Cited by 107Inflammatory Bowel DiseaseTryptophan and brain disordersPsychosomatic Disorders and Their Treatments

Psychological stress and depression: risk factors for IBD

Bernstein, Charles N.·2016·Digestive Diseases

Abstract

While it is widely accepted that chronic diseases such as inflammatory bowel disease (IBD) may trigger negative psychological emotions such as distress and even depression, it is unknown if this response to a chronic illness like IBD is solely a psychological response to an adverse situation or whether it also represents a biological response, that is, the active inflammatory state of IBD intersecting with the pathobiology of what mediates mood and anxiety disorders. There is a bi-directionality between psychological comorbidity and IBD with each influencing the course of the other when they coexist. Furthermore, there is much to learn in terms of the underlying pathobiology of depression and anxiety and how this may impact on the pathobiology of IBD. Several important questions in regards to psychological comorbidity and IBD will be reviewed in this chapter.

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Crossref · 10.1159/000442929

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65 of 65 references verified0 citation errors · 0 not checkable

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  • Although symptoms become distinctly intensified, IBD activity evaluated by the fecal calprotectin level may not be apparent during perceived stress.

    “Although the symptoms become distinctly intensified, IBD activity evaluated by the fecal calprotectin level may not be apparent during perceived stress (90).”

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Authors
Bernstein, C. N.
Affiliations
University of Manitoba (CA)
Corresponding author
Bernstein, Charles N.
Venue
Digestive Diseases
Publisher
S. Karger AG
Published
2016
Volume
34
Issue
1-2
Pages
58-63
ISSN
  • 0257-2753 (ISSN-L)
  • 1421-9875
OpenAlex
W2297033997
Cited by
107
References
65
Citations by year
2026: 3 · 2025: 3 · 2024: 11 · 2023: 30 · 2022: 14 · 2021: 11 · 2020: 11 · 2019: 9 · 2018: 8 · 2017: 5 · 2016: 2
FWCI
6.44
Type
journal article
Language
en
Open access
closed
Locations
  • Digestive Diseases (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Takeda Canada
  • AbbVie Canada
  • Janssen Canada
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords
inflammatory bowel disease, depression, psychological stress, anxiety disorders, psychological comorbidity, chronic disease, bidirectional comorbidity, inflammatory status, mood disorders, risk factors
MeSH terms
Animals, Depression, Humans, Risk Factors, Stress, Psychological, Inflammatory Bowel Diseases, Comorbidity

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