C-Reactive Protein Genotypes Affect Baseline, but not Exercise Training–Induced Changes, in C-Reactive Protein Levels
Open accessAbstract
Objective— The goal of this study is to determine whether C-reactive protein (CRP) gene variants affect baseline and training-induced changes in plasma CRP levels. Methods and Results— Sixty-three sedentary men and women aged 50 to 75 years old underwent baseline testing (V o max, body composition, CRP levels). They repeated these tests after 24 weeks of exercise training while on a low-fat diet. The CRP +219G/A variant significantly associated with CRP levels before and after training after accounting for the effects of demographic and biological variables. CRP −732A/G genotype was significantly related on a univariate basis to CRP levels after training. The CRP +29T/A variant did not affect CRP levels before or after training. In regression analyses, the +219 and −732 variants each had significant effects on CRP levels before and after training. Subjects homozygous for the common A/G −732/+219 haplotype exhibited the highest CRP levels, and having the rare allele at either site was associated with significantly lower CRP levels. CRP levels decreased significantly with training (−0.38±0.18 mg/L; P =0.03). However, none of the CRP variants was associated with the training-induced CRP changes. Conclusion— CRP +219G/A and −732A/G genotypes and haplotypes and exercise training appear to modulate CRP levels. However, training-induced CRP reductions appear to be independent of genotype at these loci.
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From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [86]
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From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [86]
Exercise increases vagus nerve activity.
“Exercise reduces levels of TNF and other cytokines, confers protection against cardiovascular disease and type 2 diabetes, increases vagus nerve activity, and confers protection against the development of atherosclerosis (84)(85)(86)(87)(88)(89)(90).”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [86]
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- Authors
- Obisesan, T. O., Leeuwenburgh, C., Phillips, T., Ferrell, R. E., Phares, D. A., Prior, S. J., & Hagberg, J. M.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2004-10
- Volume
- 24
- Issue
- 10
- Pages
- 1874-1879
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- PMC
- PMC2643022
- OpenAlex
- W2117196142
- Cited by
- 83
- References
- 36
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 5 · 2013: 2 · 2012: 3
- FWCI
- 8.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG-17474, R01AG017474, AG15389, AG00980, R01AG015389, K23AG000980)
- National Center for Research Resources (M01RR010284, RR10284)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Keywords
- C-reactive protein, CRP gene polymorphisms, exercise training, haplotypes, plasma CRP levels, low-fat diet, older adults, genetic susceptibility
- MeSH terms
- Adenine, Aged, Base Composition, Body Composition, C-Reactive Protein, Exercise Therapy, Female, Genotype, Guanine, Haplotypes, Humans, Male, Middle Aged, Thymine, Genetic Variation, Point Mutation
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