Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume.
Open accessAbstract
Hippocampal volume shrinks in late adulthood, but the neuromolecular factors that trigger hippocampal decay in aging humans remains a matter of speculation. In rodents, brain-derived neurotrophic factor (BDNF) promotes the growth and proliferation of cells in the hippocampus and is important in long-term potentiation and memory formation. In humans, circulating levels of BDNF decline with advancing age, and a genetic polymorphism for BDNF has been related to gray matter volume loss in old age. In this study, we tested whether age-related reductions in serum levels of BDNF would be related to shrinkage of the hippocampus and memory deficits in older adults. Hippocampal volume was acquired by automated segmentation of magnetic resonance images in 142 older adults without dementia. The caudate nucleus was also segmented and examined in relation to levels of serum BDNF. Spatial memory was tested using a paradigm in which memory load was parametrically increased. We found that increasing age was associated with smaller hippocampal volumes, reduced levels of serum BDNF, and poorer memory performance. Lower levels of BDNF were associated with smaller hippocampi and poorer memory, even when controlling for the variation related to age. In an exploratory mediation analysis, hippocampal volume mediated the age-related decline in spatial memory and BDNF mediated the age-related decline in hippocampal volume. Caudate nucleus volume was unrelated to BDNF levels or spatial memory performance. Our results identify serum BDNF as a significant factor related to hippocampal shrinkage and memory decline in late adulthood.
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Brain-derived neurotrophic factor plays an important role in neuroplasticity and cognition.
“which play an important role in neuroplasticity (Erickson et al., 2010, 2011; Brigadski and Leßmann, 2014) and cognition (Erickson et al., 2010; Brigadski and Leßmann, 2014; Leckie et al., 2014).”
From Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research (2019) · cites this paper as Erickson et al., 2010
Reduced levels of serum BDNF are related to a decline in hippocampal volume and poorer memory performance.
“reduced levels of serum BDNF are related to a decline in hippocampal volume and poorer memory performance (Erickson et al., 2010)”
From Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research (2019) · cites this paper as Erickson et al., 2010
Exercise can act as an inductor of neuronal plasticity, neurogenesis, and neuronal survival.
“Thus, exercise can act as an inductor of neuronal plasticity, neurogenesis and neuronal survival [208, 209].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [209]
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- Authors
- Erickson, K. I., Prakash, R. S., Voss, M. W., Chaddock, L., Heo, S., McLaren, M., Pence, B. D., Martin, S. A., Vieira, V. J., Woods, J. A., McAuley, E., & Kramer, A. F.
- Affiliations
- University of Pittsburgh (US)
- The Ohio State University (US)
- University of Illinois Urbana-Champaign (US)
- Corresponding author
- Erickson, Kirk I.
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-04-14
- Volume
- 30
- Issue
- 15
- Pages
- 5368-5375
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3069644
- OpenAlex
- W2013010572
- Cited by
- 604
- References
- 76
- Citations by year
- 2026: 30 · 2025: 44 · 2024: 43 · 2023: 46 · 2022: 51 · 2021: 48 · 2020: 43 · 2019: 46 · 2018: 43 · 2017: 36 · 2016: 32 · 2015: 31 · 2014: 32 · 2013: 28 · 2012: 21
- FWCI
- 17.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01 AG 25667, R01AG025032, R01 AG25302, R01AG025667, R01AG025302, R37AG025667, P30AG024827)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- brain-derived neurotrophic factor, hippocampal volume, hippocampal atrophy, aging, memory decline, spatial memory, serum BDNF, caudate nucleus, gray matter loss, mediation analysis, older adults
- MeSH terms
- Aged, Aged, 80 and over, Aging, Caudate Nucleus, Enzyme-Linked Immunosorbent Assay, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Memory Disorders, Middle Aged, Neuropsychological Tests, Organ Size, Brain-Derived Neurotrophic Factor
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