The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Neuropsychiatric Manifestations in Mild Cognitive Impairment: A Systematic Review of the Literature
Abstract
Background: Mild cognitive impairment (MCI) is an etiologically heterogeneous condition that is characterized by cognitive changes without impairment of activities of daily living and insufficient to represent dementia. MCI is an important risk state for dementia. Neuropsychiatric symptoms may be present in MCI. Methods: We executed a PubMed search for articles on the neuropsychiatric manifestations in MCI and reviewed their findings. Results: Behavioral abnormalities are reported in 35–75% of MCI patients with the most common being depression, apathy, anxiety and irritability. The observed variability in symptom prevalence can be explained by the different sampling methods, MCI diagnostic criteria and behavioral instruments used. There is a compelling body of evidence that MCI patients with behavioral features are more prone to develop Alzheimer’s disease (AD) than patients without these features. Conclusions: Neuropsychiatric symptoms are common features of MCI. The behavioral changes observed in MCI are similar to those of AD and may help identify the subgroup of MCI patients with prodromal AD. Large prospective longitudinal studies would greatly contribute to our understanding of the epidemiology, diagnostic and prognostic value of the neuropsychiatric features in MCI.
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Cited by
Dementia prevention, intervention, and care
Livingston, G., Sommerlad, A., Orgeta, V., Costafreda, S. G., Huntley, J., Ames, D., Ballard, C., Banerjee, S., Burns, A., Cohen-Mansfield, J., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31363-6 · Cited by 6,072
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“…from as low as 2% to as high as 85% (variability likely due to methods of assessment, diagnostic criteria, stage of AD participants, and other factors) (Mendez et al., 1990; Burns et al., 1990a; Migliorelli et al., 1995a,b; Devanand et al., 1996; Cummings, 2000; Apostolova and Cummings, 2008).”
BackgroundCooper, C., Sommerlad, A., Lyketsos, C. G., & Livingston, G. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14070878 · Cited by 570
Ismail, Z., Elbayoumi, H., Fischer, C. E., Hogan, D. B., Millikin, C. P., Schweizer, T., Mortby, M. E., Smith, E. E., Patten, S. B., & Fiest, K. M. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.3162 · Cited by 532
EFNS guidelines for the diagnosis and management of Alzheimer's disease
Hort, J., O’Brien, J. T., Gainotti, G., Pirttila, T., Popescu, B. O., Rektorova, I., Sorbi, S., Scheltens, P., & Dementia, O. B. O. T. E. S. P. O. (2010) · European Journal of Neurology · doi:10.1111/j.1468-1331.2010.03040.x · Cited by 490
Metadata
- Authors
- Apostolova, L. G., & Cummings, J. L.
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2007-12-14
- Volume
- 25
- Issue
- 2
- Pages
- 115-126
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- OpenAlex
- W2043297459
- Cited by
- 391
- References
- 47
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- closed
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