BDNF serum and CSF concentrations in Alzheimer’s disease, normal pressure hydrocephalus and healthy controls

Laske, Christoph; Stransky, Elke; Leyhe, Thomas; Eschweiler, Gerhard W.; Maetzler, Walter; Wittorf, Andreas; Soekadar, Surjo; Richartz, Elke; Koehler, Niklas; Bartels, Mathias; Buchkremer, Gerhard; Schott, Klaus

doi:10.1016/j.jpsychires.2006.01.014

Cited by 272Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchCerebrospinal fluid and hydrocephalus

BDNF serum and CSF concentrations in Alzheimer’s disease, normal pressure hydrocephalus and healthy controls

Laske, Christoph, Stransky, Elke, Leyhe, Thomas, Eschweiler, Gerhard W., Maetzler, Walter, Wittorf, Andreas, Soekadar, Surjo, Richartz, Elke +4 more·2007·Journal of Psychiatric Research

DOI 10.1016/j.jpsychires.2006.01.014

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Abstract

Alzheimer's disease (AD) and normal pressure hydrocephalus (NPH) are common forms of dementia in the elderly. Recent findings have suggested an involvement of brain-derived neurotrophic factor (BDNF) in the pathogenesis of AD. BDNF is an endogenous protein involved in the maintenance of neuronal function, synaptic plasticity and structural integrity in the adult brain. BDNF serum and cerebrospinal fluid (CSF) concentrations were assessed by a sensitive ELISA in 27 AD patients in comparison to 9 NPH patients and 28 age-matched healthy controls (10 CSF samples). We found a significant decrease of BDNF serum concentration in AD (18.6ng/ml) and NPH patients (18.1ng/ml) as compared to healthy controls (21.3ng/ml; p=0.041/p=0.017). BDNF serum concentrations did not correlate with CSF levels, age or MMSE scores both in AD and NPH patients. In unconcentrated CSF samples, BDNF could be detected in AD patients in 8/27 cases (29.6%; mean of 4.6pg/ml), in NPH patients in 1/9 cases (11.1%; mean of 6.4pg/ml) and in the control subjects in 5/10 cases (50%; mean of 1.6pg/ml) with no significant differences as regards mean concentration and frequency of detectable BDNF in CSF. The decrease of BDNF serum levels in AD and NPH may reflect a lack of trophic support and thus contribute to progressive degeneration in both diseases. In contrast to serum, CSF seems to be no useful source to determine BDNF in AD or NPH because of too low concentrations. Further examinations have to follow to elucidate the potential sources and the meaning of reduced BDNF levels in the blood in AD and NPH.

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Serum BDNF is reflective of central nervous system levels.
“BDNF crosses the blood-brain barrier with high capacity and is highly stable over time, thus serum BDNF is reflective of central nervous system levels [5], [13], [14].”
From Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia (2017) · cites this paper as [14]

Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
“Mini-mental state”
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS‐ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Neurotrophins: Roles in Neuronal Development and Function
Huang, E. J., & Reichardt, L. F. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.677 · Cited by 4,394 · see citing works
Transport of brain-derived neurotrophic factor across the blood–brain barrier
Pan, W., Banks, W. A., Fasold, M. B., Bluth, J., & Kastin, A. J. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00141-5 · Cited by 1,354 · see citing works
Increased hippocampal bdnf immunoreactivity in subjects treated with antidepressant medication
Chen, B., Dowlatshahi, D., MacQueen, G. M., Wang, J.-F., & Young, L. T. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01083-6 · Cited by 1,164 · see citing works
Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants
Shimizu, E., Hashimoto, K., Okamura, N., Koike, K., Komatsu, N., Kumakiri, C., Nakazato, M., Watanabe, H., Shinoda, N., Okada, S.-I., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00181-1 · Cited by 1,151 · see citing works
Activated Human T Cells, B Cells, and Monocytes Produce Brain-derived Neurotrophic Factor In Vitro and in Inflammatory Brain Lesions: A Neuroprotective Role of Inflammation?
Kerschensteiner, M., Gallmeier, E., Behrens, L., Vargas-Leal, V., Misgeld, T., Klinkert, W. E. F., Kolbeck, R., Hoppe, E., Oropeza-Wekerle, R. L., Bartke, I., et al. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.5.865 · Cited by 1,019 · see citing works
BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders
Mattson, M. P., Maudsley, S., & Martin, B. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.08.001 · Cited by 942 · see citing works
BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease
Phillips, H. S., Hains, J. M., Armanini, M., Laramee, G. R., Johnson, S. A., & Winslow, J. W. (1991) · Neuron · doi:10.1016/0896-6273(91)90273-3 · Cited by 921 · see citing works
The impact of age, weight and gender on BDNF levels in human platelets and plasma
Lommatzsch, M., Zingler, D., Schuhbaeck, K., Schloetcke, K., Zingler, C., Schuff‐Werner, P., & Virchow, J. C., Jr. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.03.002 · Cited by 849 · see citing works
Postnatal Developmental Profile of Brain-Derived Neurotrophic Factor in Rat Brain and Platelets
Karege, F., Schwald, M., & Cisse, M. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00529-3 · Cited by 799 · see citing works
Brain-derived Neurotrophic Factor Is Stored in Human Platelets and Released by Agonist Stimulation
Fujimura, H., Chen, R., Nakamura, T., Nakahashi, T., Kambayashi, J.-I., Sun, B., Altar, C., & Tandon, N. (2002) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613072 · Cited by 777 · see citing works
Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function
Elkabes, S., Dicicco-Bloom, E., & Black, I. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02508.1996 · Cited by 697 · see citing works
Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer’s disease
Peng, S., Wuu, J., Mufson, E. J., & Fahnestock, M. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03135.x · Cited by 691 · see citing works
Decreased β-Amyloid<sub>1-42</sub>and Increased Tau Levels in Cerebrospinal Fluid of Patients With Alzheimer Disease
Sunderland, T., Linker, G., Mirza, N., Putnam, K. T., Friedman, D. L., Kimmel, L. H., Bergeson, J., Manetti, G. J., Zimmermann, M., Tang, B., et al. (2003) · JAMA · doi:10.1001/jama.289.16.2094 · Cited by 656 · see citing works
Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF
Poduslo, J. F., & Curran, G. L. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00250-v · Cited by 614 · see citing works
Low Brain-Derived Neurotrophic Factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity
Karege, F., Bondolfi, G., Gervasoni, N., Schwald, M., Aubry, J., & Bertschy, G. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.008 · Cited by 594 · see citing works
Region-Specific Neurotrophin Imbalances in Alzheimer Disease: Decreased Levels of Brain-Derived Neurotrophic Factor and Increased Levels of Nerve Growth Factor in Hippocampus and Cortical Areas
Hock, C., Heese, K., Hulette, C., Rosenberg, C., & Otten, U. (2000) · Archives of Neurology · doi:10.1001/archneur.57.6.846 · Cited by 523 · see citing works
Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma.
Lindvall, O., Ernfors, P., Bengzon, J., Kokaia, Z., Smith, M. L., Siesjö, B. K., & Persson, H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.2.648 · Cited by 514 · see citing works
Vascular endothelial cells synthesize and secrete brain‐derived neurotrophic factor
Nakahashi, T., Fujimura, H., Altar, C. A., Li, J., Kambayashi, J.-I., Tandon, N. N., & Sun, B. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01302-8 · Cited by 430 · see citing works
Somatostatin regulates brain amyloid β peptide Aβ42 through modulation of proteolytic degradation
Saito, T., Iwata, N., Tsubuki, S., Takaki, Y., Takano, J., Huang, S.-M., Suemoto, T., Higuchi, M., & Saido, T. C. (2005) · Nature Medicine · doi:10.1038/nm1206 · Cited by 361 · see citing works
Presence of brain-derived neurotrophic factor in brain and human and rat but not mouse serum detected by a sensitive and specific immunoassay
Radka, S. F., Hoist, P. A., Fritsche, M., & Altar, C. A. (1996) · Brain Research · doi:10.1016/0006-8993(95)01321-0 · Cited by 348 · see citing works
BDNF Protein Measured by a Novel Enzyme Immunoassay in Normal Brain and after Seizure: Partial Disagreement with mRNA Levels
Nawa, H., Carnahan, J. F., & Gall, C. M. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb01148.x · Cited by 333 · see citing works
Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease
Holsinger, R. M. D., Schnarr, J., Henry, P., Castelo, V. T., & Fahnestock, M. L. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00023-1 · Cited by 328 · see citing works
Stage-dependent BDNF serum concentrations in Alzheimer’s disease
Laske, C., Stransky, E., Leyhe, T., Eschweiler, G. W., Wittorf, A., Richartz, E., Bartels, M., Buchkremer, G., & Schott, K. J. (2005) · Journal of Neural Transmission · doi:10.1007/s00702-005-0397-y · Cited by 325 · see citing works
Self-citation
Human platelets contain brain-derived neurotrophic factor
Yamamoto, H., & Gurney, M. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-11-03469.1990 · Cited by 304 · see citing works
Neurotrophin and neurotrophin receptors in vascular smooth muscle cells. Regulation of expression in response to injury.
Donovan, M. J., Miranda, R. C., Kraemer, R. T., McCaffrey, T. A., Tessarollo, L., Mahadeo, D. C., Sharif, S. F., Kaplan, D. R., Tsoulfas, P., & Parada, L. F. (1995) · Europe PMC (PubMed Central) · Cited by 287 · see citing works
Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer's disease.
Michalski, B., & Fahnestock, M. (2003) · Brain Research. Molecular Brain Research · doi:10.1016/s0169-328x(03)00003-2 · Cited by 269 · see citing works
β-Amyloid Peptide at Sublethal Concentrations Downregulates Brain-Derived Neurotrophic Factor Functions in Cultured Cortical Neurons
Tong, L., Balazs, R., Thornton, P. L., & Cotman, C. W. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5463-03.2004 · Cited by 221 · see citing works
Purification and Identification of Brain-Derived Neurotrophic Factor from Human Serum
Rosenfeld, R. D., Zeni, L., Haniu, N., Talvenheimo, J., Radka, S. F., Bennett, L., Miller, J. A., & Welcher, A. A. (1995) · Protein Expression and Purification · doi:10.1006/prep.1995.1062 · Cited by 164 · see citing works
Cellular Sources of Enhanced Brain-Derived Neurotrophic Factor Production in a Mouse Model of Allergic Inflammation Notice to Professional Recruitment and Announcement Advertisers
Braun, A. C., Lommatzsch, M., Mannsfeldt, A. G., Neuhaus‐Steinmetz, U., Fischer, A., Schnoy, N., Lewin, G. R., & Renz, H. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.21.4.3670 · Cited by 160 · see citing works
Brain-derived neurotrophic factor in patients with multiple sclerosis
Sarchielli, P., Greco, L., Stipa, A., Floridi, A., & Gallai, V. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00319-3 · Cited by 143 · see citing works
Neurofibrillary tangles and tau phosphorylation
Brion, J., Anderton, B. H., Authelet, M., Dayanandan, R., Leroy, K., Lovestone, S., Octave, J., Pradier, L., Touchet, N., & Tremp, G. L. (2001) · Biochemical Society Symposia · doi:10.1042/bss0670081 · Cited by 139 · see citing works
Role of the Immune System in the Pathogenesis, Prevention and Treatment of Alzheimer??s Disease
Blasko, I., & Grubeck-Loebenstein, B. (2003) · Drugs & Aging · doi:10.2165/00002512-200320020-00002 · Cited by 108 · see citing works
Brain‐Derived Neurotrophic Factor Protects against Multiple Forms of Brain Injury in Bacterial Meningitis
Bifrare, Y., Kummer, J., Joss, P., et al. (2004) · The Journal of Infectious Diseases · doi:10.1086/426399 · Cited by 86 · see citing works
GDNF but not BDNF is increased in cerebrospinal fluid in amyotrophic lateral sclerosis
Grundström, E., Lindholm, D., Johansson, A., Blennow, K., & Askmark, H. (2000) · Neuroreport · doi:10.1097/00001756-200006050-00037 · Cited by 86 · see citing works
Brain-derived neurotrophic factor
Laske, C., & Eschweiler, G. W. (2005) · Der Nervenarzt · doi:10.1007/s00115-005-1971-0 · Cited by 76 · see citing works
Self-citation
Brain-Derived Neurotrophic Factor Activation of TrkB Protects Neurons from HIV-1/gp120-Induced Cell Death
Mocchetti, I., & Bachis, A. (2004) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v16.i12.50 · Cited by 58 · see citing works
Brain derived neurotrophic factor is increased in cerebrospinal fluid of children suffering from asphyxia
Korhonen, L., Riikonen, R., Nawa, H., & Lindholm, D. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00937-3 · Cited by 57 · see citing works
Sustained phosphorylation and activation of protein kinase B correlates with brain-derived neurotrophic factor and insulin stimulated survival of cerebellar granule cells
Foulstone, E. J., Tavaré, J. M., & Gunn‐Moore, F. J. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00166-4 · Cited by 54 · see citing works
Expression disparity of brain-derived neurotrophic factor immunoreactivity and mRNA in ischemic hippocampal neurons
Lee, T., Kato, H., Chen, S.-T., Kogure, K., & Itoyama, Y. (2002) · Neuroreport · doi:10.1097/00001756-200212030-00020 · Cited by 48 · see citing works
Brain-derived neurotrophic factor in human platelets
Pliego-Rivero, F. B., Bayatti, N., Giannakoulopoulos, X., Glover, V. A. S., Bradford, H. F., Stern, G. M., & Sandier, M. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00073-7 · Cited by 47 · see citing works
The Neurobiology of Normal Pressure Hydrocephalus
Gleason, P., Black, P. M., & Matsumae, M. (1993) · Neurosurgery Clinics of North America · doi:10.1016/s1042-3680(18)30558-8 · Cited by 46 · see citing works
Neurotrophic factor expression in childhood low-grade astrocytomas and ependymomas
Chiaretti, A., Aloe, L., Antonelli, A., Ruggiero, A., Piastra, M., Riccardi, R., Tamburrini, G., & Rocco, C. D. (2004) · Child s Nervous System · doi:10.1007/s00381-004-0959-6 · Cited by 40 · see citing works
Rapid Stimulatory Effects of Brain-Derived Neurotrophic Factor and Neurotrophin-3 on Somatostatin Release and Intracellular Calcium Rise in Primary Hypothalamic Cell Cultures
Marmigère, F., Choby, C., Rage, F., Richard, S., & Tapia‐Arancibia, L. (2001) · Neuroendocrinology · doi:10.1159/000054669 · Cited by 36 · see citing works
Expression of neurotrophic factors in cerebrospinal fluid and plasma of children with viral and bacterial meningoencephalitis
Chiaretti, A., Antonelli, A., Piastra, M., Genovese, O., Polidori, G., & Aloe, L. (2004) · Acta Paediatrica · doi:10.1111/j.1651-2227.2004.tb02745.x · Cited by 33 · see citing works
Involvement of VIP on BDNF-induced somatostatin gene expression in cultured fetal rat cerebral cortical cells
Villuendas, G., Sánchez‐Franco, F., Palacios, N., Fernández, M., & Cacicedo, L. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00177-2 · Cited by 28 · see citing works
Elevated complement C5a receptor expression on neurons and glia in astrocyte-targeted interleukin-3 transgenic mice
Paradisis, P. M., Campbell, I. L., & Barnum, S. R. (1998) · Glia · doi:10.1002/(sici)1098-1136(199811)24:3 · Cited by 20 · see citing works

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Weinstein, G., Beiser, A. S., Choi, S. H., Preis, S. R., Chen, T. C., Vorgas, D., Au, R., Pikula, A., Wolf, P. A., DeStefano, A. L., et al. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2013.4781 · Cited by 289 · see citing works
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Müller, P., Duderstadt, Y., Lessmann, V., & Müller, N. G. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9041136 · Cited by 241 · see citing works
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Trajkovska, V., Marcussen, A. B., Vinberg, M., Hartvig, P., Aznar, S., & Knudsen, G. M. (2007) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2007.03.009 · Cited by 203 · see citing works
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Authors: Laske, C., Stransky, E., Leyhe, T., Eschweiler, G. W., Maetzler, W., Wittorf, A., Soekadar, S., Richartz, E., Koehler, N., Bartels, M., Buchkremer, G., & Schott, K.
Affiliations: University of Tübingen (DE)
Corresponding author: Laske, Christoph
ORCID: Laske, Christoph
Eschweiler, Gerhard W.
Maetzler, Walter
Soekadar, Surjo
Schott, Klaus
Venue: Journal of Psychiatric Research
Publisher: Elsevier BV
Published: 2007-08
Volume: 41
Issue: 5
Pages: 387-394
ISSN: 0022-3956 (ISSN-L)
DOI: 10.1016/j.jpsychires.2006.01.014
OpenAlex: W1973800714
Cited by: 272
References: 49
Citations by year: 2026: 7 · 2025: 9 · 2024: 14 · 2023: 18 · 2022: 10 · 2021: 14 · 2020: 20 · 2019: 16 · 2018: 18 · 2017: 15 · 2016: 18 · 2015: 16 · 2014: 18 · 2013: 19 · 2012: 13
FWCI: 5.09
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Psychiatric Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
Keywords: brain-derived neurotrophic factor, Alzheimer's disease, normal pressure hydrocephalus, serum BDNF, biomarkers, dementia, neurotrophic support, neurodegeneration
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Enzyme-Linked Immunosorbent Assay, Female, Humans, Hydrocephalus, Normal Pressure, Male, Brain-Derived Neurotrophic Factor

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BDNF serum and CSF concentrations in Alzheimer’s disease, normal pressure hydrocephalus and healthy controls

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