Cited by 530Dementia and Cognitive Impairment ResearchCancer-related cognitive impairment studiesHistorical and Modern Theater Studies

The mild behavioral impairment checklist (MBI-C): A rating scale for neuropsychiatric symptoms in pre-dementia populations

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Ismail, Zahinoor, for the NPS Professional Interest Area of the International Society of to Advance Alzheimer’s Research and Treatment (NPS-PIA of ISTAART), Agüera-Ortiz, Luis, Brodaty, Henry, Cieslak, Alicja, Cummings, Jeffrey, Fischer, Corinne E., Gauthier, Serge +12 more·2017·Journal of Alzheimer's Disease

Abstract

BACKGROUND: Mild behavioral impairment (MBI) is a construct that describes the emergence at ≥50 years of age of sustained and impactful neuropsychiatric symptoms (NPS), as a precursor to cognitive decline and dementia. MBI describes NPS of any severity, which are not captured by traditional psychiatric nosology, persist for at least 6 months, and occur in advance of or in concert with mild cognitive impairment. While the detection and description of MBI has been operationalized in the International Society to Advance Alzheimer's Research and Treatment - Alzheimer's Association (ISTAART-AA) research diagnostic criteria, there is no instrument that accurately reflects MBI as described. OBJECTIVE: To develop an instrument based on ISTAART-AA MBI criteria. METHODS: Eighteen subject matter experts participated in development using a modified Delphi process. An iterative process ensured items reflected the five MBI domains of 1) decreased motivation; 2) emotional dysregulation; 3) impulse dyscontrol; 4) social inappropriateness; and 5) abnormal perception or thought content. Instrument language was developed a priori to pertain to non-demented functionally independent older adults. RESULTS: We present the Mild Behavioral Impairment Checklist (MBI-C), a 34-item instrument, which can easily be completed by a patient, close informant, or clinician. CONCLUSION: The MBI-C provides the first measure specifically developed to assess the MBI construct as explicitly described in the criteria. Its utility lies in MBI case detection, and monitoring the emergence of MBI symptoms and domains over time. Studies are required to determine the prognostic value of MBI for dementia development, and for predicting different dementia subtypes.

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Authors
Ismail, Z., for the NPS Professional Interest Area of the International Society of to Advance Alzheimer’s Research and Treatment (NPS-PIA of ISTAART), Agüera-Ortiz, L., Brodaty, H., Cieslak, A., Cummings, J., Fischer, C. E., Gauthier, S., Geda, Y. E., Herrmann, N., Kanji, J., Lanctôt, K. L., Miller, D. S., Mortby, M. E., Onyike, C. U., Rosenberg, P. B., Smith, E. E., Smith, G. S., Sultzer, D. L., & Lyketsos, C.
Affiliations
  • University of Calgary (CA)
  • Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM,Department of Psychiatry & Research Institute i+12, Hospital, Universitario 12 de Octubre, Madrid, Spain
  • UNSW Sydney (AU)
  • Department of Clinical Neurosciences, and The Ron and Rene Ward Centre for Healthy Brain Aging Research, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
  • Cleveland Clinic (US)
  • St. Michael's Hospital (CA)
  • Douglas Mental Health University Institute (CA)
  • Mayo Clinic in Arizona (US)
  • Sunnybrook Health Science Centre (CA)
  • University of Toronto (CA)
  • Bracket Global, Wayne, PA, USA
  • Australian National University (AU)
  • Johns Hopkins University (US)
  • University of California, Los Angeles (US)
Corresponding author
Ismail, Zahinoor
Venue
Journal of Alzheimer's Disease
Published
2017-02-03
Volume
56
Issue
3
Pages
929-938
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
OpenAlex
W2570315135
Cited by
530
References
50
Citations by year
2026: 53 · 2025: 87 · 2024: 90 · 2023: 63 · 2022: 54 · 2021: 61 · 2020: 55 · 2019: 25 · 2018: 23 · 2017: 16
FWCI
26.74
Type
journal article
Language
en
Open access
Locations
  • Journal of Alzheimer s Disease (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
  • ANU Open Research (Australian National University) (submittedVersion)
Funders
  • Canadian Institutes of Health Research
  • National Institute on Aging (R01AG041633, R01AG038893, P50AG005146)
  • National Institute of General Medical Sciences (P20GM109025)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Keywords
mild behavioral impairment, neuropsychiatric symptoms
MeSH terms
Delphi Technique, Emotions, Humans, Impulsive Behavior, Motivation, Neuropsychological Tests, Perception, Severity of Illness Index, Social Behavior, Thinking, Executive Function, Cognitive Dysfunction

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