The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Circulating Exosomal MicroRNA-21 as a Biomarker in Each Tumor Stage of Colorectal Cancer
Open accessAbstract
Objective: We clarified the predictive and prognostic value of circulating plasma exosomal microRNA-21 (miR-21) in each TNM stage of colorectal cancer (CRC) patients. Methods: The microRNA (miRNA) profiles of the plasma exosomes, primary tumor tissues, and liver metastasis tissues from the same CRC patients were examined using a microarray. For validation analysis, the plasma exosome samples from 326 CRC patients were measured by TaqMan miRNA assays. Results: In the miRNA microarray analyses, miR-21 showed the highest upregulation in exosomes, primary tumor tissues, and liver metastasis tissues. Significant correlations were demonstrated between exosomal miR-21 and tissue miR-21 levels. As for the relationship to the pathological condition, exosomal miR-21 showed a significant association with liver metastasis and TNM stage. The overall survival (OS) rates and disease-free survival (DFS) rates in high-exosomal-miR-21 patients were significantly worse than those in low-miR-21 patients. Exosomal miR-21 levels were an independent prognostic factor for OS and DFS in CRC patients with TNM stage II or III, and for OS in patients with TNM stage IV. Conclusion: Plasma exosomal miR-21 levels are a useful biomarker for the prediction of recurrence and poor prognosis in CRC patients with TNM stage II, III, or IV.
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“Moreover, miR-21 has been demonstrated to be packaged within exosomes and released from different cancer types (51–54).”
From Potential Therapeutic Effects of Exosomes Packed With a miR-21-Sponge Construct in a Rat Model of Glioblastoma (2019) · cites this paper as [53]
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Siegel, R., Ma, J., Zou, Z., & Jemal, A. (2014) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21208 · Cited by 11,499
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Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715
Japanese Society for Cancer of the Colon and Rectum, Watanabe, T., Muro, K., Ajioka, Y., Hashiguchi, Y., Ito, Y., Saito, Y., Hamaguchi, T., Ishida, H., Ishiguro, M., et al. (2018) · International Journal of Clinical Oncology · doi:10.1007/s10147-017-1101-6 · Cited by 2,467
Self-citationExosomes – vesicular carriers for intercellular communication
Simons, M., & Raposo, G. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.03.007 · Cited by 2,410
Biogenesis and secretion of exosomes
Kowal, J., Tkach, M., & Théry, C. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.05.004 · Cited by 1,781
Watanabe, T., Itabashi, M., Shimada, Y., Tanaka, S., Ito, Y., Ajioka, Y., Hamaguchi, T., Hyodo, I., Igarashi, M., Ishida, H., et al. (2015) · International Journal of Clinical Oncology · doi:10.1007/s10147-015-0801-z · Cited by 596
Intercellular Communication by Exosome-Derived microRNAs in Cancer
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Serum miR-21 as a Diagnostic and Prognostic Biomarker in Colorectal Cancer
Toiyama, Y., Takahashi, M., Hur, K., Nagasaka, T., Tanaka, K., Inoue, Y., Kusunoki, M., Boland, C. R., & Goel, A. (2013) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djt101 · Cited by 504
miRNA in Plasma Exosome is Stable under Different Storage Conditions
Ge, Q., Zhou, Y., Lu, J., Bai, Y., Xie, X., & Lu, Z. (2014) · Molecules · doi:10.3390/molecules19021568 · Cited by 482
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Jayaraman, V., Apthi, S., Datta, L., Palaniyandi, K., & Gnanasampanthapandian, D. (2026) · MicroRNA · doi:10.2174/0122115366340684251213003152
Yuan, N., Ding, Y., Wang, Y., Zhang, C., Pang, X., Zhang, Z., Yang, L., & Liang, X. (2026) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-026-06579-6
Zhang, X., 潘洁贞, Lin, Y., Lin, Z., Zhu, Y., Yang, C., Zhang, Y., Yan, L., Li, Z., & Yan, X. (2026) · Talanta · doi:10.1016/j.talanta.2026.130751
Metadata
- Authors
- Tsukamoto, M., Iinuma, H., Yagi, T., Matsuda, K., & Hashiguchi, Y.
- Affiliations
- Teikyo University (JP)
- Venue
- Oncology
- Publisher
- S. Karger AG
- Published
- 2017
- Volume
- 92
- Issue
- 6
- Pages
- 360-370
- ISSN
- 0030-2414 (ISSN-L)
- 1423-0232
- OpenAlex
- W2605003516
- Cited by
- 203
- References
- 36
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 11 · 2023: 26 · 2022: 22 · 2021: 42 · 2020: 31 · 2019: 27 · 2018: 20 · 2017: 6
- FWCI
- 9.39
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Oncology (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Funders
- Japan Society for the Promotion of Science (17K10608, 15K10150, 17K10655)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
- Keywords
- colorectal cancer, circulating exosomes, plasma biomarkers, TNM stage, liver metastasis, prognostic factors, overall survival, disease-free survival, tumor recurrence prediction
- MeSH terms
- Humans, Liver Neoplasms, Neoplasm Recurrence, Local, Neoplasm Staging, Prognosis, Tumor Cells, Cultured, Biomarkers, Tumor, Colorectal Neoplasms, Gene Expression Regulation, Neoplastic, Survival Rate, MicroRNAs, Microarray Analysis
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