:10.1097/00001756-199703030-00020 · Cited by 137 · see citing works
Diurnal variations of interleukin-1β mRNA and β-actin mRNA in rat brain
Taishi, P., Bredow, S., Guha‐Thakurta, N., Obál, F., & Krueger, J. M. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00002-7 · Cited by 132 · see citing works
Sleep disruption in the intensive care unit
Gabor, J. Y., Cooper, A. B., & Hanly, P. J. (2001) · Current Opinion in Critical Care · doi:10.1097/00075198-200102000-00004 · Cited by 130 · see citing works
Effect of Age on the Circadian Pattern of Sleep and Wakefulness in the Mouse
Welsh, D. K., Richardson, G. S., & Wc, D. (1986) · Journal of Gerontology · doi:10.1093/geronj/41.5.579 · Cited by 130 · see citing works
Neurological Abnormalities Associated with Feline Immunodeficiency Virus Infection
Phillips, T. R., Prospero-Garcia, O. E., Puaoi, D. L., Lerner, D. L., Fox, H. S., Olmsted, R. A., Bloom, F. E., Henriksen, S. J., & Elder, J. H. (1994) · Journal of General Virology · doi:10.1099/0022-1317-75-5-979 · Cited by 129 · see citing works
Sleep Disturbances in Men with Asymptomatic Human Immunodeficiency (HIV) Infection
Norman, S. E., Chediak, A. D., Freeman, C., Kiel, M. H., Mendez, A., DUNCAN, R. C., Simoneau, J., & Nolan, B. (1992) · SLEEP · doi:10.1093/sleep/15.2.150 · Cited by 124 · see citing works
Enhancement of slow-wave sleep by endotoxin and lipid A
Krueger, J. M., Kubillus, S. L., Shoham, S., & Davenne, D. (1986) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1986.251.3.r591 · Cited by 124 · see citing works
Sleep disturbances after open heart surgery
Orr, W. C., & Stahl, M. L. (1977) · The American Journal of Cardiology · doi:10.1016/s0002-9149(77)80191-4 · Cited by 119 · see citing works
Sleep and Cerebrospinal Fluid Interleukin-1-Like Activity in the Cat
Lue, F. A., Bail, M., Jephthah-Ochola, J., Carayanniotis, K., Gorczynski, R. M., & Moldofsky, H. (1988) · International Journal of Neuroscience · doi:10.3109/00207458808991595 · Cited by 116 · see citing works
Neuroimmunologic aspects of sleep and sleep loss
Rogers, N. L., Szuba, M. P., Staab, J. P., Evans, D. L., & Dinges, D. F. (2001) · Seminars in Clinical Neuropsychiatry · doi:10.1053/scnp.2001.27907 · Cited by 116 · see citing works
Interleukin-6 is pyrogenic but not somnogenic
Opp, M. R., Obál, F., Cady, A. B., Johannsen, L., & Krueger, J. M. (1989) · Physiology & Behavior · doi:10.1016/0031-9384(89)90239-4 · Cited by 112 · see citing works
Self-citationMattson, K. V., Niiranen, A., Iivanainen, M., Färkkilä, M. A., Bergström, L., Holsti, L. R., Kauppinen, H., & Cantell, K. (1983) · PubMed · Cited by 108 · see citing works
Sleep disturbances in HIV-infected homosexual men
Norman, S. E., Chediak, A. D., Kiel, M. H., & Cohn, M. A. (1990) · AIDS · doi:10.1097/00002030-199008000-00009 · Cited by 108 · see citing works
Toth, L. A., Rehg, J. E., & Webster, R. G. (1995) · Journal of Neuroimmunology · doi:10.1016/0165-5728(94)00193-r · Cited by 108 · see citing works
Stress and Pathogenesis of Infectious Disease
Peterson, P. K., Chao, C., Molitor, T. W., Murtaugh, M. P., Strgar, F., & Sharp, B. M. (1991) · Clinical Infectious Diseases · doi:10.1093/clinids/13.4.710 · Cited by 105 · see citing works
How do cytokines say hello to the brain? Neural versus humoral mediation.
Dantzer, R. (1994) · PubMed · Cited by 105 · see citing works
(1989) · PubMed · Cited by 99 · see citing works
Sleep, sleep deprivation and infectious disease: Studies in animals
Toth, L. A. (1995) · Advances in Neuroimmunology · doi:10.1016/0960-5428(94)00045-p · Cited by 93 · see citing works
Interleukin-1 is involved in responses to sleep deprivation in the rabbit
Opp, M. R., & Krueger, J. M. (1994) · Brain Research · doi:10.1016/0006-8993(94)91764-7 · Cited by 93 · see citing works
Self-citationInterferon alpha-2 enhances slow-wave sleep in rabbits
Krueger, J. M., Dinarello, C. A., Shoham, S., Davenne, D., Walter, J., & Kubillus, S. L. (1987) · International Journal of Immunopharmacology · doi:10.1016/0192-0561(87)90107-x · Cited by 93 · see citing works
Cytokine Involvement in the Regulation of Sleep
Opp, M. R., Kapás, L., & Toth, L. A. (1992) · Experimental Biology and Medicine · doi:10.3181/00379727-201-43474 · Cited by 92 · see citing works
Self-citationInterleukin-6 serum levels in healthy persons correspond to the sleep-wake cycle
Bauer, J., Hohagen, F., Ebert, T. H., Timmer, J., Ganter, U., Krieger, S., Lis, S., Postler, E., Voderholzer, U., & Berger, T. (1994) · Journal of Molecular Medicine · doi:10.1007/bf00180048 · Cited by 89 · see citing works
Sleep-Wake Cycle in Human African Trypanosomiasis
Buguet, A., Bert, J., Tapie, P., Tabaraud, F., Doua, F., Lonsdorfer, J., Bogui, P., & Dumas, M. (1993) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199304000-00006 · Cited by 89 · see citing works
Effects of microbial challenge on sleep in rabbits
Toth, L. A., & Krueger, J. M. (1989) · The FASEB Journal · doi:10.1096/fasebj.3.9.2663582 · Cited by 88 · see citing works
STUDIES ON THE PHYSIOLOGY OF SLEEP
Kleitman, N. (1923) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1923.66.1.67 · Cited by 80 · see citing works
An anti-tumor necrosis factor antibody suppresses sleep in rats and rabbits
Takahashi, S., ́s, L. K., Fang, J., & Krueger, J. M. (1995) · Brain Research · doi:10.1016/0006-8993(95)00609-t · Cited by 77 · see citing works
Sleeping sickness and the brain
Enanga, B., Burchmore, R., Stewart, M. L., & Barrett, M. P. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-002-8472-0 · Cited by 76 · see citing works
Cytokine- and microbially induced sleep responses of interleukin-10 deficient mice
Toth, L. A., & Opp, M. R. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.6.r1806 · Cited by 75 · see citing works
Self-citationInfluenza Viral Infections Enhance Sleep in Mice
Fang, J., Sanborn, C., Renegar, K. B., Majde, J. A., & Krueger, J. M. (1995) · Experimental Biology and Medicine · doi:10.3181/00379727-210-43945 · Cited by 74 · see citing works
Inhibition of tumor necrosis factor attenuates physiological sleep in rabbits
Takahashi, S., Kapás, L., Seyer, J. M., Wang, Y., & Krueger, J. M. (1996) · Neuroreport · doi:10.1097/00001756-199601310-00063 · Cited by 71 · see citing works
Tumor necrosis factor-beta induces sleep, fever, and anorexia
Kapás, L., & Krueger, J. M. (1992) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1992.263.3.r703 · Cited by 70 · see citing works
Health effects of sleep deprivation.
Naitoh, P., Kelly, T. L., & Englund, C. E. (1989) · PsycEXTRA Dataset · doi:10.1037/e477532004-001 · Cited by 69 · see citing works
Lentiviral infection, immune response peptides and sleep
Darko, D. F., Mitler, M. M., & Henriksen, S. J. (1995) · Advances in Neuroimmunology · doi:10.1016/0960-5428(94)00044-o · Cited by 69 · see citing works
Interleukin-18 promotes sleep in rabbits and rats
Kubota, T., Fang, J., Brown, R. A., & Krueger, J. M. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.3.r828 · Cited by 69 · see citing works
IL-6 is essential in TNF-α-induced fever
Sundgren‐Andersson, A. K., Östlund, P., & Bartfai, T. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.6.r2028 · Cited by 69 · see citing works
Interleukin-10 Inhibits Spontaneous Sleep in Rabbits
Kushikata, T., Fang, J., & Krueger, J. M. (1999) · Journal of Interferon & Cytokine Research · doi:10.1089/107999099313244 · Cited by 69 · see citing works
The Effect of Total Sleep Deprivation on Plasma Melatonin and Cortisol in Healthy Human Volunteers
Salín-Pascual, R. J., Ortega-Soto, H. A., Huerto‐Delgadillo, L., Camacho‐Arroyo, I., Roldán-Roldán, G., & Tamarkin, L. (1988) · SLEEP · doi:10.1093/sleep/11.4.362 · Cited by 68 · see citing works
The Siesta and Mortality in the Elderly: Effect of Rest Without Sleep and Daytime Sleep Duration
Bursztyn, M., Ginsberg, G. M., & Stessman, J. (2002) · SLEEP · doi:10.1093/sleep/25.2.187 · Cited by 67 · see citing works
Electrophysiological and sleep alterations in experimental mouse rabies
Gourmelon, P., Briet, D., Court, L. A., & Tsiang, H. (1986) · Brain Research · doi:10.1016/0006-8993(86)91258-8 · Cited by 66 · see citing works
Cytokine Production during Sleep and Wakef ulness and Its Relationship to Cortisol in Healthy Humans
Hohagen, F., Timmer, J., Weyerbrock, A., Rosemarie Fritsch, M., Ganter, U., Krieger, S., Berger, T., & Bauer, J. (2008) · Neuropsychobiology · doi:10.1159/000118993 · Cited by 65 · see citing works
Kimura-Takeuchi, M., Majde, J. A., Toth, L. A., & Krueger, J. M. (1992) · The Journal of Infectious Diseases · doi:10.1093/infdis/166.6.1266 · Cited by 61 · see citing works
Psychological, Psychophysiological, and Biochemical Correlates of Prolonged Sleep Deprivation
KOLLAR, E. J., PASNAU, R. O., Rubín, R. T., Naitoh, P., Slater, G. G., & Kales, A. (1969) · American Journal of Psychiatry · doi:10.1176/ajp.126.4.488 · Cited by 61 · see citing works
Takahashi, S., Kapás, L., Fang, J., Seyer, J. M., Wang, Y., & Krueger, J. M. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.271.1.r101 · Cited by 60 · see citing works
Gourmelon, P., Briet, D., Clarençon, D., Court, L., & Tsiang, H. (1991) · Brain Research · doi:10.1016/0006-8993(91)90184-w · Cited by 58 · see citing works
INTERFERON-α ACUTELY IMPAIRS SLEEP IN HEALTHY HUMANS
Späth-Schwalbe, E., Lange, T., Perras, B., Lorenz Fehm, H., & Born, J. (2000) · Cytokine · doi:10.1006/cyto.1999.0587 · Cited by 56 · see citing works
Opp, M. R., Postlethwaite, A. E., Seyer, J. M., & Krueger, J. M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.9.3726 · Cited by 55 · see citing works
Self-citationSleep Deprivation in the Rat: VII. Immune Function
Benca, R. M., Kushida, C. A., Everson, C. A., Kalski, R., Bergmann, B. M., & Rechtschaffen, A. (1989) · Sleep · doi:10.1093/sleep/12.1.47 · Cited by 54 · see citing works
Krueger, J. M., Toth, L. A., Floyd, R., Fang, J., Kapás, L., Bredow, S., & Obál, Jr. (2010) · Neuroimmunomodulation · doi:10.1159/000097142 · Cited by 54 · see citing works
Interleukin-15 and interleukin-2 enhance non-REM sleep in rabbits
Kubota, T., Brown, R. A., Fang, J., & Krueger, J. M. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.3.r1004 · Cited by 51 · see citing works
Interleukin-13 and transforming growth factor-β1 inhibit spontaneous sleep in rabbits
Kubota, T., Fang, J., Kushikata, T., & Krueger, J. M. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.3.r786 · Cited by 48 · see citing works
Inhibition of brain interleukin-1 attenuates sleep rebound after sleep deprivation in rabbits
Takahashi, S., Fang, J., Kapás, L., Wang, Y., & Krueger, J. M. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.273.2.r677 · Cited by 48 · see citing works
Central nervous system and peripheral immune functions and the sleep-wake system.
Moldofsky, H. (1994) · PubMed Central · Cited by 47 · see citing works
Stress-Induced Changes in Immune Function in Animals: Hypothalamo–Pituitary–Adrenal Influences
Keller, S. E., Schleifer, S. J., & Demetrikopoulos, M. K. (1991) · Elsevier eBooks · doi:10.1016/b978-0-12-043780-1.50034-8 · Cited by 45 · see citing works
Brown, R., Price, R. J., King, M. G., & Husband, A. J. (1989) · Brain Behavior and Immunity · doi:10.1016/0889-1591(89)90031-7 · Cited by 45 · see citing works
Dafny, N. (1983) · PubMed · Cited by 44 · see citing works
Moldofsky, H. (1989) · PubMed · Cited by 43 · see citing works
Strain Differences in the Somnogenic Effects of Interferon Inducers in Mice
Toth, L. A. (1996) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1996.16.1065 · Cited by 42 · see citing works
Sleep during Experimental Trypanosomiasis in Rabbits
Toth, L. A., Tolley, E. A., Broady, R. C., Blakely, B. W., & Krueger, J. M. (1994) · Experimental Biology and Medicine · doi:10.3181/00379727-205-43694 · Cited by 42 · see citing works
Interferon decreases REM latency
Reite, M. L., Laudenslager, M. L., Jones, J. F., Crnic, L. S., & Kaemingk, K. L. (1987) · Biological Psychiatry · doi:10.1016/0006-3223(87)90136-3 · Cited by 41 · see citing works
Fever alters characteristics of sleep in rats
Kent, S., Price, M., & Satinoff, E. (1988) · Physiology & Behavior · doi:10.1016/0031-9384(88)90051-0 · Cited by 39 · see citing works
Mouse genotype affects inducible expression of cytokine genes
Raj, N. B., Cheung, S. C., ROSZTÓCZY, I., & Pitha, P. M. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.6.1934 · Cited by 38 · see citing works
Opp, M. R., Rady, P. L., Hughes, T. K., Cadet, P., Tyring, S. K., & Smith, E. M. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.271.2.1-a · Cited by 37 · see citing works
Self-citationIntraventricular administration of a FIV-envelope protein induces sleep architecture changes in rats
Prospero-Garcia, O. E., Herold, N., Waters, A. K., Phillips, T. R., Elder, J. H., & Henriksen, S. J. (1994) · Brain Research · doi:10.1016/0006-8993(94)90888-5 · Cited by 34 · see citing works
Toth, L. A., & Rehg, J. E. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00321-x · Cited by 33 · see citing works
Apnea and Sleep State in Infants with Nasopharyngitis
Gould, J. B., Lee, A., Cook, P. J., & Morelock, S. (1980) · PEDIATRICS · doi:10.1542/peds.65.4.713 · Cited by 31 · see citing works
Inhibition of tumor necrosis factor prevents warming-induced sleep responses in rabbits
Takahashi, S., & Krueger, J. M. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.272.4.r1325 · Cited by 30 · see citing works
Effect of extended sleep deprivation on tumor growth in rats
Bergmann, B. M., Rechtschaffen, A., Gilliland, M. A., & Quintáns, J. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.271.5.r1460 · Cited by 30 · see citing works
Neurological effects of recombinant human interferon.
Honigsberger, L., Fielding, J., & Priestman, T. J. (1983) · BMJ · doi:10.1136/bmj.286.6366.719-a · Cited by 28 · see citing works
Experimental scrapie in rats: First electrophysiological observations
Bassant, M. H., Cathala, F., Court, L., Gourmelon, P., & Hauw, J. (1984) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(84)90090-7 · Cited by 27 · see citing works
Neurobiology of Cerebral Malaria and African Sleeping Sickness
Mhlanga, J., Bentivoglio, M., & Kristensson, K. (1997) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00309-2 · Cited by 25 · see citing works
Gourmelon, P., Amyx, H. L., Baron, H., Lemercier, G., Court, L. A., & Gibbs, C. J. (1987) · Brain Research · doi:10.1016/0006-8993(87)91093-6 · Cited by 24 · see citing works
Somnogenic, pyrogenic, and hematologic effects of experimental pasteurellosis in rabbits
Toth, L. A., & Krueger, J. M. (1990) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1990.258.2.r536 · Cited by 23 · see citing works
Fb, C., Eisenberg, J., Peterson, D., & Pieper, D. R. (1974) · PubMed · Cited by 20 · see citing works
A GENE WITH QUANTITATIVE EFFECT ON CIRCULATING INTERFERON INDUCTION ‐ Further studies
Maeyer, E. D., & Maeyer‐Guignard, J. D. (1970) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1970.tb53413.x · Cited by 19 · see citing works
Human immunodeficiency virus glycoproteins 160 and 41 alter sleep and brain temperature of rats
Gemma, C., & Opp, M. R. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00052-1 · Cited by 19 · see citing works
Self-citationSomnolence: its importance in society
Dement, W. C., & Gelb, M. (1993) · Neurophysiologie Clinique · doi:10.1016/s0987-7053(05)80278-3 · Cited by 17 · see citing works
Acidic fibroblast growth factor (FGF) but not basic FGF induces sleep and fever in rabbits
Knefati, M., Somogyi, C., Kapás, L., Bourcier, T., & Krueger, J. M. (1995) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1995.269.1.r87 · Cited by 16 · see citing works
Takahashi, L. K., & Kim, H. H. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(94)00324-6 · Cited by 15 · see citing works
Anemia in Sleep-Deprived Rats Receiving Anticoagulants
Drucker-Colín, R., Jaques, L. B., & Winocur, G. (1971) · Science · doi:10.1126/science.174.4008.505 · Cited by 11 · see citing works
The Electroencephalogram in Adult Patients with Fever
Lifshitz, A., López, M., Fiorelli, S., Medina, E., Osuna, G., & Halabe, J. (1987) · Clinical Electroencephalography · doi:10.1177/155005948701800213 · Cited by 8 · see citing works
Sleep Deprivation And The Immune Response To Pathogenic And Non-Pathogenic Antigens
Brown, R., Pang, G., Husband, A. J., King, M. G., & Bull, D. F. (2019) · CRC Press eBooks · doi:10.1201/9780429260445-14 · Cited by 6 · see citing works
Monographs in Clinical Neuroscience. Volume 17
Peatfield, R. C. (2001) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.70.1.138i · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Krueger, J.M., J. Fang, & J.A. Majde:Sleep in health and disease. In: Psychoneuroimmunology. Eds: Ader, R, Felten, D.L., Cohen, N. Academic Press, New York (2001) 152.
Cited by
Sorted by citations
Sleep and inflammation: partners in sickness and in health
Irwin, M. R. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0190-z · Cited by 1,090 · see citing works
How (and why) the immune system makes us sleep
Imeri, L., & Opp, M. R. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2576 · Cited by 710 · see citing works
Self-citationSleep health: Reciprocal regulation of sleep and innate immunity
Irwin, M. R., & Opp, M. R. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.148 · Cited by 624 · see citing works
Self-citationSick and tired: does sleep have a vital role in the immune system?
Bryant, P. A., Trinder, J., & Curtis, N. (2004) · Nature Reviews Immunology · doi:10.1038/nri1369 · Cited by 551 · see citing works
Opp, M. R. (2005) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.01.002 · Cited by 393 · see citing works
Self-citationSleep, Anesthesiology, and the Neurobiology of Arousal State Control
Lydic, R., & Baghdoyan, H. A. (2005) · Anesthesiology · doi:10.1097/00000542-200512000-00024 · Cited by 251 · see citing works
Sleep Quality Prediction From Wearable Data Using Deep Learning
Sathyanarayana, A., Joty, S., Fernández-Luque, L., Ofli, F., Srivastava, J., Elmagarmid, A. K., Arora, T., & Taheri, S. (2016) · JMIR mhealth and uhealth · doi:10.2196/mhealth.6562 · Cited by 242 · see citing works
Sleep-Related Problems in Common Medical Conditions
Parish, J. M. (2009) · CHEST Journal · doi:10.1378/chest.08-0934 · Cited by 240 · see citing works
Effects of Evening Exercise on Sleep in Healthy Participants: A Systematic Review and Meta-Analysis
Stutz, J., Eiholzer, R., & Spengler, C. M. (2018) · Sports Medicine · doi:10.1007/s40279-018-1015-0 · Cited by 225 · see citing works
Lesku, J. A., Roth, T. C., Amlaner, C. J., & Lima, S. L. (2006) · The American Naturalist · doi:10.1086/506973 · Cited by 211 · see citing works
Kapsimalis, F., Richardson, G. S., Opp, M. R., & Kryger, M. H. (2005) · Current Opinion in Pulmonary Medicine · doi:10.1097/01.mcp.0000183062.98665.6b · Cited by 150 · see citing works
Self-citationMolecular Mechanisms of Cancer-Induced Sleep Disruption
Walker, W. H., II, & Borniger, J. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112780 · Cited by 146 · see citing works
Everson, C. A. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00021.2005 · Cited by 141 · see citing works
Gangwisch, J. E., Hale, L. E., St‐Onge, M., Choi, L., LeBlanc, E. S., Malaspina, D., Opler, M. G., Shadyab, A. H., Shikany, J. M., Snetselaar, L. G., et al. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz275 · Cited by 123 · see citing works
Tumour necrosis factor-α (−308) gene polymorphism in obstructive sleep apnoea–hypopnoea syndrome
Riha, R. L., Brander, P. E., Vennelle, M., McArdle, N., Kerr, S. M., Anderson, N. H., & Douglas, N. J. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00130804 · Cited by 116 · see citing works
Rabbitts, J. A., Groenewald, C. B., Tai, G. G., & Palermo, T. M. (2015) · The Journal of Pain · doi:10.1016/j.jpain.2014.11.015 · Cited by 114 · see citing works
Borniger, J. C., Walker, W. H., Surbhi, Emmer, K. M., Zhang, N., Zalenski, A. A., Muscarella, S. L., Fitzgerald, J. A., Smith, A. N., Braam, C. J., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.04.021 · Cited by 115 · see citing works
The association between interleukin-6, sleep, and demographic characteristics
Hong, S., Mills, P. J., Loredo, J. S., Adler, K. A., & Dimsdale, J. E. (2005) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2004.07.008 · Cited by 110 · see citing works
Kibayashi, M., Tanaka, M., Nishida, N., Kuboniwa, M., Kataoka, K., Nagata, H., Nakayama, K., Morimoto, K., & Shizukuishi, S. (2007) · Journal of Periodontology · doi:10.1902/jop.2007.060292 · Cited by 110 · see citing works
Kuo, T., Pike, D. H., Beizaeipour, Z., & Williams, J. A. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-17 · Cited by 110 · see citing works
Sleep disturbance, cytokines, and fatigue in women with ovarian cancer
Clevenger, L., Schrepf, A., Christensen, D., DeGeest, K., Bender, D., Ahmed, A. I., Goodheart, M. J., Penedo, F. J., Lubaroff, D. M., Sood, A. K., et al. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.04.003 · Cited by 99 · see citing works
Irwin, M., Rinetti, G., Redwine, L., Motivala, S., Dang, J., & Ehlers, C. (2004) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2004.02.001 · Cited by 95 · see citing works
Morrow, J. D., & Opp, M. R. (2004) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2004.04.001 · Cited by 94 · see citing works
Self-citationNaqvi, S. K., Sotelo, C. E., Murry, L., & Simakajornboon, N. (2007) · Sleep And Breathing · doi:10.1007/s11325-007-0123-0 · Cited by 85 · see citing works
Rodent models of insomnia: A review of experimental procedures that induce sleep disturbances
Revel, F. G., Gottowik, J., Gatti, S., Wettstein, J. G., & Moreau, J. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.03.002 · Cited by 82 · see citing works
Palma, B. D., Gabriel, A., Colugnati, F. A. B., & Tufik, S. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00186.2006 · Cited by 74 · see citing works
Jhaveri, K. A., Trammell, R. A., & Toth, L. A. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.03.007 · Cited by 74 · see citing works
Kinnucan, J. A. R., Rubin, D. T., & Ali, T. (2013) · Europe PMC (PubMed Central) · Cited by 73 · see citing works
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Sathyanarayana, A., Joty, S., Fernández-Luque, L., Ofli, F., Srivastava, J., Elmagarmid, A. K., Taheri, S., & Arora, T. (2016) · arXiv (Cornell University) · doi:10.48550/arxiv.1607.07034 · Cited by 73 · see citing works
Green, T. R. F., Ortiz, J. B., Wonnacott, S., Williams, R. J., & Rowe, R. K. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00894 · Cited by 63 · see citing works
Jackson, M. L., Butt, H., Ball, M., Lewis, D. P., & Bruck, D. (2015) · Sleep Science · doi:10.1016/j.slsci.2015.10.001 · Cited by 63 · see citing works
(2006) · Cited by 58 · see citing works
Tumor Necrosis Factor Antagonism Normalizes Rapid Eye Movement Sleep in Alcohol Dependence
Irwin, M. R., Olmstead, R., Valladares, E. M., Breen, E. C., & Ehlers, C. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.12.004 · Cited by 57 · see citing works
Sleep disordered breathing in cystic fibrosis
Milross, M., Piper, A. J., Dobbin, C. J., Bye, P. T. P., & Grunstein, R. R. (2004) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2004.03.004 · Cited by 55 · see citing works
Olivadoti, M. D., & Opp, M. R. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.008 · Cited by 53 · see citing works
Self-citationEffects of sleep deprivation on wound healing
Mostaghimi, L., Obermeyer, W. H., BALLAMUDI, B., Martı́nez-González, D., & Benca, R. M. (2005) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2005.00455.x · Cited by 52 · see citing works
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Opp, M. R. (2009) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2009.02.009 · Cited by 47 · see citing works
Self-citationThe effects of sleep and sleep deprivation on metabolic, endocrine and immune parameters.
Maurovich‐Horvat, E., Pollmächer, T., & Šonka, K. (2008) · PubMed · Cited by 43 · see citing works
Sepsis-induced alterations in sleep of rats
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Self-citationRabbitts, J. A., Zhou, C., Narayanan, A., & Palermo, T. M. (2017) · Journal of Pain · doi:10.1016/j.jpain.2017.01.004 · Cited by 43 · see citing works
Dauvilliers, Y. A., & Buguet, A. (2005) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2005.7.4/ydauvilliers · Cited by 42 · see citing works
Spontaneous, homeostatic, and inflammation-induced sleep in NF-κB p50 knockout mice
Jhaveri, K. A., Ramkumar, V., Trammell, R. A., & Toth, L. A. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00262.2006 · Cited by 40 · see citing works
Prolonged sleep fragmentation of mice exacerbates febrile responses to lipopolysaccharide
Ringgold, K. M., Barf, R. P., George, A. M., Sutton, B. C., & Opp, M. R. (2013) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2013.07.008 · Cited by 36 · see citing works
Self-citationImeri, L., Bianchi, S., & Opp, M. R. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00828.2005 · Cited by 36 · see citing works
Self-citationSleep and Psychoneuroimmunology
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Self-citationNeu, D., Cappeliez, B., Hoffmann, G., Verbanck, P., Linkowski, P., & Bon, O. L. (2009) · Journal of Clinical Neurophysiology · doi:10.1097/wnp.0b013e3181a1841b · Cited by 32 · see citing works
Opp, M. R., Jan Born, A., & Irwin, M. R. (2007) · Elsevier eBooks · doi:10.1016/b978-012088576-3/50034-4 · Cited by 29 · see citing works
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Self-citationNon-REM sleep EEG power distribution in fatigue and sleepiness
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Chen, L., Taishi, P., Majde, J. A., Peterfi, Z., Obál, F., & Krueger, J. M. (2004) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2003.12.002 · Cited by 26 · see citing works
Sleep enhances numbers and function of monocytes and improves bacterial infection outcome in mice
Hahn, J. K., Günter, M., Schuhmacher, J., Bieber, K., Pöschel, S., Schütz, M., Engelhardt, B., Oster, H., Sina, C., Lange, T., et al. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.01.001 · Cited by 23 · see citing works
Ischemic stroke selectively inhibits REM sleep of rats
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Paradoxical NREMS Distribution in “Pure” Chronic Fatigue Patients
Bon, O. L., Neu, D., Valente, F., & Linkowski, P. (2007) · Journal of Chronic Fatigue Syndrome · doi:10.1300/j092v14n02_05 · Cited by 15 · see citing works
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Sleep and the Control of Visceral Functions
Pigarev, I. N., & Pigareva, M. L. (2012) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-012-9661-4 · Cited by 12 · see citing works
Zamani, A. S., Hashim, A. H. A., Akhtar, M. M., Samdani, F., Siddiqui, A. T., Alluhayb, A., Hamza, M. A., & Ahmad, N. (2023) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2023.102927 · Cited by 11 · see citing works
Kundi, F. C. S., Özcan, K. M., Okudan, B., Coskun, N., İnan, M. A., & Özcan, M. (2020) · Journal of Sleep Research · doi:10.1111/jsr.13065 · Cited by 11 · see citing works
Riha, R. L. (2006) · Somnologie - Schlafforschung und Schlafmedizin · doi:10.1111/j.1439-054x.2006.00092.x · Cited by 11 · see citing works
Farhadnejad, H., Sadat, S., Jahromi, M. K., Teymoori, F., Tehrani, A. N., Mokhtari, E., Teymouri, H., & Mirmiran, P. (2023) · BMC Nutrition · doi:10.1186/s40795-023-00689-x · Cited by 9 · see citing works
Wang, Z., Xu, J., & Du, W. (2024) · Environmental Science and Ecotechnology · doi:10.1016/j.ese.2024.100437 · Cited by 8 · see citing works
Dauvilliers, Y. A., & Billiard, M. M. (2006) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2005.11.007 · Cited by 8 · see citing works
Rama, A. N., Cho, S. C., & Kushida, C. A. (2005) · Handbook of clinical neurophysiology · doi:10.1016/s1567-4231(09)70027-9 · Cited by 8 · see citing works
Insomnia as a Risk Factor in Disease
Pigeon, W. R. (2010) · Medical psychiatry · doi:10.3109/9781420080803.004 · Cited by 7 · see citing works
Pigarev, I. N., & Pigareva, M. L. (2017) · Journal of Integrative Neuroscience · doi:10.3233/jin-170005 · Cited by 6 · see citing works
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Cordone, S., Alfonsi, V., & Gennaro, L. D. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103902 · Cited by 5 · see citing works
An automatic estimation of the rest-interval for MotionWatch8© using uniaxial movement and lux data
Backhouse, D., Falck, R. S., & Liu-Ambrose, T. Y. L. (2020) · Sleep Science and Practice · doi:10.1186/s41606-020-00051-1 · Cited by 4 · see citing works
Psychoneuroimmunology of Fatigue and Sleep Disturbance: The Role of Pro-inflammatory Cytokines
Jain, S., Bower, J. E., & Irwin, M. R. (2012) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780195394399.013.0018 · Cited by 4 · see citing works
Perryman, J. I. (2011) · Deep Blue (University of Michigan) · Cited by 4 · see citing works
Sleep Disturbances and Glucose Homeostasis
Barf, R. P., Scheurink, A. J. W., & Student, P. (2010) · touchREVIEWS in Endocrinology · doi:10.17925/ee.2011.07.01.14 · Cited by 3 · see citing works
Moorcroft, W. H. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6467-9_6 · Cited by 2 · see citing works
Reciprocal Relationship Between Sleep and the Immune Response: A Survey
Velázquez‐Moctezuma, J., Esqueda-León, E., & Ibarra‐Coronado, E. (2010) · The Open Neuroendocrinology Journal · Cited by 2 · see citing works
Mechanisms linking sleep, innate immunity, and neuroinflammation
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Self-citationGorczynski, L. Y., Terzıoğlu, E., Waelli, T., & Gorczynski, R. M. (2007) · Springer eBooks · doi:10.1007/978-0-387-69146-6_7 · Cited by 1 · see citing works
Walker, A. K., Dantzer, R., & Kelley, K. W. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4729-0_6 · Cited by 1 · see citing works
Insomnia as a Risk Factor in Disease
Pigeon, W. R. (2016) · doi:10.3109/9781420080803-6 · Cited by 1 · see citing works
Cytokines and Sleep: Neuro-Immune Interactions and Regulations
Kushikata, T., Yoshida, H., & Yasuda, T. (2007) · Springer eBooks · doi:10.1007/978-0-387-69146-6_8 · Cited by 1 · see citing works
Sleep and immune health: How dogs, goats and ‘factor S’ shaped a field
Opp, M. R., & Imeri, L. (2025) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2025.100118 · Cited by 1 · see citing works
Self-citationSignificance of Good Sleep Quality and Interventions for the Improvement
Singh, A. P., Appukuttan, R., Rana, S., Dwivedi, R., Panwar, S., Kumar, S., Poddar, P., & Tripathi, M. (2023) · Sleep and Vigilance · doi:10.1007/s41782-023-00227-6 · Cited by 1 · see citing works
Sutton, B. C. (2013) · Deep Blue (University of Michigan)
Anatomical Networks: Structure and Function of the Nervous System
Masliah, E. (2008) · Springer eBooks · doi:10.1007/978-0-387-72573-4_3
Sleep Diary Approach of Sleep-Wake Cycle Disturbances in Cholera
Moukassa, D., & Buguet, A. (2015) · Archives of Medicine
Porkka‐Heiskanen, T., Alanko, L., & Stenberg, D. (2006) · Springer eBooks · doi:10.1007/978-0-387-30405-2_24
Sleep and its disorders: basic science
Opp, M. R., & Imeri, L. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511780868.020
Self-citationInnate and Cell-Mediated Immunity
Dhabhar, F. S. (2007)
Anatomical Networks: Structure and Function of the Nervous System
Masliah, E. (2016) · Springer eBooks · doi:10.1007/978-3-319-44022-4_7
Backhouse, D., Falck, R. S., & Liu-Ambrose, T. Y. L. (2020) · Figshare · doi:10.6084/m9.figshare.13279556
Backhouse, D., Falck, R. S., & Liu-Ambrose, T. Y. L. (2020) · Figshare · doi:10.6084/m9.figshare.13279562
Backhouse, D., Falck, R. S., & Liu-Ambrose, T. Y. L. (2020) · Figshare · doi:10.6084/m9.figshare.13279559
- Authors
- Opp, M. R.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Opp, Mark R
- ORCID
- Opp, Mark R
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 2003
- Volume
- 8
- Issue
- 4
- Pages
- d768-779
- ISSN
- 1093-4715 (ISSN-L)
- 1093-9946
- DOI
- 10.2741/1061
- OpenAlex
- W1596295539
- Cited by
- 92
- References
- 123
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 1 · 2020: 7 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 4
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Frontiers in bioscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns040220-09, 5r01rr016421-04)
- National Heart, Lung, and Blood Institute (HL-70522, R01HL070522)
- National Institute of Mental Health (MH-64843)
- National Institute of Neurological Disorders and Stroke (NS-40220)
- National Center for Research Resources (RR16421)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- sleep-immune interaction, sleep regulation, infection, sleep deprivation, immune response
- MeSH terms
- Animals, Humans, Immune System, Nervous System, Nervous System Physiological Phenomena, Sleep
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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