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Macrophages and Systemic Iron Homeostasis
Open accessAbstract
As a principal aspect of their scavenging function, splenic and hepatic macrophages phagocytize and degrade senescent and damaged erythrocytes to recover iron, mainly for the production of hemoglobin in new erythrocytes but also for other carriers and enzymes requiring iron. Splenic red pulp macrophages are specialized for iron recycling with increased expression of proteins for the uptake of hemoglobin, breakdown of heme and the export of iron. In humans, recycling macrophages contribute the majority of the iron flux into extracellular fluid, exceeding the contribution of dietary iron absorption and release of stored iron from hepatocytes. Iron release from macrophages is closely regulated by the interaction of hepcidin, a peptide hormone produced by hepatocytes, with the macrophage iron exporter ferroportin. In addition to their homeostatic role, macrophages employ multiple mechanisms to contain microbial infections by depriving microbes of iron. This review discusses the iron-scavenging function of macrophages in the context of iron homeostasis and host defense.
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“Inside infected macrophages, a pathogen's access to Fe may be limited by natural resistance-associated macrophage protein 1 (SLC11A1, formerly Nramp1).”
From Strategies of intracellular pathogens for obtaining iron from the environment (2015) · cites this paper as [20]
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Metadata
- Authors
- Ganz, T.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Ganz, Tomas
- ORCID
- Ganz, Tomas
- Venue
- Journal of Innate Immunity
- Publisher
- S. Karger AG
- Published
- 2012
- Volume
- 4
- Issue
- 5-6
- Pages
- 446-453
- ISSN
- 1662-811X (ISSN-L)
- 1662-8128
- PMC
- PMC6741611
- OpenAlex
- W2041361488
- Cited by
- 281
- References
- 47
- Citations by year
- 2026: 9 · 2025: 19 · 2024: 18 · 2023: 13 · 2022: 27 · 2021: 21 · 2020: 21 · 2019: 17 · 2018: 20 · 2017: 33 · 2016: 18 · 2015: 26 · 2014: 20 · 2013: 15 · 2012: 3
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Innate Immunity (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Physical Sciences › Materials Science › Metals and Alloys › Iron and Steelmaking Processes
- Keywords
- macrophages, hepatic macrophages, hepcidin, ferroportin, iron export, heme degradation, host defense
- MeSH terms
- Ferroportin, Adult, Animals, Erythrocytes, Homeostasis, Humans, Iron, Macrophages, Male, Antimicrobial Cationic Peptides, Cation Transport Proteins, Mice, Cytophagocytosis, Hepcidins
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