A Prospective Trial of Modafinil as an Adjunctive Treatment of Major Depression
Abstract
Modafinil is a wake-promoting agent approved by the Federal Drug Administration for the treatment of narcolepsy. Preliminary evidence indicates that modafinil may improve fatigue and excessive sleepiness associated with a variety of conditions. The purpose of this study was to investigate the utility of modafinil as an adjunctive treatment of depressed patients. Subjects with a history of major depression with partial response on a stable therapeutic dose of an antidepressant were eligible to participate. All subjects endorsed complaints of significant fatigue and/or excessive sleepiness on clinical assessment. Modafinil was added to their existing regimen at a dose of 100 to 400 mg/d for 4 weeks. Subjects were assessed at 2-week intervals for improvement using the standard depression scales (HDRS, BDI, CGI), fatigue scales (VASF, FSI), and a neuropsychologic battery. Thirty-five subjects were entered and 31 subjects completed the 4-week trial. Significant improvements were seen across all 3 measures of depression (HDRS, BDI, CGIS) and both measures of fatigue (VASF, FSI). On the neurocognitive battery, significant gains in the Stroop Interference Test were seen at 4 weeks, whereas the other cognitive tests showed no change. Modafinil may be a useful and a well-tolerated adjunctive agent to standard antidepressants in the treatment of major depression.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Modafinil increases feature-based selective attention and clinical symptoms in depressed patients.
“and increase feature-based selective attention and clinical symptoms in depressed patients119.”
From Paying attention to attention in depression (2019) · cites this paper as [119]
Modafinil has only been tested as a procognitive agent for major depressive disorder in a 4-week open-label trial enrolling 35 patients with major depressive disorder with a partial response to an antidepressant at a stable dose.
“Modafinil has only been tested as a procognitive agent for MDD in a 4-week open-label trial, enrolling 35 patients with MDD with a partial response to an antidepressant at a stable dose [147].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [147]
In the modafinil open-label trial in major depressive disorder, neurocognitive function was not a primary outcome.
“However, neurocognitive function was not a primary outcome of this small, uncontrolled trial.”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [147]
Cites
Rammohan, K. W. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.72.2.179 · Cited by 441 · see citing works
Randomized trial of modafinil for the treatment of pathological somnolence in narcolepsy
Fry (1998) · Annals of Neurology · doi:10.1002/ana.410430115 · Cited by 398 · see citing works
Randomized trial of modafinil as a treatment for the excessive daytime somnolence of narcolepsy
US Modafinil in Narcolepsy Multicenter Study Group (2000) · Neurology · doi:10.1212/wnl.54.5.1166 · Cited by 363 · see citing works
Modafinil as Adjunct Therapy for Daytime Sleepiness in Obstructive Sleep Apnea
PACK, A. I., BLACK, J. E., SCHWARTZ, J. R. L., & MATHESON, J. K. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.9.2103032 · Cited by 324 · see citing works
Broughton, R., Fleming, J. A. E., George, C. F., Hill, J. D., Kryger, M. H., Moldofsky, H., Montplaisir, J. Y., Morehouse, R. L., Moscovitch, A., & Murphy, W. F. (1997) · Neurology · doi:10.1212/wnl.49.2.444 · Cited by 285 · see citing works
Naps and modafinil as countermeasures for the effects of sleep deprivation on cognitive performance.
Batéjat, D., & Lagarde, D. (1999) · PubMed · Cited by 234 · see citing works
Tylee, A. T., Gastpar, M., Lépine, J., & MENDLEWICZ, J. (1999) · International Clinical Psychopharmacology · doi:10.1097/00004850-199905002-00001 · Cited by 221 · see citing works
Modafinil Augmentation of Antidepressant Treatment in Depression
Menza, M. A., Kaufman, K. R., & Castellanos, A. M. (2000) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v61n0510 · Cited by 203 · see citing works
TAYLOR, F. B., & Russo, J. E. (2000) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2000.10.311 · Cited by 181 · see citing works
A Potential Clinical Use for Methylphenidate with Tricyclic Antidepressants
Wharton, R. N., Perel, J. M., Dayton, P. G., & Malitz, S. (1971) · American Journal of Psychiatry · doi:10.1176/ajp.127.12.1619 · Cited by 134 · see citing works
Methylphenidate augmentation of serotonin selective reuptake inhibitors: a case series.
Stoll, A. L., Pillay, S. S., Diamond, L., Workum, S. B., & Cole, J. O. (1996) · PubMed · Cited by 130 · see citing works
CNS Stimulant Potentiation of Monoamine Oxidase
FAWCETT, J. A., Kravitz, H. M., Zajecka, J., SCHAFF, M. R., & FREISHTAT, H. W. (1991) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199104000-00010 · Cited by 118 · see citing works
Effects of Modafinil in Children With Attention-Deficit/Hyperactivity Disorder: An Open-Label Study
Rugino, T. A., & COPLEY, T. C. (2001) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200102000-00018 · Cited by 115 · see citing works
Combined MAOI, TCA, and direct stimulant therapy of treatment-resistant depression.
Feighner, J. P., Herbstein, J., & Damlouji, N. F. (1985) · PubMed · Cited by 104 · see citing works
Depressive disease: Classification and clinical characteristics
Baker, M., Dorzab, J., Winokur, G., & Cadoret, R. J. (1971) · Comprehensive Psychiatry · doi:10.1016/0010-440x(71)90073-3 · Cited by 68 · see citing works
Ferraro, L., Fuxé, K., Tanganelli, S., Tomasini, M. C., Rambert, F. A., & Antonelli, T. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10196 · Cited by 67 · see citing works
Modafinil in Obstructive Sleep Apnea-Hypopnea Syndrome: A Pilot Study in 6 Patients
Arnulf, I., Homeyer, P., Garma, L., Whitelaw, W. A., & Derenne, J.-P. (2009) · Respiration · doi:10.1159/000196661 · Cited by 64 · see citing works
Improvement of learning processes following chronic systemic administration of modafinil in mice.
Béracochéa, D., Célérier, A., Borde, N., Valleau, M., Pérès, M., & Piérard, C. (2002) · Pharmacology, Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00877-8 · Cited by 48 · see citing works
DEPRES II (Depression Research in European Society II)
Tylee, A. T., Gastpar, M., Lépine, J., & Mendlewicz, J. (1999) · International Clinical Psychopharmacology · doi:10.1097/00004850-199905030-00001 · Cited by 46 · see citing works
Maurice-Tison, S., Verdoux, H., Gay, B., Perez, P., Salamon, R., & Bourgeois, M.-L. (1998) · Europe PMC (PubMed Central) · Cited by 37 · see citing works
Treatment of a refractory depression with a combination of fluoxetine and d-amphetamine
Linet, L. S. (1989) · American Journal of Psychiatry · doi:10.1176/ajp.146.6.803b · Cited by 36 · see citing works
Venlafaxine Augmentation with Methylphenidate for Treatment-Refractory Depression
Bader, G. M., Hawley, J. M., & Short, D. D. (1998) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199806000-00014 · Cited by 26 · see citing works
Combination of Fluoxetine with Pemoline in the Treatment of Major Depressive Disorder
Metz, A. L., & Shader, R. I. (1991) · International Clinical Psychopharmacology · doi:10.1097/00004850-199100620-00003 · Cited by 23 · see citing works
Modafinil in the Treatment of Depression With Severe Comorbid Medical Illness
Schwartz, T. L., Leso, L., Beale, M. D., Ahmed, R., & Naprawa, S. A. (2002) · Psychosomatics · doi:10.1176/appi.psy.43.4.336 · Cited by 16 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cognitive impairment in depression: a systematic review and meta-analysis
Rock, P. L., Roiser, J. P., Riedel, W. J., & Blackwell, A. D. (2014) · Psychological Medicine · doi:10.1017/s0033291713002535 · Cited by 2,161 · see citing works
PRACTICE GUIDELINE FOR THE Treatment of Patients With Major Depressive Disorder
Gelenberg, A. J., Freeman, P. B., Markowitz, J. C., Rosenbaum, J. F., Thase, M. E., Trivedi, M. H., & Rhoads, R. S. (2010) · Cited by 1,372 · see citing works
Modafinil: a review of neurochemical actions and effects on cognition
Minzenberg, M. J., & Carter, C. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301534 · Cited by 713 · see citing works
Cognitive Mechanisms of Treatment in Depression
Roiser, J. P., Elliott, R., & Sahakian, B. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.183 · Cited by 535 · see citing works
Millan, M. J. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.11.006 · Cited by 549 · see citing works
Paying attention to attention in depression
Keller, A. S., Leikauf, J. E., Holt-Gosselin, B., Staveland, B. R., & Williams, L. M. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0616-1 · Cited by 329 · see citing works
Cognitive dysfunction in depression: Neurocircuitry and new therapeutic strategies
Murrough, J. W., Iacoviello, B., Neumeister, A., Charney, D. S., & Iosifescu, D. V. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.06.006 · Cited by 307 · see citing works
The many faces of fatigue in major depressive disorder
Demyttenaere, K., De Fruyt, J., & Stahl, S. M. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145704004729 · Cited by 288 · see citing works
Cognitive remission: a novel objective for the treatment of major depression?
Bortolato, B., Miskowiak, K. W., Köhler, C. A., Maes, M., Fernandes, B. S., Berk, M., & Carvalho, A. F. (2016) · BMC Medicine · doi:10.1186/s12916-016-0560-3 · Cited by 252 · see citing works
Therapeutic Options for Treatment-Resistant Depression
Shelton, R. C., Osuntokun, O. O., Heinloth, A. N., & Corya, S. A. (2010) · CNS Drugs · doi:10.2165/11530280-000000000-00000 · Cited by 205 · see citing works
Management of Cancer-Related Fatigue
Morrow, G. R., Shelke, A. R., Roscoe, J. A., Hickok, J. T., & Mustian, K. M. (2005) · Cancer Investigation · doi:10.1081/cnv-200055960 · Cited by 205 · see citing works
The Neuropsychology of Amphetamine and Opiate Dependence: Implications for Treatment
Ersche, K. D., & Sahakian, B. J. (2007) · Neuropsychology Review · doi:10.1007/s11065-007-9033-y · Cited by 166 · see citing works
Goss, A. J., Kaser, M., Costafreda, S. G., Sahakian, B. J., & Fu, C. H. Y. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13r08560 · Cited by 133 · see citing works
Gottesmann, C., & Gottesman, I. I. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.01.004 · Cited by 114 · see citing works
Carvalho, A. F., Cavalcante, J. L., Castelo, M. S., & Lima, M. C. O. (2007) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/j.1365-2710.2007.00846.x · Cited by 110 · see citing works
Cognitive Effects of Pharmacotherapy for Major Depressive Disorder: A Systematic Review
Keefe, R. S. E., McClintock, S. M., Roth, R. M., Doraiswamy, P. M., Tiger, S., & Madhoo, M. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13r08609 · Cited by 107 · see citing works
D, M. F. M., Thase, M. E., DeBattista, C., Doghramji, K., Arora, S., & Hughes, R. J. (2007) · Annals of Clinical Psychiatry · doi:10.1080/10401230701464858 · Cited by 109 · see citing works
Self-citationMedical Management of Brain Tumor Patients
Drappatz, J., Schiff, D., Kesari, S., Norden, A. D., & Wen, P. Y. (2007) · Neurologic Clinics · doi:10.1016/j.ncl.2007.07.015 · Cited by 109 · see citing works
Lundorff, L. E., Jønsson, B., & Sjøgren, P. (2009) · Palliative Medicine · doi:10.1177/0269216309106872 · Cited by 106 · see citing works
Cognition as a treatment target in depression
Kaser, M., Zaman, R., & Sahakian, B. J. (2017) · Psychological Medicine · doi:10.1017/s0033291716003123 · Cited by 96 · see citing works
Depression and multiple sclerosis: Review of a lethal combination
Wallin, M. T., Wilken, J. A., Turner, A. P., Williams, R. M., & Kane, R. (2006) · The Journal of Rehabilitation Research and Development · doi:10.1682/jrrd.2004.09.0117 · Cited by 101 · see citing works
Fox, H. C., Jackson, E. D., & Sinha, R. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.03.007 · Cited by 99 · see citing works
Pharmacologic Treatment of Cancer-Related Fatigue
Carroll, J. K., Kohli, S., Mustian, K. M., Roscoe, J. A., & Morrow, G. R. (2007) · The Oncologist · doi:10.1634/theoncologist.12-s1-43 · Cited by 98 · see citing works
Maski, K. P., Trotti, L. M., Kotagal, S., Auger, R. R., Swick, T. J., Rowley, J. A., Hashmi, S. D., & Watson, N. F. (2021) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.9326 · Cited by 92 · see citing works
A Pilot Study Evaluating the Safety and Efficacy of Modafinil for Cancer-Related Fatigue
Blackhall, L. J., Petroni, G. R., Shu, J., Baum, L. D., & Farace, E. (2009) · Journal of Palliative Medicine · doi:10.1089/jpm.2008.0230 · Cited by 87 · see citing works
Chronobiology, excessive daytime sleepiness and depression: Is there a link?
Chellappa, S. L., Schroder, C. M., & Cajochen, C. (2008) · Sleep Medicine · doi:10.1016/j.sleep.2008.05.010 · Cited by 84 · see citing works
Treatment of Anxiety and Depression in Transplant Patients
Crone, C. C., & Gabriel, G. M. (2004) · Clinical Pharmacokinetics · doi:10.2165/00003088-200443060-00002 · Cited by 81 · see citing works
Acute Modafinil Effects on Attention and Inhibitory Control in Methamphetamine-Dependent Humans
Dean, A. C., Sevak, R. J., Monterosso, J. R., Hellemann, G., Sugar, C. A., & London, E. D. (2011) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2011.72.943 · Cited by 79 · see citing works
Pharmacological Augmentation in Unipolar Depression: A Guide to the Guidelines
Taylor, R. W., Marwood, L., Oprea, E., DeAngel, V., Mather, S., Valentini, B., Zahn, R., Young, A. H., & Cleare, A. J. (2020) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa033 · Cited by 76 · see citing works
Strategies to enhance the therapeutic efficacy of antidepressants: targeting residual symptoms
Kurian, B. T., Greer, T. L., & Trivedi, M. H. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.53 · Cited by 73 · see citing works
Cognitive dysfunction in major depression: From assessment to novel therapies
Atique-Ur-Rehman, H., & Neill, J. C. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.05.013 · Cited by 72 · see citing works
Salagre, E., Solé, B., Tomioka, Y., Fernandes, B. S., Hidalgo-Mazzei, D., Garriga, M., Jimenez, E., Sanchez-Moreno, J., Vieta, E., & Grande, I. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.06.034 · Cited by 71 · see citing works
Benefits of Adjunct Modafinil in an Open-Label, Pilot Study in Patients With Schizophrenia
Rosenthal, M., & Bryant, S. (2003) · Clinical neuropharmacology · doi:10.1097/00002826-200401000-00011 · Cited by 86 · see citing works
Cognition as a target in major depression: new developments.
Solé, B., Jiménez, E., Martinez-Aran, A., & Vieta, E. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.12.004 · Cited by 68 · see citing works
Psychostimulants in the Treatment of Depression
Orr, K., & Taylor, D. (2007) · CNS Drugs · doi:10.2165/00023210-200721030-00004 · Cited by 46 · see citing works
Thase, M. E. (2004) · CNS Spectrums · doi:10.1017/s1092852900002236 · Cited by 67 · see citing works
Cognitive Dysfunction in Major Depressive Disorder: Assessment, Impact, and Management
Chakrabarty, T., Hadjipavlou, G., & Lam, R. W. (2016) · Focus · doi:10.1176/appi.focus.20150043 · Cited by 84 · see citing works
A Comparative Meta-Analysis of Clinical Global Impressions Change in Antidepressant Trials
Spielmans, G. I., & McFall, J. P. (2006) · The Journal of Nervous and Mental Disease · doi:10.1097/01.nmd.0000244554.91259.27 · Cited by 63 · see citing works
Executive dysfunction in major depressive disorder
DeBattista, C. (2005) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.5.1.79 · Cited by 62 · see citing works
Self-citationA critical review of pharmacotherapy for major depressive disorder.
Dupuy, J. M., Ostacher, M. J., Huffman, J., Perlis, R. H., & Nierenberg, A. A. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000083 · Cited by 61 · see citing works
Colwell, M., Tagomori, H., Chapman, S., Gillespie, A. L., Cowen, P. J., Harmer, C. J., & Murphy, S. E. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02249-6 · Cited by 63 · see citing works
Thase, M. E., D, M. F. M., DeBattista, C., Arora, S., & Hughes, R. J. (2006) · CNS Spectrums · doi:10.1017/s1092852900010622 · Cited by 61 · see citing works
Self-citationAbolfazli, R., Hosseini, M., Ghanizadeh, A. J., Ghaleiha, A., Tabrizi, M. H., Raznahan, M., Golalizadeh, M., & Akhondzadeh, S. (2011) · Depression and Anxiety · doi:10.1002/da.20801 · Cited by 60 · see citing works
Kaşer, M., Deakin, J., Michael, A., Zapata, C. D., Bansal, R., Ryan, D., Cormack, F. K., Rowe, J. B., & Sahakian, B. J. (2016) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2016.11.009 · Cited by 56 · see citing works
Dunlop, B., Crits-Christoph, P., Evans, D., Hirschowitz, J., Solvason, H., Rickels, K., Garlow, S. J., Gallop, R., & Ninan, P. (2007) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31815abefb · Cited by 52 · see citing works
Self-citationModafinil and unconstrained motor activity in schizophrenia
Farrow, T. F. D., Hunter, M. D., Haque, R., & Spence, S. A. (2006) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.105.017335 · Cited by 54 · see citing works
A Randomized, Double-Blind, Crossover Trial of Modafinil on Mood
Taneja, I., Haman, K., Shelton, R. C., & Robertson, D. (2007) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31802eb7ea · Cited by 54 · see citing works
Augmentation and combination strategies for depression
DeBattista, C. (2006) · Journal of Psychopharmacology · doi:10.1177/1359786806064310 · Cited by 47 · see citing works
Self-citationA Critical Overview of the Pharmacologic Management of Treatment-Resistant Depression
Nierenberg, A. A., Katz, J., & D, M. F. M. (2007) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2007.01.001 · Cited by 47 · see citing works
Saligan, L. N., Luckenbaugh, D. A., Slonena, E. E., Machado‐Vieira, R., & Zarate, C. A. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.01.009 · Cited by 46 · see citing works
Ferraro, L., Fuxé, K., Agnati, L. F., Tanganelli, S., Tomasini, M. C., & Antonelli, T. (2005) · Synapse · doi:10.1002/syn.20111 · Cited by 46 · see citing works
The use of stimulant medications for non-core aspects of ADHD and in other disorders.
Sinita, E., & Coghill, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.06.014 · Cited by 40 · see citing works
Modafinil Activates Cortical and Subcortical Sites in the Sleep-Deprived State
THOMAS, R. J., & Kwong, K. K. (2006) · SLEEP · doi:10.1093/sleep/29.11.1471 · Cited by 45 · see citing works
Psychiatric aspects of organic sleep disorders
Haba‐Rubio, J. (2005) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2005.7.4/jhabarubio · Cited by 44 · see citing works
Modafinil‐induced conditioned place preference via dopaminergic system in mice
Nguyen, T., Tian, Y., You, I., Lee, S., & Jang, C. (2010) · Synapse · doi:10.1002/syn.20892 · Cited by 41 · see citing works
Chronic treatment with modafinil may not be beneficial in patients with chronic fatigue syndrome
Randall, D. C., Cafferty, F. H., Shneerson, J. M., Smith, I. E., Llewelyn, M. B., & File, S. E. (2005) · Journal of Psychopharmacology · doi:10.1177/0269881105056531 · Cited by 41 · see citing works
Barowsky, J., & Schwartz, T. L. (2006) · PubMed Central · Cited by 40 · see citing works
A review of the use of modafinil for attention-deficit hyperactivity disorder
Turner, D. C. (2006) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.6.4.455 · Cited by 34 · see citing works
Fochtmann, L. J., & Gelenberg, A. J. (2005) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/foc.3.1.34 · Cited by 38 · see citing works
Bobo, W. V., Woodward, N. D., Sim, M. Y., Jayathilake, K., & Meltzer, H. Y. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.05.015 · Cited by 38 · see citing works
An Overview of Psychiatric Issues in Liver Disease for the Consultation–Liaison Psychiatrist
Crone, C. C., Gabriel, G. M., & DiMartini, A. (2006) · Psychosomatics · doi:10.1176/appi.psy.47.3.188 · Cited by 34 · see citing works
Depression-like deficits in rats improved by subchronic modafinil
Regenthal, R., Koch, H., Köhler, C., Preiß, R., & Krügel, U. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1493-8 · Cited by 33 · see citing works
Sleep disorders in Parkinson's disease
Thorpy, M. J. (2004) · Clinical cornerstone · doi:10.1016/s1098-3597(04)90013-0 · Cited by 33 · see citing works
Is Schizophrenia Associated with Narcolepsy?
Walterfang, M., Upjohn, E. J., & Velakoulis, D. (2005) · Cognitive and Behavioral Neurology · doi:10.1097/01.wnn.0000160822.53577.2c · Cited by 32 · see citing works
Keith, J. M., Gomez, L. A., Wolin, R. L., Barbier, A., Wilson, S. J., Boggs, J. D., Mazur, C., Fraser, I. C., Lord, B., Aluisio, L. E., et al. (2007) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2007.01.106 · Cited by 31 · see citing works
Diagnostic and Therapeutic Challenges in Narcolepsy-Related Psychosis
Kondziella, D., & Arlien-Søborg, P. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n1122b · Cited by 30 · see citing works
Modafinil in sports: ethical considerations
Kaufman, K. R. (2005) · British Journal of Sports Medicine · doi:10.1136/bjsm.2004.016303 · Cited by 30 · see citing works
Adjunctive atomoxetine for residual fatigue in major depressive disorder
Papakostas, G. I., PETERSEN, T., BURNS, A., & D, M. F. M. (2005) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.04.013 · Cited by 29 · see citing works
Current Concepts of Memory Disorder in Epilepsy: Edging Towards a Network Account
Rayner, G., & Tailby, C. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0765-7 · Cited by 28 · see citing works
Modafinil: new indications for wake promotion
Schwartz, J. R. L. (2005) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.6.1.115 · Cited by 28 · see citing works
Fluoxetine-Mirtazapine Interaction May Induce Restless Legs Syndrome
Prospero-Garcia, K. A., Torres-Ruiz, A., Ramírez‐Bermúdez, J., Velázquez‐Moctezuma, J., Arana-Lechuga, Y., & Terán-Pérez, G. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n1122d · Cited by 28 · see citing works
McElhiney, M. C., Rabkin, J. G., van Gorp, W. G., & Rabkin, R. (2009) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803390903201769 · Cited by 27 · see citing works
Modafinil for Atypical Depression
Vaishnavi, S., Gadde, K. M., Alamy, S., Zhang, W., Connor, K. M., & Davidson, J. R. T. (2006) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000227700.263.75.39 · Cited by 27 · see citing works
Manic Switch in a Patient With Treatment-Resistant Bipolar Depression Treated With Modafinil
Wolf, J., Fiedler, U., Anghelescu, I. G., & Schwertfeger, N. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n1122a · Cited by 27 · see citing works
Abbasowa, L., Kessing, L., & Vinberg, M. (2013) · Nordic Journal of Psychiatry · doi:10.3109/08039488.2012.752035 · Cited by 25 · see citing works
Conley, C. C., Kamen, C. S., Heckler, C. E., Janelsins, M. C., Morrow, G. R., Peppone, L. J., Scalzo, A. J., Gross, H. M., Dakhil, S. R., Mustian, K. M., et al. (2015) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000442 · Cited by 26 · see citing works
Hawkins, M. A. W., Dolansky, M. A., Schaefer, J. T., Fulcher, M. J., Gunstad, J., Redle, J. D., Josephson, R., & Hughes, J. W. (2014) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0000000000000178 · Cited by 27 · see citing works
A Review of Psychostimulants for Adults With Depression.
Pary, R., Scarff, J. R., Jijakli, A., TOBIAS, C. R., & Lippmann, S. (2015) · Europe PMC (PubMed Central) · Cited by 24 · see citing works
Lam, J. Y., Freeman, M. K., & Cates, M. E. (2007) · Annals of Pharmacotherapy · doi:10.1345/aph.1h526 · Cited by 25 · see citing works
Sousa, A. C., & Dinis‐Oliveira, R. J. (2020) · Substance Abuse · doi:10.1080/08897077.2019.1700584 · Cited by 24 · see citing works
Sagheddu, C., Pintori, N., Kalaba, P., Dragačević, V., Piras, G., Lubec, J., Simola, N., Luca, M. A. D., Lübec, G., & Pistis, M. (2020) · Biomolecules · doi:10.3390/biom10050779 · Cited by 22 · see citing works
Modafinil and nicotine interactions in abstinent smokers
Sofuoglu, M., Waters, A. J., & Mooney, M. E. (2007) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.878 · Cited by 21 · see citing works
The Black Book of Psychotropic Dosing and Monitoring
DeBattista, C., & Schatzberg, A. F. (2025) · Psychopharmacology Bulletin · doi:10.64719/pb.4493 · Cited by 22 · see citing works
Self-citationUltra short manic-like episodes after antidepressant augmentation with modafinil
Fountoulakis, K. Ν., Siamouli, M., Panagiotidis, P., Magiria, S., Kantartzis, S., Iacovides, A., & KAPRINIS, G. S. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.11.006 · Cited by 20 · see citing works
Modafinil as adjunctive therapy in depressed outpatients.
Nasr, S. (2004) · Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists · doi:10.1080/10401230490486954 · Cited by 22 · see citing works
Contemporary methods of improving cognitive dysfunction in clinical depression
Knight, M. J., Mills, N. T., & Baune, B. T. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1610395 · Cited by 17 · see citing works
Joos, L., Goudriaan, A. E., Schmaal, L., van den Brink, W., Sabbe, B. G., & Dom, G. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113503505 · Cited by 17 · see citing works
Rational antidepressant selection: applying evidence-based medicine to complex real-world patients.
Zetin, M., Hoepner, C. T., & Bjornson, L. (2006) · PubMed · Cited by 17 · see citing works
Modafinil, an atypical CNS stimulant?
Hersey, M., & Tanda, G. (2023) · Advances in pharmacology · doi:10.1016/bs.apha.2023.10.006 · Cited by 15 · see citing works
Tactile Hallucinations Associated With Therapeutic Doses of Bupropion in 2 Patients
Charuvastra, A., & Yaeger, D. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n1122e · Cited by 15 · see citing works
The Measurement of Fatigue in Depression
Ferentinos, P. P., Kontaxakis, V. P., Havaki-Kontaxaki, B. J., Paplos, K. G., & Soldatos, C. R. (2007) · Psychopathology · doi:10.1159/000098494 · Cited by 15 · see citing works
Insight into the Mechanism of Formation of Channel Hydrates via Templating
Stokes, S. P., Seaton, C. C., Eccles, K. S., Maguire, A. R., & Lawrence, S. E. (2014) · Crystal Growth & Design · doi:10.1021/cg401660h · Cited by 14 · see citing works
The Use of Modafinil in the Intensive Care Unit
Gajewski, M., & Weinhouse, G. L. (2015) · Journal of Intensive Care Medicine · doi:10.1177/0885066615571899 · Cited by 12 · see citing works
Pharmacological treatment approaches to difficult‐to‐treat depression
Chan, H., Mitchell, P. B., Loo, C. K. A., & Harvey, S. B. (2013) · The Medical Journal of Australia · doi:10.5694/mja12.10495 · Cited by 11 · see citing works
Konuk, N., Atasoy, N., Atik, L., & Akay, Ö. (2006) · Advances in Therapy · doi:10.1007/bf02850053 · Cited by 11 · see citing works
Post, R. M. (2005) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.6.4.531 · Cited by 11 · see citing works
Monoaminergic‐based Pharmacotherapy for Depression
Papakostas, G. I., & D, M. F. M. (2005) · Wiley eBooks · doi:10.1002/9783527619672.ch6 · Cited by 11 · see citing works
A multi-pronged investigation of option generation using depression, PET and modafinil
Ang, Y.-S., Cusin, C., Petibon, Y., Dillon, D. G., Breiger, M., Belleau, E. L., Normandin, M. D., Schroder, H. S., Boyden, S., Hayden, E. R., et al. (2021) · Brain · doi:10.1093/brain/awab429 · Cited by 10 · see citing works
Spreitzer, I., Keife, J., Strasser, T., Kalaba, P., Lubec, J., Neuhaus, W., Lübec, G., Langer, T., Wackerlig, J., & Loryan, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316956 · Cited by 10 · see citing works
Omidi-Ardali, H., Badi, A. G., Saghaei, E., & Amini-Khoei, H. (2020) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2020-0021 · Cited by 10 · see citing works
- Authors
- DeBattista, C., Lembke, A., Solvason, H. B., Ghebremichael, R., & Poirier, J.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- DeBattista, Charles
- Venue
- Journal of Clinical Psychopharmacology
- Published
- 2004-02
- Volume
- 24
- Issue
- 1
- Pages
- 87-90
- ISSN
- 0271-0749 (ISSN-L)
- OpenAlex
- W1986635669
- Cited by
- 144
- References
- 24
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 5 · 2019: 8 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 6 · 2014: 4 · 2013: 7 · 2012: 3
- FWCI
- 12.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- modafinil, major depressive disorder, adjunctive therapy, fatigue, excessive sleepiness, wakefulness-promoting agents, antidepressant response, cognitive function, Stroop interference, neuropsychological assessment
- MeSH terms
- Modafinil, Adult, Aged, Antidepressive Agents, Benzhydryl Compounds, Major Depressive Disorder, Double-Blind Method, Drug Administration Schedule, Drug Therapy, Combination, Drug Tolerance, Fatigue, Female, Humans, Disorders of Excessive Somnolence, Male, Middle Aged, Prospective Studies, Psychiatric Status Rating Scales, Time Factors, Treatment Outcome, Diagnostic and Statistical Manual of Mental Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
