Does diabetes mellitus increase the requirement for vitamin C?
Abstract
This paper reviews the scientific evidence regarding the vitamin C status of people with diabetes mellitus and whether they might have increased dietary vitamin C requirements. English language articles published from 1935 to the present that either compare ascorbic acid concentrations of persons with and without diabetes mellitus or assess the impact of vitamin C supplementation on various health outcomes among persons with diabetes mellitus were examined. Most studies have found people with diabetes mellitus to have at least 30% lower circulating ascorbic acid concentrations than people without diabetes mellitus. Vitamin C supplementation had little impact on blood glucose concentrations, but was found to lower cellular sorbitol concentrations and to reduce capillary fragility. Much of the past research in this area has been methodologically weak. To further understand the relation of ascorbic acid and diabetes mellitus, randomized clinical trials of ascorbic acid supplementation should be a high priority for research.
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TNF-a infusion into rodents impairs insulin signalling in vivo.
“The impairment of insulin signalling by TNF-a has also been observed in vivo after infusion of the cytokine into rodents (133,134) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [133]
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“It also lowers accumulation of the sugar sorbitol (Will and Tyers, 1996), which can damage acid lowers blood histamine. eyes and kidneys.”
Background
- Authors
- Will, J. C., & Byers, T.
- Affiliations
- Centers for Disease Control and Prevention (US)
- University of Colorado Health (US)
- Corresponding author
- Will, Julie C.
- Venue
- Nutrition Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-04-27
- Volume
- 54
- Issue
- 7
- Pages
- 193-202
- ISSN
- 0029-6643 (ISSN-L)
- 1753-4887
- OpenAlex
- W2092774300
- Cited by
- 156
- References
- 74
- Citations by year
- 2025: 4 · 2024: 3 · 2023: 5 · 2022: 6 · 2021: 4 · 2020: 3 · 2019: 8 · 2018: 1 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 6 · 2013: 8 · 2012: 2
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
- Keywords
- diabetes mellitus, vitamin C, vitamin C supplementation, sorbitol, capillary fragility, blood glucose
- MeSH terms
- Ascorbic Acid, Diabetes Mellitus, Food, Fortified, Health Status, Humans
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