Light Treatment in Depressive Illness
Abstract
Objective and subjective quality of sleep and awakening as well as circadian rhythms in Cortisol, temperature and well-being were investigated in 10 female hospitalized depressed patients diagnosed as major depressive disorders according to RDC criteria before (baseline), during (intervention) and after (recovery) treatment with biologically active or bright light (BL) and were compared with the findings in 10 normals. Polysomnographic evaluation demonstrated in depressed patients an increased sleep latency, decreased total sleep time, attenuated S4 and augmented REM sleep, as well as a shortened REM latency and a statistically significant increased average REM length as compared with normals. BL tended to shorten sleep onset, decrease number of awakenings, increase REM latency and significantly attenuated the average REM length. Subjective sleep quality tended to improve as did the subjective awakening quality after the recovery night. There was, however, a statistically significant improvement of the objetively evaluated quality of awakening and early morning behavior characterized by an improved attention, reaction time and performance in the reaction time task, while concentration and psychomotor activity tended to improve as well. BL effects were also seen in hormonal secretion patterns: circadian Cortisol secretion maxima occurred earlier in depressed patients than in normals before and after BL treatment, while during BL intervention this difference disappeared. Circadian temperature rhythms did not exhibit any significant findings with the exception of an earlier occurring minimum in depressed patients than in normals after treatment. Finally, subjective well-being as rated by means of an analogue scale was significally worse in depressed patients than normals before but not during and after light treatment. The findings are discussed.
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Depression is related to disturbances of the circadian clock.
“Depression is related to disturbances of the circadian clock, and light therapy and other treatment affecting the circadian clock are used as a therapy for depression 83, 88, 89, 90, 91, 92, 93, 94, 95, 96.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [89]
Light therapy and other treatments affecting the circadian clock are used as a therapy for depression.
“Depression is related to disturbances of the circadian clock, and light therapy and other treatment affecting the circadian clock are used as a therapy for depression 83, 88, 89, 90, 91, 92, 93, 94, 95, 96.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [89]
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- Authors
- Dietzel, M., Saletu, B., Lesch, O. M., Sieghart, W., & Schjerve, M.
- ORCID
- Sieghart, W.
- Venue
- European Neurology
- Publisher
- S. Karger AG
- Published
- 2008-02-05
- Volume
- 25 Suppl 2
- Pages
- 93-103
- ISSN
- 0014-3022 (ISSN-L)
- 1421-9913
- OpenAlex
- W2077906219
- Cited by
- 64
- References
- 0
- Citations by year
- 2023: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2017: 1 · 2015: 1 · 2013: 2 · 2012: 1
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- bright light therapy, major depressive disorder, sleep quality, REM sleep, sleep latency, circadian temperature rhythm, subjective well-being, female patients
- MeSH terms
- Adult, Body Temperature, Circadian Rhythm, Depression, Electroencephalography, Female, Humans, Hydrocortisone, Middle Aged, Phototherapy, Sleep Stages, Wakefulness
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