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Cited by 532Dementia and Cognitive Impairment ResearchMental Health Treatment and AccessAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Prevalence of Depression in Patients With Mild Cognitive Impairment: A Systematic Review and Meta-analysis

Ismail, Zahinoor, Elbayoumi, Heba, Fischer, Corinne E., Hogan, David B., Millikin, Colleen P., Schweizer, Tom, Mortby, Moyra E., Smith, Eric E. +2 more·2017·JAMA Psychiatry
DOI 10.1001/jamapsychiatry.2016.3162
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Abstract

Importance Depression is common in individuals with mild cognitive impairment (MCI) and may confer a higher likelihood of progression to dementia. Prevalence estimates of depression in those with MCI are required to guide both clinical decisions and public health policy, but published results are variable and lack precision. Objective To provide a precise estimate of the prevalence of depression in individuals with MCI and identify reasons for heterogeneity in the reported results. Data sources A search of literature from database inception to March 2016 was performed using Medline, Embase, and PsycINFO. Hand searching of all included articles was performed, including a Google Scholar search of citations of included articles. Study selection Articles were included if they (1) were published in English, (2) reported patients with MCI as a primary study group, (3) reported depression or depressive symptoms using a validated instrument, and (4) reported the prevalence of depression in patients with MCI. Data extraction and synthesis All abstracts, full-text articles, and other sources were reviewed, with data extracted in duplicate. The overall prevalence of depression in patients with MCI was pooled using a random-effects model. Heterogeneity was explored using stratification and random-effects meta-regression. Main outcomes and measures The prevalence of depression in patients with MCI, reported as a percentage with 95% CIs. Estimates were also stratified by population source…

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  • Depressive symptoms may be direct manifestations of AD pathophysiology at the preclinical stage, prior to the onset of mild cognitive impairment.

    “Depressive symptoms may be direct manifestations of AD pathophysiology at the preclinical stage, prior to the onset of mild cognitive impairment [37–39].”

    From APOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline (2021) · cites this paper as [39]

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Authors
Ismail, Z., Elbayoumi, H., Fischer, C. E., Hogan, D. B., Millikin, C. P., Schweizer, T., Mortby, M. E., Smith, E. E., Patten, S. B., & Fiest, K. M.
Affiliations
  • University of Calgary (CA)
  • St. Michael's Hospital (CA)
  • University of Manitoba (CA)
  • Australian National University (AU)
Corresponding author
Ismail, Zahinoor
ORCID
Venue
JAMA Psychiatry
Publisher
American Medical Association (AMA)
Published
2017-01-01
Volume
74
Issue
1
Pages
58
ISSN
2168-622X (ISSN-L)
DOI
10.1001/jamapsychiatry.2016.3162
OpenAlex
W2552864116
Cited by
532
References
13
Citations by year
2026: 61 · 2025: 70 · 2024: 70 · 2023: 69 · 2022: 73 · 2021: 70 · 2020: 38 · 2019: 43 · 2018: 21 · 2017: 17
FWCI
20.63
Type
journal article
Language
en
Open access
closed
Locations
  • JAMA Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • ANU Open Research (Australian National University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
mild cognitive impairment, depression, prevalence, dementia risk, informant-based assessment, depressive symptoms, pooled prevalence estimates
MeSH terms
Cross-Sectional Studies, Depressive Disorder, Humans, Comorbidity, Cognitive Dysfunction

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