The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity
Open accessAbstract
We have recently shown that BCG (Bacillus Calmette-Guérin) vaccination in healthy volunteers induces epigenetic reprogramming of monocytes, leading to increased cytokine production in response to nonrelated pathogens for up to 3 months after vaccination. This phenomenon was named ‘trained immunity'. In the present study we assessed whether BCG was able to induce long-lasting effects on both trained immunity and heterologous T helper 1 (Th1) and Th17 immune responses 1 year after vaccination. The production of TNFα and IL-1β to mycobacteria or unrelated pathogens was higher after 2 weeks and 3 months postvaccination, but these effects were less pronounced 1 year after vaccination. However, monocytes recovered 1 year after vaccination had an increased expression of pattern recognition receptors such as CD14, Toll-like receptor 4 (TLR4) and mannose receptor, and this correlated with an increase in proinflammatory cytokine production after stimulation with the TLR4 ligand lipopolysaccharide. The heterologous production of Th1 (IFN-γ) and Th17 (IL-17 and IL-22) immune responses to nonmycobacterial stimulation remained strongly elevated even 1 year after BCG vaccination. In conclusion, BCG induces sustained changes in the immune system associated with a nonspecific response to infections both at the level of innate trained immunity and at the level of heterologous Th1/Th17 responses.
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Kleinnijenhuis, J., Quintin, J., Preijers, F., Joosten, L. A. B., Ifrim, D. C., Saeed, S., Jacobs, C., van Loenhout, J., de Jong, D., Stunnenberg, H. G., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202870109 · Cited by 1,728
Self-citationTrained Immunity: A Memory for Innate Host Defense
Netea, M. G., Quintin, J., & van der Meer, J. W. M. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.04.006 · Cited by 1,682
Self-citationAdaptive immune features of natural killer cells
Sun, J. C., Beilke, J. N., & Lanier, L. L. (2009) · Nature · doi:10.1038/nature07665 · Cited by 1,619
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Self-citationThe Role of Hemocytes in Anopheles gambiae Antiplasmodial Immunity
Ramirez, J. L., Garver, L. S., Brayner, F. A., Alves, L. C., Rodrigues, J., Molina-Cruz, A., & Barillas-Mury, C. (2014) · Journal of Innate Immunity · doi:10.1159/000353765 · Cited by 1,084
THE INFLUENCE OF IMMUNOLOGICALLY COMMITTED LYMPHOID CELLS ON MACROPHAGE ACTIVITY IN VIVO
Mackaness, G. B. (1969) · The Journal of Experimental Medicine · doi:10.1084/jem.129.5.973 · Cited by 931
THE IMMUNOLOGICAL BASIS OF ACQUIRED CELLULAR RESISTANCE
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Self-citationA Specific Primed Immune Response in Drosophila Is Dependent on Phagocytes
Pham, L. N., Dionne, M. S., Shirasu-Hiza, M., & Schneider, D. S. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030026 · Cited by 571
Cited by
Trained immunity: A program of innate immune memory in health and– disease
Netea, M. G., Joosten, L. A. B., Latz, E., Mills, K. H. G., Natoli, G., Stunnenberg, H. G., O’Neill, L. A. J., & Xavier, R. J. (2016) · Science · doi:10.1126/science.aaf1098 · Cited by 2,768
Self-citationInnate and Adaptive Immune Memory: an Evolutionary Continuum in the Host’s Response to Pathogens
Netea, M. G., Schlitzer, A., Placek, K., Joosten, L. A. B., & Schultze, J. L. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2018.12.006 · Cited by 599
Self-citationPrevention of tuberculosis in macaques after intravenous BCG immunization
Darrah, P. A., Zeppa, J. J., Maiello, P., Hackney, J. A., Wadsworth, M. H., Hughes, T. K., Pokkali, S., Swanson, P. A., Grant, N. L., Rodgers, M. A., et al. (2020) · Nature · doi:10.1038/s41586-019-1817-8 · Cited by 586
BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment
Cirovic, B., de Bree, L. C. J., Groh, L., Blok, B. A., Chan, J., van der Velden, W. J. F. M., Bremmers, M. E. J., van Crevel, R., Händler, K., Picelli, S., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.05.014 · Cited by 510
Self-citationNon-specific effects of BCG vaccine on viral infections
Moorlag, S. J. C. F. M., Arts, R. J. W., van Crevel, R., & Netea, M. G. (2019) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2019.04.020 · Cited by 479
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Metadata
- Authors
- Kleinnijenhuis, J., Quintin, J., Preijers, F., Benn, C. S., Joosten, L. A. B., Jacobs, C., van Loenhout, J., Xavier, R. J., Aaby, P., van der Meer, J. W. M., van Crevel, R., & Netea, M. G.
- Venue
- Journal of Innate Immunity
- Publisher
- S. Karger AG
- Published
- 2013-10-30
- Volume
- 6
- Issue
- 2
- Pages
- 152-158
- ISSN
- 1662-811X (ISSN-L)
- 1662-8128
- OpenAlex
- W2144072179
- Cited by
- 620
- References
- 36
- FWCI
- 7.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kleinnijenhuis, J., Quintin, J., Preijers, F., Benn, C. S., Joosten, L. A. B., Jacobs, C., van Loenhout, J., Xavier, R. J., Aaby, P., van der Meer, J. W. M., van Crevel, R., & Netea, M. G. (2014). Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity. Journal of Innate Immunity. https://doi.org/10.1159/000355628
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
