Cited by 304Neuroendocrine regulation and behaviorStress Responses and CortisolNeuropeptides and Animal Physiology

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Oxytocin unlike vasopressin is a stress hormone in the rat.

Lang, Rudolf E., Heil, Jürgen W.E., Ganten, Detlev, Hermann, Klaus, Unger, Thomas, Rascher, Wolfgang·2008·Neuroendocrinology

DOI 10.1159/000123566

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Abstract

The functions of oxytocin in the female are thought to be confined to the processes of milk ejection and parturition. In this study the role of oxytocin in the body's response to stressful stimuli has been examined. Physical immobilization of rats and forced swimming caused large increases in the secretion of the hormone, whereas vasopressin levels remained unchanged. These findings classify oxytocin, in contrast to vasopressin, as a so-called 'stress hormone' and suggest its importance in processes other than those related to reproduction.

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Keck, M. E., Hatzinger, M., Wotjak, C. T., Landgraf, R., Holsboer, F., & Neumann, I. D. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00030.x · Cited by 79
Oxytocin Enhancement of Emotional Empathy: Generalization Across Cultures and Effects on Amygdala Activity
Geng, Y., Zhao, W., Zhou, F., Ma, X., Yao, S., Hurlemann, R., Becker, B., & Kendrick, K. M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00512 · Cited by 78
Differential effects of naloxone on neuroendocrine responses to fear-related emotional stress
Onaka, T., & Yagi, K. (1990) · Experimental Brain Research · doi:10.1007/bf00230100 · Cited by 77
Oxytocin, Vasoactive-Intestinal Peptide, and Serotonin Regulate the Mating-Induced Surges of Prolactin Secretion in the Rat*
Arey, B. J., & Freeman, M. E. (1990) · Endocrinology · doi:10.1210/endo-126-1-279 · Cited by 77
Stress-induced negative mood moderates the relation between oxytocin administration and trust: Evidence for the tend-and-befriend response to stress?
Cardoso, C., Ellenbogen, M. A., Serravalle, L., & Linnen, A. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.05.006 · Cited by 76
“Oxytocin has long been described as a stress hormone, with increased release into the blood in humans and animals through the posterior pituitary gland (Lang et al., 1983) and actions as a neuromodulator in distinct brain regions in response to emotional”
Background
Hypothalamic vasopressin systems are more sensitive to the long term effects of social defeat in males versus females
Steinman, M. Q., Laredo, S. A., Lopez, E. M., Manning, C. E., Hao, R. C., Doig, I. E., Campi, K. L., Flowers, A. E., Knight, J. K., & Trainor, B. C. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.09.009 · Cited by 73
“Furthermore, in rats plasma AVP is not elevated by immobilization or forced swim (Lang et al., 1983), suggesting that elevated levels of plasma AVP in male California mice were not due to exposure to the novel arena used for social interaction testing.”
Background
Neonatal manipulation of oxytocin affects expression of estrogen receptor alpha
Yamamoto, Y., Carter, C. S., & Cushing, B. S. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.065 · Cited by 70
“Factors that could affect endogenous OT include stress (Lang et al., 1983; Englemann et al., 1999), maternal/offspring interaction (Francis et al., 2002), and treatment with drugs such as Pitocin, a synthetic OT, used for labor induction/enhancement (Malek et al., 1996) or Atosiban, an OTA, used to…”
Forced swimming-induced oxytocin release into blood and brain: Effects of adrenalectomy and corticosterone treatment
Torner, L., Plotsky, P. M., Neumann, I. D., & A, T. R. D. J. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.12.006 · Cited by 73
Enhanced Up‐Regulation of Corticotropin‐Releasing Hormone Gene Expression in Response to Restraint Stress in the Hypothalamic Paraventricular Nucleus of Oxytocin Gene‐Deficient Male Mice
Nomura, M., Saito, J., Ueta, Y., Muglia, L. J., Pfaff, D. W., & Ogawa, S. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.01095.x · Cited by 69
Chronic variable stress alters hypothalamic–pituitary–adrenal axis function in the female mouse
Borrow, A. P., Heck, A. L., Miller, A. M., Sheng, J. A., Stover, S. A., Daniels, R. M., Bales, N. J., Fleury, T. K., & Handa, R. J. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112613 · Cited by 68
“Although restraint stress has been shown to induce activation of PVN OT neurons [58], OT mRNA [44] and OT secretion [59] in male rats, we also observed no effect of restraint stress on OT mRNA in control animals in our studies.”
Result
Sex differences in hormonal responses to social conflict in the monogamous California mouse
Trainor, B. C., Takahashi, E. Y., Silva, A. L., Crean, K. K., & Hostetler, C. M. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.04.008 · Cited by 66
“Oxytocin is released peripherally under a number of stressful contexts including forced swim (Wotjak et al. 1998) and restraint (Lang et al. 1983).”
Background
The cardiovascular effects of oxytocin in conscious male rats
Petty, M. A., Lang, R. E., Unger, T., & Ganten, D. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90497-2 · Cited by 65
Self-citation
Serotonergic involvement in stress-induced vasopressin and oxytocin secretion
Jorgensen, H., Knigge, U., Kjær, A., & Warberg, J. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1470815 · Cited by 66
“Cold-swim stress stimulated OT but not AVP secretion, which is in agreement with previous observations ( 6 , 59).”
Result
Release of vasopressin within the brain contributes to neuroendocrine and behavioral regulation
Landgraf, R., Wotjak, C. T., Neumann, I. D., & Engelmann, M. (1999) · Progress in brain research · doi:10.1016/s0079-6123(08)61571-x · Cited by 66
Prepartal chronic stress increases anxiety and decreases aggression in lactating female mice.
Maestripieri, D., Badiani, A., & Puglisi‐Allegra, S. (1991) · Behavioral Neuroscience · doi:10.1037/0735-7044.105.5.663 · Cited by 65
Expression of Corticotropin-Releasing Hormone Type 1 Receptor in Paraventricular Nucleus after Acute Stress
Imaki, T., Katsumata, H., Miyata, M., Naruse, M., Imaki, J., & Minami, S. (2001) · Neuroendocrinology · doi:10.1159/000054646 · Cited by 64
“Thus, vasopressin gene expression in parvocellular as well as magnocellular neurons is increased in response to stress. Our observation that stress induced the expression of c- fos mRNA in a subset of the vasopressin neurons of the PVN further supports the role of vasopressin in the stress response. Stress-induced exp…”
Background
Oxytocin-induced inhibition of feeding and drinking: No sexual dimorphism in rats
Benelli, A., Bertolini, A., & Arletti, R. (1991) · Neuropeptides · doi:10.1016/0143-4179(91)90040-p · Cited by 61
Distribution of preproadrenomedullin mRNA in the rat central nervous system and its modulation by physiological stressors
Shan, J., & Krukoff, T. L. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1090 · Cited by 62
“Our data also suggest that ADM may affect oxytocin production in, or release from, magnocellular neurons, as oxytocin is released into the plasma in response to psychological stressors (Lang et al., 1983; Jezova et al., 1995; Hashiguchi et al., 1997; Nishioka et al., 1998).”
Method
Temporal changes of c-fos expression in oxytocinergic magnocellular neuroendocrine cells of the rat hypothalamus with restraint stress
Miyata, S., Itoh, T., Lin, S., Ishiyama, M., Nakashima, T., & Kiyohara, T. (1995) · Brain Research Bulletin · doi:10.1016/0361-9230(95)00017-8 · Cited by 62
Oxytocin at physiological concentrations evokes adrenocorticotropin (ACTH) release from corticotrophs by increasing intracellular free calcium mobilized mainly from intracellular stores. Oxytocin displays synergistic or additive effects on ACTH-releasing factor or arginine vasopressin-induced ACTH secretion, respectively
Link, H., Dayanithi, G., Föhr, K. J., & Gratzl, M. (1992) · Endocrinology · doi:10.1210/endo.130.4.1312449 · Cited by 61
Vasopressin from hypothalamic magnocellular neurons has opposite actions at the adenohypophysis and in the supraoptic nucleus on ACTH secretion
Wotjak, C. T., Ludwig, M., Ebner, K., Russell, J. A., Singewald, N., Landgraf, R., & Engelmann, M. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02101.x · Cited by 61
“Indeed, a variety of stressors stimulate the release of OXT, but not AVP, from magnocellular neurons into the blood circulation (Lang et al., 1983; Kasting, 1988; Wotjak et al., 1998a).”
Background

Authors: Lang, R. E., Heil, J. W. E., Ganten, D., Hermann, K., Unger, T., & Rascher, W.
Affiliations: Heidelberg University (DE)
ORCID: Unger, Thomas
Rascher, Wolfgang
Venue: Neuroendocrinology
Publisher: S. Karger AG
Published: 2008-03-27
Volume: 37
Issue: 4
Pages: 314-316
ISSN: 0028-3835 (ISSN-L)
1423-0194
DOI: 10.1159/000123566
OpenAlex: W2072568231
Cited by: 304
References: 0
Citations by year: 2025: 3 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 7 · 2018: 10 · 2017: 6 · 2016: 8 · 2015: 5 · 2014: 4 · 2013: 6 · 2012: 4
FWCI: 8.45
Type: journal article
Language: en
Open access: closed
Licence: karger.com/pages/terms-and-conditions (vor)
karger.com/pages/terms-and-conditions (tdm)
Locations: Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin, vasopressin, stress hormones, stress response, restraint stress, forced swim test, hormone secretion
MeSH terms: Animals, Cold Temperature, Physical Exertion, Female, Immobilization, Male, Oxytocin, Rats, Inbred Strains, Stress, Physiological, Vasopressins, Rats

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Oxytocin unlike vasopressin is a stress hormone in the rat.

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