Association between Physical Activity and Markers of Inflammation in a Healthy Elderly Population

Geffken, Dominic F.; Cushman, Mary; Burke, Gregory L.; Polak, Joseph F.; Sakkinen, Pamela A.; Tracy, Russell P.

doi:10.1093/aje/153.3.242

Cited by 599Physical Activity and HealthExercise and Physiological ResponsesAdipokines, Inflammation, and Metabolic Diseases

Association between Physical Activity and Markers of Inflammation in a Healthy Elderly Population

Geffken, Dominic F., Cushman, Mary, Burke, Gregory L., Polak, Joseph F., Sakkinen, Pamela A., Tracy, Russell P.·2001·American Journal of Epidemiology

DOI 10.1093/aje/153.3.242

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Abstract

Higher levels of physical activity are associated with lower risk of cardiovascular disease. There is growing evidence that the development of the atherosclerotic plaque is associated with inflammation. In this study, the authors investigated the cross-sectional association between physical activity and markers of inflammation in a healthy elderly population. Data obtained in 1989–1990 and 1992–1993 from the Cardiovascular Health Study, a cohort of 5,888 men and women aged ≥65 years, were analyzed. Concentrations of the inflammation markers–C-reactive protein, fibrinogen, Factor VIII activity, white blood cells, and albumin–were compared cross-sectionally by quartile of self-reported physical activity. Compared with persons in the lowest quartile, those in the highest quartile of physical activity had 19%, 6%, 4%, and 3% lower concentrations of C-reactive protein, white blood cells, fibrinogen, and Factor VIII activity, respectively, after adjustment for gender, the presence of cardiovascular disease, age, race, smoking, body mass index, diabetes, and hypertension. Multivariate regression models suggested that the association of higher levels of physical activity with lower levels of inflammation markers may be mediated by body mass index and glucose. There was no association between physical activity and albumin. Higher levels of physical activity were associated with lower concentrations of four out of five inflammation markers in this elderly cohort. These data suggest that increased exercise is associated with reduced inflammation. Prospective studies will be required for verification of these findings.

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Cross-sectional studies demonstrate an association between physical inactivity and low-grade systemic inflammation in healthy subjects, elderly people, and patients with intermittent claudication.
“Cross-sectional studies demonstrate an association between physical inactivity and low-grade systemic inflammation in healthy subjects [71–75], in elderly people [76, 77], and in patients with intermittent claudication [78].”
From Exercise as a Mean to Control Low‐Grade Systemic Inflammation (2008) · cites this paper as [73]

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Association of Physical Activity with Inflammation Markers Geffken et al. Association between Physical Activity and Markers of Inflammation in a Healthy Elderly Population
Tracy, R. P. (2000)
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Association of leisure-time physical activity on inflammation markers (C-reactive protein, white cell blood count, serum amyloid A, and fibrinogen) in healthy subjects (from the ATTICA study)
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Physical Activity and Inflammatory Markers Over 10 Years: Follow-Up in Men and Women From the Whitehall II Cohort Study
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Authors: Geffken, D. F., Cushman, M., Burke, G. L., Polak, J. F., Sakkinen, P. A., & Tracy, R. P.
Affiliations: University of Vermont (US)
ORCID: Cushman, Mary
Burke, Gregory L.
Polak, Joseph F.
Tracy, Russell P.
Venue: American Journal of Epidemiology
Publisher: Oxford University Press (OUP)
Published: 2001-02-01
Volume: 153
Issue: 3
Pages: 242-250
ISSN: 0002-9262 (ISSN-L)
1476-6256
DOI: 10.1093/aje/153.3.242
OpenAlex: W2145710413
Cited by: 599
References: 55
Citations by year: 2026: 7 · 2025: 14 · 2024: 9 · 2023: 8 · 2022: 20 · 2021: 14 · 2020: 11 · 2019: 19 · 2018: 10 · 2017: 22 · 2016: 31 · 2015: 30 · 2014: 32 · 2013: 30 · 2012: 30
FWCI: 14.15
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Epidemiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (n01hc085079-024, 5k08hl003618-05)
National Heart, Lung, and Blood Institute (R01HL046696, T32-HL07594, R01-HL-46696, K08 HL-03618, N01-HC85079-85086, T32HL007594)
Topics: Health Sciences › Medicine › Physiology › Physical Activity and Health
Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords: physical activity, inflammatory markers, C-reactive protein, fibrinogen, factor VIII activity, white blood cell count, albumin, older adults, body mass index, glucose, atherosclerosis, Cardiovascular Health Study
MeSH terms: Aged, Analysis of Variance, C-Reactive Protein, Cardiovascular Diseases, Physical Exertion, Factor VIII, Female, Fibrinogen, Humans, Inflammation, Leukocyte Count, Male, Sex Factors, Smoking, Biomarkers

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Association between Physical Activity and Markers of Inflammation in a Healthy Elderly Population

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