Neurodegenerative Changes after Mild Traumatic Brain Injury
Abstract
A link between mild traumatic brain injury (mTBI) and neurodegenerative diseases, specifically Alzheimer's disease and chronic traumatic encephalopathy (CTE), has long been suspected. Shared clinical symptomology - most notably the prominent role of central auditory dysfunction and sleep-wake disturbances in both disease states - and similar findings on postmortem pathological examination has further reinforced suspected commonality between these seemingly disparate entities. However, conventional imaging techniques, including computed tomography and anatomic magnetic resonance, are unable to detect the symptomatic injuries in mTBI patients and therefore detection of neurodegenerative changes in vivo has previously not been reported. Recent research using diffusion tensor imaging, a novel imaging technique, and focused on patient-reported symptoms has for the first time demonstrated imaging findings in mTBI patients in vivo that are strikingly similar to Alzheimer's dementia and CTE. Moving forward, research will focus on identifying what renders certain patients with mTBI susceptible to developing full-fledged Alzheimer's disease and CTE later in life.
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A history of mTBI is associated with an increased risk of being diagnosed with dementia and/or a neurodegenerative disease.
“a history of mTBI has been associated with an increased risk of being diagnosed with dementia and/or a neurodegenerative disease [36, 44, 90]”
From DNA repair deficiency and senescence in concussed professional athletes involved in contact sports (2019) · cites this paper as [36]
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- Authors
- Fakhran, S., & Alhilali, L.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Progress in Neurological Surgery
- Publisher
- S. Karger AG
- Published
- 2014
- Volume
- 28
- Pages
- 234-242
- ISSN
- 0079-6492 (ISSN-L)
- 1662-3924
- OpenAlex
- W1598956242
- Cited by
- 12
- References
- 23
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2015: 1 · 2014: 1 · 2013: 1
- FWCI
- 2.05
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Progress in neurological surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- mild traumatic brain injury, neurodegeneration, Alzheimer's disease, chronic traumatic encephalopathy, diffusion tensor imaging, central auditory dysfunction, sleep-wake disturbances, patient-reported symptoms, postmortem pathology
- MeSH terms
- Brain Injuries, Humans, Neurodegenerative Diseases, Brain Injury, Chronic, Diffusion Tensor Imaging
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