Cited by 203Extracellular vesicles in diseaseMicroRNA in disease regulationCircular RNAs in diseases

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Circulating Exosomal MicroRNA-21 as a Biomarker in Each Tumor Stage of Colorectal Cancer

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Tsukamoto, Mitsuo, Iinuma, Hisae, Yagi, Takahiro, Matsuda, Keiji, Hashiguchi, Yojiro·2017·Oncology

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Abstract

Objective: We clarified the predictive and prognostic value of circulating plasma exosomal microRNA-21 (miR-21) in each TNM stage of colorectal cancer (CRC) patients. Methods: The microRNA (miRNA) profiles of the plasma exosomes, primary tumor tissues, and liver metastasis tissues from the same CRC patients were examined using a microarray. For validation analysis, the plasma exosome samples from 326 CRC patients were measured by TaqMan miRNA assays. Results: In the miRNA microarray analyses, miR-21 showed the highest upregulation in exosomes, primary tumor tissues, and liver metastasis tissues. Significant correlations were demonstrated between exosomal miR-21 and tissue miR-21 levels. As for the relationship to the pathological condition, exosomal miR-21 showed a significant association with liver metastasis and TNM stage. The overall survival (OS) rates and disease-free survival (DFS) rates in high-exosomal-miR-21 patients were significantly worse than those in low-miR-21 patients. Exosomal miR-21 levels were an independent prognostic factor for OS and DFS in CRC patients with TNM stage II or III, and for OS in patients with TNM stage IV. Conclusion: Plasma exosomal miR-21 levels are a useful biomarker for the prediction of recurrence and poor prognosis in CRC patients with TNM stage II, III, or IV.

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Additional file 1 of The plasma exosomal miR-1180-3p serves as a novel potential diagnostic marker for cutaneous melanoma
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Additional file 5 of The plasma exosomal miR-1180-3p serves as a novel potential diagnostic marker for cutaneous melanoma
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Additional file 6 of The plasma exosomal miR-1180-3p serves as a novel potential diagnostic marker for cutaneous melanoma
Guo, Y., Zhang, X., Wang, L., Li, M., Shen, M., Zhou, Z., Zhu, S., Li, K., Fang, Z., Yan, B., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16650029
Additional file 2 of The plasma exosomal miR-1180-3p serves as a novel potential diagnostic marker for cutaneous melanoma
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Additional file 3 of The plasma exosomal miR-1180-3p serves as a novel potential diagnostic marker for cutaneous melanoma
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Authors: Tsukamoto, M., Iinuma, H., Yagi, T., Matsuda, K., & Hashiguchi, Y.
Affiliations: Teikyo University (JP)
ORCID: Matsuda, Keiji
Hashiguchi, Yojiro
Venue: Oncology
Publisher: S. Karger AG
Published: 2017
Volume: 92
Issue: 6
Pages: 360-370
ISSN: 0030-2414 (ISSN-L)
1423-0232
DOI: 10.1159/000463387
OpenAlex: W2605003516
Cited by: 203
References: 36
Citations by year: 2026: 8 · 2025: 10 · 2024: 11 · 2023: 26 · 2022: 22 · 2021: 42 · 2020: 31 · 2019: 27 · 2018: 20 · 2017: 6
FWCI: 9.39
Type: journal article
Language: en
Open access: green
teikyo-u.repo.nii.ac.jp
Licence: cc-by-nc-nd
www.karger.com/Services/SiteLicenses (vor)
www.karger.com/Services/SiteLicenses (tdm)
Locations: Oncology (publishedVersion)
PubMed (publishedVersion)
Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
Funders: Japan Society for the Promotion of Science (17K10608, 15K10150, 17K10655)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
Keywords: colorectal cancer, circulating exosomes, plasma biomarkers, TNM stage, liver metastasis, prognostic factors, overall survival, disease-free survival, tumor recurrence prediction
MeSH terms: Humans, Liver Neoplasms, Neoplasm Recurrence, Local, Neoplasm Staging, Prognosis, Tumor Cells, Cultured, Biomarkers, Tumor, Colorectal Neoplasms, Gene Expression Regulation, Neoplastic, Survival Rate, MicroRNAs, Microarray Analysis

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Circulating Exosomal MicroRNA-21 as a Biomarker in Each Tumor Stage of Colorectal Cancer

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