Tryptase is not cleared by the kidneys into the urine
Open accessAbstract
BACKGROUND: Patients with chronic kidney disease have been reported to have increased concentrations of blood tryptase. Detection of tryptase in the urine of healthy subjects has been reported. OBJECTIVE: The objective is to determine whether tryptase is indeed cleared by the kidneys. METHODS: Blood and urine collections were performed in healthy and systemic mastocytosis subjects. Total and mature tryptase concentrations in blood and total tryptase concentrations in urine were determined. RESULTS: Total tryptase levels in urine were below the limit of detection in both healthy subjects and those with systemic mastocytosis, even after concentrating the urine 10-fold. Thus, both mature and protryptase levels in urine are <0.2 ng/ml. CONCLUSION: Tryptase is not cleared by the kidneys into the urine.
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Probably, elevated baseline serum tryptase in impaired renal function is due to an elevated SCF since tryptase is not cleared by kidneys.
“Probably, this is due to an elevated SCF since tryptase is not cleared by kidneys [74].”
From Diagnostic Significance of Tryptase for Suspected Mast Cell Disorders (2023) · cites this paper as [74]
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Human mast cell tryptase in biology and medicine
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HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies
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MethodIn Vitro Diagnosis of Immediate Drug Hypersensitivity During Anesthesia: A Review of the Literature
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Anaphylaxis as a clinical manifestation of clonal mast cell disorders
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Tryptase in type I hypersensitivity
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“Conversely, determinations ofb-tryptase in urine for diagnostic purposes have only been occasionally performed in the clinical field and with contradictory results [3,4].”
BackgroundDiagnostic Significance of Tryptase for Suspected Mast Cell Disorders
Beyens, M., Toscano, A., Ebo, D., Gülen, T., & Sabato, V. (2023) · Diagnostics · doi:10.3390/diagnostics13243662 · Cited by 22 · see citing works
“Probably, this is due to an elevated SCF since tryptase is not cleared by kidneys [74].”
BackgroundSerum concentrations of mast cell tryptase are reduced in heavy drinkers
Beceiro, C., Campos, J., Valcarcel, M.-A., Fenger, R. V., Lojo, S., Linneberg, A., Vidal, C., & Gonzalez-Quintela, A. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12682 · Cited by 9 · see citing works
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“Elevated serum tryptase concentrations are observed in conditions such as systemic mastocytosis (>1 ng/mL), anaphylaxis, hypereosinophilic syndrome, many cases of mast cell activation syndrome (MCAS), and a subset of acute myelocytic leukemia [102].”
Hypersensitive Reactions During Hemodialysis Treatment: What Do We Need to Know?
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“Some suggest that lack of clearance due to impaired renal function is responsible [22], but others suggested that decreased renal clearance is not responsible for elevated tryptase [23].”
BackgroundSerum mast cell tryptase in patients with renal failure and its relation to severity of pruritus
Hafez, S. A. E., Hagag, M., Azmy, R., & Kasem, H. (2021) · Menoufia Medical Journal · doi:10.4103/mmj.mmj_320_19 · Cited by 1 · see citing works
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“Altre situazioni in cui la triptasi sierica può risultare elevata sono: le forme di orticaria particolarmente severe, l’insufficienza renale cronica, le malattie mieloproliferative tra cui la leucemia mieloide acuta [21, 22].”
BackgroundPremières étapes dans l'interaction hôte-pathogène : rôle de l'immunité locale et innée
Michel, M. (2022) · theses.fr (ABES) · doi:10.70675/4647f4d2zd802z40abza572z8ff228db523f
- Authors
- Simon, M. R., Jan, M., Yee, J., Nori, U. S., Hu, J., Akin, C., & Schwartz, L. B.
- Affiliations
- Beaumont Health (US)
- Henry Ford Health (US)
- Virginia Commonwealth University (US)
- Venue
- International Archives of Allergy and Immunology
- Publisher
- S. Karger AG
- Published
- 2009-11-24
- Volume
- 152
- Issue
- 1
- Pages
- 28-31
- ISSN
- 1018-2438 (ISSN-L)
- 1423-0097
- PMC
- PMC2956006
- OpenAlex
- W1989034502
- Cited by
- 21
- References
- 7
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 1 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 1
- FWCI
- 0.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- International Archives of Allergy and Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R01AI020487, AI20487, R21AI020487, R37AI020487)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- tryptase, renal clearance, kidney, systemic mastocytosis, chronic kidney disease, mast cells
- MeSH terms
- Anaphylaxis, Humans, Kidney, Mastocytosis, Systemic, Tryptases
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