Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation

Roseweir, Antonia K.; Kauffman, Alexander S.; Smith, Jeremy T.; Guerriero, Kathryn A.; Morgan, Kevin; Pielecka-Fortuna, Justyna; Pineda, Rafael; Gottsch, Michelle L.; Tena-Sempere, Manuel; Moenter, Suzanne M.; Terasawa, Ei; Clarke, Iain J.; Steiner, Robert A.; Millar, Robert P.

doi:10.1523/jneurosci.5740-08.2009

Cited by 380Hypothalamic control of reproductive hormonesNeuropeptides and Animal PhysiologyRegulation of Appetite and Obesity

Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation

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Roseweir, Antonia K., Kauffman, Alexander S., Smith, Jeremy T., Guerriero, Kathryn A., Morgan, Kevin, Pielecka-Fortuna, Justyna, Pineda, Rafael, Gottsch, Michelle L. +6 more·2009·The Journal of Neuroscience

DOI 10.1523/jneurosci.5740-08.2009PMC PMC3035813

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Abstract

Neurons that produce gonadotropin-releasing hormone (GnRH) are the final common pathway by which the brain regulates reproduction. GnRH neurons are regulated by an afferent network of kisspeptin-producing neurons. Kisspeptin binds to its cognate receptor on GnRH neurons and stimulates their activity, which in turn provides an obligatory signal for GnRH secretion, thus gating down-stream events supporting reproduction. We have developed kisspeptin antagonists to facilitate the direct determination of the role of kisspeptin neurons in the neuroendocrine regulation of reproduction. In vitro and in vivo studies of analogues of kisspeptin-10 with amino substitutions have identified several potent and specific antagonists. A selected antagonist was shown to inhibit the firing of GnRH neurons in the brain of the mouse and to reduce pulsatile GnRH secretion in female pubertal monkeys; the later supporting a key role of kisspeptin in puberty onset. This analog also inhibited the kisspeptin-induced release of luteinizing hormone (LH) in rats and mice and blocked the postcastration rise in LH in sheep, rats, and mice, suggesting that kisspeptin neurons mediate the negative feedback effect of sex steroids on gonadotropin secretion in mammals. The development of kisspeptin antagonists provides a valuable tool for investigating the physiological and pathophysiological roles of kisspeptin in the regulation of reproduction and could offer a unique therapeutic agent for treating hormone-dependent disorders of reproduction, including precocious puberty, endometriosis, and metastatic prostate cancer.

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Chronic kisspeptin administration stimulated gonadal development in pre-pubertal male yellowtail kingfish (Seriola lalandi; Perciformes) during the breeding and non-breeding season
Nocillado, J. N., Zohar, Y., Biran, J., Levavi‐Sivan, B., & Elizur, A. (2013) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2013.06.005 · Cited by 60 · see citing works
Chronic Administration of the Metastin/Kisspeptin Analog KISS1-305 or the Investigational Agent TAK-448 Suppresses Hypothalamic Pituitary Gonadal Function and Depletes Plasma Testosterone in Adult Male Rats
Matsui, H., Tanaka, A., Yokoyama, K., Takatsu, Y., Ishikawa, K., Asami, T., Nishizawa, N., Suzuki, A., Kumano, S., Terada, M., et al. (2012) · Endocrinology · doi:10.1210/en.2012-1388 · Cited by 59 · see citing works
Recent Discoveries on the Control of Gonadotrophin‐Releasing Hormone Neurones in Nonhuman Primates
Terasawa, E., Kurian, J. R., Guerriero, K. A., Kenealy, B. P., Hutz, E. D., & Keen, K. L. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02027.x · Cited by 58 · see citing works

Kisspeptin antagonists: Unraveling the role of kisspeptin in reproductive physiology
Millar, R. P., Roseweir, A. K., Tello, J. A., Anderson, R. A., George, J. T., Morgan, K., & Pawson, A. J. (2010) · Brain Research · doi:10.1016/j.brainres.2010.09.044 · Cited by 69 · see citing works
Dissection of Kisspeptin's Role in the Neuroendocrine Regulation of Gonadotropin Using Antagonists.Robert P. Millar, Ph.D.
Millar, R. P. (2009) · Biology of Reproduction · doi:10.1093/biolreprod/81.s1.127
Kisspeptin Antagonists
Roseweir, A. K., & Millar, R. P. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6199-9_8 · Cited by 32 · see citing works
Kisspeptins and the control of gonadotrophin secretion
Dedes, I. (2012) · Systems Biology in Reproductive Medicine · doi:10.3109/19396368.2011.651555 · Cited by 42 · see citing works
Functional analyses of the role of kisspeptins and their receptor, gpr-54 in the biology of reproductive tissues
Roseweir, A. K. (2010) · ERA

Authors: Roseweir, A. K., Kauffman, A. S., Smith, J. T., Guerriero, K. A., Morgan, K., Pielecka-Fortuna, J., Pineda, R., Gottsch, M. L., Tena-Sempere, M., Moenter, S. M., Terasawa, E., Clarke, I. J., Steiner, R. A., & Millar, R. P.
Affiliations: The Queen's Medical Research Institute (GB)
University of Washington (US)
Monash University (AU)
University of Wisconsin–Madison (US)
University of Virginia (US)
Universidad de Córdoba (CO)
University of Cape Town (ZA)
Corresponding author: Millar, Robert P.
ORCID: Roseweir, Antonia K.
Kauffman, Alexander S.
Guerriero, Kathryn A.
Morgan, Kevin
Pineda, Rafael
Moenter, Suzanne M.
Terasawa, Ei
Clarke, Iain J.
Steiner, Robert A.
Millar, Robert P.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2009-03-25
Volume: 29
Issue: 12
Pages: 3920-3929
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.5740-08.2009
PMC: PMC3035813
OpenAlex: W2058657335
Cited by: 379
References: 53
Citations by year: 2026: 6 · 2025: 9 · 2024: 7 · 2023: 9 · 2022: 14 · 2021: 18 · 2020: 17 · 2019: 14 · 2018: 26 · 2017: 25 · 2016: 20 · 2015: 34 · 2014: 39 · 2013: 39 · 2012: 29
FWCI: 39.79
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 184 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
UWA Profiles and Research Repository (UWA) (submittedVersion)
Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
Funders: National Institutes of Health (5u54hd012629-31)
U.S. Public Health Service (K99 056157)
Medical Research Council (MC_EX_G0701682)
National Health and Medical Research Council
Instituto de Salud Carlos III (PI042082, RCMN C03/08, C03/08)
National Institute of Child Health and Human Development
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD 27142, R01-HD-11355, R01HD41469, R01HD015433, R01 HD15433, U54-HD-12629, U54HD-012629, K99HD056157, R01HD011355, R01HD027142, R01HD041469)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: kisspeptin, kisspeptin-10, GnRH neurons, gonadotropin regulation, puberty onset, luteinizing hormone secretion, neuroendocrine regulation of reproduction, precocious puberty, endometriosis, metastatic prostate cancer
MeSH terms: Receptors, Kisspeptin-1, Action Potentials, Animals, Brain, Castration, Cricetulus, Female, Cricetinae, Humans, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Macaca mulatta, Male, Peptides, Sheep, Structure-Activity Relationship, CHO Cells, Microdialysis, Tumor Suppressor Proteins, Receptors, G-Protein-Coupled, Mice, Rats, Kisspeptins, In Vitro Techniques

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Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation

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