Cited by 123Tryptophan and brain disordersAdipokines, Inflammation, and Metabolic DiseasesStress Responses and Cortisol

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Unraveling the Mechanisms Responsible for the Comorbidity between Metabolic Syndrome and Mental Health Disorders

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Nousen, Elizabeth K., Franco, Juliana G., Sullivan, Elinor L.·2013·Neuroendocrinology

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Abstract

The increased prevalence and high comorbidity of metabolic syndrome (MetS) and mental health disorders (MHDs) have prompted investigation into the potential contributing mechanisms. There is a bidirectional association between MetS and MHDs including schizophrenia, bipolar disorder, depression, anxiety, attention-deficit/hyperactivity disorder, and autism spectrum disorders. Medication side effects and social repercussions are contributing environmental factors, but there are a number of shared underlying neurological and physiological mechanisms that explain the high comorbidity between these two disorders. Inflammation is a state shared by both disorders, and it contributes to disruptions of neuroregulatory systems (including the serotonergic, dopaminergic, and neuropeptide Y systems) as well as dysregulation of the hypothalamic-pituitary-adrenal axis. MetS in pregnant women also exposes the developing fetal brain to inflammatory factors that predispose the offspring to MetS and psychopathologies. Due to the shared nature of these conditions, treatment should address aspects of both mental health and metabolic disorders. Additionally, interventions that can interrupt the transfer of increased risk of the disorders to the next generation need to be developed.

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Psychische Störungen bei somatischen Krankheiten
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[Retracted] Prevalence and Correlation of Metabolic Syndrome in Patients with Bipolar Disorder in NGHA, Riyadh
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Retracted
Investigation of the interaction between Genetic Risk Score (GRS) and fatty acid quality indices on mental health among overweight and obese women
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Intergenerational neurotoxicity mediated by maternal plasma metabolite profile remodeling following maternal atrazine exposure
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Neurological observations
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Comorbidity Between Severe Mental Disorders and Metabolic Disease
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Authors: Nousen, E. K., Franco, J. G., & Sullivan, E. L.
Affiliations: Oregon National Primate Research Center (US)
ORCID: Nousen, Elizabeth K.
Sullivan, Elinor L.
Venue: Neuroendocrinology
Publisher: S. Karger AG
Published: 2013
Volume: 98
Issue: 4
Pages: 254-266
ISSN: 0028-3835 (ISSN-L)
1423-0194
DOI: 10.1159/000355632
PMC: PMC4121390
OpenAlex: W2040707068
Cited by: 123
References: 249
Citations by year: 2026: 5 · 2025: 15 · 2024: 11 · 2023: 8 · 2022: 14 · 2021: 8 · 2020: 8 · 2019: 9 · 2018: 4 · 2017: 12 · 2016: 14 · 2015: 9 · 2014: 6
FWCI: 0.63
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.karger.com/Services/SiteLicenses (vor)
www.karger.com/Services/SiteLicenses (tdm)
Locations: Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (UL1TR000128)
Oregon Clinical and Translational Research Institute
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK079194)
National Center for Research Resources (P51RR000163)
National Center for Advancing Translational Sciences
Eunice Kennedy Shriver National Institute of Child Health and Human Development (L40 HD059242)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: metabolic syndrome, mental illness, comorbidities, inflammation, serotonergic system, dopaminergic system, neuropeptide Y, hypothalamic-pituitary-adrenal axis, maternal metabolic syndrome, fetal brain development, schizophrenia, bipolar disorder, depression, anxiety, attention deficit hyperactivity disorder, autism spectrum disorder, bidirectional relationship
MeSH terms: Animals, Mental Disorders, Female, Humans, Metabolic Diseases, Models, Neurological, Pregnancy, Prenatal Exposure Delayed Effects, Comorbidity

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Unraveling the Mechanisms Responsible for the Comorbidity between Metabolic Syndrome and Mental Health Disorders

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