Matricellular proteins as modulators of wound healing and the foreign body response
Abstract
Summary: Matricellular proteins form a group of extracellular matrix (ECM) proteins that do not subserve a primary structural role, but rather function as modulators of cell-matrix interactions (1). Members of the group, including thrombospondin (TSP) -1, TSP-2, SPARC, tenascin (TN)-C, and osteopontin (OPN), have been shown to participate in a number of processes related to tissue repair. Specifically, studies in knockout mice have indicated that a deficiency in one or more of these proteins can alter the course of wound healing. More recently, TSP1, TSP2, and SPARC have also been implicated in the foreign body response, an unusual reaction to injury that occurs after the implantation of biomaterials. This review will focus on the roles of these proteins in the response to injury in mice and will show how studies of this pathophysiological process can elucidate some of the intrinsic properties of these matricellular proteins.
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In adults, CCN1 controls inflammation, wound healing, and fibrogenesis.
“regulates inflammation, wound healing and fibrogenesis in the adult”
From CCN1/CYR61: the very model of a modern matricellular protein (2011) · cites this paper as [3]
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- Authors
- Kyriakides, T., & Bornstein, P.
- Affiliations
- University of Washington (US)
- ORCID
- Kyriakides, Themis
- Venue
- Thrombosis and Haemostasis
- Publisher
- Georg Thieme Verlag KG
- Published
- 2003
- Volume
- 90
- Issue
- 12
- Pages
- 986-992
- ISSN
- 0340-6245 (ISSN-L)
- 2567-689X
- OpenAlex
- W2071366784
- Cited by
- 151
- References
- 62
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 6 · 2022: 5 · 2021: 9 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 4 · 2015: 11 · 2014: 11 · 2013: 10 · 2012: 9
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Thrombosis and Haemostasis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Washington
- Scheme for Promotion of Academic and Research Collaboration
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR045418, AR-45418)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
- Keywords
- matricellular proteins, wound healing, foreign body reaction, thrombospondin-1, thrombospondin-2, SPARC, tenascin-C, osteopontin, extracellular matrix, cell-matrix interactions, tissue repair, biomaterial implantation, knockout mice
- MeSH terms
- Animals, Extracellular Matrix, Foreign-Body Reaction, Skin, Wound Healing, Extracellular Matrix Proteins, Mice, Knockout, Mice
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