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Cited by 69Ovarian function and disordersHypothalamic control of reproductive hormonesReproductive Biology and Fertility

Menstrual Irregularities in Adolescents: Hormonal Pattern and Ovarian Morphology

Venturoli, S., Porcu, E., Fabbri, R., Paradisi, R., Ruggeri, S., Bolelli, G., Orsini, L.F., Gabbi, D. +1 more·2008·Hormone Research
DOI 10.1159/000180567
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Abstract

The endocrine pattern and ovarian characteristics of 110 healthy adolescents with menstrual irregularities were investigated during the early follicular and premenstrual phases and were compared to those of 14 adolescents with regular menstrual cycles and 20 adults.Over a period of six gynecological years a low ovulation rate (49%) was found in the group of subjects with irregular cycles and regular ovulation was noted in only a few subjects. Slight differences in endocrine pattern and ovarian morphology were observed between the group of adolescents with regular cylces and the group of adults. In contrast, adolescents with irregular menses had higher mean values of luteinizing hormone (LH), testosterone (T), and androstenedione (A) in comparison with the other two groups both in follicular and premenstrual phases. Nearly 35% of the subjects with irregular cycles had levels of T, A and LH which were higher than the upper limit of the adult normal range. Lower progesterone (P), 17P and oestradiol values were observed in the premenstrual phase. Within the group of subjects with irregular menses, LH levels were higher in anovulatory than in ovulatory cycles, in both phases of the cycle, while T and A levels were higher and prolactin levels were lower in the premenstrual phase of anovulatory cycles. Unlike irregular anovulatory cycles, irregular ovulatory cycles showed a hormonal pattern similar to that found in the adult group. By ultrasound evaluation, a high percentage of subjects with irregular menses had multicystic ovaries (57.9%) and the mean ( ± SEM) ovarian volume was higher (10.6 ± 0.5 cm3) than that found in adolescents with regular menses (6.7 ± 0.8 cm3) and in the adult group (7.7 ± 0.3 cm3). With the increase in frequency and continuity of ovulation an improvement in the direction of adult volume and ovarian structure was observed. Besides the endocrine similarity the data emphasize the striking similarity, already documented by histological studies, between pubertal ovaries and those seen in micropolycystic ovary syndrome. These endocrine and ovarian characteristics are typical of a large number of adolescents with irregular menstrual cycles: these features may be representative of a developmental step toward adult normality, although the possibility of a pathological evolution for some subjects cannot be excluded.

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  • Follow-up of oligomenorrheic girls from 15 to 18 years showed that body mass index predicted ongoing menstrual abnormality better than androgen levels.

    “Follow-up of these oligomenorrheic girls from 15 to 18 years showed that the body mass index (BMI) predicted ongoing menstrual abnormality better than androgen levels [52]”

    From The Diagnosis of Polycystic Ovary Syndrome during Adolescence (2015) · cites this paper as [52]

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Authors
Venturoli, S., Porcu, E., Fabbri, R., Paradisi, R., Ruggeri, S., Bolelli, G., Orsini, L. F., Gabbi, D., & Flamigni, C.
Affiliations
Ospedale G.B. Morgagni - L.Pierantoni (IT)
ORCID
Venue
Hormone Research
Publisher
S. Karger AG
Published
2008-11-28
Volume
24
Issue
4
Pages
269-279
ISSN
  • 0301-0163 (ISSN-L)
  • 1423-0046
DOI
10.1159/000180567
OpenAlex
W2041434444
Cited by
69
References
0
Citations by year
2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 1
FWCI
2.32
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Hormone Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords
menstrual irregularity, adolescents, anovulation, ovulation rate, luteinizing hormone, testosterone, androstenedione, progesterone, estradiol, prolactin, ovarian morphology, multicystic ovaries, ovarian volume, pubertal development, polycystic ovary syndrome, menstrual cycle phases
MeSH terms
Adolescent, Adult, Child, Cross-Sectional Studies, Female, Hormones, Humans, Menstrual Cycle, Menstruation Disturbances, Ovarian Cysts, Ovary, Ovulation, Pituitary Hormones, Gonadal Steroid Hormones

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