A systematic review of existing peripheral biomarkers of cognitive aging: Is there enough evidence for biomarker proxies in behavioral modification interventions?
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Abstract
Peripheral biomarkers have shown significant value in predicting brain health and may serve as a useful proxy measurement in the assessment of evidence-based lifestyle behavior modification programs, including physical activity and nutrition programs, that aim to maintain cognitive function in late life. The aim of this systematic review was to elucidate which peripheral biomarkers are robustly associated with cognitive function among relatively healthy non-demented older adults. Following the standards for systematic reviews (PICO, PRIMSA), and employing MEDLINE and Scopus search engines, 222 articles were included in the review. Based on the review of biomarker proxies of cognitive health, it is recommended that a comprehensive biomarker panel, or biomarker signature, be developed as a clinical end point for behavior modification trials aimed at enhancing cognitive function in late life. The biomarker signature should take a multisystemic approach, including lipid, immune/inflammatory, and metabolic biomarkers in the biological signature index of cognitive health.
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In non-demented individuals, lipid, inflammatory, and metabolic profiles predict cognitive performance and its trajectory.
“In non‐demented individuals, lipid, inflammatory, and metabolic profiles predict cognitive performance and its trajectory. 14 , 15”
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- Authors
- Fiocco, A. J., Krieger, L., D’Amico, D., Parrott, M. D., Laurin, D., Gaudreau, P., Greenwood, C., & Ferland, G.
- Affiliations
- Toronto Metropolitan University (CA)
- Concordia University (CA)
- Université Laval (CA)
- Université de Montréal (CA)
- University of Toronto (CA)
- Corresponding author
- Fiocco, Alexandra J.
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 52
- Pages
- 72-119
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W2942592125
- Cited by
- 21
- References
- 26
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 6 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 1
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- peripheral biomarkers, cognitive aging, cognitive function in older adults, biomarker signatures, lifestyle intervention, physical activity, nutrition, lipid biomarkers, inflammatory markers, metabolic biomarkers, clinical trial endpoints
- MeSH terms
- Cognitive Aging, Healthy Lifestyle, Diet, Healthy, Aging, Behavior Therapy, Cognition, Humans, Nutritional Status, Biomarkers, Exercise
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