The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Advanced vaginal opening and precocious activation of the reproductive axis by KiSS‐1 peptide, the endogenous ligand of GPR54
Abstract
The awakening of the gonadotrophic axis at puberty is the end‐point of a complex cascade of sex developmental events that leads to the attainment of reproductive capacity. Recently, loss‐of‐function mutations of the gene encoding GPR54, the putative receptor for the KiSS‐1‐derived peptide metastin, have been linked to hypogonadotrophic hypogonadism, both in rodents and humans. However, the actual role of the KiSS‐1/GPR54 system in the timing of puberty onset remains unexplored. We report herein that chronic central administration of KiSS‐1 peptide to immature female rats induced the precocious activation of the gonadotrophic axis, as estimated by advanced vaginal opening, elevated uterus weight, and increased serum levels of luteinizing hormone (LH) and oestrogen. The central effect of KiSS‐1 upon LH release appeared to be mediated via the hypothalamic LH‐releasing hormone. In contrast, despite the well‐documented permissive role of body fat stores and the adipocyte‐derived hormone leptin in puberty maturation, acute activation of the gonadotrophic axis by KiSS‐1 was persistently observed in pubertal animals under food deprivation, after central immunoneutralization of leptin, and in a model of leptin resistance. Overall, the present results, together with our recent data on maximum expression of KiSS‐1 and GPR54 genes in the hypothalamus at puberty, provide novel evidence for a role of the KiSS‐1 system as a downstream element in the hypothalamic network triggering the onset of puberty.
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Cites
The GPR54 Gene as a Regulator of Puberty
Seminara, S. B., Messager, S., Chatzidaki, E. E., Thresher, R. R., Acierno, J. S., Shagoury, J. K., Bo-Abbas, Y., Kuohung, W., Schwinof, K. M., Hendrick, A. G., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035322 · Cited by 2,557
Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
de Roux, N., Genin, E., Carel, J.-C., Matsuda, F., Chaussain, J.-L., & Milgrom, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834399100 · Cited by 2,431 · cited 4×
“Considering the proposed function of KiSS-1 in puberty onset (de Roux et al. 2003; Seminara et al. 2003; and the present results), we aimed at evaluating the potential interaction between leptin (as peripheral permissive signal) and KiSS-1 (as central triggering signal) in the acute regulation of…”
BackgroundInfluentialParent, A.-S., Teilmann, G., Juul, A., Skakkebaek, N. E., Toppari, J., & Bourguignon, J.-P. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0019 · Cited by 1,762
Kotani, M., Detheux, M., Vandenbogaerde, A., Communi, D., Vanderwinden, J.-M., Le Poul, E., Brézillon, S., Tyldesley, R., Suarez-Huerta, N., Vandeput, F., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104847200 · Cited by 1,546
The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system
Funes, S., Hedrick, J. A., Vassileva, G., Markowitz, L., Abbondanzo, S., Golovko, A., Yang, S., Monsma, F. J., & Gustafson, E. L. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.066 · Cited by 675
Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat
Matsui, H., Takatsu, Y., Kumano, S., Matsumoto, H., & Ohtaki, T. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.05.185 · Cited by 520
Cited by
State-of-the-science of endocrine disrupting chemicals, 2012
Bergman, Å., Heindel, J., Jobling, S., Kidd, K., & Zoeller, R. T. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.03.020 · Cited by 1,388
Pubertal hormones organize the adolescent brain and behavior
Sisk, C. L., & Zehr, J. L. (2005) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2005.10.003 · Cited by 1,082
Han, S.-K., Gottsch, M. L., Lee, K. J., Popa, S. M., Smith, J. T., Jakawich, S. K., Clifton, D. K., Steiner, R. A., & Herbison, A. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3328-05.2005 · Cited by 1,036
Clarkson, J., & Herbison, A. E. (2006) · Endocrinology · doi:10.1210/en.2006-0787 · Cited by 875
Kisspeptin Signaling in the Brain
Oakley, A. E., Clifton, D. K., & Steiner, R. A. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0005 · Cited by 842
Metadata
- Authors
- Navarro, V. M., Fernández‐Fernández, R., Castellano, J. M., Roa, J., Mayen, A., Barreiro, M. L., Gaytan, F., Aguilar, E., Pinilla, L., Dieguez, C., & Tena‐Sempere, M.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2004-11-26
- Volume
- 561
- Issue
- 2
- Pages
- 379-386
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W2171036048
- Cited by
- 469
- References
- 6
- FWCI
- 24.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Advanced vaginal opening and precocious activation of the reproductive axis by KiSS‐1 peptide, the endogenous ligand of GPR54. https://app.cochat.ai/papers/10.1113/jphysiol.2004.072298
- The paper
- Navarro, V. M., Fernández‐Fernández, R., Castellano, J. M., Roa, J., Mayen, A., Barreiro, M. L., Gaytan, F., Aguilar, E., Pinilla, L., Dieguez, C., & Tena‐Sempere, M. (2004). Advanced vaginal opening and precocious activation of the reproductive axis by KiSS‐1 peptide, the endogenous ligand of GPR54. The Journal of Physiology. https://doi.org/10.1113/jphysiol.2004.072298
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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