Cited by 151Connective Tissue Growth Factor ResearchWound Healing and TreatmentsBone and Dental Protein Studies

Matricellular proteins as modulators of wound healing and the foreign body response

Kyriakides, Themis, Bornstein, Paul·2003·Thrombosis and Haemostasis

Abstract

Summary: Matricellular proteins form a group of extracellular matrix (ECM) proteins that do not subserve a primary structural role, but rather function as modulators of cell-matrix interactions (1). Members of the group, including thrombospondin (TSP) -1, TSP-2, SPARC, tenascin (TN)-C, and osteopontin (OPN), have been shown to participate in a number of processes related to tissue repair. Specifically, studies in knockout mice have indicated that a deficiency in one or more of these proteins can alter the course of wound healing. More recently, TSP1, TSP2, and SPARC have also been implicated in the foreign body response, an unusual reaction to injury that occurs after the implantation of biomaterials. This review will focus on the roles of these proteins in the response to injury in mice and will show how studies of this pathophysiological process can elucidate some of the intrinsic properties of these matricellular proteins.

Integrity signals

Registry

Crossref · 10.1160/th03-06-0399

Cites

62 of 62 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Kyriakides, T., & Bornstein, P.
Affiliations
University of Washington (US)
Venue
Thrombosis and Haemostasis
Published
2003
Volume
90
Issue
12
Pages
986-992
ISSN
  • 0340-6245 (ISSN-L)
  • 2567-689X
OpenAlex
W2071366784
Cited by
151
References
62
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 6 · 2022: 5 · 2021: 9 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 4 · 2015: 11 · 2014: 11 · 2013: 10 · 2012: 9
FWCI
1.73
Type
journal article
Language
en
Open access
closed
Locations
  • Thrombosis and Haemostasis (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Washington
  • Scheme for Promotion of Academic and Research Collaboration
  • National Institutes of Health
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR045418, AR-45418)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
Keywords
matricellular proteins, wound healing, foreign body reaction, thrombospondin-1, thrombospondin-2, SPARC, tenascin-C, osteopontin, extracellular matrix, cell-matrix interactions, tissue repair, biomaterial implantation, knockout mice
MeSH terms
Animals, Extracellular Matrix, Foreign-Body Reaction, Skin, Wound Healing, Extracellular Matrix Proteins, Mice, Knockout, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review