Progesterone Triggers Selective Mast Cell Secretion of 5-Hydroxytryptamine

Vliagoftis, Harissis; Dimitriadou, Violetta; Theoharides, Theoharis C.

doi:10.1159/000235289

Cited by 49Mast cells and histamineFood Allergy and Anaphylaxis ResearchAsthma and respiratory diseases

Progesterone Triggers Selective Mast Cell Secretion of 5-Hydroxytryptamine

Vliagoftis, Harissis, Dimitriadou, Violetta, Theoharides, Theoharis C.·2009·International Archives of Allergy and Applied Immunology

DOI 10.1159/000235289

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Abstract

Mast cells are involved in allergic reactions where they secrete numerous mediators in response to immunoglobulin E and antigen. However, they have recently been implicated in neuroinflammatory conditions with a higher prevalence in women, and there have been clinical reports of progesterone anaphylaxis. When tested on purified rat peritoneal mast cells, progesterone alone stimulated release only of 5-hydroxy-tryptamine (serotonin) in a dose- and time-dependent manner. Serotonin release by progesterone was exceptional because it was not accompanied by histamine release or degranulation and was either augmented or unaffected by drugs which inhibit secretion induced by the classic mast cell secretagogue, compound 48/80. These findings indicate that mast cells are capable of selective serotonin secretion, previously shown only after pretreatement with certain tricyclic drugs, and may be involved in neuroendocrine syndromes.

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Authors: Vliagoftis, H., Dimitriadou, V., & Theoharides, T. C.
Affiliations: Tufts University (US)
ORCID: Dimitriadou, Violetta
Theoharides, Theoharis C.
Venue: International Archives of Allergy and Applied Immunology
Publisher: S. Karger AG
Published: 2009-08-07
Volume: 93
Issue: 2-3
Pages: 113-119
ISSN: 0020-5915 (ISSN-L)
2571-6662
DOI: 10.1159/000235289
OpenAlex: W2057710446
Cited by: 49
References: 0
Citations by year: 2026: 1 · 2023: 1 · 2021: 1 · 2017: 1 · 2016: 5 · 2015: 4 · 2013: 3 · 2012: 1
FWCI: 0.57
Type: journal article
Language: en
Open access: closed
Licence: karger.com/pages/terms-and-conditions (vor)
karger.com/pages/terms-and-conditions (tdm)
Locations: International Archives of Allergy and Applied Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01dk042409-03)
National Institute of Diabetes and Digestive and Kidney Diseases (DK42409-01)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Keywords: progesterone, mast cells, serotonin release, serotonin, neuroinflammation, histamine release, compound 48/80, peritoneal mast cells, sex differences
MeSH terms: Animals, Calcium, Cells, Cultured, Male, Mast Cells, Progesterone, Rats, Inbred Strains, Serotonin, Rats

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Progesterone Triggers Selective Mast Cell Secretion of 5-Hydroxytryptamine

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