A paradigm shift: biomaterials that heal
Abstract
Biomaterials based on synthetic polymers have been explored in medicine since early in the 20th century. The inert nature of polymeric materials and their many fabrication options suggested possibilities in medicine to surgeons having to deal with repair and replacement of diseased or injured organs and tissues. Now the biomaterials/medical device industry is estimated at US$ 150 billion worldwide and saves the lives of millions and improves the quality of life for millions more. In spite of the success of biomaterials and medical devices, there are issues with ‘biocompatible’ biomaterials that have an on impact medical practice and stimulate scientific questions. This perspective discusses the fact that although we have been reasonably successful with implants, there is much room for improvement. Copyright © 2007 Society of Chemical Industry
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Most long-term medical implants are considered biocompatible or inert once the foreign body response resolves and the device is encapsulated by a collagen layer.
“Most long-term medical implants to date are considered biocompatible or inert once the FBR resolves and the device is encapsulated by a collagen layer.89”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [89]
Cites
Biomaterials Science: An Introduction to Materials in Medicine
Ratner, B. D., Hoffman, A. S., Schöen, F. J., & Lemons, J. E. (1996) · doi:10.1016/c2009-0-02433-7 · Cited by 5,125 · see citing works
Self-citationMatricellular proteins as modulators of wound healing and the foreign body response
Kyriakides, T., & Bornstein, P. (2003) · Thrombosis and Haemostasis · doi:10.1160/th03-06-0399 · Cited by 151 · see citing works
Controlling osteopontin orientation on surfaces to modulate endothelial cell adhesion
Liu, L., Chen, S., Giachelli, C. M., et al. (2005) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30221 · Cited by 84 · see citing works
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Quantitative characterization of sphere‐templated porous biomaterials
Marshall, A. J., & Ratner, B. D. (2005) · AIChE Journal · doi:10.1002/aic.10390 · Cited by 63 · see citing works
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Sussman, E. M., Halpin, M. C., Muster, J., Moon, R. T., & Ratner, B. D. (2014) · Annals of Biomedical Engineering · doi:10.1007/s10439-013-0933-0 · Cited by 416 · see citing works
Self-citationLi, L., Xiang, S., Cao, S., Zhang, J., Ouyang, G., Chen, L., & Su, C.-Y. (2013) · Nature Communications · doi:10.1038/ncomms2757 · Cited by 394 · see citing works
Biocompatible Materials for Continuous Glucose Monitoring Devices
Nichols, S. P., Koh, A., Storm, W. L., Shin, J. H., & Schoenfisch, M. H. (2013) · Chemical Reviews · doi:10.1021/cr300387j · Cited by 347 · see citing works
- Authors
- Ratner, B. D.
- Affiliations
- University of Washington (US)
- Corresponding author
- Ratner, Buddy D
- ORCID
- Ratner, Buddy D
- Venue
- Polymer International
- Publisher
- Wiley
- Published
- 2007-07-04
- Volume
- 56
- Issue
- 10
- Pages
- 1183-1185
- ISSN
- 0959-8103 (ISSN-L)
- 1097-0126
- OpenAlex
- W2021881473
- Cited by
- 162
- References
- 5
- Citations by year
- 2025: 2 · 2023: 1 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 5 · 2016: 11 · 2015: 13 · 2014: 19 · 2013: 27 · 2012: 25
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Polymer International (publishedVersion)
- Funders
- National Science Foundation
- National Institutes of Health
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Keywords
- biomaterials, synthetic polymers, biocompatibility, biomedical implants, tissue engineering, medical devices, tissue repair, organ replacement
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