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Cited by 63Hypothalamic control of reproductive hormonesReproductive Biology and FertilityNeuropeptides and Animal Physiology

Differential Roles of Hypothalamic AVPV and Arcuate Kisspeptin Neurons in Estradiol Feedback Regulation of Female Reproduction

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Wang, Luhong, Moenter, Suzanne M.·2020·Neuroendocrinology
DOI 10.1159/000503006PMC PMC7047625
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Abstract

Mammalian reproductive function includes puberty onset and completion, reproductive cyclicity, steroidogenesis, gametogenesis, fertilization, pregnancy, and lactation; all are indispensable to perpetuate species. Reproductive cycles are critical for providing the hormonal milieu needed for follicular development and maturation of eggs, but cycles, in and of themselves, do not guarantee ovulation will occur. Here, we review the roles in female reproductive neuroendocrine function of two hypothalamic populations that produce the neuropeptide kisspeptin, demonstrating distinct roles in maintaining cycles and ovulation.

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  • In rodents and humans, pituitary LH secretion is stimulated by GnRH neurons that are prevalently activated by kisspeptin, released by two groups of neurons, one in the preoptic area (POA) and one in the arcuate nucleus (ARC).

    “In rodents and humans, pituitary LH secretion is stimulated by GnRH neurons that are prevalently activated by the neurotransmitter kisspeptin, released by two other groups of neurons, one located rostrally in the preoptic area (POA), and the other more caudally in the arcuate nucleus (ARC) [96,97].”

    From Fibromyalgia pathogenesis explained by a neuroendocrine multistable model (2024) · cites this paper as [96]

    The ‘Reproductive axis and estradiol feedback’ section says GnRH stimulates pituitary LH secretion, and ‘Kisspeptin signaling’ says kisspeptin increases GnRH activity and subsequent LH release. The latter section locates two kisspeptin populations in the mouse hypothalamus—the AVPV and arcuate nucleus—but does not establish the same two-population arrangement in humans or that GnRH neurons are predominantly activated by kisspeptin. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Wang, L., & Moenter, S. M.
Affiliations
University of Michigan (US)
ORCID
Venue
Neuroendocrinology
Publisher
S. Karger AG
Published
2019-08-30
Volume
110
Issue
3-4
Pages
172-184
ISSN
  • 0028-3835 (ISSN-L)
  • 1423-0194
DOI
10.1159/000503006
PMC
PMC7047625
OpenAlex
W2976798017
Cited by
63
References
17
Citations by year
2026: 7 · 2025: 6 · 2024: 11 · 2023: 11 · 2022: 10 · 2021: 11 · 2020: 7
FWCI
0.99
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD041469)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
kisspeptin, kisspeptin neurons, arcuate nucleus, hypothalamus, estradiol feedback, female reproduction, reproductive cycle, ovulation, puberty, neuroendocrine regulation
MeSH terms
Animals, Arcuate Nucleus of Hypothalamus, Estradiol, Female, Humans, Hypothalamus, Anterior, Ovulation, Reproduction, Kisspeptins

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