Identifying inflamed carotid plaques using in vivo USPIO-enhanced MR imaging to label plaque macrophages
Abstract
BACKGROUND: Inflammation within atherosclerotic lesions contributes to plaque instability and vulnerability to rupture. We set out to evaluate the use of a macrophage labeling agent to identify carotid plaque inflammation by in vivo magnetic resonance imaging (MRI). METHODS AND RESULTS: Thirty patients with symptomatic severe carotid stenosis scheduled for carotid endarterectomy underwent multi-sequence MRI of the carotid bifurcation before and after injection of ultrasmall superparamagnetic particles of iron oxide (USPIOs). USPIO particles accumulated in macrophages in 24 of 30 plaques (80%). Areas of signal intensity reduction, corresponding to USPIO/macrophage-positive histological sections, were visualized in 24 of 27 (89%) patients, with an average reduction in signal intensity induced by the USPIO particles of 24% (range, 3.1% to 60.8%). CONCLUSIONS: USPIO-enhanced MRI can identify plaque inflammation in vivo by accumulation of USPIO within macrophages in carotid plaques.
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USPIO/SPION uptake is increased in vulnerable or ruptured atherosclerotic plaques in rabbits and humans.
“Several groups have shown an increase in USPIO/ SPION uptake in vulnerable or ruptured atherosclerotic plaques in rabbits [171] and humans [172, 173] (Figure 4 A).”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [173]
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- Authors
- Trivedi, R. A., Mallawarachi, C., U-King-Im, J.-M., Graves, M. J., Horsley, J., Goddard, M. J., Brown, A., Wang, L., Kirkpatrick, P. J., Brown, J., & Gillard, J. H.
- Affiliations
- GlaxoSmithKline (United Kingdom) (GB)
- Venue
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2006-07
- Volume
- 26
- Issue
- 7
- Pages
- 1601-1606
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2161739492
- Cited by
- 330
- References
- 12
- Citations by year
- 2026: 6 · 2025: 1 · 2024: 6 · 2023: 7 · 2022: 9 · 2021: 6 · 2020: 9 · 2019: 15 · 2018: 10 · 2017: 16 · 2016: 17 · 2015: 24 · 2014: 21 · 2013: 20 · 2012: 29
- FWCI
- 23.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cerebrovascular and Carotid Artery Diseases
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- carotid plaque, plaque inflammation, ultrasmall superparamagnetic iron oxide, USPIO-enhanced MRI, carotid artery stenosis, plaque vulnerability, carotid endarterectomy, in vivo imaging
- MeSH terms
- Contrast Media, Dextrans, Coloring Agents, Humans, Image Enhancement, Image Processing, Computer-Assisted, Inflammation, Iron, Macrophages, Magnetic Resonance Imaging, Oxides, Staining and Labeling, Tissue Distribution, Carotid Stenosis, Ferrosoferric Oxide, Magnetite Nanoparticles
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