The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Hypothalamic Sites of Leptin Action Linking Metabolism and Reproduction
Abstract
A critical amount of energy reserve is necessary for puberty initiation, for normal sexual maturation and maintenance of cyclicity and fertility in females of most species. Therefore, the existence of circulating metabolic cues which directly modulate the hypothalamus-pituitary-gonad axis is predictable. The adipocyte-derived hormone leptin is one of these cues having been studied extensively in the context of regulating the reproductive physiology. Humans and mice lacking leptin (ob/ob) or leptin receptor (LepR, db/db) are infertile. Leptin administration to leptin-deficient subjects and ob/ob mice induces puberty and restores fertility. LepR is expressed in brain, pituitary gland and gonads, but studies using genetically engineered mouse models determined that the brain plays a major role. Recently, it has been made clear that leptin acts indirectly on gonadotropin-releasing hormone (GnRH)-secreting cells via actions on interneurons. However, the exact site(s) of leptin action has been difficult to determine. In this review, we discuss the recent advances in the field focused on the identification of potential site(s) or specific neuronal populations involved in leptin’s effects in the neuroendocrine reproductive axis.
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“Although leptin receptors are expressed at multiple levels of the male HPT axis, preclinical studies suggest that leptin action at the hypothalamus is sufficient to maintain reproductive function (36).”
From Dysregulation of the Hypothalamic-Pituitary-Testicular Axis due to Energy Deficit (2021) · cites this paper as [36]
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Sex differences in the physiology of eating
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Metabolic regulation of kisspeptin — the link between energy balance and reproduction
Navarro, V. M. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0363-7 · Cited by 240
Dysregulation of the Hypothalamic-Pituitary-Testicular Axis due to Energy Deficit
Grossmann, M., & Wittert, G. A. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab517 · Cited by 24
Metadata
- Authors
- Donato, Jr., Cravo, R. M., Frazão, R., & Elias, C. F.
- Venue
- Neuroendocrinology
- Publisher
- S. Karger AG
- Published
- 2010-11-24
- Volume
- 93
- Issue
- 1
- Pages
- 9-18
- ISSN
- 0028-3835
- 1423-0194
- Cited by
- 104
- References
- 9
- Language
- en
- Licence
- www.karger.com/Services/SiteLicenses (vor)
- www.karger.com/Services/SiteLicenses (tdm)
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