Gray Matter Atrophy in Behavioral Variant Frontotemporal Dementia: A Meta-Analysis of Voxel-Based Morphometry Studies
Abstract
BACKGROUND: Structural neuroimaging studies on behavioral variant frontotemporal dementia (bvFTD) using the voxel-based morphometry (VBM) method reported not entirely consistent findings. METHODS: A systematic review of VBM studies of bvFTD patients and healthy controls (HC) published in PubMed and Embase databases from 2000 to June 2011 was conducted. Meta-analysis was performed using a newly improved voxel-based meta-analytic tool, namely, effect size signed differential mapping, to quantitatively explore the gray matter (GM) changes between bvFTD patients and HC subjects. RESULTS: 11 VBM studies involving 237 bvFTD patients and 297 HC subjects met the inclusion criteria. Considerable regional GM volume decrease was detected in the anterior medial frontal cortex (BA 9), extending to other frontal areas (BA 8, 10, 46, 24, 32), and other brain areas, such as the insula cortex, as well as the subcortical striatal regions in patients with bvFTD compared with HC subjects. The findings of the present study remain largely unchanged in the entire brain jackknife sensitivity analyses. CONCLUSIONS: The present meta-analysis provides evidence of GM changes in the frontal-striatal-limbic brain areas in patients with bvFTD. Furthermore, GM atrophy in the fron-toinsular cortex and anterior cingulate cortex may be important anatomical changes for the diagnosis of patients with bvFTD.
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bvFTD is neuroanatomically characterized by predominant atrophy in the frontal lobes, generally right more than left lateralized.
“Behavioral-variant FTD (bvFTD) is the most prevalent FTD syndrome,1 clinically characterized by behavioral and personality changes and neuroanatomically by predominant atrophy in the frontal lobes, generally right more than left lateralized.2,3”
From Automated Speech Analysis to Differentiate Frontal and Right Anterior Temporal Lobe Atrophy in Frontotemporal Dementia (2025) · cites this paper as [2]
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“…as well as histopathological findings CONTACT Ahmad Alsemari Ahmad_Alsemari@williamjames.edu Clinical Psychology, William James College, Newton, MA, USA 2019 Informa UK Limited, trading as Taylor & Francis Group (Kim et al., 2012; Meyer et al., 2017; Pan et al., 2012; Schroeter et al., 2014).”
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“…neuroanatomical profiles: nonfluent variant (PNFA) relevance concentrated in left inferior frontal cortex and anterior insula [34]; semantic variant in left temporal pole, amygdala, and hippocampus [35]; and behavioural variant in anterior cingulate, medial prefrontal cortex, and striatum [36].”
Joshy, M., Liu, L.-S., Dassanayake, P., Aiello, M., Cecca, A. D., Cavaliere, C., Anazodo, U., Finger, E., & Lawrence, K. S. (2025) · Human Brain Mapping · doi:10.1002/hbm.70388 · Cited by 2 · see citing works
“As bvFTD is characterized by significant gray matter atrophy (Marino et al. 2019; Pan et al. 2012), which could potentially bias voxel-wise comparisons (Xie et al. 2015), probabilistic maps of gray matter were added as covariates.”
Tafuri, B., Filardi, M., Frisullo, M. E., Blasi, R. D. D., Rizzo, G., Nigro, S., & Logroscino, G. (2023) · Brain and Behavior · doi:10.1002/brb3.2896 · Cited by 2 · see citing works
“Indeed, the thalamus may play a role in the genesis of frontal/behavioral symptoms (Gordon et al., 2016; Pan et al., 2012) associatedwith emotional, behavioral, and”
BackgroundMichelutti, M., Urso, D., Gnoni, V., Giugno, A., Zecca, C., Vilella, D., Accadia, M., Barone, R., Dell'Abate, M. T., Blasi, R. D. D., et al. (2024) · Journal of Alzheimer's Disease · doi:10.3233/jad-230779 · Cited by 1 · see citing works
Brain atrophy patterns in patients with frontotemporal dementia: voxel-based morphometry
Akhmadullina, Konovalov, R., Shpilyukova, Y., Grishina, D., Berdnikovich, E. S., Фоменко, С. С., Fedotova, E., & Illarioshkin, S. N. (2020) · Bulletin of Russian State Medical University · doi:10.24075/brsmu.2020.075 · Cited by 1 · see citing works
A rostral prefrontal mediolateral gradient predicts creativity in frontotemporal dementia
Altmayer, V., Ovando‐Tellez, M., Bieth, T., Batrancourt, B. M., Rametti‐Lacroux, A., Moreno-Rodriguez, S., Bouzigues, A., Ledu, V., Garcin, B., Lopez‐Persem, A., et al. (2026) · Brain · doi:10.1093/brain/awag032 · Cited by 1 · see citing works
Voxel-Based Morphometry in Frontotemporal Dementia
Akhmadullina, D. R., Shpilyukova, Y. A., Коновалов, Р. Н., Fedotova, E. Y., & Illarioshkin, S. N. (2020) · Human Physiology · doi:10.1134/s0362119720080137
Positron emission tomography in vivo characterisation of the pathology of frontotemporal dementia
Bevan-Jones, W. R. (2020) · Apollo (University of Cambridge) · doi:10.17863/cam.49075
“At a group level, imaging in these patients reveals predominantly frontal atrophy affecting the prefrontal cortex, anterior cingulate cortices, insula, anterior temporal lobes, striatum and thalamus (Gordon et al., 2016; Pan et al., 2012; Schroeter, Raczka, Neumann, & Cramon, 2007).”
BackgroundNeuroanatomical Basis of Art Therapy and Dementia: A Correlative Review and Implications
Benjamin, R., Jeon, J., & Benjamin, S. (2025) · World Journal of Neuroscience · doi:10.4236/wjns.2025.153018
Degenerative Diseases of the CNS
Capizzano, A. A., Moritani, T., & Capizzano, J. N. (2021) · Springer eBooks · doi:10.1007/978-3-030-62120-9_14
Pathophysiologic Insights from Biomarker Studies in Neurological Disorders
Moccia, M. (2020) · Frontiers Research Topics · doi:10.3389/978-2-88963-643-3
Neuropsychological profile of frontotemporal lobar degeneration
Carmona‐Abellán, M., Luquín, M. R., Lamet, I., Giménez, N. P., Esteve‐Belloch, P., & Rivero, M. E. J. (2015) · Anales del Sistema Sanitario de Navarra · doi:10.4321/s1137-66272015000100009 · Cited by 1 · see citing works
- Authors
- Pan, P. L., Song, W., Yang, J., Huang, R., Chen, K., Gong, Q. Y., Zhong, J. G., Shi, H. C., & Shang, H. F.
- Affiliations
- Sichuan University (CN)
- Pediatrics and Genetics (US)
- Yancheng Third People's Hospital (CN)
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2012
- Volume
- 33
- Issue
- 2-3
- Pages
- 141-148
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- OpenAlex
- W2103270909
- Cited by
- 90
- References
- 0
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 5 · 2023: 5 · 2022: 11 · 2021: 8 · 2020: 4 · 2019: 10 · 2018: 7 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 3 · 2013: 9 · 2012: 2
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- behavioral variant frontotemporal dementia, gray matter atrophy, voxel-based morphometry, gray matter volume, frontal cortex, anterior cingulate cortex, insula, striatum, limbic system, brain atrophy
- MeSH terms
- Atrophy, Behavioral Symptoms, Brain Mapping, Frontal Lobe, Gyrus Cinguli, Humans, Neuroanatomy, Organ Size, Frontotemporal Dementia
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