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Discovery of NV-5138, the first selective Brain mTORC1 activator

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Recent insights into the biological functions of sestrins in health and disease

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Piperine induces autophagy by enhancing protein phosphotase 2A activity in a rotenone-induced Parkinson's disease model

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Sestrin2: Its Potential Role and Regulatory Mechanism in Host Immune Response in Diseases

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AMPK in Neurodegenerative Diseases

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Recent progress in the role of autophagy in neurological diseases

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Emerging Roles of Sestrins in Neurodegenerative Diseases: Counteracting Oxidative Stress and Beyond

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Cilostazol Mediated Nurr1 and Autophagy Enhancement: Neuroprotective Activity in Rat Rotenone PD Model

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Sestrins as a Therapeutic Bridge between ROS and Autophagy in Cancer

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Neuroinflammation and Autophagy in Parkinson’s Disease—Novel Perspectives

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P2X7 Receptor is Involved in Mitochondrial Dysfunction Induced by Extracellular Alpha Synuclein in Neuroblastoma SH-SY5Y Cells

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Sestrin2 overexpression alleviates hydrogen peroxide-induced apoptosis and oxidative stress in retinal ganglion cells by enhancing Nrf2 activation via Keap1 downregulation

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The interplay between oxidative stress and autophagy in chronic obstructive pulmonary disease

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Apelin-36 exerts the cytoprotective effect against MPP+-induced cytotoxicity in SH-SY5Y cells through PI3K/Akt/mTOR autophagy pathway

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Exploring the Role of Autophagy Dysfunction in Neurodegenerative Disorders

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Sestrin2 as a potential therapeutic target for cardiovascular diseases

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Novel mechanistic insights towards the repositioning of alogliptin in Parkinson's disease

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Neuroprotective effects of indole-3-carbinol on the rotenone rat model of Parkinson's disease: Impact of the SIRT1-AMPK signaling pathway

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The disturbance of protein synthesis/degradation homeostasis is a common trait of age-related neurodegenerative disorders

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Parkinson Disease Signaling Pathways, Molecular Mechanisms, and Potential Therapeutic Strategies: A Comprehensive Review

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Sestrin2 expression is a favorable prognostic factor in patients with non-small cell lung cancer.

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The interplay involving oxidative stress and autophagy: Mechanisms, implications, and therapeutic opportunities

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Bacopa monnieri‐Induced Protective Autophagy Inhibits Benzo[a]pyrene‐Mediated Apoptosis

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Sestrin 2 attenuates neonatal rat cardiomyocyte hypertrophy induced by phenylephrine via inhibiting ERK1/2

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Inhibition of deubiquitination by PR‐619 induces apoptosis and autophagy via ubi‐protein aggregation‐activated ER stress in oesophageal squamous cell carcinoma

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Increased plasma sestrin2 concentrations in patients with chronic heart failure and predicted the occurrence of major adverse cardiac events: A 36-month follow-up cohort study

Wang, H., Li, N., Shao, X., Li, J., Guo, L., Yu, X., Sun, Y., Hao, J., Niu, H., Xiang, J., et al. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.04.084 · Cited by 32 · see citing works

Flavonoids from Scutellaria barbata D. Don exert antitumor activity in colorectal cancer through inhibited autophagy and promoted apoptosis via ATF4/sestrin2 pathway

Liu, L., Liu, T., Tao, W., Liao, N., Yan, Q., Li, L., Tan, J., Shen, W., Cheng, H., & Sun, D. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154007 · Cited by 30 · see citing works

Cypermethrin Activates Autophagosome Formation Albeit Inhibits Autophagy Owing to Poor Lysosome Quality: Relevance to Parkinson’s Disease

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Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins

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Brain Hepcidin Suppresses Major Pathologies in Experimental Parkinsonism

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Sestrin2 as Serum Protein Marker and Potential Therapeutic Target for Parkinson’s Disease

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Inhibition of microRNA‐148b‐3p alleviates oxygen‐glucose deprivation/reoxygenation‐induced apoptosis and oxidative stress in HT22 hippocampal neuron via reinforcing Sestrin2/Nrf2 signalling

Du, Y., Ma, X., Ma, L., Li, S., Zheng, J., Lv, J., Cui, L., & Lv, J. (2019) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13231 · Cited by 25 · see citing works

Hydroxychloroquine antiparkinsonian potential: Nurr1 modulation versus autophagy inhibition

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Eupatilin protects chondrocytes from apoptosis via activating sestrin2-dependent autophagy

Lou, Y., Wu, J., Liang, J., Yang, C., Wang, K., Wang, J., & Guo, X. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.105748 · Cited by 24 · see citing works

Dietary Amino Acids Impact LRRK2-Induced Neurodegeneration in Parkinson's Disease Models

Chittoor-Vinod, V. G., Villalobos-Cantor, S., Roshak, H., Shea, K., Abalde-Atristain, L., & Martin, I. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2809-19.2020 · Cited by 22 · see citing works

Sestrin-like protein from Dictyostelium discoideum is involved in autophagy under starvation stress

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Sestrin 2 controls the cardiovascular aging process via an integrated network of signaling pathways

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Sestrin2 protects against traumatic brain injury by reinforcing the activation of Nrf2 signaling

Liu, X., Li, M., Zhu, J., Huang, W., & Song, J. (2020) · Human & Experimental Toxicology · doi:10.1177/0960327120984224 · Cited by 19 · see citing works

Sestrins are Gatekeepers in the Way from Stress to Aging and Disease

Dalina, A. A., Kovaleva, I. E., & Budanov, A. V. (2018) · Molecular Biology · doi:10.1134/s0026893318060043 · Cited by 20 · see citing works

Sestrin2 and mitochondrial quality control: potential impact in myogenic differentiation.

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RACK1 T50 Phosphorylation by AMPK Potentiates Its Binding with IRF3/7 and Inhibition of Type 1 IFN Production

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Sestrin2 inhibits RANKL-induced osteoclastogenesis through AMPK activation and ROS inhibition

Kim, K., Kim, J. H., Kim, I., Seong, S., Koh, J., & Kim, N. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.12.009 · Cited by 17 · see citing works

Dietary fiber may benefit chondrocyte activity maintenance

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Mito-metformin protects against mitochondrial dysfunction and dopaminergic neuronal degeneration by activating upstream PKD1 signaling in cell culture and MitoPark animal models of Parkinson’s disease

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Cестрины – шлагбаумы на путях от стресса к старению и болезням

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Potential Roles of Sestrin2 in Alzheimer’s Disease: Antioxidation, Autophagy Promotion, and Beyond

Chen, S., Yang, J., Hsieh, Y.-H., Lin, T., Lin, Y., Chao, A., & Yang, D. (2021) · Biomedicines · doi:10.3390/biomedicines9101308 · Cited by 12 · see citing works

New Targets for Parkinson's Disease: Adhesion G Protein-Coupled Receptor B1 is Downregulated by AMP-Activated Protein Kinase Activation

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Knockout of AMPKα2 Blocked the Protection of Sestrin2 Overexpression Against Cardiac Hypertrophy Induced by Pressure Overload

Zhang, N., Liao, H.-H., Feng, H., Mou, S.-Q., Li, W., Aiyasiding, X., Lin, Z., Ding, W., Zhou, Z., Yan, H., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.716884 · Cited by 11 · see citing works

Activation of Sestrin2 accelerates deep second-degree burn wound healing through PI3K/AKT pathway

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Sestrin2 protects against hypoxic nerve injury by regulating mitophagy through SESN2/AMPK pathway

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Sestrin2 can alleviate endoplasmic reticulum stress to improve traumatic brain injury by activating AMPK/mTORC1 signaling pathway

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The impact of proteostasis dysfunction secondary to environmental and genetic causes on neurodegenerative diseases progression and potential therapeutic intervention

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The effects of whole-body vibration therapy on immune and brain functioning: current insights in the underlying cellular and molecular mechanisms

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Serum Response Factor Promotes Dopaminergic Neuron Survival via Activation of Beclin 1-Dependent Autophagy

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Salidroside alleviates doxorubicin-induced hepatotoxicity via Sestrin2/AMPK-mediated pyroptotic inhibition

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CK and LRRK2 Involvement in Neurodegenerative Diseases

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Association between the antioxidant properties of SESN proteins and anti-cancer therapies

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The role of adenosine monophosphate-activated protein kinase in neurodegeneration in Parkinson's disease

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Exploring the role of AMPK-JNK signaling pathways in Parkinson's disease: Pathophysiology to therapeutic strategies

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Potential role of mitochondrial ROS in Sestrin2 degradation

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Blockage of CXCR2 Activity Suppressed Inflammatory Cytokine Release and Ferroptosis in Rotenone-Induced SH-SY5Y Cell Model with PD-Like Lesions

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Adiponectin protects HL-1 cardiomyocytes against rotenone-induced cytotoxicity through AMPK activation

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Elucidating Mechanisms of Benzo[a]pyrene Mediated Apoptotic and Autophagic Cell Death and its Prevention with Phytotherapeutics

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SESN2 as a Novel Diagnostic and Prognostic Biomarker for Kawasaki Disease and Coronary Artery Lesions

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Sestryny jako modulatory procesów starzenia i chorób związanych z wiekiem*

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The Role of Sestrins in the Regulation of the Cellular Response to Stress

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Eupatilin: Sources, Extraction, Derivatives, and Pharmacological Activity

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Emerging Therapeutic Approaches for Neurodegenerative Diseases

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Integrative assessment of RNA sequencing and in silico analysis to pinpoint mRNAs, lncRNAs, and circRNAs interactions with miRNAs underlying arsenic-induced neurotoxicity

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Rôle de la dérégulation neuronale de la protéine kinase activée par l’AMP (AMPK) dans la pathologie tau, l’intégrité des synapses et le métabolisme énergétique : relevance pour la maladie d’Alzheimer

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Sestrin2 protects dopaminergic cells against rotenone toxicity through AMPK-dependent autophagy activation.Mol

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Autophagy protects the rotenone-induced cell death in α-synuclein overexpressing SH-SY5Y cells

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AMPK-dependent autophagy activation and alpha-Synuclein clearance: a putative mechanism behind alpha-mangostin’s neuroprotection in a rotenone-induced mouse model of Parkinson’s disease

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Apelin-13 Protects Dopaminergic Neurons against Rotenone—Induced Neurotoxicity through the AMPK/mTOR/ULK-1 Mediated Autophagy Activation

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Ursolic acid inhibits autophagy-dependent neuronal cell death by reducing oxidative stress levels in an in vitro model of Parkinson’s disease

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