The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Cellular Senescence and the Biology of Aging, Disease, and Frailty
Open accessAbstract
Population aging simultaneously highlights the remarkable advances in science, medicine, and public policy, and the formidable challenges facing society. Indeed, aging is the primary risk factor for many of the most common chronic diseases and frailty, which result in profound social and economic costs. Population aging also reveals an opportunity, i.e. interventions to disrupt the fundamental biology of aging could significantly delay the onset of age-related conditions as a group, and, as a result, extend the healthy life span, or health span. There is now considerable evidence that cellular senescence is an underlying mechanism of aging and age-related conditions. Cellular senescence is a process in which cells lose the ability to divide and damage neighboring cells by the factors they secrete, collectively referred to as the senescence-associated secretory phenotype (SASP). Herein, we discuss the concept of cellular senescence, review the evidence that implicates cellular senescence and SASP in age-related deterioration, hyperproliferation, and inflammation, and propose that this underlying mechanism of aging may play a fundamental role in the biology of frailty.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The use of senotherapeutic drugs could potentially be effective in treating a variety of conditions primarily or secondarily mediated by accumulation of senescent cells [6, 33, 67–87].”
From Reducing Senescent Cell Burden in Aging and Disease (2020) · cites this paper as [72]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670
Self-citationThe Achilles' heel of senescent cells: from transcriptome to senolytic drugs
Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., et al. (2015) · Aging Cell · doi:10.1111/acel.12344 · Cited by 2,584
Self-citationA complex secretory program orchestrated by the inflammasome controls paracrine senescence
Acosta, J. C., Banito, A., Wuestefeld, T., Georgilis, A., Janich, P., Morton, J. P., Athineos, D., Kang, T.-W., Lasitschka, F., Andrulis, M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2784 · Cited by 2,278
Frailty as a predictor of surgical outcomes in older patients
Makary, M. A., Segev, D. L., Pronovost, P. J., Syin, D., Bandeen-Roche, K., Patel, P., Takenaga, R., Devgan, L., Holzmueller, C. G., Tian, J., et al. (2010) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2010.01.028 · Cited by 2,184
Four faces of cellular senescence
Rodier, F., & Campisi, J. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201009094 · Cited by 2,070
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
Tchkonia, T., Zhu, Y., van Deursen, J., Campisi, J., & Kirkland, J. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64098 · Cited by 1,774
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Sarcopenia: Aging-Related Loss of Muscle Mass and Function
Larsson, L., Degens, H., Li, M., Salviati, L., Lee, Y. I., Thompson, W., Kirkland, J. L., & Sandri, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00061.2017 · Cited by 1,797
Self-citationTargeting cellular senescence prevents age-related bone loss in mice
Farr, J. N., Xu, M., Weivoda, M. M., Monroe, D. G., Fraser, D. G., Onken, J. L., Negley, B. A., Sfeir, J. G., Ogrodnik, M. B., Hachfeld, C. M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4385 · Cited by 1,182
Self-citationA new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
Saul, D., Kosinsky, R. L., Atkinson, E. J., Doolittle, M. L., Zhang, X., LeBrasseur, N. K., Pignolo, R. J., Robbins, P. D., Niedernhofer, L. J., Ikeno, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32552-1 · Cited by 1,022
Self-citationCellular senescence: a translational perspective
Kirkland, J. L., & Tchkonia, T. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.04.013 · Cited by 1,013
Self-citationFisetin is a senotherapeutic that extends health and lifespan
Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.09.015 · Cited by 1,032
Self-citationZhang, P., Kishimoto, Y., Grammatikakis, I., Gottimukkala, K., Cutler, R. G., Zhang, S., Abdelmohsen, K., Bohr, V. A., Misra Sen, J., Gorospe, M., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0372-9 · Cited by 977
Kalinkovich, A., & Livshits, G. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.008 · Cited by 882
Identification of HSP90 inhibitors as a novel class of senolytics
Fuhrmann-Stroissnigg, H., Ling, Y. Y., Zhao, J., McGowan, S. J., Zhu, Y., Brooks, R. W., Grassi, D., Gregg, S. Q., Stripay, J. L., Dorronsoro, A., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00314-z · Cited by 701
Self-citationThe role of cellular senescence in ageing and endocrine disease
Khosla, S., Farr, J. N., Tchkonia, T., & Kirkland, J. L. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0335-y · Cited by 523
Self-citationDefined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan
Grosse, L., Wagner, N., Emelyanov, A., Molina, C., Lacas-Gervais, S., Wagner, K.-D., & Bulavin, D. V. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.05.002 · Cited by 460
The senescence-associated secretome as an indicator of age and medical risk
Schafer, M. J., Zhang, X., Kumar, A., Atkinson, E. J., Zhu, Y., Jachim, S., Mazula, D. L., Brown, A. K., Berning, M., Aversa, Z., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.133668 · Cited by 401
Self-citationHöhn, A., Weber, D., Jung, T., Ott, C., Hugo, M., Kochlik, B., Kehm, R., König, J., Grune, T., & Castro, J. P. (2016) · Redox Biology · doi:10.1016/j.redox.2016.12.001 · Cited by 388
Aged-senescent cells contribute to impaired heart regeneration
Lewis‐McDougall, F. C., Ruchaya, P. J., Domenjo‐Vila, E., Shin Teoh, T., Prata, L., Cottle, B. J., Clark, J. E., Punjabi, P. P., Awad, W., Torella, D., et al. (2019) · Aging Cell · doi:10.1111/acel.12931 · Cited by 317
Self-citationPhysiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty
Stout, M. B., Justice, J. N., Nicklas, B. J., & Kirkland, J. L. (2017) · Physiology · doi:10.1152/physiol.00012.2016 · Cited by 272
Self-citationObesity and aging: Molecular mechanisms and therapeutic approaches
Santos, A. L., & Sinha, S. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101268 · Cited by 249
Junius‐Walker, U., Onder, G., Soleymani, D., Wiese, B., Albaina, O., Bernabei, R., & Marzetti, E. (2018) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2018.04.023 · Cited by 231
Biology of premature ageing in survivors of cancer
Cupit-Link, M. C., Kirkland, J. L., Ness, K. K., Armstrong, G. T., Tchkonia, T., LeBrasseur, N. K., Armenian, S. H., Ruddy, K. J., & Hashmi, S. K. (2017) · ESMO Open · doi:10.1136/esmoopen-2017-000250 · Cited by 214
Self-citationKiss, T., Nyúl-Tóth, Á., Balasubramanian, P., Tarantini, S., Ahire, C., DelFavero, J., Yabluchanskiy, A., Csipo, T., Farkas, E., Wiley, G., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00177-1 · Cited by 203
Reducing Senescent Cell Burden in Aging and Disease
Pignolo, R. J., Passos, J. F., Khosla, S., Tchkonia, T., & Kirkland, J. L. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.03.005 · Cited by 177
Self-citationFrailty and nutrition: From epidemiological and clinical evidence to potential mechanisms
Yannakoulia, M., Ntanasi, E., Anastasiou, C. A., & Scarmeas, N. (2016) · Metabolism · doi:10.1016/j.metabol.2016.12.005 · Cited by 172
Dorronsoro, A., Santiago, F. E., Grassi, D., Zhang, T., Lai, R. C., McGowan, S. J., Angelini, L., Lavasani, M., Corbo, L., Lu, A., et al. (2021) · Aging Cell · doi:10.1111/acel.13337 · Cited by 153
Crooke, S. N., Ovsyannikova, I. G., Poland, G. A., & Kennedy, R. B. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110632 · Cited by 146
Sarcopenia and Cognitive Function: Role of Myokines in Muscle Brain Cross-Talk
Scisciola, L., Fontanella, R. A., Surina, S., Cataldo, V., Paolisso, G., & Barbieri, M. (2021) · Life · doi:10.3390/life11020173 · Cited by 153
Justice, J. N., Gregory, H., Tchkonia, T., LeBrasseur, N. K., Kirkland, J. L., Kritchevsky, S. B., & Nicklas, B. J. (2018) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glx134 · Cited by 129
Self-citationGreen, C. L., Trautman, M. E., Chaiyakul, K., Jain, R., Alam, Y. H., Babygirija, R., Pak, H. H., Sonsalla, M. M., Calubag, M. F., Yeh, C., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.10.005 · Cited by 121
Application of mesenchymal stem cell therapy for aging frailty: from mechanisms to therapeutics
Zhu, Y., Ge, J., Huang, C., Liu, H., & Jiang, H. (2021) · Theranostics · doi:10.7150/thno.46436 · Cited by 126
Biological basis and treatment of frailty and sarcopenia
Sato, R., Vatic, M., da Fonseca, G. W. P., Anker, S. D., & von Haehling, S. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae073 · Cited by 130
Cellular senescence in aging and age-related diseases: Implications for neurodegenerative diseases
(2020) · International Review of Neurobiology · doi:10.1016/bs.irn.2020.03.019 · Cited by 114
Self-citationThe road ahead for health and lifespan interventions
Gonzalez-Freire, M., Diaz-Ruiz, A., Hauser, D., Martinez-Romero, J., Ferrucci, L., Bernier, M., & de Cabo, R. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101037 · Cited by 118
NAP1L2 drives mesenchymal stem cell senescence and suppresses osteogenic differentiation
Hu, M., Xing, L., Zhang, L., Liu, F., Wang, S., Xie, Y., Wang, J., Jiang, H., Guo, J. R., Li, X., et al. (2022) · Aging Cell · doi:10.1111/acel.13551 · Cited by 119
Aquino-Martinez, R., Rowsey, J. L., Fraser, D. G., Eckhardt, B. A., Khosla, S., Farr, J. N., & Monroe, D. G. (2020) · Bone · doi:10.1016/j.bone.2019.115220 · Cited by 114
“Indeed, cellular senescence and SASP factors play a crucial role in the genesis and/or progression of age-related diseases [40].”
BackgroundCellular Senescence and Ageing: Mechanisms and Interventions
Mylonas, A., & O’Loghlen, A. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.866718 · Cited by 114
A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse
Deepa, S. S., Bhaskaran, S., Espinoza, S. E., Brooks, S. V., McArdle, A., Jackson, M. J., Remmen, H. V., & Richardson, A. G. (2017) · GeroScience · doi:10.1007/s11357-017-9975-9 · Cited by 100
Tarantini, S., Balasubramanian, P., DelFavero, J., Csípő, T., Yabluchanskiy, A., Kiss, T., Nyúl‐Tóth, Á., Mukli, P., Tóth, P., Ahire, C., et al. (2021) · GeroScience · doi:10.1007/s11357-021-00440-z · Cited by 103
Aging of the Immune System: Research Challenges to Enhance the Health Span of Older Adults
Haynes, L. (2020) · Frontiers in Aging · doi:10.3389/fragi.2020.602108 · Cited by 106
Perspective: Targeting the JAK/STAT pathway to fight age-related dysfunction
Xu, M., Tchkonia, T., & Kirkland, J. L. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.05.015 · Cited by 99
Self-citationExtracellular vesicles and aging
Robbins, P. D. (2017) · Stem Cell Investigation · doi:10.21037/sci.2017.12.03 · Cited by 93
de Carvalho, F. G., Justice, J. N., de Freitas, E. C., Kershaw, E. E., & Sparks, L. M. (2019) · Nutrients · doi:10.3390/nu11112553 · Cited by 93
Biomarkers of cellular senescence and risk of death in humans
Sauver, J. L. S., Weston, S. A., Atkinson, E. J., Gree, M. E. M., Mielke, M. M., White, T. A., Heeren, A. A., Olson, J. E., Rocca, W. A., Palmer, A. K., et al. (2023) · Aging Cell · doi:10.1111/acel.14006 · Cited by 86
Self-citationChallenges in adult vaccination
de Gomensoro, E., Giudice, G. D., & Doherty, T. M. (2018) · Annals of Medicine · doi:10.1080/07853890.2017.1417632 · Cited by 85
The biology of frailty in humans and animals: Understanding frailty and promoting translation
Bisset, E. S., & Howlett, S. E. (2019) · Aging Medicine · doi:10.1002/agm2.12058 · Cited by 87
Accelerated aging in schizophrenia and related disorders: Future research
Kirkpatrick, B. W., & Kennedy, B. K. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.06.034 · Cited by 85
Fielding, R. A., Atkinson, E. J., Aversa, Z., White, T. A., Heeren, A. A., Achenbach, S. J., Mielke, M. M., Cummings, S. R., Pahor, M., Leeuwenburgh, C., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00685-2 · Cited by 75
Self-citationFrailty in CKD and Transplantation
Lorenz, E. C., Kennedy, C. C., Rule, A. D., LeBrasseur, N. K., Kirkland, J. L., & Hickson, L. J. (2021) · Kidney International Reports · doi:10.1016/j.ekir.2021.05.025 · Cited by 79
Self-citationHeterochronic parabiosis regulates the extent of cellular senescence in multiple tissues
Yousefzadeh, M. J., Wilkinson, J. E., Hughes, B., Gadela, N., Ladiges, W. C., Vo, N., Niedernhofer, L. J., Huffman, D. M., & Robbins, P. D. (2020) · GeroScience · doi:10.1007/s11357-020-00185-1 · Cited by 70
Cottage, C. T., Peterson, N., Kearley, J., Berlin, A., Xiong, X., Huntley, A., Zhao, W., Brown, C., Migneault, A., Zerrouki, K., et al. (2019) · Communications Biology · doi:10.1038/s42003-019-0532-1 · Cited by 71
Neuregulin-1 attenuates stress-induced vascular senescence
Shakeri, H., Gevaert, A. B., Schrijvers, D. M., Meyer, G. R. Y. D., Keulenaer, G. W. D., Guns, P., Lemmens, K., & Segers, V. F. M. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy059 · Cited by 70
Lipotoxicity, aging, and muscle contractility: does fiber type matter?
Carter, C. S., Justice, J. N., & Thompson, L. (2019) · GeroScience · doi:10.1007/s11357-019-00077-z · Cited by 66
Doolittle, M. L., Saul, D., Kaur, J., Rowsey, J. L., Vos, S. J., Pavelko, K. D., Farr, J. N., Monroe, D. G., & Khosla, S. (2023) · Nature Communications · doi:10.1038/s41467-023-40393-9 · Cited by 57
Li, Q., Cheng, J. C. Y., Jiang, Q. Y., & Lee, W. (2021) · Aging Cell · doi:10.1111/acel.13301 · Cited by 60
A New Gene Set Identifies Senescent Cells and Predicts Senescence-Associated Pathways Across Tissues
(2021) · doi:10.1101/2021.12.10.472095 · Cited by 58
Self-citationDoolittle, M. L., Saul, D., Kaur, J., Rowsey, J. L., Vos, S. J., Pavelko, K. D., Farr, J. N., Monroe, D. G., & Khosla, S. (2023) · doi:10.1101/2023.01.12.523760 · Cited by 57
Li, P., Zhang, C., Gao, S., Zhang, Y., Liang, X., Wang, C., Zhu, T., & Li, W. (2023) · Journal of Medical Internet Research · doi:10.2196/46298 · Cited by 60
Energetic interventions for healthspan and resiliency with aging
Huffman, D. M., Schafer, M. J., & LeBrasseur, N. K. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.05.012 · Cited by 54
Self-citationAcute ischemic stroke triggers a cellular senescence-associated secretory phenotype
Torres-Querol, C., Torres, P., Vidal, N., Portero‐Otín, M., Arqué, G., & Purroy, F. F. (2021) · Scientific Reports · doi:10.1038/s41598-021-95344-5 · Cited by 58
Tissue-Specific Landscape of Metabolic Dysregulation during Ageing
Zhang, F., Kerbl-Knapp, J., Akhmetshina, A., Korbelius, M., Kuentzel, K. B., Vujić, N., Hörl, G., Paar, M., Kratky, D., Steyrer, E., et al. (2021) · Biomolecules · doi:10.3390/biom11020235 · Cited by 52
Roxithromycin attenuates bleomycin-induced pulmonary fibrosis by targeting senescent cells
Zhang, X., Dong, Y., Li, W.-C., Tang, B., Li, J., & Zang, Y. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00618-3 · Cited by 55
Translating the Biology of Aging into New Therapeutics for Alzheimer's Disease: Senolytics
Rießland, M., & Orr, M. E. (2023) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2023.104 · Cited by 58
Mullen, M. T., Nelson, A. L., Goff, A., Billings, J., Kloser, H., Huard, C., Mitchell, J., Hambright, W. S., Ravuri, S. K., & Huard, J. (2023) · Stem Cells · doi:10.1093/stmcls/sxad036 · Cited by 55
Cellular Senescence and Periodontitis: Mechanisms and Therapeutics
Chen, S., Zhou, D., Liu, O., Chen, H., Wang, Y., & Zhou, Y. (2022) · Biology · doi:10.3390/biology11101419 · Cited by 51
The Senolytic Drug Fisetin Attenuates Bone Degeneration in the Zmpste24−/− Progeria Mouse Model
Hambright, W. S., Mu, X., Gao, X., Guo, P., Kawakami, Y., Mitchell, J., Mullen, M., Nelson, A.-L., Bahney, C., Nishimura, H., et al. (2023) · Journal of Osteoporosis · doi:10.1155/2023/5572754 · Cited by 44
Li, Y., Meng, Y., Zhu, X., Saadiq, I. M., Jordan, K. L., Eirin, A., & Lerman, L. O. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00624-8 · Cited by 45
Growth and differentiation factor-15: A link between inflammaging and cardiovascular disease
Nyárády, B. B., Kiss, L. Z., Bagyura, Z., Merkely, B. P., Dósa, E., Láng, O., Kőhidai, L., & Pállinger, É. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116475 · Cited by 44
Targeting Cellular Senescence for Age-Related Diseases: Path to Clinical Translation
Wyles, S. P., Tchkonia, T., & Kirkland, J. L. (2021) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000009669 · Cited by 42
Self-citationSignal Transduction, Ageing and Disease
Zhang, L. J., Yousefzadeh, M. J., Suh, Y., Niedernhofer, L. J., & Robbins, P. D. (2019) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-3681-2_9 · Cited by 40
Fielding, R. A., Atkinson, E. J., Aversa, Z., White, T. A., Heeren, A. A., Mielke, M. M., Cummings, S. R., Pahor, M., Leeuwenburgh, C., & LeBrasseur, N. K. (2024) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glad257 · Cited by 38
Self-citationFrailty syndrome: A target for functional nutrients?
Davinelli, S., Corbi, G., & Scapagnini, G. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111441 · Cited by 38
Cognitive Ability in Late Life and Onset of Physical Frailty: The Lothian Birth Cohort 1936
Galé, C. R., Ritchie, S. J., Cooper, C. C., Starr, J. M., & Deary, I. J. (2017) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14787 · Cited by 37
Identifying Characteristics of Frailty in Female Mice Using a Phenotype Assessment Tool
Kwak, D., Baumann, C. W., & Thompson, L. V. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz092 · Cited by 36
Doroszkiewicz, J., Mroczko, J., Winkel, I., & Mroczko, B. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13175057 · Cited by 36
Endothelial Senescence and Chronic Fatigue Syndrome, a COVID-19 Based Hypothesis
Sfera, A., Osorio, C. P., del Campo, C. M. Z.-M., Pereida, S., Maurer, S., Maldonado, J. C., & Kozlakidis, Z. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.673217 · Cited by 34
Biological Aspects of Inflamm-Aging in Childhood Cancer Survivors
Rossi, F., Paola, A. D., Pota, E., Argenziano, M., Pinto, D., Marrapodi, M. M., Leva, C. D., Martino, M. D., & Tortora, C. (2021) · Cancers · doi:10.3390/cancers13194933 · Cited by 37
Murine models of accelerated aging and musculoskeletal disease
Hambright, W. S., Niedernhofer, L. J., Huard, J., & Robbins, P. D. (2019) · Bone · doi:10.1016/j.bone.2019.03.002 · Cited by 32
Frailty syndrome among elderly and associated factors: comparison of two cities
Rodrigues, R. A. P., Fhon, J. R. S., Pontes, M. D. L. D. F., Silva, A. O., Haas, V. J., & Santos, J. L. F. (2018) · Revista Latino-Americana de Enfermagem · doi:10.1590/1518-8345.2897.3100 · Cited by 31
Connecting the dots: Neuronal senescence, stress granules, and neurodegeneration
Ma, Y., & Farny, N. G. (2023) · Gene · doi:10.1016/j.gene.2023.147437 · Cited by 30
Zhang, Y., Gao, D., Yuan, Y., Zheng, R., Sun, M., Jia, S., & Liu, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076554 · Cited by 29
Culibrk, R. A., & Hahn, M. S. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.583884 · Cited by 28
Sutanto, H., Fetarayani, D., Narendra, M. R., & Nasution, S. A. (2025) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2025.106488 · Cited by 30
Angelini, F., Pagano, F., Bordin, A., Picchio, V., De Falco, E., & Chimenti, I. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00062 · Cited by 25
Philipp, J., Azimzadeh, O., Subramanian, V., Merl‐Pham, J., Lowe, D., Hladik, D., Erbeldinger, N., Ktitareva, S., Fournier, C., Atkinson, M. J., et al. (2017) · Journal of Proteome Research · doi:10.1021/acs.jproteome.7b00536 · Cited by 26
Appetite, Metabolism and Hormonal Regulation in Normal Ageing and Dementia
Nifli, A. (2018) · Diseases · doi:10.3390/diseases6030066 · Cited by 23
Common Factors of Alzheimer’s Disease and Rheumatoid Arthritis—Pathomechanism and Treatment
Trzeciak, P., Herbet, M., & Dudka, J. (2021) · Molecules · doi:10.3390/molecules26196038 · Cited by 24
Sun, R., He, T., Pan, Y., & Katušić, Z. S. (2018) · Aging · doi:10.18632/aging.101362 · Cited by 25
Senolytic controls bone marrow mesenchymal stem cells fate improving bone formation.
Zhang, D., Yu, K., Yang, J., Xie, S., Yang, J., & Tan, L. (2020) · PubMed Central · Cited by 23
Aging: Treating the Older Patient
Rosko, A. E., & Artz, A. S. (2016) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2016.11.007 · Cited by 22
Biomarkers of cellular senescence and major health outcomes in older adults
Cummings, S. R., Lui, L., Aversa, Z., Mau, T., Fielding, R. A., Atkinson, E. J., Patel, S., & LeBrasseur, N. K. (2024) · GeroScience · doi:10.1007/s11357-024-01474-9 · Cited by 22
Self-citationFrailty as a prognostic indicator in the radical cystectomy population: a review
Parikh, N., & Sharma, P. (2019) · International Urology and Nephrology · doi:10.1007/s11255-019-02189-z · Cited by 20
Metformin Prevents H₂O₂-Induced Senescence in Human Lens Epithelial B3 Cells
Zhang, C., Chen, M., Zhou, N., & Qi, Y. (2020) · Medical science monitor basic research/Medical science monitor. Basic research · doi:10.12659/msmbr.923391 · Cited by 23
Sai, X., Qin, C., Yan, W. S., Zhao, Y., & Bian, T. (2020) · Journal of International Medical Research · doi:10.1177/0300060520923522 · Cited by 20
The Potential Role of miRNAs in Cognitive Frailty
Carini, G., Musazzi, L., Bolzetta, F., Cester, A., Fiorentini, C., Ieraci, A., Maggi, S., Popoli, M., Veronese, N., & Barbon, A. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.763110 · Cited by 19
Bone and Soft Tissue Turnover in Relation to All-cause Mortality in Postmenopausal Women
Bager, C. L., Willumsen, N., Christiansen, C., Bay‐Jensen, A., Nielsen, H. B., & Karsdal, M. A. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly163 · Cited by 18
Beyond pathogens: the intriguing genetic legacy of endogenous retroviruses in host physiology
da Silva, A. L., Guedes, B. L. M., Santos, S. N., Correa, G. F., Nardy, A., Nali, L. H. D. S., Bachi, A. L. L., & Romano, C. M. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1379962 · Cited by 19
Amato, M., Polizzi, A., Viglianisi, G., Leonforte, F., Mascitti, M., & Isola, G. (2025) · Metabolites · doi:10.3390/metabo15010035 · Cited by 23
Cho, D., Choi, G. M., Lee, Y. S., Hong, J.-P., Yeom, M., Lee, B., & Hahm, D. (2021) · Journal of Ginseng Research · doi:10.1016/j.jgr.2021.12.001 · Cited by 16
Stem Cell-Derived Extracellular Vesicles in Skin Antiaging Treatments
Park, J. Y., Jung, S. Y., Yoo, D., Lee, S., Go, D., Bui, V. D., Jung, W., You, D. G., Park, J. H., & Um, W. (2025) · ACS Nano · doi:10.1021/acsnano.4c17406 · Cited by 18
Chae, U., Park, J., Lee, S., Lee, H. J., Lee, H., & Lee, D. (2019) · Aging · doi:10.18632/aging.102259 · Cited by 15
Giovos, G., Yavropoulou, M. P., & Yovos, J. G. (2019) · HORMONES · doi:10.1007/s42000-019-00132-6 · Cited by 16
Sharma, G., Banerjee, R., & Srivastava, S. (2023) · ACS Omega · doi:10.1021/acsomega.3c07480 · Cited by 13
Liu, Q., Song, Y., Cui, Y., Hu, C., Luo, Y., Hu, D., Wang, H., Li, K., Chen, J., & Xiao, H. (2021) · SSRN Electronic Journal · doi:10.1016/j.biocel.2022.106343 · Cited by 11
A DNA Methylation Fingerprint of Cellular SenescencePreprint
Levine, M. E., Leung, D. L., Minteer, C. J., & González, J. T. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/674580 · Cited by 13
Metadata
- Authors
- LeBrasseur, N. K., Tchkonia, T., & Kirkland, J. L.
- Venue
- Nestlé Nutrition Institute Workshop Series
- Publisher
- S. Karger AG
- Published
- 2015
- Volume
- 83
- Pages
- 11-18
- ISSN
- 1664-2147 (ISSN-L)
- 1664-2155
- PMC
- PMC4780350
- OpenAlex
- W1758822526
- Cited by
- 147
- References
- 31
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 12 · 2023: 17 · 2022: 9 · 2021: 26 · 2020: 20 · 2019: 19 · 2018: 12 · 2017: 12 · 2016: 7
- FWCI
- 55.80
- Type
- conference paper
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nestlé Nutrition Institute Workshop series (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Mayo Clinic
- Glenn Foundation for Medical Research
- National Institutes of Health
- National Institute on Aging (AG-41122, P01AG041122)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- cellular senescence, senescence-associated secretory phenotype, aging, frailty, age-related diseases, healthspan, chronic inflammation, hyperproliferation, population aging
- MeSH terms
- Aged, 80 and over, Aging, Chronic Disease, Humans, Inflammation, Life Style, Models, Biological, Risk Factors, Frail Elderly, Cellular Senescence, Models, Immunological, Cell Proliferation, Elder Nutritional Physiological Phenomena
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
