Cited by 67Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

Brain-Derived Neurotrophic Factor Serum Levels and Hippocampal Volume in Mild Cognitive Impairment and Dementia due to Alzheimer Disease

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Borba, Ericksen Mielle, Duarte, Juliana Avila, Bristot, Giovana, Scotton, Ellen, Camozzato, Ana Luiza, Chaves, Márcia Lorena Fagundes·2016·Dementia and Geriatric Cognitive Disorders Extra

Abstract

Background/Aims: Hippocampal atrophy is a recognized biomarker of Alzheimer disease (AD) pathology. Serum brain-derived neurotrophic factor (BDNF) reduction has been associated with neurodegeneration. We aimed to evaluate BDNF serum levels and hippocampal volume in clinical AD (dementia and mild cognitive impairment [MCI]). Methods: Participants were 10 patients with MCI and 13 with dementia due to AD as well as 10 healthy controls. BDNF serum levels were determined by ELISA and volumetric measures with NeuroQuant®. Results: MCI and dementia patients presented lower BDNF serum levels than healthy participants; dementia patients presented a smaller hippocampal volume than MCI patients and healthy participants. Discussion: The findings support that the decrease in BDNF might start before the establishment of neuronal injury expressed by the hippocampal reduction.

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Authors
Borba, E. M., Duarte, J. A., Bristot, G., Scotton, E., Camozzato, A. L., & Chaves, M. L. F.
Affiliations
Universidade Federal do Rio Grande do Sul (BR)
Corresponding author
Chaves, Márcia Lorena Fagundes
Venue
Dementia and Geriatric Cognitive Disorders Extra
Publisher
S. Karger AG
Published
2016-12-09
Volume
6
Issue
3
Pages
559-567
ISSN
1664-5464 (ISSN-L)
OpenAlex
W2560444406
Cited by
67
References
54
Citations by year
2026: 5 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 9 · 2021: 7 · 2020: 8 · 2019: 9 · 2018: 10 · 2017: 7
FWCI
7.70
Type
journal article
Language
en
Open access
Locations
  • Dementia and Geriatric Cognitive Disorders Extra (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Americanae (AECID Library) (publishedVersion, other-oa)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
  • Hospital de Clínicas de Porto Alegre
  • Fundação Instituto de Pesquisas Econômicas
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
brain-derived neurotrophic factor, serum BDNF, hippocampal volume, hippocampal atrophy, mild cognitive impairment, Alzheimer's disease, dementia, neurodegeneration, biomarkers

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