Nutrition and longevity—From mechanisms to uncertainties

The Hallmarks of Aging

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Aging: a theory based on free radical and radiation chemistry

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DNA methylation age of human tissues and cell types

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Resveratrol improves health and survival of mice on a high-calorie diet

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Upstream and downstream of mTOR

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Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

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Ageing populations: the challenges ahead

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Epigenetic differences arise during the lifetime of monozygotic twins

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A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance

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Extending Healthy Life Span—From Yeast to Humans

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Geroscience: Linking Aging to Chronic Disease

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Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

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Pathophysiology of human visceral obesity: an update

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Fruit and vegetable intake and the risk of cardiovascular disease, total cancer and all-cause mortality - a systematic review and dose-response meta-analysis of prospective studies

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Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

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Telomere length predicts replicative capacity of human fibroblasts.

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Autophagy and Aging

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Cochrane Database of Systematic Reviews

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Asia Pacific Journal of Clinical Nutrition

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Sirtuins in mammals: insights into their biological function

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Adherence to Mediterranean diet and health status: meta-analysis

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Induction of autophagy by spermidine promotes longevity

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mTOR is a key modulator of ageing and age-related disease

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SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

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Fruit and vegetable consumption and mortality from all causes, cardiovascular disease, and cancer: systematic review and dose-response meta-analysis of prospective cohort studies

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Antioxidants prevent health-promoting effects of physical exercise in humans

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Obesity, cigarette smoking, and telomere length in women

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Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

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Promoting Health and Longevity through Diet: From Model Organisms to Humans

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Cardioprotection and lifespan extension by the natural polyamine spermidine

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Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

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Spermidine in health and disease

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Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

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The insulin and insulin-like growth factor receptor family in neoplasia: an update

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Whole grain consumption and risk of cardiovascular disease, cancer, and all cause and cause specific mortality: systematic review and dose-response meta-analysis of prospective studies

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Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan

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FOXO3A genotype is strongly associated with human longevity

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Vegetarian, vegan diets and multiple health outcomes: A systematic review with meta-analysis of observational studies

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Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism

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Epigenetic mechanisms of longevity and aging

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Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population

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The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice

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Long-Term Calorie Restriction Is Highly Effective in Reducing the Risk for Atherosclerosis in Humans

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AMPK, insulin resistance, and the metabolic syndrome

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Modulation of cellular function by polyamines

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Caloric restriction improves health and survival of rhesus monkeys

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Metabolic Effects of Intermittent Fasting

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Distinct DNA methylomes of newborns and centenarians

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Protein Turnover Via Autophagy: Implications for Metabolism

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Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysis

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Lifespan and healthspan: past, present, and promise

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Metabolic Control of Longevity

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Methionine‐deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF‐I and insulin levels, and increases hepatocyte MIF levels and stress resistance

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Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population

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Functions of Polyamines in Mammals

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Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

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Aging of the innate immune system

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Low methionine ingestion by rats extends life span.

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The GH/IGF-1 axis in ageing and longevity

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Association of <i>FOXO3A</i> variation with human longevity confirmed in German centenarians

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Calorie restriction in humans: An update

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Polyamines in aging and disease

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Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity

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Genetic influence on human lifespan and longevity

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The molecular targets of resveratrol

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Sirtuins, a promising target in slowing down the ageing process

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Redox theory of aging: implications for health and disease

Go, Y., & Jones, D. P. (2017) · Clinical Science · doi:10.1042/cs20160897 · Cited by 173 · see citing works

Caloric restriction: From soup to nuts

Spindler, S. R. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.10.003 · Cited by 168 · see citing works

Food Sources of Saturated Fat and the Association With Mortality: A Meta-Analysis

O’Sullivan, T. A., Hafekost, K., Mitrou, F., & Lawrence, D. (2013) · American Journal of Public Health · doi:10.2105/ajph.2013.301492 · Cited by 168 · see citing works

Whole-grain intake and total, cardiovascular, and cancer mortality: a systematic review and meta-analysis of prospective studies

Chen, G., Tong, X., Xu, J., Han, S.-F., Wan, Z., Qin, J., & Qin, L. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.122432 · Cited by 167 · see citing works

Inflammaging and human longevity in the omics era

Monti, D., Ostan, R., Borelli, V., Castellani, G., & Franceschi, C. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.12.008 · Cited by 167 · see citing works

Regulation of reproduction and longevity by nutrient-sensing pathways

Templeman, N. M., & Murphy, C. T. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201707168 · Cited by 166 · see citing works

ROLE of IGF-1 System in the Modulation of Longevity: Controversies and New Insights From a Centenarians’ Perspective

Vitale, G., Pellegrino, G., Vollery, M., & Hofland, L. J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00027 · Cited by 166 · see citing works

Polyamines in foods: development of a food database

Ali, M. A., Poortvliet, E., Strömberg, R., & Yngve, A. (2011) · Food & Nutrition Research · doi:10.3402/fnr.v55i0.5572 · Cited by 163 · see citing works

Optimal body weight for health and longevity: bridging basic, clinical, and population research

Fontana, L., & Hu, F. B. (2014) · Aging Cell · doi:10.1111/acel.12207 · Cited by 157 · see citing works

Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension

Catterson, J. H., Khericha, M., Dyson, M. C., Vincent, A. J., Callard, R., Haveron, S. M., Rajasingam, A., Ahmad, M., & Partridge, L. (2018) · Current Biology · doi:10.1016/j.cub.2018.04.015 · Cited by 154 · see citing works

Revisiting Telomere Shortening in Cancer

Okamoto, K., & Seimiya, H. (2019) · Cells · doi:10.3390/cells8020107 · Cited by 153 · see citing works

New advances in CMV and immunosenescence

Sansoni, P., Vescovini, R., Fagnoni, F. F., Akbar, A., Arens, R., Chiu, Y.-L., Čičin-Šain, L., Dechanet-Merville, J., Derhovanessian, E., Ferrando-Martinez, S., et al. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.03.020 · Cited by 150 · see citing works

Lifestyle Factors Related to Mortality and Survival: A Mini-Review

Rizzuto, D., & Fratiglioni, L. (2014) · Gerontology · doi:10.1159/000356771 · Cited by 149 · see citing works

Decline in Sirtuin-1 expression and activity plays a critical role in blood-brain barrier permeability in aging

Stamatovic, S. M., Martínez-Revollar, G., Hu, A., Choi, J. H. K., Keep, R. F., & Andjelkovic, A. V. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.09.006 · Cited by 149 · see citing works

A systematic review and meta-analysis of nut consumption and incident risk of CVD and all-cause mortality

Mayhew, A. J., de Souza, R. J., Meyre, D., Anand, S. S., & Mente, A. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114515004316 · Cited by 147 · see citing works

Dietary Protein, Metabolism, and Aging

Soultoukis, G. A., & Partridge, L. (2016) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060815-014422 · Cited by 147 · see citing works

Toxicity of Methionine in Humans

Garlick, P. J. (2006) · Journal of Nutrition · doi:10.1093/jn/136.6.1722s · Cited by 144 · see citing works

Frequency and Circadian Timing of Eating May Influence Biomarkers of Inflammation and Insulin Resistance Associated with Breast Cancer Risk

Marinac, C. R., Sears, D. D., Natarajan, L., Gallo, L. C., Breen, C. I., & Patterson, R. E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136240 · Cited by 144 · see citing works

Spermidine and spermine are enriched in whole blood of nona/centenarians

Pucciarelli, S., Moreschini, B., Micozzi, D., De Fronzo, G. S., Carpi, F. M., Polzonetti, V., Vincenzetti, S., Mignini, F., & Napolioni, V. (2012) · Rejuvenation Research · doi:10.1089/rej.2012.1349 · Cited by 144 · see citing works

The low-methionine content of vegan diets may make methionine restriction feasible as a life extension strategy

McCarty, M. F., Barroso-Aranda, J., & Contreras, F. (2008) · Medical Hypotheses · doi:10.1016/j.mehy.2008.07.044 · Cited by 137 · see citing works

IGF-1, the Cross Road of the Nutritional, Inflammatory and Hormonal Pathways to Frailty

Maggio, M. G., Vita, F. D., Lauretani, F., Buttò, V., Bondi, G., Cattabiani, C., Nouvenne, A., Meschi, T., Dall’Aglio, E., & Ceda, G. P. (2013) · Nutrients · doi:10.3390/nu5104184 · Cited by 135 · see citing works

Fish consumption and all-cause mortality: a meta-analysis of cohort studies

Zhao, L.-G., Sun, J.-W., Yang, Y., Ma, X., Wang, Y.-Y., & Xiang, Y.-B. (2016) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2015.72 · Cited by 132 · see citing works

Whole-Grain Intake and Mortality from All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies

Benisi-Kohansal, S., Saneei, P., Salehi‐Marzijarani, M., Larijani, B. A., & Esmaillzadeh, A. (2016) · Advances in Nutrition · doi:10.3945/an.115.011635 · Cited by 132 · see citing works

Dietary inflammatory index and all-cause mortality in large cohorts: The SUN and PREDIMED studies

García‐Arellano, A., Martínez‐González, M. Á., Ramallal, R., Salas‐Salvadó, J., Hébert, J. R., Corella, D., Shivappa, N., Forga, L., Schröder, H., Muñoz-Bravo, C., et al. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.05.003 · Cited by 128 · see citing works

The significance of caloric restriction mimetics as anti-aging drugs

Nassar, K., El-mekawey, D., Elmasry, A. E., Refaey, M. S., El-Sayed Ghoneim, M., & Elshaier, Y. A. M. M. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.149354 · Cited by 16 · see citing works

Molecular Targets of 20-Hydroxyecdysone in Mammals, Mechanism of Action: Is It a Calorie Restriction Mimetic and Anti-Aging Compound?

Zádor, E. (2025) · Cells · doi:10.3390/cells14060431 · Cited by 9 · see citing works

Population Attributable Fractions for Modifiable Factors of Longevity and Healthy Longevity Among the Late-Elderly Aged 75 Years or Older — China, 1998–2018

Zhou, J., Gao, X., Wei, Y., et al. (2023) · China CDC Weekly · doi:10.46234/ccdcw2023.005 · Cited by 2 · see citing works

Queen Honeybee and Me: Forever Young? Conserved Pathways for Longevity

Knäblein, J., & Huber, R. (2013) · Wiley eBooks · doi:10.1002/9783527669417.ch26

Influence of Temperature and Nutrition on Adult Longevity of Microplitis tuberculiferWesmael

Li, J. (2010) · Journal of Hebei Agricultural Sciences · Cited by 1 · see citing works

Predictors of Exceptional Longevity: Gender Differences in Effects of Early-Life and Midlife Conditions

Gavrilov, L. A., & Gavrilova, N. S. (2016) · Applied demography series · doi:10.1007/978-3-319-43688-3_6 · Cited by 1 · see citing works

Longevity, Biological

Carnes, B. A. (2015) · The Encyclopedia of Adulthood and Aging · doi:10.1002/9781118521373.wbeaa004