The hypothalamic arcuate nucleus: A key site for mediating leptin’s effects on glucose homeostasis and locomotor activity
Open accessAbstract
Leptin is required for normal energy and glucose homeostasis. The hypothalamic arcuate nucleus (ARH) has been proposed as an important site of leptin action. To assess the physiological significance of leptin signaling in the ARH, we used mice homozygous for a FLPe-reactivatable, leptin receptor null allele (Lepr(neo/neo) mice). Similar to Lepr(db/db) mice, these mice are obese, hyperglycemic, hyperinsulinemic, infertile, and hypoactive. To selectively restore leptin signaling in the ARH, we generated an adeno-associated virus expressing FLPe-recombinase, which was delivered unilaterally into the hypothalamus using stereotaxic injections. We found that unilateral restoration of leptin signaling in the ARH of Lepr(neo/neo) mice leads to a modest decrease in body weight and food intake. In contrast, unilateral reactivation markedly improved hyperinsulinemia and normalized blood glucose levels and locomotor activity. These data demonstrate that leptin signaling in the ARH is sufficient for mediating leptin's effects on glucose homeostasis and locomotor activity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Unilateral selective restoration of leptin signaling to the ARC in Leprneo/neo mice has only modest effects on food intake and body weight while markedly improving hyperinsulinemia and normalizing blood glucose levels.
“unilateral, selective restoration of leptin signaling to the ARC was found to have only modest effects on food intake and body weight, while it markedly improved hyperinsulinemia and normalized blood glucose levels (40).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [40]
Genetic studies in mice suggest that the arcuate hypothalamic nucleus plays a major role in mediating effects of leptin on glucose balance and on voluntary locomotor activity.
“Genetic studies in mice suggest that the arcuate hypothalamic nucleus plays a major role in mediating effects of leptin on glucose balance and on voluntary locomotor activity (Coppari et al., 2005), however the specific arcuate neurons responsible remain unspecified.”
From Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons (2009) · cites this paper as Coppari et al., 2005
Unilateral restoration of leptin receptor expression in the ARC of leptin receptor deficient Leprdb/db mice leads to long term reduction of body weight and food intake.
“Moreover, unilateral restoration of leptin receptor expression in the ARC of leptin receptor deficient Leprdb/db mice leads to long term reduction of body weight and food intake (Coppari et al., 2005)”
From Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons (2009) · cites this paper as Coppari et al., 2005
Restoration of leptin-receptors in arcuate neurons greatly increases voluntary locomotor activity in Leprdb/db mice.
“Restoration of leptin-receptors in arcuate neurons greatly increases voluntary locomotor activity in Leprdb/db mice (Coppari et al., 2005), but the specific neurons mediating this action remain unknown.”
From Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons (2009) · cites this paper as Coppari et al., 2005
Unilateral, not bilateral, restoration of endogenous leptin receptors in arcuate neurons of leptin-receptor deficient mice results in a phenotype.
“unilateral, not bilateral, restoration of endogenous leptin receptors in arcuate neurons of leptin-receptor deficient mice (Coppari et al., 2005) results in a phenotype”
From Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons (2009) · cites this paper as Coppari et al., 2005
Restoration of endogenous leptin receptors solely in the arcuate nucleus of leptin-receptor deficient mice normalizes serum glucose levels.
“and a normalization of serum glucose levels”
From Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons (2009) · cites this paper as Coppari et al., 2005
Restoration of endogenous leptin receptors solely in the arcuate nucleus of leptin-receptor deficient mice normalizes locomotor activity.
“and of locomotor activity (Coppari et al., 2005).”
From Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons (2009) · cites this paper as Coppari et al., 2005
Restoration of endogenous leptin receptors solely in the arcuate nucleus of leptin-receptor deficient mice results in a partial reduction in body weight and food intake.
“restoration of endogenous leptin receptors solely in the arcuate nucleus, accomplished by stereotaxic delivery of adeno viruses expressing FLPe-recombinase in otherwise leptin-receptor deficient mice, also results in a partial reduction in body weight and food intake”
From Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons (2009) · cites this paper as Coppari et al., 2005
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works
Effects of the <i>obese</i> Gene Product on Body Weight Regulation in <i>ob</i> / <i>ob</i> Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017 · see citing works
Identification and expression cloning of a leptin receptor, OB-R.
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496 · see citing works
Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243 · see citing works
Role of leptin in the neuroendocrine response to fasting
Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature · doi:10.1038/382250a0 · Cited by 3,117 · see citing works
Self-citationObesity and the regulation of energy balance
Spiegelman, B. M., & Flier, J. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00240-9 · Cited by 2,398 · see citing works
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356 · see citing works
Abnormal splicing of the leptin receptor in diabetic mice
Lee, G.-H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I., & Friedman, J. M. (1996) · Nature · doi:10.1038/379632a0 · Cited by 2,327 · see citing works
Chen, H., Charlat, O., Tartaglia, L. A., Woolf, E. A., Weng, X., Ellis, S. J., Lakey, N. D., Culpepper, J., More, K. J., Breitbart, R. E., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81294-5 · Cited by 2,214 · see citing works
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
Minokoshi, Y., Kim, Y.-B., Peroni, O. D., Fryer, L. G. D., Müller, C., Carling, D., & Kahn, B. B. (2002) · Nature · doi:10.1038/415339a · Cited by 2,053 · see citing works
Leptin Regulates Bone Formation via the Sympathetic Nervous System
Takeda, S., Elefteriou, F., Levasseur, R., Liu, X., Zhao, L., Parker, K. L., Armstrong, D., Ducy, P., & Karsenty, G. (2002) · Cell · doi:10.1016/s0092-8674(02)01049-8 · Cited by 1,735 · see citing works
The role of neuropeptide Y in the antiobesity action of the obese gene product
Stephens, T. W., Basinski, M., Bristow, P. K., Bue-Valleskey, J. M., Burgett, S. G., Craft, L., Hale, J., Hoffmann, J., Hsiung, H. M., Kriauciunas, A., et al. (1995) · Nature · doi:10.1038/377530a0 · Cited by 1,498 · see citing works
Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice
Coleman, D. L. (1978) · Diabetologia · doi:10.1007/bf00429772 · Cited by 1,307 · see citing works
Trophic Action of Leptin on Hypothalamic Neurons That Regulate Feeding
Bouret, S. G., Draper, S. J., & Simerly, R. B. (2004) · Science · doi:10.1126/science.1095004 · Cited by 1,219 · see citing works
Elmquist, J. K., Elias, C. F., & Saper, C. B. (1999) · Neuron · doi:10.1016/s0896-6273(00)81084-3 · Cited by 1,160 · see citing works
Self-citationSaper, C. B., Chou, T. C., & Elmquist, J. K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00969-8 · Cited by 1,120 · see citing works
Self-citationFlier, J. S. (2004) · Cell · doi:10.1016/s0092-8674(03)01081-x · Cited by 1,105 · see citing works
Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor
Chua, S. C., Chung, W. K., Wu-Peng, X. S., Zhang, Y., Liu, S.-M., Tartaglia, L. A., & Leibel, R. L. (1996) · Science · doi:10.1126/science.271.5251.994 · Cited by 1,071 · see citing works
Self-citationLeptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S., & Goldstein, J. L. (1999) · Nature · doi:10.1038/43448 · Cited by 1,038 · see citing works
STAT3 signalling is required for leptin regulation of energy balance but not reproduction
Bates, S. H., Stearns, W. H., Dundon, T. A., Schubert, M., Tso, A. W. K., Wang, Y., Banks, A. S., Lavery, H. J., Haq, A. K., Maratos-Flier, E., et al. (2003) · Nature · doi:10.1038/nature01388 · Cited by 1,010 · cited 3× · see citing works
“Also, in agreement with this, mice lacking leptin-mediated STAT3 activation, which are obese but have normal hypothalamic Npy gene expression, are fertile (Bates et al., 2003).”
BackgroundRapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin
Pinto, S., Roseberry, A. G., Liu, H., Diano, S., Shanabrough, M., Cai, X., Friedman, J. M., & Horvath, T. L. (2004) · Science · doi:10.1126/science.1089459 · Cited by 987 · see citing works
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
Balthasar, N., Coppari, R., McMinn, J., Liu, S. M., Lee, C. E., Tang, V., Kenny, C. D., McGovern, R. A., Chua, S. C., Elmquist, J. K., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.004 · Cited by 935 · see citing works
Self-citationLeptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area
Elias, C. F., Aschkenasi, C., Lee, C., Kelly, J., Ahima, R. S., Bjorbæk, C., Flier, J. S., Saper, C. B., & Elmquist, J. K. (1999) · Neuron · doi:10.1016/s0896-6273(01)80035-0 · Cited by 924 · see citing works
Self-citationSchwartz, M. W., Baskin, D. G., Bukowski, T. R., Kuijper, J. L., Foster, D., Lasser, G., Prunkard, D. E., Porte, D., Woods, S. C., Seeley, R. J., et al. (1996) · Diabetes · doi:10.2337/diab.45.4.531 · Cited by 904 · cited 3× · see citing works
“Within the brain, abundant expression of LEPR-B has been found in several sites including hypothalamic groups such as the arcuate (ARH), the ventromedial (VMH), the dorsomedial (DMH), and the ventral premammillary (PMV) nuclei (Mercer et al., 1996; Elmquist et al., 1998; Fei et al., 1997; Schwartz et al., 1996; Thornt…”
BackgroundMercer, J. G., Hoggard, N., Williams, L. M., Lawrence, C. B., Hannah, L. T., & Trayhurn, P. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00473-5 · Cited by 880 · see citing works
Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus
Schwartz, M. W., Seeley, R. J., Woods, S. C., Weigle, D. S., Campfield, L. A., Burn, P., & Baskin, D. G. (1997) · Diabetes · doi:10.2337/diab.46.12.2119 · Cited by 879 · see citing works
The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.
Baumann, H., Morella, K. K., White, D. W., Dembski, M., Bailon, P., Kim, H., Lai, C. F., & Tartaglia, L. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8374 · Cited by 810 · see citing works
Attenuation of the Obesity Syndrome of ob/ob Mice by the Loss of Neuropeptide Y
Erickson, J. C., Hollopeter, G., & Palmiter, R. D. (1996) · Science · doi:10.1126/science.274.5293.1704 · Cited by 794 · see citing works
Genetics of body-weight regulation
Barsh, G. S., Farooqi, I. S., & O’Rahilly, S. (2000) · Nature · doi:10.1038/35007519 · Cited by 775 · see citing works
Fei, H., Okano, H. J., Li, C., Lee, G.-H., Zhao, C., Darnell, R., & Friedman, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.7001 · Cited by 766 · see citing works
Acute stimulation of glucose metabolism in mice by leptin treatment
Kamohara, S., Burcelin, R., Halaas, J. L., Friedman, J. M., & Charron, M. J. (1997) · Nature · doi:10.1038/38717 · Cited by 708 · see citing works
Selective deletion of leptin receptor in neurons leads to obesity
Cohen, P., Zhao, C., Cai, X., Montez, J. M., Rohani, S., Feinstein, P. G., Mombaerts, P., & Friedman, J. M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13914 · Cited by 657 · see citing works
Selective deletion of leptin receptor in neurons leads to obesity
Cohen, P., Zhao, C., Cai, X., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113914 · Cited by 554 · see citing works
Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice
Thornton, J. E., Cheung, C. C., Clifton, D. K., & Steiner, R. A. (1997) · Endocrinology · doi:10.1210/endo.138.11.5651 · Cited by 437 · cited 2× · see citing works
“(Schwartz et al., 1997; Thornton et al., 1997).”
BackgroundOrexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus
van den Top, M., Lee, K., Whyment, A. D., Blanks, A. M., & Spanswick, D. (2004) · Nature Neuroscience · doi:10.1038/nn1226 · Cited by 435 · see citing works
Mizuno, T. M., & Mobbs, C. V. (1999) · Endocrinology · doi:10.1210/endo.140.2.6491 · Cited by 387 · see citing works
Liu, H., Kishi, T., Roseberry, A. G., Cai, X., Lee, C. E., Montez, J. M., Friedman, J. M., & Elmquist, J. K. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-18-07143.2003 · Cited by 375 · see citing works
Self-citationMinireview: From Anorexia to Obesity—The Yin and Yang of Body Weight Control
Zigman, J. M., & Elmquist, J. K. (2003) · Endocrinology · doi:10.1210/en.2003-0241 · Cited by 375 · see citing works
Self-citationCentral melanocortin receptors regulate insulin action
Obici, S., Feng, Z., Tan, J., Liu, L., Karkanias, G. B., & Rossetti, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12954 · Cited by 370 · see citing works
Central melanocortin receptors regulate insulin action
Obici, S., Feng, Z., Tan, J., Liu, L., Karkanias, G., & Rossetti, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112954 · Cited by 370 · see citing works
Modern science versus the stigma of obesity
Friedman, J. M. (2004) · Nature Medicine · doi:10.1038/nm0604-563 · Cited by 368 · see citing works
Is the Energy Homeostasis System Inherently Biased Toward Weight Gain?
Schwartz, M. W., Woods, S. C., Seeley, R. J., Barsh, G. S., Baskin, D. G., & Leibel, R. L. (2003) · Diabetes · doi:10.2337/diabetes.52.2.232 · Cited by 351 · see citing works
Münzberg, H., Huo, L., Nillni, E. A., Hollenberg, A. N., & Bjørbæk, C. (2003) · Endocrinology · doi:10.1210/en.2002-221037 · Cited by 328 · see citing works
The Central Melanocortin System Can Directly Regulate Serum Insulin Levels*
Fan, W., Dinulescu, D. M., Butler, A. A., Zhou, J., Marks, D. L., & Cone, R. D. (2000) · Endocrinology · doi:10.1210/endo.141.9.7665 · Cited by 294 · see citing works
Chamberlin, N. L., Du, B., de Lacalle, S., & Saper, C. B. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00169-3 · Cited by 221 · see citing works
Brain Stem Is a Direct Target for Leptin’s Action in the Central Nervous System
Hosoi, T., Kawagishi, T., Okuma, Y., Tanaka, J., & Nomura, Y. (2002) · Endocrinology · doi:10.1210/en.2002-220077 · Cited by 205 · see citing works
Roseberry, A. G., Liu, H., Jackson, A. C., Cai, X., & Friedman, J. M. (2004) · Neuron · doi:10.1016/s0896-6273(04)00074-1 · Cited by 198 · see citing works
Li, C., & Friedman, J. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9677 · Cited by 177 · see citing works
Morton, G. J., Niswender, K. D., Rhodes, C. J., Myers, M. G., Blevins, J. E., Baskin, D. G., & Schwartz, M. W. (2003) · Endocrinology · doi:10.1210/en.2002-0115 · Cited by 158 · see citing works
Transgenic Complementation of Leptin-Receptor Deficiency
Kowalski, T. J., Liu, S.-M., Leibel, R. L., & Chua, S. C. (2001) · Diabetes · doi:10.2337/diabetes.50.2.425 · Cited by 150 · see citing works
Self-citationElectrophysiological Actions of Peripheral Hormones on Melanocortin Neurons
Cowley, M. A., Cone, R. D., Enriori, P. J., Louiselle, I., Williams, S., & Evans, A. E. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb03178.x · Cited by 121 · see citing works
An allelic series for the leptin receptor gene generated by CRE and FLP recombinase
McMinn, J. E., Liu, S.-M., Dragatsis, I., Dietrich, P., Ludwig, T. E., Eiden, S., & Chua, S. C. (2004) · Mammalian Genome · doi:10.1007/s00335-004-2340-1 · Cited by 81 · see citing works
Self-citationYamamoto, Y., Ueta, Y., Serino, R., Nomura, M. J., Shibuya, I., & Yamashita, H. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00271-3 · Cited by 64 · see citing works
Elmquist (1998) · doi:10.1002/(sici)1096-9861(19980615)395:4
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Franklin, K.B.J., and Paxinos, G. (1997). The Mouse Brain in Sterotaxic Co- Balthasar, N., Coppari, R., McMinn, J., Liu, S.M., Lee, C.E., Tang, V., Kenny, ordinates (San Diego: Academic Press).
Cited by
Sorted by citations
Adipokines and Insulin Resistance
Rabe, K., Lehrke, M., Parhofer, K. G., & Broedl, U. C. (2008) · Molecular Medicine · doi:10.2119/2008-00058.rabe · Cited by 814 · see citing works
Rehman, K., & Akash, M. S. H. (2016) · Journal of Biomedical Science · doi:10.1186/s12929-016-0303-y · Cited by 685 · see citing works
Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism
Park, H. K., & Ahima, R. S. (2014) · Metabolism · doi:10.1016/j.metabol.2014.08.004 · Cited by 675 · see citing works
Yadav, V. K., Oury, F., Suda, N., Liu, Z.-W., Gao, X.-B., Confavreux, C., Klemenhagen, K. C., Tanaka, K. F., Gingrich, J. A., Guo, X. E., et al. (2009) · Cell · doi:10.1016/j.cell.2009.06.051 · Cited by 661 · see citing works
Neuronal PTP1B regulates body weight, adiposity and leptin action
Bence, K. K., Delibegovic, M., Xue, B., Gorgun, C. Z., Hotamisligil, G. S., Neel, B. G., & Kahn, B. B. (2006) · Nature Medicine · doi:10.1038/nm1435 · Cited by 633 · see citing works
Diet-Induced Obesity Causes Severe but Reversible Leptin Resistance in Arcuate Melanocortin Neurons
Enriori, P. J., Evans, A. E., Sinnayah, P., Jobst, E. E., Tonelli-Lemos, L., Billes, S. K., Glavas, M. M., Grayson, B. E., Perello, M., Nillni, E. A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.02.004 · Cited by 552 · see citing works
Molecular and anatomical determinants of central leptin resistance
Münzberg, H., & Myers, M. G. (2005) · Nature Neuroscience · doi:10.1038/nn1454 · Cited by 550 · see citing works
Hypothalamic Tanycytes Are an ERK-Gated Conduit for Leptin into the Brain
Balland, É., Dam, J., Langlet, F., Caron, É., Steculorum, S. M., Messina, A., Rasika, S., Falluel‐Morel, A., Anouar, Y., Dehouck, B., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.015 · Cited by 500 · see citing works
Leptin targets in the mouse brain
Scott, M. M., Lachey, J. L., Sternson, S. M., Lee, C. E., Elias, C. F., Friedman, J. M., & Elmquist, J. K. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.22025 · Cited by 484 · see citing works
Self-citationStructure, production and signaling of leptin
Münzberg, H., & Morrison, C. D. (2014) · Metabolism · doi:10.1016/j.metabol.2014.09.010 · Cited by 455 · see citing works
Varela, L., & Horvath, T. L. (2012) · The EMBO Reports · doi:10.1038/embor.2012.174 · Cited by 426 · see citing works
From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior
Williams, K. W., & Elmquist, J. K. (2012) · Nature Neuroscience · doi:10.1038/nn.3217 · Cited by 421 · see citing works
Self-citationLeptin signaling and leptin resistance
Zhou, Y., & Rui, L. (2013) · Frontiers of Medicine · doi:10.1007/s11684-013-0263-5 · Cited by 417 · see citing works
Central nervous system control of metabolism
Myers, M. G., & Olson, D. P. (2012) · Nature · doi:10.1038/nature11705 · Cited by 399 · see citing works
Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism
Roh, E., Song, D. K., & Kim, M.-S. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.4 · Cited by 391 · see citing works
Hill, J. W., Elias, C. F., Fukuda, M., Williams, K. W., Berglund, E. D., Holland, W. L., Cho, Y.-R., Chuang, J.-C., Xu, Y., Choi, M., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.002 · Cited by 391 · see citing works
Self-citationIdentifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis
Elmquist, J. K., Coppari, R., Balthasar, N., Ichinose, M., & Lowell, B. B. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20786 · Cited by 388 · see citing works
Self-citationSixteen years and counting: an update on leptin in energy balance
Gautron, L., & Elmquist, J. K. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45888 · Cited by 367 · see citing works
Self-citationDonato, J., Cravo, R. M., Frazão, R., Gautron, L., Scott, M. M., Lachey, J. L., de Castro, I. A., Margatho, L. O., Lee, S., Lee, C., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci45106 · Cited by 356 · see citing works
Self-citationBerglund, E. D., Vianna, C. R., Donato, J., Kim, M. H., Chuang, J.-C., Lee, C. E., Lauzon, D. A., Lin, P., Brule, L. J., Scott, M. M., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59816 · Cited by 352 · see citing works
Self-citationLeinninger, G. M., Opland, D. M., Jo, Y., Faouzi, M., Christensen, L., Cappellucci, L., Rhodes, C. J., Gnegy, M. E., Becker, J. B., Pothos, E. N., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.016 · Cited by 346 · see citing works
Regulation of Blood Glucose by Hypothalamic Pyruvate Metabolism
Lam, T. K. T., Gutierrez-Juarez, R., Pocai, A., & Rossetti, L. (2005) · Science · doi:10.1126/science.1112085 · Cited by 341 · see citing works
Leptin and the Central Nervous System Control of Glucose Metabolism
Morton, G. J., & Schwartz, M. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00007.2010 · Cited by 338 · see citing works
“(40) studied mice in which the endogenous Lepr allele was replaced by a mutant construct through which gene expression is GREGORY J.”
Backgroundvan de Wall, E., Leshan, R., Xu, A. W., Balthasar, N., Coppari, R., Liu, S. M., Jo, Y. H., MacKenzie, R. G., Allison, D. B., Dun, N. J., et al. (2008) · Endocrinology · doi:10.1210/en.2007-1132 · Cited by 338 · see citing works
Self-citationArcuate Glucagon-Like Peptide 1 Receptors Regulate Glucose Homeostasis but Not Food Intake
Sandoval, D. A., Bagnol, D., Woods, S. C., D’Alessio, D. A., & Seeley, R. J. (2008) · Diabetes · doi:10.2337/db07-1824 · Cited by 316 · see citing works
Adipokines and the Peripheral and Neural Control of Energy Balance
Ahima, R. S., & Lazar, M. A. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0529 · Cited by 314 · see citing works
Cooperation between brain and islet in glucose homeostasis and diabetes
Schwartz, M. W., Seeley, R. J., Tschöp, M. H., Woods, S. C., Morton, G. J., Myers, M. G., & D’Alessio, D. A. (2013) · Nature · doi:10.1038/nature12709 · Cited by 311 · see citing works
Obesity in Dogs and Cats: A Metabolic and Endocrine Disorder
Zoran, D. L. (2010) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2009.10.009 · Cited by 297 · see citing works
Upper intestinal lipids trigger a gut–brain–liver axis to regulate glucose production
Wang, P. Y. T., Caspi, L., Lam, C., Chari, M., Li, X., Light, P. E., Juárez, R. G., Ang, M. L. T., Schwartz, G. J., & Lam, T. K. T. (2008) · Nature · doi:10.1038/nature06852 · Cited by 293 · see citing works
Leptin revisited: its mechanism of action and potential for treating diabetes
Coppari, R., & Bjørbæk, C. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3757 · Cited by 295 · see citing works
Self-citationThe Geometry of Leptin Action in the Brain: More Complicated Than a Simple ARC
Myers, M. G., Münzberg, H., Leinninger, G. M., & Leshan, R. L. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.001 · Cited by 294 · see citing works
Morton, G. J., Gelling, R. W., Niswender, K. D., Morrison, C. D., Rhodes, C. J., & Schwartz, M. W. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.10.009 · Cited by 292 · see citing works
Sarruf, D. A., Thaler, J. P., Morton, G. J., German, J. P., Fischer, J. D., Ogimoto, K., & Schwartz, M. W. (2010) · Diabetes · doi:10.2337/db09-1878 · Cited by 287 · see citing works
Enriori, P. J., Evans, A. E., Sinnayah, P., & Cowley, M. A. (2006) · Obesity · doi:10.1038/oby.2006.319 · Cited by 281 · see citing works
Cytokines and abnormal glucose and lipid metabolism
Shi, J., Fan, J., Su, Q., & Yang, Z. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00703 · Cited by 282 · see citing works
CNS leptin and insulin action in the control of energy homeostasis
Belgardt, B., & Brüning, J. C. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05799.x · Cited by 275 · see citing works
Brain regulation of food intake and appetite: molecules and networks
Broberger, C. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01553.x · Cited by 267 · see citing works
Enhanced Orexin Receptor-2 Signaling Prevents Diet-Induced Obesity and Improves Leptin Sensitivity
Funato, H., Tsai, A. L., Willie, J. T., Kisanuki, Y. Y., Williams, S. C., Sakurai, T., & Yanagisawa, M. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.10.010 · Cited by 262 · see citing works
The adipocyte as an active participant in energy balance and metabolism
Badman, M. K., & Flier, J. S. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.058 · Cited by 256 · see citing works
Kim, J. J., & Sears, D. D. (2010) · Gastroenterology Research and Practice · doi:10.1155/2010/212563 · Cited by 249 · see citing works
Kievit, P., Howard, J. K., Badman, M. K., Balthasar, N., Coppari, R., Mori, H., Lee, C. E., Elmquist, J. K., Yoshimura, A., & Flier, J. S. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.06.010 · Cited by 242 · see citing works
Self-citationTissue-Specific Effects of Leptin on Glucose and Lipid Metabolism
Pereira, S., Cline, D. L., Glavas, M. M., Covey, S. D., & Kieffer, T. J. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa027 · Cited by 247 · see citing works
Obesity and adipokines: effects on sympathetic overactivity
Smith, M. M., & Minson, C. T. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.221036 · Cited by 237 · see citing works
Merikangas, K. R., Swendsen, J., Hickie, I. B., Cui, L., Shou, H., Merikangas, A. K., Zhang, J., Lamers, F., Crainiceanu, C., Volkow, N. D., et al. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2018.3546 · Cited by 231 · see citing works
The role of leptin in the control of insulin-glucose axis
Amitani, M. S., Asakawa, A., Amitani, H., & Inui, A. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00051 · Cited by 228 · see citing works
Critical role of STAT3 in leptin's metabolic actions
Buettner, C., Pocai, A., Muse, E. D., Etgen, A. M., Myers, M. G., & Rossetti, L. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.014 · Cited by 228 · see citing works
Developmental programming of hypothalamic feeding circuits
Bouret, S., & Simerly, R. (2006) · Clinical Genetics · doi:10.1111/j.1399-0004.2006.00684.x · Cited by 227 · see citing works
Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons
Huo, L., Gamber, K., Greeley, S., Silva, J., Huntoon, N., Leng, X.-H., & Bjørbæk, C. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.05.003 · Cited by 226 · see citing works
“Furthermore, unilateral, not bilateral, restoration of endogenous leptin receptors in arcuate neurons of leptin-receptor deficient mice (Coppari et al., 2005) results in a phenotype strikingly similar to that of our HA-ObRb/Pomc-Cre/Leprdb/db mice.”
InfluentialMicroRNAs in Obesity and Related Metabolic Disorders
Landrier, J., Derghal, A., & Mounien, L. (2019) · Cells · doi:10.3390/cells8080859 · Cited by 196 · see citing works
Leptin Receptor Signaling and Action in the Central Nervous System
Leshan, R. L., Björnholm, M., Münzberg, H., & Myers, M. G. (2006) · Obesity · doi:10.1038/oby.2006.310 · Cited by 221 · see citing works
Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice
Fujikawa, T., Chuang, J.-C., Sakata, I., Ramadori, G., & Coppari, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008025107 · Cited by 221 · see citing works
Self-citationThe glucoregulatory actions of leptin
D'souza, A. M., Neumann, U. H., Glavas, M. M., & Kieffer, T. J. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.04.011 · Cited by 214 · see citing works
PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice
Banno, R., Zimmer, D., De Jonghe, B. C., Atienza, M., Rak, K., Yang, W., & Bence, K. K. (2010) · Journal of Clinical Investigation · doi:10.1172/jci39620 · Cited by 214 · see citing works
Gorski, J. N., Dunn-Meynell, A. A., Hartman, T. G., & Levin, B. E. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00138.2006 · Cited by 214 · see citing works
Hypothalamic control of energy expenditure and thermogenesis
Tran, L. T., Park, S., Kim, S. K., Lee, J. S., Kim, K. W., & Kwon, O. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00741-z · Cited by 208 · see citing works
Differential Accessibility of Circulating Leptin to Individual Hypothalamic Sites
Faouzi, M., Leshan, R. L., Björnholm, M., Hennessey, T., Jones, J. C., & Münzberg, H. (2007) · Endocrinology · doi:10.1210/en.2007-0655 · Cited by 205 · see citing works
Rezai-Zadeh, K. P., Yu, S., Jiang, Y., Laque, A., Schwartzenburg, C., Morrison, C. D., Derbenev, A. V., Zsombok, A., & Münzberg, H. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.07.008 · Cited by 193 · see citing works
Scott, M. M., Williams, K. W., Rossi, J., Lee, C. E., & Elmquist, J. K. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43703 · Cited by 191 · see citing works
Self-citationBrain regulation of food intake and appetite: molecules and networks
Roberger, C. B. (2005) · Cited by 191 · see citing works
Leptin signaling and circuits in puberty and fertility
Elias, C. F., & Purohit, D. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1095-1 · Cited by 190 · see citing works
Hypothalamic-autonomic control of energy homeostasis
Seoane‐Collazo, P., Fernø, J., González, F., Diéguez, C., Leis, R., Nogueiras, R., & López, M. (2015) · Endocrine · doi:10.1007/s12020-015-0658-y · Cited by 188 · see citing works
Organization of circadian functions: interaction with the body
Buijs, R. M., Scheer, F. A. J. L., Kreier, F., Yi, C., Bos, N. P. A., Goncharuk, V. D., & Kalsbeek, A. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)53020-1 · Cited by 189 · see citing works
Molecular and neural mediators of leptin action
Robertson, S., Leinninger, G. M., & Myers, M. G. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.04.005 · Cited by 186 · see citing works
Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function
Björnholm, M., Münzberg, H., Leshan, R. L., Villanueva, E. C., Bates, S. H., Louis, G. W., Jones, J. C., Ishida-Takahashi, R., Bjørbaek, C., & Myers, M. G. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30688 · Cited by 183 · see citing works
Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling
Zhang, Z., Dodd, G. T., & Tiganis, T. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.07.003 · Cited by 181 · see citing works
Hypothalamic Arcuate Nucleus Mediates the Sympathetic and Arterial Pressure Responses to Leptin
Rahmouni, K., & Morgan, D. A. (2006) · Hypertension · doi:10.1161/01.hyp.0000254827.59792.b2 · Cited by 180 · see citing works
Neurodevelopmental actions of leptin
Bouret, S. G. (2010) · Brain Research · doi:10.1016/j.brainres.2010.04.011 · Cited by 178 · see citing works
The pancreatic β cell is a key site for mediating the effects of leptin on glucose homeostasis
Covey, S. D., Wideman, R. D., McDonald, C. M., Unniappan, S., Huynh, F. K., Asadi, A., Speck, M., Webber, T. D., Chua, S. C., & Kieffer, T. J. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.09.005 · Cited by 174 · see citing works
Self-citationArble, D. M., Bass, J., Behn, C. D., Butler, M. P., Challet, E., Czeisler, C., Depner, C. M., Elmquist, J., Franken, P., Grandner, M. A., et al. (2015) · Sleep · doi:10.5665/sleep.5226 · Cited by 173 · see citing works
Self-citationMinireview: CNS Mechanisms of Leptin Action
Flak, J. N., & Myers, M. G. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1232 · Cited by 175 · see citing works
Park, H.-K., & Ahima, R. S. (2014) · F1000Prime Reports · doi:10.12703/p6-73 · Cited by 171 · see citing works
Zhang, Y., Reichel, J. M., Han, C., Zuniga-Hertz, J. P., & Cai, D. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.002 · Cited by 164 · see citing works
Permeability of the blood–brain barrier to a novel satiety molecule nesfatin-1
Price, T. O., Samson, W. K., Niehoff, M. L., & Banks, W. A. (2007) · Peptides · doi:10.1016/j.peptides.2007.10.008 · Cited by 165 · see citing works
German, J., Kim, F., Schwartz, G. J., Havel, P. J., Rhodes, C. J., Schwartz, M. W., & Morton, G. J. (2009) · Endocrinology · doi:10.1210/en.2009-0445 · Cited by 164 · see citing works
Hormone Interactions Regulating Energy Balance During Pregnancy
Ladyman, S. R., Augustine, R. A., & Grattan, D. R. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02017.x · Cited by 161 · see citing works
The role of leptin in health and disease
Ramos-Lobo, A. M., & Donato, J. (2017) · Temperature · doi:10.1080/23328940.2017.1327003 · Cited by 166 · see citing works
Leptin brain entry via a tanycytic LepR–EGFR shuttle controls lipid metabolism and pancreas function
Duquenne, M., Folgueira, C., Bourouh, C., Millet, M., Silva, A. J., Clasadonte, J., Imbernón, M., Fernandois, D., Martínez‐Corral, I., Kusumakshi, S., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00432-5 · Cited by 161 · see citing works
Hypothalamic inflammation: a double‐edged sword to nutritional diseases
Cai, D., & Liu, T. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06388.x · Cited by 159 · see citing works
Hypothalamic mechanisms in cachexia
Grossberg, A. J., Scarlett, J. M., & Marks, D. L. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.03.011 · Cited by 160 · see citing works
Early Life Origins of Obesity: Role of Hypothalamic Programming
Bouret, S. G. (2009) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181977375 · Cited by 160 · see citing works
Leptin Deficiency Causes Insulin Resistance Induced by Uncontrolled Diabetes
German, J. P., Wisse, B. E., Thaler, J. P., Oh-I, S., Sarruf, D. A., Ogimoto, K., Kaiyala, K. J., Fischer, J. D., Matsen, M. E., Taborsky, G. J., et al. (2010) · Diabetes · doi:10.2337/db09-1918 · Cited by 159 · see citing works
SIRT1 Deacetylase in SF1 Neurons Protects against Metabolic Imbalance
Ramadori, G., Fujikawa, T., Anderson, J. G., Berglund, E. D., Frazão, R., Michán, S., Vianna, C. R., Sinclair, D. A., Elias, C. F., & Coppari, R. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.014 · Cited by 158 · see citing works
Self-citationMüller, T. D., Sullivan, L. M., Habegger, K., Yi, C., Kabra, D., Grant, E., Ottaway, N., Krishna, R., Holland, J., Hembree, J., et al. (2012) · Journal of Peptide Science · doi:10.1002/psc.2408 · Cited by 156 · see citing works
Central nervous system regulation of organismal energy and glucose homeostasis
Myers, M. G., Affinati, A. H., Richardson, N. E., & Schwartz, M. W. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00408-5 · Cited by 154 · see citing works
Role of leptin in the pancreatic β-cell: effects and signaling pathways
Marroquí, L., González, A., Ñeco, P., Caballero‐Garrido, E., Vieira, E. C., Ripoll, C., Nadal, Á., & Quesada, I. (2012) · Journal of Molecular Endocrinology · doi:10.1530/jme-12-0025 · Cited by 151 · see citing works
Serotonin and the regulation of mammalian energy balance
Donovan, M. H., & Tecott, L. H. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00036 · Cited by 150 · see citing works
Distribution of leptin‐sensitive cells in the postnatal and adult mouse brain
Caron, É., Sachot, C., Prévot, V., & Bouret, S. G. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22219 · Cited by 147 · see citing works
Lee, E., Jung, D. Y., Kim, J. H., Patel, P. R., Hu, X., Lee, Y., Azuma, Y., Wang, H.-F., Tsitsilianos, N., Shafiq, U., et al. (2015) · The FASEB Journal · doi:10.1096/fj.14-268300 · Cited by 147 · see citing works
Farr, O. M., Tsoukas, M. A., & Mantzoros, C. S. (2014) · Metabolism · doi:10.1016/j.metabol.2014.07.004 · Cited by 146 · see citing works
Conditional gene targeting in the mouse nervous system: Insights into brain function and diseases
Gavériaux‐Ruff, C., & Kieffer, B. L. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.12.003 · Cited by 146 · see citing works
Harlan, S. M., Morgan, D. A., Agassandian, K., Guo, D.-F., Cassell, M. D., Sigmund, C. D., Mark, A. L., & Rahmouni, K. (2011) · Circulation Research · doi:10.1161/circresaha.111.240226 · Cited by 144 · see citing works
Bouret, S. G., Bates, S. H., Chen, S. H., Myers, M. G., & Simerly, R. B. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2277-11.2012 · Cited by 144 · see citing works
Morgan, J., Corrigan, F., & Baune, B. T. (2015) · Journal of Molecular Psychiatry · doi:10.1186/s40303-015-0010-8 · Cited by 143 · see citing works
Development of Leptin‐Sensitive Circuits
Bouret, S. G., & Simerly, R. B. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2007.01563.x · Cited by 143 · see citing works
Hypothalamic Sites of Leptin Action Linking Metabolism and Reproduction
Donato, J., Cravo, R. M., Frazão, R., & Elias, C. F. (2010) · Neuroendocrinology · doi:10.1159/000322472 · Cited by 141 · see citing works
Ghrelin Directly Stimulates Glucagon Secretion from Pancreatic α-Cells
Chuang, J.-C., Sakata, I., Kohno, D., Perello, M., Osborne-Lawrence, S., Repa, J. J., & Zigman, J. M. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-1001 · Cited by 141 · see citing works
Chemerin: a potential endocrine link between obesity and type 2 diabetes
Roman, A. A., Parlee, S. D., & Sinal, C. J. (2012) · Endocrine · doi:10.1007/s12020-012-9698-8 · Cited by 139 · see citing works
Putting desire on a budget: dopamine and energy expenditure, reconciling reward and resources
Beeler, J. A., Frazier, C. R. M., & Zhuang, X. (2012) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2012.00049 · Cited by 136 · see citing works
Laposky, A. D., Bradley, M. A., Williams, D. L., Bass, J., & Turek, F. W. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00026.2008 · Cited by 135 · see citing works
Donato, J., Silva, R. J., Sita, L. V., Lee, S., Lee, C., Lacchini, S., Bittencourt, J. C., Franci, C. R., Canteras, N. S., & Elias, C. F. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0405-09.2009 · Cited by 133 · see citing works
Self-citation
- Authors
- Coppari, R., Ichinose, M., Lee, C. E., Pullen, A. E., Kenny, C. D., McGovern, R. A., Tang, V., Liu, S. M., Ludwig, T., Chua, S. C., Lowell, B. B., & Elmquist, J. K.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Columbia University (US)
- Corresponding author
- Lowell, Bradford B.
- Elmquist, Joel K.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 1
- Issue
- 1
- Pages
- 63-72
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2017709986
- Cited by
- 457
- References
- 52
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 6 · 2023: 13 · 2022: 11 · 2021: 12 · 2020: 23 · 2019: 22 · 2018: 15 · 2017: 28 · 2016: 22 · 2015: 25 · 2014: 23 · 2013: 23 · 2012: 36
- FWCI
- 10.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- National Institute of Mental Health (R01MH061583, MH61583)
- National Institute of Diabetes and Digestive and Kidney Diseases (P01DK56116, DK53301, P01DK056116, R01DK057621, DK57621, DK 26687, P30DK026687)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- leptin, arcuate nucleus, hypothalamus, glucose homeostasis, locomotor activity, leptin receptor, adeno-associated virus, hyperinsulinemia, obesity, dietary intake, body weight, hyperglycemia, infertility
- MeSH terms
- Alleles, Animals, Arcuate Nucleus of Hypothalamus, Body Composition, Body Weight, Cell Nucleus, DNA Nucleotidyltransferases, Fertility, Glucose, Homeostasis, Homozygote, Hypothalamus, Immunohistochemistry, Male, Mice, Inbred C57BL, Mice, Transgenic, Models, Genetic, Motor Activity, Neurons, Oxygen Consumption, Receptors, Cell Surface, Time Factors, Signal Transduction, Leptin, Green Fluorescent Proteins, Mice, Receptors, Leptin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
