The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Macrophages and Systemic Iron Homeostasis
Open accessAbstract
As a principal aspect of their scavenging function, splenic and hepatic macrophages phagocytize and degrade senescent and damaged erythrocytes to recover iron, mainly for the production of hemoglobin in new erythrocytes but also for other carriers and enzymes requiring iron. Splenic red pulp macrophages are specialized for iron recycling with increased expression of proteins for the uptake of hemoglobin, breakdown of heme and the export of iron. In humans, recycling macrophages contribute the majority of the iron flux into extracellular fluid, exceeding the contribution of dietary iron absorption and release of stored iron from hepatocytes. Iron release from macrophages is closely regulated by the interaction of hepcidin, a peptide hormone produced by hepatocytes, with the macrophage iron exporter ferroportin. In addition to their homeostatic role, macrophages employ multiple mechanisms to contain microbial infections by depriving microbes of iron. This review discusses the iron-scavenging function of macrophages in the context of iron homeostasis and host defense.
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“Inside infected macrophages, a pathogen's access to Fe may be limited by natural resistance-associated macrophage protein 1 (SLC11A1, formerly Nramp1).”
From Strategies of intracellular pathogens for obtaining iron from the environment (2015) · cites this paper as [20]
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Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803
Self-citationNemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420945 · Cited by 2,650
Self-citationIdentification of the haemoglobin scavenger receptor
Kristiansen, M., Graversen, J. H., Jacobsen, C., Sonne, O., Hoffman, H.-J., Law, S. K. A., & Moestrup, S. K. (2001) · Nature · doi:10.1038/35051594 · Cited by 1,712
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
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Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency
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Trophic macrophages in development and disease
Pollard, J. W. (2009) · Nature Reviews Immunology · doi:10.1038/nri2528 · Cited by 1,178
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Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
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Heme oxygenase 1 is required for mammalian iron reutilization
Poss, K. D., & Tonegawa, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10919 · Cited by 1,016
Muckenthaler, M. U., Galy, B., & Hentze, M. W. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155521 · Cited by 701
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From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation
Italiani, P., & Boraschi, D. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00514 · Cited by 2,067
“cell debris from blood (128, 129) Fibrosis (130), impaired erythrocyte”
BackgroundDavies, L. C., Jenkins, S. J., Allen, J. E., & Taylor, P. R. (2013) · Nature Immunology · doi:10.1038/ni.2705 · Cited by 2,096
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Varol, C., Mildner, A., & Jung, S. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112220 · Cited by 962
“Red pulp macrophages (RPMs) are specialized in iron recovery and prominently express proteins involved in all recycling phases, starting from the scavenging of senescent or damaged erythrocytes, the uptake of hemoglobin, and finally heme breakdown and iron export (185).”
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Ngambenjawong, C., Gustafson, H. H., & Pun, S. H. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.04.010 · Cited by 858
“Kupffer cells in the liver clear foreign, pathogenic, and waste materials from circulation [11].”
Regulation of macrophage development and function in peripheral tissues
Lavin, Y., Mortha, A., Rahman, A., & Merad, M. (2015) · Nature Reviews Immunology · doi:10.1038/nri3920 · Cited by 680
Metadata
- Authors
- Ganz, T.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Ganz, Tomas
- ORCID
- Ganz, Tomas
- Venue
- Journal of Innate Immunity
- Publisher
- S. Karger AG
- Published
- 2012
- Volume
- 4
- Issue
- 5-6
- Pages
- 446-453
- ISSN
- 1662-811X (ISSN-L)
- 1662-8128
- PMC
- PMC6741611
- OpenAlex
- W2041361488
- Cited by
- 281
- References
- 47
- Citations by year
- 2026: 9 · 2025: 19 · 2024: 18 · 2023: 13 · 2022: 27 · 2021: 21 · 2020: 21 · 2019: 17 · 2018: 20 · 2017: 33 · 2016: 18 · 2015: 26 · 2014: 20 · 2013: 15 · 2012: 3
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Innate Immunity (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Physical Sciences › Materials Science › Metals and Alloys › Iron and Steelmaking Processes
- Keywords
- macrophages, hepatic macrophages, hepcidin, ferroportin, iron export, heme degradation, host defense
- MeSH terms
- Ferroportin, Adult, Animals, Erythrocytes, Homeostasis, Humans, Iron, Macrophages, Male, Antimicrobial Cationic Peptides, Cation Transport Proteins, Mice, Cytophagocytosis, Hepcidins
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