Magnesium and Ascorbic Acid Supplementation in Diabetes mellitus
Abstract
The effect of magnesium (Mg) and ascorbic acid (AA) supplementation on metabolic control was assessed in 56 outpatient diabetics. A 90-day run-in period was followed by two 90-day treatment periods, during which Mg (600 mg/day) and AA (2 g/day) were administered in a randomized double-blind cross-over fashion. A decrease in systolic and diastolic blood pressure (132 +/- 3 vs. 138 +/- 4 and 77 +/- 2 vs. 82 +/- 2 mm Hg; p < 0.05) was observed in insulin-dependent diabetes mellitus subjects during Mg supplementation. No beneficial effect of Mg supplementation was observed on glycemic control, lipids or blood pressure in non-insulin-dependent diabetes mellitus (NIDDM) subjects. AA supplementation improved glycemic control among NIDDM subjects and both fasting blood glucose (9.1 +/- 0.5 vs. 10.1 +/- 0.6 mmol/l; p < 0.05) and HbA1c (8.5 +/- 0.3 vs. 9.3 +/- 0.3%; p < 0.05) improved. Beneficial effects of AA supplementation on cholesterol (5.9 +/- 0.2 vs. 6.2 +/- 0.2 mmol/l; p < 0.05) and triglycerides (2.2 +/- 0.2 vs. 2.5 +/- 0.2; p < 0.05) were also observed in NIDDM subjects. The results suggest that high-dose AA supplementation may have a beneficial effect in NIDDM subjects on both glycemic control and blood lipids.
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In non-insulin-dependent diabetic patients, vitamin C (2 g/day for 90 days) improved glycemic control, HbA1c, fasting blood glucose, cholesterol, and triglycerides.
“Supplementation with vitamin C improved glycemic control in non-insulin-dependent diabetic patients as well as glycated hemoglobin (HA1c) and fasting blood glucose. In addition, supplementation with vitamin C improved the level of cholesterol and triglycerides showing the beneficial effect of vitamin C on glycemic control and lipids in non-insulin-dependent diabetic subjects.”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Eriksson and Kohvakka 1995
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Nayaka, M. R. R. (2015) · International Journal of Pharmacological Research · doi:10.7439/ijpr.v5i4.1961 · Cited by 2 · see citing works
“In a study conducted by Erriksons et al[13], Finland 2 g of vitamin C for 90 days showed significant reduction in triglyceride in type II Diabetes patients.”
MethodDiabetes Mellitus Types I and II
Murray, M. T. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-43044-9.00165-5 · Cited by 2 · see citing works
Type 2-diabetes og det metaboliske syndrom - diagnostik og behandling
Beck‐Nielsen, H., Henriksen, J. E., Hermansen, K., Madsen, L. D., Mandrup-Poulsen, T. R., Richelsen, B., & Schmitz, O. (2000) · Research at the University of Copenhagen (University of Copenhagen) · Cited by 2 · see citing works
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Study of role of vitamin C in type 2 diabetes mellitus patients
Eda, S., Motgi, S., Singh, R., et al. (2021) · International Journal of Basic & Clinical Pharmacology · doi:10.18203/2319-2003.ijbcp20214890 · Cited by 1 · see citing works
“Similarly, Eriksson et al reported that Ascorbic acid improved glycemic control, lowering both FPS and HBA1c.13 So, also Sargent et al in their prospective population-based study from 1995 to 1998 in Norfolk, UK found an inverse association between plasma vitamin C and HBA1c, and recommended dietary measures to increa…”
BackgroundVitamin D and diabetic peripheral neuropathy
Pinzon, R. T., Angela, A., Veronica, V., et al. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-89835-5.00007-7 · Cited by 1 · see citing works
Magnesium and Relationship with Diabetes
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“Currently, an association between low plasma magnesium levels and insulin resistance is observed (Mostafavi et al. 2003; Mansouri et al. 2006; Nvrsadqy et al. 2007; Eriksson and Kohvakka 1995).”
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Evaluation and analysis of the vitamin levels in the self-selected diets of senile diabetics
Huang, S.-X., Wang, Q., & Lin, X. (2002) · Journal of Zhejiang University Science · doi:10.1007/bf03396447
- Authors
- Eriksson, J., & Kohvakka, A.
- Affiliations
- City of Helsinki (FI)
- Venue
- Annals of Nutrition and Metabolism
- Publisher
- S. Karger AG
- Published
- 1995
- Volume
- 39
- Issue
- 4
- Pages
- 217-223
- ISSN
- 0250-6807 (ISSN-L)
- 1421-9697
- OpenAlex
- W2051475246
- Cited by
- 115
- References
- 0
- Citations by year
- 2026: 3 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 2 · 2018: 5 · 2017: 7 · 2016: 9 · 2015: 7 · 2014: 9 · 2013: 6 · 2012: 5
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Nutrition and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- magnesium supplementation, vitamin C supplementation, vitamin C, diabetes mellitus, type 1 diabetes, type 2 diabetes, glycemic control, HbA1c, blood pressure, serum lipids, cholesterol, triglycerides, fasting blood glucose
- MeSH terms
- Adult, Ascorbic Acid, Blood Glucose, Blood Pressure, Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Double-Blind Method, Humans, Lipids, Magnesium, Middle Aged, Cross-Over Studies
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