Psychological stress and depression: risk factors for IBD
Abstract
While it is widely accepted that chronic diseases such as inflammatory bowel disease (IBD) may trigger negative psychological emotions such as distress and even depression, it is unknown if this response to a chronic illness like IBD is solely a psychological response to an adverse situation or whether it also represents a biological response, that is, the active inflammatory state of IBD intersecting with the pathobiology of what mediates mood and anxiety disorders. There is a bi-directionality between psychological comorbidity and IBD with each influencing the course of the other when they coexist. Furthermore, there is much to learn in terms of the underlying pathobiology of depression and anxiety and how this may impact on the pathobiology of IBD. Several important questions in regards to psychological comorbidity and IBD will be reviewed in this chapter.
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Although symptoms become distinctly intensified, IBD activity evaluated by the fecal calprotectin level may not be apparent during perceived stress.
“Although the symptoms become distinctly intensified, IBD activity evaluated by the fecal calprotectin level may not be apparent during perceived stress (90).”
From Stress triggers flare of inflammatory bowel disease in children and adults (2019) · cites this paper as [90]
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- Authors
- Bernstein, C. N.
- Affiliations
- University of Manitoba (CA)
- Corresponding author
- Bernstein, Charles N.
- Venue
- Digestive Diseases
- Publisher
- S. Karger AG
- Published
- 2016
- Volume
- 34
- Issue
- 1-2
- Pages
- 58-63
- ISSN
- 0257-2753 (ISSN-L)
- 1421-9875
- OpenAlex
- W2297033997
- Cited by
- 107
- References
- 65
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 11 · 2023: 30 · 2022: 14 · 2021: 11 · 2020: 11 · 2019: 9 · 2018: 8 · 2017: 5 · 2016: 2
- FWCI
- 6.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Digestive Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Takeda Canada
- AbbVie Canada
- Janssen Canada
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- inflammatory bowel disease, depression, psychological stress, anxiety disorders, psychological comorbidity, chronic disease, bidirectional comorbidity, inflammatory status, mood disorders, risk factors
- MeSH terms
- Animals, Depression, Humans, Risk Factors, Stress, Psychological, Inflammatory Bowel Diseases, Comorbidity
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