The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Epithelial-Mesenchymal Transition: A Hallmark in Metastasis Formation Linking Circulating Tumor Cells and Cancer Stem Cells
Abstract
The occurrence of either regional or distant metastases is an indicator of poor prognosis for cancer patients. The mechanism of their formation has not yet been fully uncovered, which limits the possibility of developing new therapeutic strategies. Nevertheless, the discovery of circulating tumor cells (CTCs), which are responsible for tumor dissemination, and cancer stem cells (CSCs), required for tumor growth maintenance, shed light on the metastatic cascade. It seems that CTCs and CSCs are not necessarily separate populations of cancer cells, as CTCs generated in the process of epithelial-mesenchymal transition (EMT) can bear features characteristic of CSCs. This article describes the mechanisms of CTC and CSC formation and characterizes their molecular hallmarks. Moreover, we present different types of EMT occurring in physiological and pathological conditions, and we demonstrate its crucial role in providing CTCs with a CSC phenotype. The article delineates molecular changes acquired by cancer cells undergoing EMT that facilitate metastasis formation. Deeper understanding of those processes is of fundamental importance for the development of new strategies of early cancer detection and effective cancer treatment approaches that will be translated into clinical practice.
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Cites
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Cited by
Crossing the endothelial barrier during metastasis
Reymond, N., d'Água, B. B., & Ridley, A. J. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3628 · Cited by 922
EMT, CTCs and CSCs in tumor relapse and drug-resistance
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Association of circulating tumor cells and IMP3 expression with metastasis of osteosarcoma
Dai, S., Shao, X., Wei, Q., Du, S., Hou, C., Li, H., & Jin, D. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.819357 · Cited by 20
Metadata
- Authors
- Książkiewicz, M., Markiewicz, A., & Żaczek, A. J.
- Venue
- Pathobiology
- Publisher
- S. Karger AG
- Published
- 2012
- Volume
- 79
- Issue
- 4
- Pages
- 195-208
- ISSN
- 1015-2008 (ISSN-L)
- 1423-0291
- OpenAlex
- W2015654354
- Cited by
- 190
- References
- 12
- FWCI
- 8.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Książkiewicz, M., Markiewicz, A., & Żaczek, A. J. (2012). Epithelial-Mesenchymal Transition: A Hallmark in Metastasis Formation Linking Circulating Tumor Cells and Cancer Stem Cells. Pathobiology. https://doi.org/10.1159/000337106
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
