The Alzheimer's disease cooperative study prevention instrument project: longitudinal outcome of behavioral measures as predictors of cognitive decline
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BACKGROUND/METHODS: The Alzheimer's Disease Cooperative Study Prevention Instrument Project is a longitudinal study that recruited 644 cognitively healthy older subjects (aged between 75 and 93 years, 58% women) at baseline and evaluated their cognitive change over 4 years. The study was structured like a clinical trial to anticipate a prevention trial and to determine the performance of novel trial instruments in a longitudinal non-interventional trial framework. Behavioral symptoms were assessed at baseline. RESULTS: The existence of participant-reported behavioral symptoms at baseline predicted conversion to Clinical Dementia Rating scale score ≥0.5 over the 4-year period. CONCLUSIONS: The results imply that early anxiety and depression may be harbingers of future cognitive decline, and that patients exhibiting such symptoms, even in the absence of co-occurring cognitive symptoms, should be closely followed over time.
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The presence of neuropsychiatric symptoms is associated with more severe progression of cognitive decline in older adults with and without cognitive impairments.
“Indeed, the presence of neuropsychiatric symptoms is associated with more severe progression of cognitive decline in older adults with (40) and without cognitive impairments (41).”
From The impact of COVID-19 infection and enforced prolonged social isolation on neuropsychiatric symptoms in older adults with and without dementia: A review (2020) · cites this paper as [41]
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- Authors
- Banks, S. J., Raman, R., He, F., Salmon, D. P., Ferris, S., Aisen, P., & Cummings, J.
- Affiliations
- Cleveland Clinic (US)
- University of California San Diego (US)
- NYU Langone Health (US)
- Corresponding author
- Banks, Sarah Jane
- Venue
- Dementia and Geriatric Cognitive Disorders Extra
- Publisher
- S. Karger AG
- Published
- 2014-12-18
- Volume
- 4
- Issue
- 3
- Pages
- 509-516
- ISSN
- 1664-5464 (ISSN-L)
- PMC
- PMC4307008
- OpenAlex
- W2014743198
- Cited by
- 68
- References
- 35
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 9 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 12 · 2019: 7 · 2018: 3 · 2017: 6 · 2016: 7 · 2015: 1
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Dementia and Geriatric Cognitive Disorders Extra (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute on Aging (P50AG005131, P30AG008051, U19AG010483)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, cognitive decline, behavioral symptoms, anxiety, depression, Clinical Dementia Rating, conversion to dementia, older adults, behavioral assessment instruments, dementia prevention, longitudinal outcomes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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