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Cellular Senescence and the Biology of Aging, Disease, and Frailty
Open accessAbstract
Population aging simultaneously highlights the remarkable advances in science, medicine, and public policy, and the formidable challenges facing society. Indeed, aging is the primary risk factor for many of the most common chronic diseases and frailty, which result in profound social and economic costs. Population aging also reveals an opportunity, i.e. interventions to disrupt the fundamental biology of aging could significantly delay the onset of age-related conditions as a group, and, as a result, extend the healthy life span, or health span. There is now considerable evidence that cellular senescence is an underlying mechanism of aging and age-related conditions. Cellular senescence is a process in which cells lose the ability to divide and damage neighboring cells by the factors they secrete, collectively referred to as the senescence-associated secretory phenotype (SASP). Herein, we discuss the concept of cellular senescence, review the evidence that implicates cellular senescence and SASP in age-related deterioration, hyperproliferation, and inflammation, and propose that this underlying mechanism of aging may play a fundamental role in the biology of frailty.
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“The use of senotherapeutic drugs could potentially be effective in treating a variety of conditions primarily or secondarily mediated by accumulation of senescent cells [6, 33, 67–87].”
From Reducing Senescent Cell Burden in Aging and Disease (2020) · cites this paper as [72]
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Metadata
- Authors
- LeBrasseur, N. K., Tchkonia, T., & Kirkland, J. L.
- Venue
- Nestlé Nutrition Institute Workshop Series
- Publisher
- S. Karger AG
- Published
- 2015
- Volume
- 83
- Pages
- 11-18
- ISSN
- 1664-2147 (ISSN-L)
- 1664-2155
- PMC
- PMC4780350
- OpenAlex
- W1758822526
- Cited by
- 147
- References
- 31
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 12 · 2023: 17 · 2022: 9 · 2021: 26 · 2020: 20 · 2019: 19 · 2018: 12 · 2017: 12 · 2016: 7
- FWCI
- 55.80
- Type
- conference paper
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nestlé Nutrition Institute Workshop series (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Mayo Clinic
- Glenn Foundation for Medical Research
- National Institutes of Health
- National Institute on Aging (AG-41122, P01AG041122)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- cellular senescence, senescence-associated secretory phenotype, aging, frailty, age-related diseases, healthspan, chronic inflammation, hyperproliferation, population aging
- MeSH terms
- Aged, 80 and over, Aging, Chronic Disease, Humans, Inflammation, Life Style, Models, Biological, Risk Factors, Frail Elderly, Cellular Senescence, Models, Immunological, Cell Proliferation, Elder Nutritional Physiological Phenomena
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