The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.
Chemokines in ischemia and reperfusion
Abstract
Summary: Chemokine signaling plays an important role in the postischemic inflammatory response. Overlapping pathways involving reactive oxygen intermediates,Toll-like receptor (TLR) activation, the complement cascade and the nuclear factor (NF)- κ B system induce both CXC and CC chemokines in ischemic tissues. Reperfusion accentuates chemokine expression promoting an intense inflammatory reaction. ELR-containing CXC chemokines regulate neutrophil infiltration in the ischemic area, whereas CXCR3 ligands may mediate recruitment of Th1 cells. CC chemokines, on the other hand, induce mononuclear cell infiltration and macrophage activation.Evidence suggests that chemokine signaling mediates actions beyond leukocyte chemotaxis and activation, regulating angiogenesis and fibrous tissue deposition. Effective repair of ischemic tissue is dependent on a wellorchestrated cellular response and on timely induction and suppression of chemokines in a locally restricted manner. This manuscript reviews the evidence suggesting a role for chemokine- mediated effects in ischemia/reperfusion and discusses the potential significance of these interactions in injury and repair of ischemic tissues.
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Self-citationThe role of IL-1 in the pathogenesis of heart disease
Bujak, M., & Frangogiannis, N. G. (2009) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-009-0024-y · Cited by 307
Self-citationDobaczewski, M., Xia, Y., Bujak, M., Gonzalez-Quesada, C., & Frangogiannis, N. G. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.090759 · Cited by 301
Self-citationCardiac Oxidative Stress and Inflammatory Cytokines Response after Myocardial Infarction
Neri, M., Fineschi, V., Paolo, M., Pomara, C., Riezzo, I., Turillazzi, E., & Cerretani, D. (2015) · Current Vascular Pharmacology · doi:10.2174/15701611113119990003 · Cited by 294
Fan, Q., Tao, R., Zhang, H., Xie, H., Lu, L., Wang, T., Su, M., Hu, J., Zhang, Q., Chen, Q., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.036044 · Cited by 292
Metadata
- Authors
- Frangogiannis, N.
- Venue
- Thrombosis and Haemostasis
- Publisher
- Georg Thieme Verlag KG
- Published
- 2007
- Volume
- 97
- Issue
- 05
- Pages
- 738-747
- ISSN
- 0340-6245 (ISSN-L)
- 2567-689X
- OpenAlex
- W1987767880
- Cited by
- 276
- References
- 123
- FWCI
- 10.56
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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