Membrane-Initiated Actions of Estrogens in Neuroendocrinology: Emerging Principles

A transmembrane intracellular estrogen receptor mediates rapid cell signaling

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Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase

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Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones*

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Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase

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Identity of an Estrogen Membrane Receptor Coupled to a G Protein in Human Breast Cancer Cells

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Mechanisms of Estrogen Receptor Signaling: Convergence of Genomic and Nongenomic Actions on Target Genes

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Cell Membrane and Nuclear Estrogen Receptors (ERs) Originate from a Single Transcript: Studies of ERα and ERβ Expressed in Chinese Hamster Ovary Cells

Razandi, M., Pedram, A., Greene, G. L., & Levin, E. R. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.2.0239 · Cited by 1,046 · see citing works

Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation.

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Estrogen receptor α mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen

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Phosphatidylinositol 3-Kinase/AKT-mediated Activation of Estrogen Receptor α

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Virtual and biomolecular screening converge on a selective agonist for GPR30

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Akt/Protein Kinase B Up-regulates Bcl-2 Expression through cAMP-response Element-binding Protein

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Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes

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Gender-Linked Brain Injury in Experimental Stroke

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Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor

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Integration of the extranuclear and nuclear actions of estrogen

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Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes.

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Rapid actions of plasma membrane estrogen receptors

Kelly, M. J., & Levin, E. R. (2001) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(01)00377-0 · Cited by 643 · see citing works

Untitled work

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Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones

Pratt, W. B. (1997) · Endocrine Reviews · doi:10.1210/er.18.3.306 · Cited by 641 · see citing works

Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor

Mermelstein, P. G., Becker, J., & Surmeier, D. J. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-02-00595.1996 · Cited by 633 · see citing works

Membrane Estrogen Receptor Engagement Activates Endothelial Nitric Oxide Synthase via the PI3-Kinase–Akt Pathway in Human Endothelial Cells

Haynes, M. P., Sinha, D., Russell, K. S., Collinge, M., Fulton, D. J., Morales‐Ruiz, M., Sessa, W. C., & Bender, J. R. (2000) · Circulation Research · doi:10.1161/01.res.87.8.677 · Cited by 576 · see citing works

Estrogen Modulation of Endothelial Nitric Oxide Synthase

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Identification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factor.

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Estradiol Protects against Ischemic Injury

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ER-X: A Novel, Plasma Membrane-Associated, Putative Estrogen Receptor That Is Regulated during Development and after Ischemic Brain Injury

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Drug Transporters in the Central Nervous System: Brain Barriers and Brain Parenchyma Considerations

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Neurotrophic and Neuroprotective Actions of Estrogens and Their Therapeutic Implications

Lee, S. H., & McEwen, B. S. (2001) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.569 · Cited by 533 · see citing works

Nature of Functional Estrogen Receptors at the Plasma Membrane

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Ligand-independent recruitment of SRC-1 to estrogen receptor beta through phosphorylation of activation function AF-1.

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Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat

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Estradiol Increases Dendritic Spine Density by Reducing GABA Neurotransmission in Hippocampal Neurons

Murphy, D., Cole, N., Greenberger, V., & Segal, M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02550.1998 · Cited by 506 · see citing works

Rapid Membrane Effects of Steroids in Neuroblastoma Cells: Effects of Estrogen on Mitogen Activated Protein Kinase Signalling Cascade and c-fos Immediate Early Gene Transcription

Watters, J. J., Campbell, J. S., Cunningham, M. J., Krebs, E. G., & Dorsa, D. M. (1997) · Endocrinology · doi:10.1210/endo.138.9.5489 · Cited by 490 · see citing works

Estrogen receptor phosphorylation.

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Estrogen receptor interaction with co-activators and co-repressors☆

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PI3‐kinase in concert with Src promotes the S‐phase entry of oestradiol‐stimulated MCF‐7 cells

Castoria, G., Migliaccio, A., Bilancio, A., Domenico, M. D., de Falco, A., Lombardi, M., Fiorentino, R., Varricchio, L., Barone, M. V., & Auricchio, F. (2001) · The EMBO Journal · doi:10.1093/emboj/20.21.6050 · Cited by 469 · see citing works

Estrogen-Induced Activation of Mitogen-Activated Protein Kinase in Cerebral Cortical Explants: Convergence of Estrogen and Neurotrophin Signaling Pathways

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Rapid Signaling of Estrogen in Hypothalamic Neurons Involves a Novel G-Protein-Coupled Estrogen Receptor that Activates Protein Kinase C

Qiu, J., Bosch, M. A., Tobias, S. C., Grandy, D. K., Scanlan, T. S., Rønnekleiv, O. K., & Kelly, M. J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-29-09529.2003 · Cited by 460 · see citing works

Regulation of Dendritic Spine Density in Cultured Rat Hippocampal Neurons by Steroid Hormones

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Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity.

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CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior

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Palmitoylation-dependent Estrogen Receptor α Membrane Localization: Regulation by 17β-Estradiol

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Stimulation of estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insulin-like growth factor-I.

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AIB1 Is a Conduit for Kinase-Mediated Growth Factor Signaling to the Estrogen Receptor

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Estrogen Receptor α and Endothelial Nitric Oxide Synthase Are Organized Into a Functional Signaling Module in Caveolae

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Linkage of Rapid Estrogen Action to MAPK Activation by ERα-Shc Association and Shc Pathway Activation

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Adenosine 3',5'-monophosphate in rat uterus: acute elevation by estrogen.

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ERs Associate with and Regulate the Production of Caveolin: Implications for Signaling and Cellular Actions

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Human vascular endothelial cells contain membrane binding sites for estradiol, which mediate rapid intracellular signaling

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Selective estrogen receptor modulators: structure, function, and clinical use.

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Oestrogen receptors – an overview

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Estradiol Activates Group I and II Metabotropic Glutamate Receptor Signaling, Leading to Opposing Influences on cAMP Response Element-Binding Protein

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Rapid Actions of Steroid Receptors in Cellular Signaling Pathways

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Nongenomic actions of estrogens and xenoestrogens by binding at a plasma membrane receptor unrelated to estrogen receptor α and estrogen receptor β

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Estrogen induction of the cyclin D1 promoter: Involvement of a cAMP response-like element

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Estrogen-Mediated Neuroprotection After Experimental Stroke in Male Rats

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Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K.

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17β-Estradiol Potentiates Kainate-Induced Currents via Activation of the cAMP Cascade

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pp90rsk1 Regulates Estrogen Receptor-Mediated Transcription through Phosphorylation of Ser-167

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Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium

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Neuroprotective Effects of Female Gonadal Steroids in Reproductively Senescent Female Rats

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Plasma Membrane Estrogen Receptors Exist and Functions as Dimers

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Identification of a Structural Determinant Necessary for the Localization and Function of Estrogen Receptor α at the Plasma Membrane

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Combined Targeting of the Estrogen Receptor and the Epidermal Growth Factor Receptor in Non–Small Cell Lung Cancer Shows Enhanced Antiproliferative Effects

Stabile, L. P., Lyker, J. S., Gubish, C. T., Zhang, W., Grandis, J. R., & Siegfried, J. M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-1872 · Cited by 307 · see citing works

Crosstalk between steroid receptors and the c-Src-receptor tyrosine kinase pathways: implications for cell proliferation

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Selective Phosphorylations of the SRC-3/AIB1 Coactivator Integrate Genomic Reponses to Multiple Cellular Signaling Pathways

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Enhanced Estrogen Receptor (ER) α, ERBB2, and MAPK Signal Transduction Pathways Operate during the Adaptation of MCF-7 Cells to Long Term Estrogen Deprivation

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Activation of Estrogen Receptor α by S118 Phosphorylation Involves a Ligand-Dependent Interaction with TFIIH and Participation of CDK7

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Proteasome-Mediated Proteolysis of Estrogen Receptor: A Novel Component in Autologous Down-Regulation

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Integration of the Non-genomic and Genomic Actions of Estrogen

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Morphological plasticity of dendritic spines in central neurons is mediated by activation of cAMP response element binding protein

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Plasma Membrane Estrogen Receptors Are Coupled to Endothelial Nitric-oxide Synthase through Gαi

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Hippocampal Excitability Increases during the Estrous Cycle in the Rat: A Potential Role for Brain-Derived Neurotrophic Factor

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ERβ Has Nongenomic Action in Caveolae

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Phosphorylation of Human Estrogen Receptor α by Protein Kinase A Regulates Dimerization

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Neural Mechanisms of Female Reproductive Behavior

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Estradiol upregulates Bcl-2 expression in adult brain neurons

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Estrogen Dendrimer Conjugates that Preferentially Activate Extranuclear, Nongenomic Versus Genomic Pathways of Estrogen Action

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Gonadal hormone modulation of dendrites in the mammalian CNS

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8-Bromo-Cyclic AMP Induces Phosphorylation of Two Sites in SRC-1 That Facilitate Ligand-Independent Activation of the Chicken Progesterone Receptor and Are Critical for Functional Cooperation between SRC-1 and CREB Binding Protein

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Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons

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Auditory thalamocortical projections in the cat: Laminar and areal patterns of input

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A Role for Akt in Mediating the Estrogenic Functions of Epidermal Growth Factor and Insulin-Like Growth Factor I1

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Plasma Membrane Estrogen Receptors Signal to Antiapoptosis in Breast Cancer

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Rapid effects of estrogen to modulate G protein-coupled receptors via activation of protein kinase A and protein kinase C pathways

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17β-estradiol induced Ca2+ influx via L-type calcium channels activates the Src/ERK/cyclic-AMP response element binding protein signal pathway and BCL-2 expression in rat hippocampal neurons: A potential initiation mechanism for estrogen-induced neuroprotection

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Molecular mechanism of endocrine-disruptive effects induced by Bisphenol A: The role of transmembrane G-protein estrogen receptor 1 and integrin αvβ3

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Hippocampal cytosolic estrogen receptors regulate fear generalization in females

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Estrogen Receptor β as a Prognostic Marker of Tumor Progression in Colorectal Cancer with Familial Adenomatous Polyposis and Sporadic Polyps

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Hippocampal dynorphin immunoreactivity increases in response to gonadal steroids and is positioned for direct modulation by ovarian steroid receptors

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Hormone Effects on Specific and Global Brain Functions

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Rapid Regulation of Brain Oestrogen Synthesis: The Behavioural Roles of Oestrogens and their Fates

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Hormones and the Development and Expression of Aggressive Behavior

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Estrogens and thyroid hormone: Non-genomic effects are coupled to transcription.

Zhao, X., Pfaff, D. W., & Vasudevan, N. (2005) · CentAUR (University of Reading)

Estrogens and Thyroid Hormones: Non-Genomic Effects are Coupled to Transcription

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