The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Impact of Weight Loss on Inflammatory Proteins and Their Association With the Insulin Resistance Syndrome in Morbidly Obese Patients
Abstract
Objective— Obesity is closely linked to the insulin resistance syndrome (IRS), type 2 diabetes, and cardiovascular disease, the primary cause of morbidity and mortality in these patients. Elevated levels of C-reactive protein (CRP) and interleukin-6 (IL-6), indicating chronic subclinical inflammation, have been associated with features of the IRS and incident cardiovascular disease. Methods and Results— We studied the cross-sectional and longitudinal relation of CRP, IL-6, and tumor necrosis factor-α (TNF-α) with features of the IRS in 37 morbidly obese patients with different stages of glucose tolerance before and 14 months after gastric surgery. Weight loss after gastric surgery induced a significant shift from diabetes (37% vs 3%) to impaired glucose tolerance (40% vs 33%) and normal glucose tolerance (23% vs 64%). The baseline concentration of IL-6 was correlated with TNF-α ( r =0.59, P <0.01) and CRP ( r =0.44, P <0.05) levels. TNF-α, IL-6, and CRP were significantly correlated with insulin resistance estimated by the homeostatic model assessment ( r =0.48, P <0.05; r =0.56, P <0.01; and r =0.35, P <0.05, respectively). Concentrations of CRP and IL-6 decreased after weight loss (median, 8.6 and interquartile range, 2.7/14.5 vs 2.5 and 1.2/4.1 mg/L; P <0.006, and 5.13 and 2.72/12.15 vs 3.95 and 1.97/5.64 pg/mL, P <0.02, respectively), whereas serum levels of TNF-α remained unchanged (8.6 and 6.3/18.8 vs 11.7 and 5.8/17.2 pg/mL; NS.). Multiple regression analysis revealed that the decrease in insulin resistance remained independently and significantly correlated with the decrease in IL-6 concentrations ( P <0.01) and the decrease in body mass index with the decrease in CRP ( P <0.05), respectively. Conclusions— Weight loss in morbidly obese patients induces a significant decrease of CRP and IL-6 concentrations in association with an improvement of the IRS.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Most tests of Fe status, however, are affected in response to subclinical inflammation and infections (690 -692) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [692]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus* (2002) · Diabetes Care · doi:10.2337/diacare.25.2007.s5 · Cited by 10,325
(1998) · PsycEXTRA Dataset · doi:10.1037/e565682010-001 · Cited by 9,453
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504
Yudkin, J. S., Stehouwer, C. D. A., Emeis, J. J., & Coppack, S. W. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.4.972 · Cited by 2,465
Ridker, P. M., Rifai, N., Stampfer, M. J., & Hennekens, C. H. (2000) · Circulation · doi:10.1161/01.cir.101.15.1767 · Cited by 2,429
Chronic Subclinical Inflammation as Part of the Insulin Resistance Syndrome
Festa, A., D’Agostino, R., Howard, G., Mykkänen, L., Tracy, R. P., & Haffner, S. M. (2000) · Circulation · doi:10.1161/01.cir.102.1.42 · Cited by 2,366
Self-citationSubcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo1
Mohamed‐Ali, V., Goodrick, S., Rawesh, A., Katz, D. R., Miles, J. M., Yudkin, J. S., Klein, S., & Coppack, S. W. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4450 · Cited by 2,032
Research works printed but not linked: 15
- 1982, Am Physiol, 243, E15
- 1999, Diabetes Care, 22, C14
- 1998, J Clin Endocrinol Metab, 83, 847
- 10.1161/circ.101.15.1767 · DOI
- 10.1161/circ.102.1.42 · DOI
- 2001, Circulation, 103, 1913
- 10.1161/atvb.19.4.972 · DOI
- 10.1161/atvb.21.6.961 · DOI
- 2000, J Clin Endocrinol Metab, 85, 3338
- 10.1161/atvb.21.6.968 · DOI
- 10.1161/circ.105.5.564 · DOI
- 1997, J Clin Endocrinol Metab, 82, 4196
- 10.1210/jcem.86.9.7873 · DOI · Paper page
- 10.1161/circ.100.3.230 · DOI
- 10.1161/circ.100.8.793 · DOI
Cited by
Sorted by citations
Items 101–200 of 425
Influence of obesity physical inactivity and weight cycling on chronic inflammation
McFarlin, B. K. (2010) · Frontiers in Bioscience-Elite · doi:10.2741/e70 · Cited by 94
Poitou, C., Lacorte, J., Coupaye, M., Bertrais, S., Bedel, J., Lafon, N., Bouillot, J., Galan, P., Borson‐Chazot, F., Basdevant, A., et al. (2005) · Obesity Surgery · doi:10.1381/0960892052993431 · Cited by 92
Weigert, C., Hennige, A. M., Brodbeck, K., Häring, H. U., & Schleicher, E. D. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00448.2004 · Cited by 94
“In individuals with obesity and overt type 2 diabetes, IL-6 plasma levels are two- to three-fold higher than in control subjects and are associated with reduced insulin action (1, 8, 12, 15, 20).”
BackgroundWeight Loss Reduces Circulating Asymmetrical Dimethylarginine Concentrations in Morbidly Obese Women
Krzyżanowska, K., Mittermayer, F., Kopp, H.-P., Wolzt, M., & Schernthaner, G. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0672 · Cited by 89
“Chronic subclinical inflammation is closely related to obesity, and reduction of BMI results in a decrease of inflammatory markers (18).”
BackgroundSelf-citationThe Role of Obesity as a Modifying Factor in Patients Undergoing Non‐Surgical Periodontal Therapy
Zuza, E. P., Barroso, E. M., Carrareto, A. L. V., Pires, J. R., Carlos, I. Z., Theodoro, L. H., & de Toledo, B. E. C. (2010) · Journal of Periodontology · doi:10.1902/jop.2010.100545 · Cited by 85
Cardiac and Metabolic Variables in Obese Dogs
Tropf, M. A., Nelson, O. L., Lee, P. M., & Weng, H. (2017) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.14775 · Cited by 86
“The most commonly found inflammatory biomarkers in human ORCD and metabolic syndrome, CRP, TNF-alpha, and IL-6 were not significantly different between the groups of dogs.(52,53) This difference may represent a difference in the inflammatory profiles of obesity-related inflammation in dogs compared to people.”
BackgroundSchernthaner, G.-H., Kopp, H.-P., Kriwanek, S., Krzyzanowska, K., Satler, M., Koppensteiner, R., & Schernthaner, G. (2006) · Obesity Surgery · doi:10.1381/096089206777346763 · Cited by 83
The role of inflamed adipose tissue in the insulin resistance
Torres‐Leal, F. L., Fonseca‐Alaniz, M. H., Rogero, M. M., & Tirapegui, J. (2010) · Cell Biochemistry and Function · doi:10.1002/cbf.1706 · Cited by 87
Obesity, Lutein Metabolism, and Age-Related Macular Degeneration: A Web of Connections
Johnson, E. J. (2005) · Nutrition Reviews · doi:10.1111/j.1753-4887.2005.tb00105.x · Cited by 82
Boesing, F., Patiño, J. S. R., Silva, V. R. G. D., & Moreira, E. A. M. (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2008.00555.x · Cited by 83
“A similar study (25) found that the serum levels of interleukin-6 and C-reactive protein were raised in patients with morbid obesity and significantly correlated with insulin resistance.”
BackgroundObesity and inflammation in children
Schwarzenberg, S. J., & Sinaiko, A. R. (2006) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2006.08.002 · Cited by 80
Advances in the Prevention and Treatment of Obesity-Driven Effects in Breast Cancers
Chen, K., Zhang, J., Beeraka, N. M., Tang, C., Babayeva, Y. V., Sinelnikov, M. Y., Zhang, X., Zhang, J., Liu, J., Reshetov, I. V., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.820968 · Cited by 81
YKL-40 is Elevated in Morbidly Obese Patients and Declines After Weight Loss
Hempen, M., Kopp, H.-P., Elhenicky, M., Höbaus, C., Brix, J., Koppensteiner, R., Schernthaner, G., & Schernthaner, G.-H. (2009) · Obesity Surgery · doi:10.1007/s11695-009-9917-4 · Cited by 79
“have been described [6].”
BackgroundInfluentialSelf-citationLiu, J., Young, T. K., Zinman, B., Harris, S. B., Connelly, P. W., & Hanley, A. J. (2006) · Obesity · doi:10.1038/oby.2006.65 · Cited by 80
“Several interventional studies have also demonstrated that weight loss can decrease proinflammatory marker (such as CRP and IL-6) levels (47,48).”
BackgroundRaj, P., Gomes, R. M., Kumar, S. S., Senthilnathan, P., Karthikeyan, P., Annapoorni, S., & Palanivelu, C. (2015) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2015.02.006 · Cited by 80
Lin, E., Phillips, L. S., Ziegler, T. R., Schmotzer, B. J., Wu, K., Gu, L. H., Khaitan, L., Lynch, S. A., Torres, W. E., Smith, C. D., et al. (2007) · Diabetes · doi:10.2337/db06-1161 · Cited by 80
Low Carbohydrate, High Fat Diet Increases C-Reactive Protein during Weight Loss
Rankin, J. W., & Turpyn, A. D. (2007) · Journal of the American College of Nutrition · doi:10.1080/07315724.2007.10719598 · Cited by 79
“Some studies find that IL-6 and CRP change in concert with dietary manipulation [12, 33]; other studies report substantial reductions in serum CRP but no effect on IL-6 following weight loss [34, 35].”
BackgroundCatalase and nonalcoholic fatty liver disease
Shin, S., Cho, H.-W., Song, S.-E., & Song, D. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2195-z · Cited by 81
Metabolic inflammation: role of cytokines in the crosstalk between adipose tissue and liver
Gerner, R. R., Wieser, V. E., Moschen, A. R., & Tilg, H. (2013) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2013-0050 · Cited by 79
“It already has been demonstrated (more than 10 years ago) that serum concentrations of IL-6 decrease in parallel with weight loss and improvement of insulin resistance in patients undergoing bariatric surgery (Kopp et al. 2003).”
BackgroundGuenther, L., & Gulliver, W. P. F. (2009) · Journal of Cutaneous Medicine and Surgery · doi:10.2310/7750.2009.00024 · Cited by 78
Viardot, A., Lord, R. V., & Samaras, K. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2371 · Cited by 79
Retinol and α-Tocopherol in Morbid Obesity and Nonalcoholic Fatty Liver Disease
Botella-Carretero, J. I., Balsa, J. A., Vázquez, C., Peromingo, R., Díaz-Enriquez, M., & Escobar-Morreale, H. F. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9686-5 · Cited by 77
CRP reduction following gastric bypass surgery is most pronounced in insulin-sensitive subjects
Holdstock, C., Lind, L., Engstrom, B. E., Ohrvall, M., Sundbom, M., Larsson, A., & Karlsson, F. A. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803000 · Cited by 73
Increase in visfatin after weight loss induced by gastroplastic surgery
Krzyzanowska, K., Mittermayer, F., Krugluger, W., Kopp, H. P., & Schernthaner, G. (2006) · Obesity · doi:10.1038/oby.2006.219 · Cited by 71
“Introduction Severe obesity is associated with an adverse cardiovascular risk profile including insulin resistance, hyperinsulinemia, and chronic subclinical inflammation, all of which are improved through weight loss after gastroplastic surgery (1).”
BackgroundResultSelf-citationTeixeira‐Lemos, E., Reis, F., Baptista, S., Pinto, R. M. A., Sepodes, B. M. N., Vala, H., Rocha‐Pereira, P., Santos‐Silva, A., & Teixeira, F. J. (2007) · PubMed · Cited by 68
Cellular inflammatory responses: Novel insights for obesity and insulin resistance
Chen, H. (2006) · Pharmacological Research · doi:10.1016/j.phrs.2006.03.003 · Cited by 68
McLaughlin, T., Deng, A. C., Gonzales, O., Aillaud, M., Yee, G., Lamendola, C. A., Abbasi, F., Connolly, A. J., Sherman, A., Cushman, S. W., et al. (2008) · Diabetologia · doi:10.1007/s00125-008-1148-z · Cited by 68
Laimer, M. W., Kaser, S., Kranebitter, M., Sandhofer, A., Mühlmann, G., Schwelberger, H. G., Weiss, H., Patsch, J. R., & Ebenbichler, C. F. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0802897 · Cited by 65
Cabrera, E. J., Valezi, A. C., Delfino, V. D. A., Lavado, E. L., & Barbosa, D. S. (2009) · Obesity Surgery · doi:10.1007/s11695-009-9988-2 · Cited by 66
“In agreement with other studies that have demonstrated a relation between weight loss and reduced CRP levels [25, 26], a positive correlation was observed between leptin and CRP levels 12 months postsurgery.”
ResultThe Effect of Weight Loss on a Stable Biomarker of Inflammation, C-Reactive Protein
Dietrich, M., & Jialal, I. (2005) · Nutrition Reviews · doi:10.1111/j.1753-4887.2005.tb00107.x · Cited by 66
Insulin Resistance is Increased in Patients with Vitiligo
Karadağ, A. S., Tutal, E., & Ertuğrul, D. T. (2011) · Acta Dermato Venereologica · doi:10.2340/00015555-1141 · Cited by 66
Surgical Management of Obesity and the Relationship to Cardiovascular Disease
Vest, A. R., Heneghan, H., Schauer, P. R., & Young, J. B. (2013) · Circulation · doi:10.1161/circulationaha.112.103275 · Cited by 66
“Circulating C-reactive protein and interleukin-6 levels have been observed to fall by as much as 81% and 23%, respectively, paralleling the improvements in insulin sensitivity.(86) Gastric bypass and SG lead to rapid reductions in leptin levels as early as 1 week postoperatively, with ongoing decreases until 12 months…”
BackgroundInflammatory Cytokines and Antipsychotic-Induced Weight Gain: Review and Clinical Implications
Fonseka, T. M., Müller, D. J., & Kennedy, S. H. (2016) · Complex Psychiatry · doi:10.1159/000441521 · Cited by 68
Zarrati, M., Shidfar, F., Nourijelyani, K., Mofid, V., Hosseinzadeh‐Attar, M. J., Bidad, K., Najafi, F., Gheflati, Z., Chamari, M., & Salehi, E. (2013) · BioFactors · doi:10.1002/biof.1128 · Cited by 69
Wang, P., Xu, S., Li, W., Wang, F., Yang, Z., Jiang, L., Wang, Q., Huang, M., & Zhou, P. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000362999 · Cited by 62
Segovia, S. A., Vickers, M. H., & Reynolds, C. M. (2017) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174417000204 · Cited by 65
“They also confirmed elevated TNFα expression in the adipose tissue of obese humans, which strongly correlated with the degree of hyperinsulinemia.29 TNFα has since been shown as a major regulator of lipid metabolism, acting through multiple mechanisms, including increasing free fatty acid production, inducing lipolysi…”
BackgroundInfluentialBariatric Surgery in Patients With Morbid Obesity and Type 2 Diabetes
Schernthaner, G., & Morton, J. M. (2008) · Diabetes Care · doi:10.2337/dc08-s270 · Cited by 63
Self-citationObesity and Inflammation: Lessons From Bariatric Surgery
Compher, C. W., & Badellino, K. O. (2008) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607108326070 · Cited by 60
Obesity and Cardiovascular Disease: The Emerging Role of Inflammation
Khafagy, R. T. M., & Dash, S. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.768119 · Cited by 69
“Bariatric surgery is associated with decreases in CRP and interleukin-6 concentrations in proportion to weight less, however, TNF-alpha levels did not change (51, 94) Despite this, insulin resistance was not normalized and some adipose pathology remained post-surgery (51).”
BackgroundTreating diabetes and prediabetes by focusing on obesity management
Khaodhiar, L., Cummings, S., & Apovian, C. M. (2009) · Current Diabetes Reports · doi:10.1007/s11892-009-0055-0 · Cited by 56
“A study of patients at different stages of glucose tolerance before and 14 months after banded gastroplasty surgery demonstrated a signifi cant reduction in the levels of C-reactive protein (CRP) (a liver-derived reporter that increased when infl ammatory cytokines are increased) and IL-6 (a proinfl ammatory cytokine)…”
ResultThe Multiple Facets of the Fat Tissue
Rocha, V. Z., & Libby, P. (2008) · Thyroid · doi:10.1089/thy.2007.0296 · Cited by 61
McCarty, M. F. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2004.03.041 · Cited by 59
Belza, A., Toubro, S., Stender, S., & Astrup, A. V. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.27 · Cited by 62
Dao, M. C., & Meydani, S. N. (2013) · Advances in Nutrition · doi:10.3945/an.113.004424 · Cited by 59
Hsueh, H. W., Zhou, Z., Whelan, J., Allen, K. G. D., Moustaïd‐Moussa, N., Kim, H., & Claycombe, K. (2011) · Journal of Nutrition · doi:10.3945/jn.110.132571 · Cited by 57
Metabolic Surgery for Hypertension in Patients With Obesity
Pareek, M., Bhatt, D. L., Schiavon, C. A., & Schauer, P. R. (2019) · Circulation Research · doi:10.1161/circresaha.118.313320 · Cited by 61
Zouhal, H., Abderrahman, A. B., Khodamoradi, A., Saeidi, A., Jayavel, A., Hackney, A. C., Laher, I., Algotar, A. M., & Jabbour, G. (2020) · Obesity Reviews · doi:10.1111/obr.13039 · Cited by 66
Lastra, G., & Sowers, J. R. (2013) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2013-0025 · Cited by 55
“Markers of systemic inflammation such as IL-6 and CRP are also significantly decreased after bariatric surgery [50].”
BackgroundPiva, S. J., Tatsch, E., de Carvalho, J. A. M., Bochi, G. V., Kober, H., Duarte, T., Duarte, M. M. M. F., da Cruz, I. B. M., Moretto, M. B., & Moresco, R. N. (2012) · Inflammation · doi:10.1007/s10753-012-9538-2 · Cited by 53
“Obesity is considered an important risk factor leading to the development of health problems, such as coronary heart disease, diabetes, hypertension, dyslipidemia, stroke, some kinds of cancers, arthritis, and allcause mortality [23, 24].”
BackgroundLicciardone, J. C., Kearns, C. M., Hodge, L. M., & Minotti, D. E. (2013) · PubMed · Cited by 54
The impact of bariatric surgery on inflammation: quenching the fire of obesity?
Hafida, S., Mirshahi, T., & Nikolajczyk, B. S. (2016) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000277 · Cited by 53
“not correlate with HOMA-IR 14 months after gastroplasty, but instead independently correlated with BMI reduction [40].”
BackgroundResultMetabolic syndrome: A marker of patients at high cardiovascular risk
Lau, D., Yan, H., & Dhillon, B. (2006) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(06)70992-8 · Cited by 57
Bovbjerg, K. K. L., Jørgensen, N. B., Just, R., Heegaard, P. M. H., & Madsbad, S. (2015) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-015-0012-9 · Cited by 50
“The reductions in IL-6 concentrations we report one year after RYGB is in agreement with some other RYGB studies [41,42] and consistent with other weight loss intervention studies reporting 1-year follow-ups, either through dietary restriction [30] or other types of bariatric surgery procedures [40,43,49].”
ResultMetabolic syndrome and ALT: a community study in adult Koreans
Jeong, S.-K., Nam, H.-S., Rhee, J.-A., Shin, J.-H., Kim, J.-M., & Cho, K.-H. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802698 · Cited by 50
Zeng, L., Zhong, F.-W., Chen, Z.-L., Li, G.-X., & Zhu, Q. (2022) · Food Science and Human Wellness · doi:10.1016/j.fshw.2022.03.031 · Cited by 49
The obesity paradox and diabetes
Gravina, G., Ferrari, F., & Nebbiai, G. (2020) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-020-01015-1 · Cited by 52
Khosravi-Largani, M., Nojomi, M., Aghili, R., Otaghvar, H. A., Tanha, K., Seyedi, S. H. S., & Mottaghi, A. (2018) · Obesity Surgery · doi:10.1007/s11695-018-3550-z · Cited by 48
Bariatric surgery and its impact on sleep architecture, sleep-disordered breathing, and metabolism
Pannain, S., & Mokhlesi, B. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.07.007 · Cited by 48
Fructose-induced ROS generation impairs glucose utilization in L6 skeletal muscle cells
Jaiswal, N., Maurya, C. K., Pandey, J., Rai, A. K., & Tamrakar, A. K. (2015) · Free Radical Research · doi:10.3109/10715762.2015.1031662 · Cited by 49
What does irritable bowel syndrome share with non-alcoholic fatty liver disease?
Scalera, A. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i33.5402 · Cited by 48
Iannelli, A., Anty, R., Piche, T., Dahman, M., Gual, P., Tran, A., & Gugenheim, J. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9764-8 · Cited by 46
“Amelioration in the inflammatory process after massive weight loss might explain the improvement in MS [ 25 ].”
BackgroundResultA therapeutic role for vitamin D on obesity-associated inflammation and weight-loss intervention
Slusher, A. L., McAllister, M. J., & Huang, C. (2015) · Inflammation Research · doi:10.1007/s00011-015-0847-4 · Cited by 47
“, gastric bypass surgery), decreases in inflammation, especially IL-6 and TNF-a, have been observed [133], while serum vitamin D levels have shown to increase in obese populations in a manner dependent upon weight loss [134, 135].”
BackgroundImpact of bariatric surgery on obstructive sleep apnoea–hypopnea syndrome in morbidly obese patients
Aggarwal, S., Priyadarshini, P., Singh, V., Garg, H., Sinha, S., & Guleria, R. (2017) · Journal of Minimal Access Surgery · doi:10.4103/jmas.jmas_5_17 · Cited by 44
“[17] Level of soluble TNF‑ α receptor 2 has been found to decrease after bariatric surgery which is an independent predictor of sleep apnoea improvement.”
Shadid, S., Stehouwer, C. D. A., & Jensen, M. D. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0015 · Cited by 45
“Nonetheless, lifestyle changes have been reported to affect adiponectin (15, 19, 32), CRP (19, 24, 32, 33), IL-6 (15, 32, 33), and TNF (7, 15) favorably in type 2 diabetic volunteers; effects on resistin are variable (16, 19).”
BackgroundBasal high-sensitivity-C-reactive protein levels in patients with spontaneous venous thromboembolism
Vormittag, R., Vukovich, T., Schönauer, V., Lehr, S., Minar, E., Bialonczyk, C., Hirschl, M., & Pabinger, I. (2005) · Thrombosis and Haemostasis · doi:10.1160/th04-11-0745 · Cited by 44
“These data are underlined by the observation that basal CRP levels decrease as soon as a weight reduction is achieved (27, 28), for instance, in morbidly obese patients, who underwent vertical ring gastroplasty (29).”
BackgroundSelf-citationIacovides, S., & Meiring, R. M. (2018) · Trials · doi:10.1186/s13063-018-2462-5 · Cited by 43
“It is also important to note that their results are further confounded by the populations studied, given that both CRP and adipocytokines are affected by obesity and weight loss [65, 66].”
ResultObesity and Periodontal Disease: A Narrative Review on Current Evidence and Putative Molecular Links
Spirito, F. D., Sbordone, L., Pilone, V., & D’Ambrosio, F. (2019) · The Open Dentistry Journal · doi:10.2174/1874210601913010526 · Cited by 45
Ethanol extract of propolis regulates type 2 diabetes in mice via metabolism and gut microbiota
Guan, R., Ma, N., Liu, G., Qiu, W., Su, S., Wang, J., & Geng, Y. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116385 · Cited by 71
Gervois, P. P., Fruchart, J., & Staels, B. (2004) · International Journal of Clinical Practice · doi:10.1111/j.1368-504x.2004.00376.x · Cited by 42
Stolberg, C. R., Mundbjerg, L. H., Funch-Jensen, P. M., Gram, B., Bladbjerg, E., & Juhl, C. B. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.04.002 · Cited by 42
Dysregulation of maternal serum adiponectin in preterm labor
Mazaki‐Tovi, S., Romero, R. J., Vaisbuch, E., Erez, O., Mittal, P., Chaiworapongsa, T., Kim, S. K., Pacora, P., Yeo, L., Gotsch, F., et al. (2009) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050902994655 · Cited by 45
“Intra-amniotic inflammation was diagnosed by an amniotic fluid IL-6 concentration 2.6 ng/ml [133].”
BackgroundInfluentialPreeclampsia and Obesity—The Preventive Role of Exercise
Poniedziałek‐Czajkowska, E., Mierzyński, R., & Leszczyńska‐Gorzelak, B. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20021267 · Cited by 73
Fain, J. N., Bahouth, S. W., & Madan, A. K. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.02.009 · Cited by 41
Solutions in weight control: lessons from gastric surgery
Blackburn, G. L. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.1.248s · Cited by 41
“Current metabolic studies of patients with diabetes undergoing weight loss surgery have shown the following: a recovery of acute insulin response (26); significant decreases of inflammatory indicators (C-reactive protein and interleukin) (27); improvement in insulin sensitivity correlated with increases in plasma adip…”
BackgroundMuramoto, A., Tsushita, K., Kato, A., Ozaki, N., Tabata, M., Endo, M., Oike, Y., & Oiso, Y. (2011) · Nutrition and Diabetes · doi:10.1038/nutd.2011.16 · Cited by 39
Adipose tissue, estradiol levels, and bone health in obese men with metabolic syndrome
Ørnstrup, M. J., Kjær, T. N., Harsløf, T., Stødkilde‐Jørgensen, H., HOUGAARD, D. M., Cohen, A. S., Pedersen, S. B., & Langdahl, B. L. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0792 · Cited by 40
Obesity Surgery: Evidence for Diabetes Prevention/Management
Cummings, S., Apovian, C. M., & Khaodhiar, L. (2008) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2008.01.017 · Cited by 40
Mach, F. (2008) · Clinical Interventions in Aging · doi:10.2147/cia.s2706 · Cited by 40
“Weight loss and the reduction of adiposity were showed to induce favorable changes in hsCRP level (Tchernof et al 2002; Esposito et al 2003; Kopp et al 2003).”
Parameters of Inflammation in Morbid Obesity: Lack of Effect of Moderate Weight Loss
Solá, E., Jover, A., López‐Ruiz, A., Jarabo-Bueno, M. M., Vayá, A., Morillas, C., Gómez‐Balaguer, M., & Hernández‐Mijares, A. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9772-8 · Cited by 38
“Like us, others have reported an absence of changes in inflammatory cytokines in patients that have lost weight through a very low calorie diet [38] or 4–12 months after bariatric surgery [22, 23, 29].”
BackgroundSoluble CD40L in patients with morbid obesity: significant reduction after bariatric surgery
Schernthaner, G.-H., Kopp, H., Krzyżanowska, K., Kriwanek, S., Koppensteiner, R., & Schernthaner, G. (2006) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2006.01649.x · Cited by 38
Self-citationOrtiz, S., Zapater, P., Estrada, J. L., Enriquez, P., Rey, M., Abad, Á. L., Such, J. M., Lluı́s, F., & Francés, R. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4483 · Cited by 37
Impact of Bariatric Surgical Intervention on Peripheral Blood Neutrophil (PBN) Function in Obesity
Roberts, H. M., Grant, M. M., Hubber, N. A., Super, P., Singhal, R., & Chapple, I. (2017) · Obesity Surgery · doi:10.1007/s11695-017-3063-1 · Cited by 40
Cardiovascular Risk Reduction Associated with Pharmacological Weight Loss: A Meta-Analysis
Kane, J. A., Mehmood, T., Munir, I., Kamran, H., Kariyanna, P. T., Zhyvotovska, A., Yusupov, D., Suleman, U., Gustafson, D., & McFarlane, S. I. (2019) · International Journal of Clinical Research & Trials · doi:10.15344/2456-8007/2019/131 · Cited by 37
Guarnotta, V., Bianco, M. J., Vigneri, E., Panto’, F., Lo Sasso, B., Ciaccio, M., Pizzolanti, G., & Giordano, C. (2021) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2021.07.015 · Cited by 36
Appachi, S., Kelly, K. R., Schauer, P. R., Kirwan, J. P., Hazen, S. L., Gupta, M. K., & Kashyap, S. R. (2011) · Obesity Surgery · doi:10.1007/s11695-011-0447-5 · Cited by 36
“The change in TNF-α following bariatric surgery is a controversial topic in the literature, with some studies showing this cytokine decreases postsurgery [36, 37], and others indicating there is no change [38, 39].”
Inflammation, adipokines et obésité
Clément, K., & Vignes, S. (2009) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2009.03.363 · Cited by 40
Schernthaner, G.-H., & Schernthaner, G. (2005) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510500236119 · Cited by 35
Self-citationGlucocorticoids Inhibit the Cerebral Microvascular Dysfunction Associated with Sepsis in Obese Mice
Vachharajani, V., Vital, S. A., Russell, J., Scott, L. K., & Granger, D. N. (2006) · Microcirculation · doi:10.1080/10739680600777599 · Cited by 35
“The chronic inflammatory hypothesis for the morbidity associated with obesity is largely based on reports describing elevated plasma concentrations of cytokines and other inflammatory mediators that correlate with markers of adipocyte mass, with weight loss resulting in a reduction of inflammatory mediators and a corr…”
BackgroundResultLiu, C.-W., Tsai, H., Huang, C., Tsai, C., Su, Y.-B., Lin, M., Lee, K., Hsieh, Y., Li, T., Huang, S., et al. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00094.2017 · Cited by 35
Mansoori, N., Tripathi, M., Alam, R., Luthra, K., Ramakrishnan, L., Parveen, S., & Mukhopadhyay, A. K. (2010) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000321666 · Cited by 32
Obesity-related cardiorenal disease: the benefits of bariatric surgery
Fenske, W., Athanasiou, T., Harling, L., Drechsler, C., Darzi, A. W., & Ashrafian, H. (2013) · Nature Reviews Nephrology · doi:10.1038/nrneph.2013.145 · Cited by 32
Cure of Type 2 Diabetes by Metabolic Surgery? A Critical Analysis of the Evidence in 2010
Schernthaner, G., Brix, J. M., Kopp, H.-P., & Schernthaner, G.-H. (2011) · Diabetes Care · doi:10.2337/dc11-s253 · Cited by 30
Self-citationGut Microbiome, Obesity-Related Comorbidities, and Low-Grade Chronic Inflammation
Tarantino, G. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2074 · Cited by 32
Konukoğlu, D., Uzun, H., Fırtına, S., Arica, P. Ç., Kocael, A., & Taşkın, M. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9113-3 · Cited by 31
Link Between Metabolic Syndrome, Inflammation, and Eye Diseases
Pieńczykowska, K., Bryl, A., & Mrugacz, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052174 · Cited by 30
“…mechanisms driving the progression of metabolic syndrome converge to create a pro-inflammatory state, which accounts for the elevated levels of inflammatory markers like Interleukin 6 (IL-6), C-reactive protein (CRP), and Tumor Necrosis Factor Alpha (TNF α ) observed in individuals with MetS [17].”
Kopp, H.-P., Krzyżanowska, K., Schernthaner, G.-H., Kriwanek, S., & Schernthaner, G. (2006) · Obesity Surgery · doi:10.1381/096089206778392130 · Cited by 30
Self-citationFathy, S. M., & Morshed, G. (2014) · Archives of Medical Science · doi:10.5114/aoms.2014.46209 · Cited by 30
“Data on the effect of weight loss after bariatric surgery on inflammation and immune cells are emerging, suggesting the reduction in the circulating inflammatory markers [25]; another study also showed that immune cell activation can be regulated by acute energy restriction [26].”
BackgroundIndependent Evolution of Heart Autonomic Function and Insulin Sensitivity During Weight Loss
Bobbioni‐Harsch, E., Sztajzel, J. M., Barthassat, V., Makoundou, V., Gastaldi, G., Sievert, K., Chassot, G., Huber, O., Morel, P., Assimacopoulos‐Jeannet, F., et al. (2008) · Obesity · doi:10.1038/oby.2008.532 · Cited by 30
“On the other hand, the adipocyte secretor activity is deeply influenced by weight reduction, both during the active phase (35) and after weight loss (36,37).”
BackgroundThe key role of inflammation in the pathogenesis and management of obesity and CVD
Boutari, C., Hill, M. A., Procaccini, C., Matarese, G., & Mantzoros, C. S. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155627 · Cited by 30
Metadata
- Authors
- Kopp, H. P., Kopp, C. W., Festa, A., Krzyzanowska, K., Kriwanek, S., Minar, E., Roka, R., & Schernthaner, G.
- Affiliations
- Vienna General Hospital (AT)
- From the Department of Medicine 1 (H.P.K., A.F., K.K., G.S.), Rudolfstiftung Hospital; the Department of Medicine 2 (C.W.K., E.M.), General Hospital of Vienna; and the Department of Surgery 1 and Ludwig Boltzmann Institute for Endocrine Surgery (S.K., R.K.), Rudolfstiftung Hospital, Vienna, Austria.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2003-06
- Volume
- 23
- Issue
- 6
- Pages
- 1042-1047
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2102170193
- Cited by
- 427
- References
- 45
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 10 · 2023: 14 · 2022: 9 · 2021: 10 · 2020: 10 · 2019: 13 · 2018: 17 · 2017: 10 · 2016: 6 · 2015: 24 · 2014: 24 · 2013: 25 · 2012: 15
- FWCI
- 20.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Universität Wien
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- morbid obesity, weight loss, metabolic syndrome, C-reactive protein, interleukin-6, TNF-α, chronic inflammation, gastric bypass, bariatric surgery, impaired glucose tolerance, type 2 diabetes, HOMA, body mass index, glucose tolerance, cardiovascular risk factors, adipokines, adipose tissue inflammation, hepatic insulin resistance
- MeSH terms
- Adult, Blood Glucose, C-Reactive Protein, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Fibrinogen, Humans, Inflammation, Insulin, Insulin Resistance, Lipids, Longitudinal Studies, Male, Middle Aged, Obesity, Morbid, Tumor Necrosis Factor-alpha, Gastroplasty, Weight Loss, Interleukin-6, Body Mass Index
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
