Cited by 304Neuroendocrine regulation and behaviorStress Responses and CortisolNeuropeptides and Animal Physiology

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Oxytocin unlike vasopressin is a stress hormone in the rat.

Lang, Rudolf E., Heil, Jürgen W.E., Ganten, Detlev, Hermann, Klaus, Unger, Thomas, Rascher, Wolfgang·2008·Neuroendocrinology

DOI 10.1159/000123566

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Abstract

The functions of oxytocin in the female are thought to be confined to the processes of milk ejection and parturition. In this study the role of oxytocin in the body's response to stressful stimuli has been examined. Physical immobilization of rats and forced swimming caused large increases in the secretion of the hormone, whereas vasopressin levels remained unchanged. These findings classify oxytocin, in contrast to vasopressin, as a so-called 'stress hormone' and suggest its importance in processes other than those related to reproduction.

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“Anxiogenic and stressful stimuli activate the body’s OT system, which is reflected by increased electrophysiological, synthetic and secretory activity of OT neurons (Lang et al. 1983; for a review, see Engelmann et al. 2004).”
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“reports in the literature that suggest OT is a stressresponsive hormone released within the PVN (Lang et al., 1983; Callahan et al., 1992; Jezova et al., 1993; Morris et al., 1995; Nishioka et al., 1998; Wotjak et al., 1998).”
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“by certain stressful factor(s) inherent in the dehydration paradigms presently used because both OT and CRH are known as stress hormones (Vale et al., 1981; Lang et al., 1983; Gibbs, 1984).”
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RESPONSES OF NEUROHYPOPHYSIAL PEPTIDES TO HYPERTONIC SALINE AND INSULIN‐INDUCED HYPOGLYCAEMIA IN MAN
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Authors: Lang, R. E., Heil, J. W. E., Ganten, D., Hermann, K., Unger, T., & Rascher, W.
Affiliations: Heidelberg University (DE)
ORCID: Unger, Thomas
Rascher, Wolfgang
Venue: Neuroendocrinology
Publisher: S. Karger AG
Published: 2008-03-27
Volume: 37
Issue: 4
Pages: 314-316
ISSN: 0028-3835 (ISSN-L)
1423-0194
DOI: 10.1159/000123566
OpenAlex: W2072568231
Cited by: 304
References: 0
Citations by year: 2025: 3 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 7 · 2018: 10 · 2017: 6 · 2016: 8 · 2015: 5 · 2014: 4 · 2013: 6 · 2012: 4
FWCI: 8.45
Type: journal article
Language: en
Open access: closed
Licence: karger.com/pages/terms-and-conditions (vor)
karger.com/pages/terms-and-conditions (tdm)
Locations: Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin, vasopressin, stress hormones, stress response, restraint stress, forced swim test, hormone secretion
MeSH terms: Animals, Cold Temperature, Physical Exertion, Female, Immobilization, Male, Oxytocin, Rats, Inbred Strains, Stress, Physiological, Vasopressins, Rats

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Oxytocin unlike vasopressin is a stress hormone in the rat.

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