The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.
Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host’s Response to Pathogens
Open accessAbstract
Immunological memory is an important evolutionary trait that improves host survival upon reinfection. Memory is a characteristic recognized within both the innate and adaptive arms of the immune system. Although the mechanisms and properties through which innate and adaptive immune memory are induced are distinct, they collude to improve host defense to pathogens. Here, we propose that innate immune memory, or "trained immunity," is a primitive form of adaptation in host defense, resulting from chromatin structure rearrangement, which provides an increased but non-specific response to reinfection. In contrast, adaptive immune memory is more advanced, with increased magnitude of response mediated through epigenetic changes, as well as specificity mediated by gene recombination. An integrative model of immune memory is important for broad understanding of host defense, and for identifying the most effective approaches to modulate it for the benefit of patients with infections and immune-mediated diseases.
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Trained immunity: A program of innate immune memory in health and– disease
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Self-citationA human memory T cell subset with stem cell–like properties
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The history of toll-like receptors - redefining innate immunity
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Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity
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Self-citationTrained Immunity: A Memory for Innate Host Defense
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Self-citationAdaptive immune features of natural killer cells
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Innate immune recognition: mechanisms and pathways
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Defining trained immunity and its role in health and disease
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Self-citationKinase inhibition in autoimmunity and inflammation
Zarrin, A. A., Bao, K., Lupardus, P., & Vucic, D. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0082-8 · Cited by 431
Imprinting of the immune system by the microbiota early in life
Al Nabhani, Z., & Eberl, G. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-0257-y · Cited by 301
Roquilly, A., Jacqueline, C., Davieau, M., Mollé, A., Sadek, A., Fourgeux, C., Rooze, P., Broquet, A., Misme-Aucouturier, B., Chaumette, T., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0673-x · Cited by 259
Biofilm-Innate Immune Interface: Contribution to Chronic Wound Formation
Versey, Z., da Cruz Nizer, W. S., Russell, E., Zigic, S., DeZeeuw, K. G., Marek, J. E., Overhage, J., & Cassol, E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.648554 · Cited by 253
Metadata
- Authors
- Netea, M. G., Schlitzer, A., Placek, K., Joosten, L. A. B., & Schultze, J. L.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 25
- Issue
- 1
- Pages
- 13-26
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2910765752
- Cited by
- 599
- References
- 123
- FWCI
- 20.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Netea, M. G., Schlitzer, A., Placek, K., Joosten, L. A. B., & Schultze, J. L. (2019). Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host’s Response to Pathogens. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2018.12.006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
