Prediction of anti-cancer nanotherapy efficacy by imaging

Magnetic iron oxide nanoparticles: Synthesis, stabilization, vectorization, physicochemical characterizations and biological applications

Laurent, S., Forge, D., Port, M., Roch, A., Robic, C., Vander Elst, L., & Muller, R. N. (2008) · Chemical Reviews · doi:10.1021/cr068445e · Cited by 6,852 · see citing works

Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review

Maeda, H., Wu, J., Sawa, T., Matsumura, Y., & Hori, K. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00248-5 · Cited by 6,565 · see citing works

Cancer nanomedicine: progress, challenges and opportunities

Shi, J., Kantoff, P. W., Wooster, R., & Farokhzad, O. C. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2016.108 · Cited by 5,873 · see citing works

Analysis of nanoparticle delivery to tumours

Wilhelm, S., Tavares, A. J., Dai, Q., Ohta, S., Audet, J., Dvorak, H. F., & Chan, W. C. W. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.14 · Cited by 5,218 · see citing works

Long-Circulating and Target-Specific Nanoparticles: Theory to Practice

Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01494-7 · Cited by 3,521 · see citing works

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

Pyonteck, S. M., Akkari, L., Schuhmacher, A. J., Bowman, R. L., Sevenich, L., Quail, D. F., Olson, O. C., Quick, M. L., Huse, J. T., Teijeiro, V., et al. (2013) · Nature Medicine · doi:10.1038/nm.3337 · Cited by 2,463 · see citing works

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

Cabral, H., Matsumoto, Y., Mizuno, K., Chen, Q., Murakami, M., Kimura, M., Terada, Y., Kano, M. R., Miyazono, K., Uesaka, M., et al. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.166 · Cited by 2,429 · see citing works

Association of PD-1, PD-1 Ligands, and Other Features of the Tumor Immune Microenvironment with Response to Anti–PD-1 Therapy

Taube, J. M., Klein, A., Brahmer, J. R., Xu, H., Pan, X., Kim, J. H., Chen, L., Pardoll, D. M., Topalian, S. L., & Anders, R. A. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-3271 · Cited by 2,324 · see citing works

Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma

Provenzano, P. P., Cuevas, C., Chang, A. E., Goel, V. K., Von Hoff, D. D., & Hingorani, S. R. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.01.007 · Cited by 2,195 · see citing works

Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil–Based Paclitaxel in Women With Breast Cancer

Gradishar, W. J., Tjulandin, S., Davidson, N. G. P., Shaw, H., Desai, N. P., Bhar, P., Hawkins, M., & O’Shaughnessy, J. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.04.937 · Cited by 2,159 · see citing works

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

Rhim, A. D., Oberstein, P. E., Thomas, D. H., Mirek, E. T., Palermo, C. F., Sastra, S. A., Dekleva, E. N., Saunders, T., Becerra, C. P., Tattersall, I. W., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.021 · Cited by 2,085 · see citing works

Noninvasive detection of clinically occult lymph-node metastases in prostate cancer

Harisinghani, M. G., Barentsz, J., Hahn, P. F., Deserno, W. M., Tabatabaei, S., van de Kaa, C. H., de la Rosette, J., & Weissleder, R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022749 · Cited by 1,971 · see citing works

Reduced cardiotoxicity and comparable efficacy in a phase IIItrial of pegylated liposomal doxorubicin HCl(CAELYX™/Doxil®) versus conventional doxorubicin forfirst-line treatment of metastatic breast cancer

O’Brien, M. E. R., Wigler, N., Inbar, M., Rosso, R., Grischke, E., Santoro, A., Catane, R., Kieback, D., Tomczak, P., Ackland, S. P., et al. (2004) · Annals of Oncology · doi:10.1093/annonc/mdh097 · Cited by 1,739 · see citing works

Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues

Zanganeh, S., Hutter, G., Spitler, R., Lenkov, O., Mahmoudi, M., Shaw, A., Pajarinen, J. S., Nejadnik, H., Goodman, S., Moseley, M., et al. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.168 · Cited by 1,647 · see citing works

Antibody Targeting of Long-Circulating Lipidic Nanoparticles Does Not Increase Tumor Localization but Does Increase Internalization in Animal Models

Kirpotin, D. B., Drummond, D. C., Shao, Y., Shalaby, M. R., Hong, K., Nielsen, U. B., Marks, J. D., Benz, C. C., & Park, J. W. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4199 · Cited by 1,129 · see citing works

An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice

Sindrilaru, A., Peters, T., Wieschalka, S., Baican, C., Baican, A., Peter, H., Hainzl, A., Schatz, S., Qi, Y., Schlecht, A., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44490 · Cited by 1,100 · see citing works

Superparamagnetic iron oxide: pharmacokinetics and toxicity

Weissleder, R., Stark, D., Engelstad, B. L., Bacon, B., Compton, C. C., White, D., Jacobs, P. M., & Lewis, J. M. (1989) · American Journal of Roentgenology · doi:10.2214/ajr.152.1.167 · Cited by 1,045 · see citing works

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

Chauhan, V. P., Martin, J. D., Liu, H., Lacorre, D. A., Jain, S. R., Kozin, S. V., Stylianopoulos, T., Mousa, A. S., Han, X., Adstamongkonkul, P., et al. (2013) · Nature Communications · doi:10.1038/ncomms3516 · Cited by 1,031 · see citing works

Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging.

Weissleder, R., Elizondo, G., WITTENBERG, J., Rabito, C. A., Bengele, H. H., & Josephson, L. (1990) · Radiology · doi:10.1148/radiology.175.2.2326474 · Cited by 1,027 · see citing works

Cell-specific targeting of nanoparticles by multivalent attachment of small molecules

Weissleder, R., Kelly, K., Sun, E. Y., Shtatland, T., & Josephson, L. (2005) · Nature Biotechnology · doi:10.1038/nbt1159 · Cited by 898 · see citing works

Magnetic relaxation switches capable of sensing molecular interactions

Pérez, J. M. S., Josephson, L., O'Loughlin, T., Högemann, D., & Weissleder, R. (2002) · Nature Biotechnology · doi:10.1038/nbt720 · Cited by 889 · see citing works

The BATTLE Trial: Personalizing Therapy for Lung Cancer

Kim, E. S., Herbst, R. S., Wistuba, I. I., Lee, J. J., Blumenschein, G. R., Tsao, A. S., Stewart, D. J., Hicks, M. E., Erasmus, J. J., Gupta, S. K., et al. (2011) · Cancer Discovery · doi:10.1158/2159-8274.cd-10-0010 · Cited by 888 · see citing works

Imaging macrophages with nanoparticles

Weissleder, R., Nahrendorf, M., & Pittet, M. J. (2014) · Nature Materials · doi:10.1038/nmat3780 · Cited by 809 · see citing works

Clinical Translation of Nanomedicine

Min, Y., Caster, J. M., Eblan, M. J., & Wang, A. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00116 · Cited by 795 · see citing works

In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy

Arlauckas, S. P., Garris, C. S., Kohler, R. H., Kitaoka, M., Cuccarese, M. F., Yang, K. S., Miller, M. A., Carlson, J. C., Freeman, G. J., Anthony, R. M., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aal3604 · Cited by 669 · see citing works

Dextran-coated iron oxide nanoparticles: a versatile platform for targeted molecular imaging, molecular diagnostics, and therapy

Tassa, C., Shaw, S. Y., & Weissleder, R. (2011) · Accounts of Chemical Research · doi:10.1021/ar200084x · Cited by 653 · see citing works

Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage–Derived VEGFA

Harney, A. S., Arwert, E. N., Entenberg, D. R., Wang, Y., Guo, P., Qian, B., Oktay, M. H., Pollard, J. W., Jones, J. G., & Condeelis, J. S. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0012 · Cited by 622 · see citing works

Effective targeting of solid tumors in patients with locally advanced cancers by radiolabeled pegylated liposomes.

Harrington, K. J., Mohammadtaghi, S., Uster, P. S., Glass, D. M., Peters, A. M., Vile, R. G., & Stewart, J. S. W. (2001) · PubMed · Cited by 575 · see citing works

Magnetic Iron Oxide Nanoparticles: Synthesis, Stabilization, Vectorization, Physicochemical Characterizations, and Biological Applications

Laurent, S., Forge, D., Port, M., Roch, A., Pujolle-Robic, C., Elst, L. V., & Müller, R. N. (2009) · Chemical Reviews · doi:10.1021/cr900197g · Cited by 523 · see citing works

Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo

Dhar, S., Kolishetti, N., Lippard, S. J., & Farokhzad, O. C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011379108 · Cited by 513 · see citing works

Monocrystalline iron oxide nanocompounds (MION): Physicochemical properties

Shen, T. T., Weissleder, R., Papisov, M. I., Bogdanov, A. A., Jr., & Brady, T. J. (1993) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910290504 · Cited by 496 · see citing works

FDA report: Ferumoxytol for intravenous iron therapy in adult patients with chronic kidney disease

Lu, M., Cohen, M. H., Rieves, D., & Pazdur, R. (2010) · American Journal of Hematology · doi:10.1002/ajh.21656 · Cited by 443 · see citing works

Tumour‐associated macrophages act as a slow‐release reservoir of nano‐therapeutic Pt(IV) pro‐drug

Miller, M. A., Zheng, Y.-R., Gadde, S., Pfirschke, C., Zope, H., Engblom, C., Kohler, R. H., Iwamoto, Y., Yang, K. S., Askevold, B., et al. (2015) · Nature Communications · doi:10.1038/ncomms9692 · Cited by 441 · see citing works

Selective tumor localization and improved therapeutic index of anthracyclines encapsulated in long-circulating liposomes.

Gabizón, A. (1992) · PubMed · Cited by 421 · see citing works

Positive contrast magnetic resonance imaging of cells labeled with magnetic nanoparticles

Cunningham, C. H., Arai, T., Yang, P. C.-M., McConnell, M. V., Pauly, J. M., & Conolly, S. (2005) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20477 · Cited by 403 · see citing works

64Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer

Lee, H., Shields, A. F., Siegel, B. A., Miller, K. D., Krop, I. E., Ma, C. X., LoRusso, P. M., Münster, P. N., Campbell, K., Gaddy, D. F., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-3193 · Cited by 397 · see citing works

Development of a Highly Active Nanoliposomal Irinotecan Using a Novel Intraliposomal Stabilization Strategy

Drummond, D. C., Noble, C. O., Guo, Z., Hong, K., Park, J. W., & Kirpotin, D. B. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4007 · Cited by 381 · see citing works

Emerging applications for ferumoxytol as a contrast agent in MRI

Bashir, M. R., Bhatti, L., Marin, D., & Nelson, R. C. (2014) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.24691 · Cited by 373 · see citing works

Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle

Miller, M. A., Gadde, S., Pfirschke, C., Engblom, C., Sprachman, M. M., Köhler, R. H., Yang, K. S., Laughney, A. M., Wojtkiewicz, G. R., Kamaly, N., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac6522 · Cited by 349 · see citing works

TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma

Liu, J., Liao, S., Diop-Frimpong, B., Chen, W., Goel, S., Naxerova, K., Ancukiewicz, M., Boucher, Y., Jain, R. K., & Xu, L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117610109 · Cited by 332 · see citing works

Identifying inflamed carotid plaques using in vivo USPIO-enhanced MR imaging to label plaque macrophages

Trivedi, R. A., Mallawarachi, C., U-King-Im, J.-M., Graves, M. J., Horsley, J., Goddard, M. J., Brown, A., Wang, L., Kirkpatrick, P. J., Brown, J., et al. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000222920.59760.df · Cited by 330 · see citing works

MRI of Tumor-Associated Macrophages with Clinically Applicable Iron Oxide Nanoparticles

Daldrup-Link, H. E., Golovko, D. M., Ruffell, B., DeNardo, D. G., Castaneda, R., Ansari, C., Rao, J., Tikhomirov, G. A., Wendland, M. F., Corot, C., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-3420 · Cited by 302 · see citing works

Meta-analysis of clinical and preclinical studies comparing the anticancer efficacy of liposomal versus conventional non-liposomal doxorubicin

Petersen, G. H., Alzghari, S. K., Chee, W., Sankari, S. S., & La-Beck, N. M. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.04.028 · Cited by 291 · see citing works

Phase I Study of PSMA-Targeted Docetaxel-Containing Nanoparticle BIND-014 in Patients with Advanced Solid Tumors

Hoff, D. D. V., Mita, M. M., Ramanathan, R. K., Weiss, G. J., Mita, A. C., LoRusso, P. M., Burris, H. A., Hart, L. L., Low, S. C., Parsons, D. M., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-2548 · Cited by 289 · see citing works

Stromal barriers and strategies for the delivery of nanomedicine to desmoplastic tumors

Miao, L., Lin, C. M., & Huang, L. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.08.017 · Cited by 264 · see citing works

Uptake of dextran‐coated monocrystalline iron oxides in tumor cells and macrophages

Moore, A., Weissleder, R., & Bogdanov, A. A., Jr. (1997) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.1880070629 · Cited by 263 · see citing works

First-in-human phase 1/2a trial of CRLX101, a cyclodextrin-containing polymer-camptothecin nanopharmaceutical in patients with advanced solid tumor malignancies

Weiss, G. J., Chao, J., Neidhart, J. D., Ramanathan, R. K., Bassett, D., Neidhart, J. A., Choi, C. H. J., Chow, W. A., Chung, V. M., Forman, S. J., et al. (2013) · Investigational New Drugs · doi:10.1007/s10637-012-9921-8 · Cited by 234 · see citing works

First‐pass contrast‐enhanced magnetic resonance angiography in humans using ferumoxytol, a novel ultrasmall superparamagnetic iron oxide (USPIO)‐based blood pool agent

Li, W., Tutton, S., Vu, A. T., Pierchala, L., Li, B. S. Y., Lewis, J. M., Prasad, P. V., & Edelman, R. R. (2004) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.20235 · Cited by 233 · see citing works

Amine-modified single-walled carbon nanotubes protect neurons from injury in a rat stroke model

Lee, H. J., Park, J., Yoon, O. J., Kim, H., Lee, D., Kim, D. H., Lee, W. B., Lee, N., Bonventre, J. V., & Kim, S. S. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2010.281 · Cited by 226 · see citing works

Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts

Miller, M. A., Chandra, R. A., Cuccarese, M. F., Pfirschke, C., Engblom, C., Stapleton, S., Adhikary, U., Köhler, R. H., Mohan, J. F., Pittet, M. J., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aal0225 · Cited by 226 · see citing works

Comparative risk of anaphylactic reactions associated With intravenous iron products

Wang, C., Graham, D. J., Kane, R. C., Xie, D., Wernecke, M., Levenson, M., MaCurdy, T. E., Houstoun, M., Ryan, Q., Wong, S., et al. (2015) · JAMA · doi:10.1001/jama.2015.15572 · Cited by 219 · see citing works

Safety and technique of ferumoxytol administration for MRI

Vasanawala, S. S., Nguyen, K., Hope, M. D., Bridges, M. D., Hope, T. A., Reeder, S. B., & Bashir, M. R. (2016) · Magnetic Resonance in Medicine · doi:10.1002/mrm.26151 · Cited by 210 · see citing works

Magneto/Optical Annexin V, a Multimodal Protein

Schellenberger, E. A., Sosnovik, D. E., Weissleder, R., & Josephson, L. (2004) · Bioconjugate Chemistry · doi:10.1021/bc049905i · Cited by 207 · see citing works

Angiotensin II Drives the Production of Tumor-Promoting Macrophages

Cortez‐Retamozo, V., Etzrodt, M., Newton, A., Ryan, R. J. H., Pucci, F., Sio, S. W. S., Kuswanto, W. F., Rauch, P. J., Chudnovskiy, A., Iwamoto, Y., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.10.015 · Cited by 199 · see citing works

Liposomal Doxorubicin and Conventionally Fractionated Radiotherapy in the Treatment of Locally Advanced Non–Small-Cell Lung Cancer and Head and Neck Cancer

Koukourakis, M. I., Koukouraki, S. I., Giatromanolaki, A. N., Archimandritis, S. C., Skarlatos, J., Beroukas, K., Bizakis, J. G., Retalis, G., Karkavitsas, N., & Helidonis, E. S. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.11.3512 · Cited by 191 · see citing works

Gradient echo acquisition for superparamagnetic particles with positive contrast (GRASP): Sequence characterization in membrane and glass superparamagnetic iron oxide phantoms at 1.5T and 3T

Mani, V., Briley-Saebo, K. C., Itskovich, V. V., Samber, D. D., & Fayad, Z. A. (2005) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20739 · Cited by 191 · see citing works

Ferumoxytol as an Intravenous Iron Replacement Therapy in Hemodialysis Patients

Provenzano, R., Schiller, B. M., Rao, M., Coyne, D. W., Brenner, L., & Pereira, B. J. G. (2009) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.02840608 · Cited by 187 · see citing works

Correlation between Ferumoxytol Uptake in Tumor Lesions by MRI and Response to Nanoliposomal Irinotecan in Patients with Advanced Solid Tumors: A Pilot Study

Ramanathan, R. K., Korn, R. L., Raghunand, N., Sachdev, J. C., Newbold, R. G., Jameson, G., Fetterly, G. J., Prey, J., Klinz, S. G., Kim, J., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-1990 · Cited by 183 · see citing works

Targeted superparamagnetic iron oxide nanoparticles for early detection of cancer: Possibilities and challenges

Bakhtiary, Z., Saei, A. A., Hajipour, M. J., Raoufi, M., Vermesh, O., & Mahmoudi, M. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.10.019 · Cited by 180 · see citing works

High-Resolution Magnetic Resonance Imaging Enhanced With Superparamagnetic Nanoparticles Measures Macrophage Burden in Atherosclerosis

Morishige, K., Kacher, D. F., Libby, P., Josephson, L., Ganz, P., Weissleder, R., & Aikawa, M. (2010) · Circulation · doi:10.1161/circulationaha.109.891804 · Cited by 168 · see citing works

Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging

Cuccarese, M. F., Dubach, J. M., Pfirschke, C., Engblom, C., Garris, C. S., Miller, M. A., Pittet, M., & Weissleder, R. (2017) · Nature Communications · doi:10.1038/ncomms14293 · Cited by 167 · see citing works

Pharmacokinetics of liposome-encapsulated anti-tumor drugs

Juliano, R. L., & Stamp, D. (1978) · Biochemical Pharmacology · doi:10.1016/0006-2952(78)90252-6 · Cited by 166 · see citing works

Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle

Thorek, D. L. J., Ulmert, D., Diop, N.-F. M., Lupu, M. E., Doran, M. G., Huang, R., Abou, D. S., Larson, S. M., & Grimm, J. (2014) · Nature Communications · doi:10.1038/ncomms4097 · Cited by 163 · see citing works

Intact Doxil is taken up intracellularly and released doxorubicin sequesters in the lysosome: Evaluated by in vitro / in vivo live cell imaging

Seynhaeve, A. L. B., Dicheva, B. M., Hoving, S., et al. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.08.034 · Cited by 156 · see citing works

Increased Tumor Homing and Tissue Penetration of the Filamentous Plant Viral Nanoparticle Potato virus X

Shukla, S., Ablack, A. L., Wen, A. M., Lee, K. L., Lewis, J. D., & Steinmetz, N. F. (2012) · Molecular Pharmaceutics · doi:10.1021/mp300240m · Cited by 154 · see citing works

Potential for Differentiation of Pseudoprogression From True Tumor Progression With Dynamic Susceptibility-Weighted Contrast-Enhanced Magnetic Resonance Imaging Using Ferumoxytol vs. Gadoteridol: A Pilot Study

Gahramanov, S., Raslan, A. M., Muldoon, L. L., Hamilton, B. E., Rooney, W. D., Várallyay, C. G., Njus, J. M., Haluska, M., & Neuwelt, E. A. (2010) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2009.10.072 · Cited by 151 · see citing works

Imaging of myocardial infarction using ultrasmall superparamagnetic iron oxide nanoparticles: a human study using a multi-parametric cardiovascular magnetic resonance imaging approach

Yılmaz, A., Dengler, M. A., van der Kuip, H., Yildiz, H., Rösch, S., Klumpp, S., Klingel, K., Kandolf, R., Helluy, X., Hiller, K., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs366 · Cited by 149 · see citing works

Remodeling Tumor Vasculature to Enhance Delivery of Intermediate-Sized Nanoparticles

Jiang, W., Huang, Y., An, Y., & Kim, B. Y. S. (2015) · ACS Nano · doi:10.1021/acsnano.5b02028 · Cited by 148 · see citing works

Physicochemical properties of ferumoxytol, a new intravenous iron preparation

Balakrishnan, V. S., Rao, M., Kausz, A. T., Brenner, L., Pereira, B. J. G., Frigo, T. B., & Lewis, J. M. (2009) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2009.02130.x · Cited by 144 · see citing works

SPION primes THP1 derived M2 macrophages towards M1-like macrophages

Laskar, A., Eilertsen, J., Li, W., & Yuan, X.-M. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.10.115 · Cited by 138 · see citing works

Nanoreporter PET predicts the efficacy of anti-cancer nanotherapy

Pérez-Medina, C., Abdel-Atti, D., Tang, J., Zhao, Y., Fayad, Z. A., Lewis, J. S., Mulder, W. J. M., & Reiner, T. (2016) · Nature Communications · doi:10.1038/ncomms11838 · Cited by 128 · see citing works

Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients

Gaglia, J. L., Harisinghani, M. G., Aganj, I., Wojtkiewicz, G. R., Hedgire, S., Benoist, C. O., Mathis, D. J., & Weissleder, R. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1424993112 · Cited by 123 · see citing works

MR imaging of phagocytosis in experimental gliomas.

Zimmer, C., Weissleder, R., Poss, K., Bogdanova, A., Wright, S. C., & Enochs, W. S. (1995) · Radiology · doi:10.1148/radiology.197.2.7480707 · Cited by 121 · see citing works

Blood Pool MR Angiography of Aortic Stent-Graft Endoleak

Ersoy, H., Jacobs, P., Kent, C. K., & Prince, M. R. (2004) · American Journal of Roentgenology · doi:10.2214/ajr.182.5.1821181 · Cited by 119 · see citing works

Current Status of Companion and Complementary Diagnostics: Strategic Considerations for Development and Launch

Scheerens, H., Malong, A., Bassett, K., Boyd, Z. S., Gupta, V., Harris, J. M., Mesick, C. P., Simnett, S., Stevens, H., Gilbert, H., et al. (2017) · Clinical and Translational Science · doi:10.1111/cts.12455 · Cited by 118 · see citing works

Behavior of Endogenous Tumor-Associated Macrophages Assessed In Vivo Using a Functionalized Nanoparticle

Leimgruber, A., Berger, C., Cortez‐Retamozo, V., Etzrodt, M., Newton, A., Waterman, P. R., de Figueiredo, J. L., Köhler, R. H., Elpek, N. M., Mempel, T. R., et al. (2009) · Neoplasia · doi:10.1593/neo.09356 · Cited by 115 · see citing works

Ultrasmall Supraparamagnetic Iron Oxide-Enhanced Magnetic Resonance Imaging of Antigen-Induced Arthritis

SIMON, G. H., von Vopelius‐Feldt, J., Fu, Y., Schlegel, J., Pinotek, G., Wendland, M. F., Chen, M., & Daldrup-Link, H. E. (2005) · Investigative Radiology · doi:10.1097/01.rli.0000191367.61306.83 · Cited by 108 · see citing works

Pharmacokinetic Study of Ferumoxytol: A New Iron Replacement Therapy in Normal Subjects and Hemodialysis Patients

Landry, R., Jacobs, P. M., Davis, R., Shenouda, M., & Bolton, W. K. (2005) · American Journal of Nephrology · doi:10.1159/000087212 · Cited by 108 · see citing works

Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching

Kaittanis, C., Shaffer, T. M., Ogirala, A., Santra, S., Perez, J. M., Chiosis, G., Li, Y., Josephson, L., & Grimm, J. (2014) · Nature Communications · doi:10.1038/ncomms4384 · Cited by 107 · see citing works

Ferumoxtran-10–Enhanced MRI of the Hypercholesterolemic Rabbit Aorta

Hyafil, F., Laissy, J., Mazighi, M., Tchétché, D., Louedec, L., Adle‐Biassette, H., Chillon, S., Hénin, D., Jacob, M., Letourneur, D., et al. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000194098.82677.57 · Cited by 106 · see citing works

Advances in MRI Assessment of Gliomas and Response to Anti-VEGF Therapy

Pope, W. B., Young, J. R., & Ellingson, B. M. (2011) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-011-0179-x · Cited by 105 · see citing works

Monocytes and macrophages as nanomedicinal targets for improved diagnosis and treatment of disease

Lameijer, M., Tang, J., Nahrendorf, M., Beelen, R. H. J., & Mulder, W. J. M. (2013) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2013.819216 · Cited by 98 · see citing works

Imaging Nanoprobe for Prediction of Outcome of Nanoparticle Chemotherapy by Using Mammography

Karathanasis, E., Suryanarayanan, S., Balusu, S. R., McNeeley, K. M., Sechopoulos, I., Karellas, A., Annapragada, A., & Bellamkonda, R. V. (2009) · Radiology · doi:10.1148/radiol.2502080801 · Cited by 97 · see citing works

Utility of a New Bolus-injectable Nanoparticle for Clinical Cancer Staging

Harisinghani, M. G., Ross, R. W., Guimarães, A. R., & Weissleder, R. (2007) · Neoplasia · doi:10.1593/neo.07940 · Cited by 97 · see citing works

MRI Assessment of Hepatic Iron Clearance Rates After USPIO Administration in Healthy Adults

Storey, P., Lim, R., Chandarana, H., Rosenkrantz, A. B., Kim, D., Stoffel, D. R., & Lee, V. S. (2012) · Investigative Radiology · doi:10.1097/rli.0b013e31826dc151 · Cited by 79 · see citing works

Tumor microvascular characterization using ultrasmall superparamagnetic iron oxide particles (USPIO) in an experimental breast cancer model

Turetschek, K., Roberts, T. P. L., Floyd, E., et al. (2001) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.1126 · Cited by 76 · see citing works

Nanoparticle uptake in tumors is mediated by the interplay of vascular and collagen density with interstitial pressure

Torosean, S., Flynn, B. P., Axelsson, J., Gunn, J. R., Samkoe, K. S., Hasan, T. G., Doyley, M. M., & Pogue, B. W. (2012) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2012.07.002 · Cited by 74 · see citing works

In vivo MRI using positive‐contrast techniques in detection of cells labeled with superparamagnetic iron oxide nanoparticles

Liu, W., Dahnke, H., Jordan, E. K., et al. (2007) · NMR in Biomedicine · doi:10.1002/nbm.1187 · Cited by 72 · see citing works

MRI Using Ferumoxytol Improves the Visualization of Central Nervous System Vascular Malformations

Dósa, E., Tuladhar, S., Muldoon, L. L., Hamilton, B. E., Rooney, W. D., & Neuwelt, E. A. (2011) · Stroke · doi:10.1161/strokeaha.110.607994 · Cited by 72 · see citing works

Quantitative CT Imaging of the Spatial and Temporal Distribution of Liposomes in a Rabbit Tumor Model

Zheng, J., Jaffray, D. A., & Allen, C. J. (2009) · Molecular Pharmaceutics · doi:10.1021/mp800234r · Cited by 69 · see citing works

Proof of concept for next-generation nanoparticle drugs in humans

Sheridan, C. (2012) · Nature Biotechnology · doi:10.1038/nbt0612-471 · Cited by 69 · see citing works

A Phase I Dosing Study of Ferumoxytol for MR Lymphography at 3 T in Patients With Prostate Cancer

Türkbey, B., Agarwal, H. K., Shih, J. H., Bernardo, M., McKinney, Y. L., Daar, D., Griffiths, G. L., Sankineni, S., Johnson, L., Grant, K. B., et al. (2015) · American Journal of Roentgenology · doi:10.2214/ajr.14.13009 · Cited by 64 · see citing works

Cyclophosphamide-Mediated Tumor Priming for Enhanced Delivery and Antitumor Activity of HER2-Targeted Liposomal Doxorubicin (MM-302)

Geretti, E., Leonard, S. C., Dumont, N., Lee, H., Zheng, J., Souza, R. D., Gaddy, D. F., Espelin, C. W., Jaffray, D. A., Moyo, V. M., et al. (2015) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0314 · Cited by 61 · see citing works

Tumor Cell Endocytosis Imaging Facilitates Delineation of the Glioma–Brain Interface

Zimmer, C., Wright, S. C., Engelhardt, R. T., Johnson, G. A., Kramm, C., Breakefield, X. O., & Weissleder, R. (1997) · Experimental Neurology · doi:10.1006/exnr.1996.6350 · Cited by 60 · see citing works

Ferumoxytol-Enhanced MRI to Image Inflammation Within Human Brain Arteriovenous Malformations: a Pilot Investigation

Hasan, D. M., Amans, M. R., Tihan, T., Hess, C. P., Guo, Y., Cha, S., Su, H., Martin, A. J., Lawton, M. T., Neuwelt, E. A., et al. (2012) · Translational Stroke Research · doi:10.1007/s12975-012-0172-y · Cited by 57 · see citing works

Tumor perfusion imaging predicts the intra-tumoral accumulation of liposomes

Stapleton, S., Allen, C. J., Pintilie, M., & Jaffray, D. A. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.08.296 · Cited by 54 · see citing works

High liposomal doxorubicin tumour tissue distribution, as determined by radiopharmaceutical labelling with 99mTc-LD, is associated with the response and survival of patients with unresectable pleural mesothelioma treated with a combination of liposomal doxorubicin and cisplatin

Arrieta, O. G., Medina, L. A., Estrada-Lobato, E., Ramírez-Tirado, L.-A., Mendoza-García, V. O., & de la Garza-Salazar, J. (2014) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-014-2477-x · Cited by 51 · see citing works

Ferumoxytol nanoparticle uptake in brain during acute neuroinflammation is cell-specific

McConnell, H., Schwartz, D. L., Richardson, B. E., Woltjer, R. L., Muldoon, L. L., & Neuwelt, E. A. (2016) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2016.03.009 · Cited by 50 · see citing works

Different Capacity of Monocyte Subsets to Phagocytose Iron-Oxide Nanoparticles

Settles, M., Etzrodt, M., Kosanke, K., Schiemann, M., Zimmermann, A., Meier, R., Braren, R., Huber, A. M. A., Rummeny, E. J., Weissleder, R., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025197 · Cited by 45 · see citing works

In vivo labelling of resting monocytes in the reticuloendothelial system with fluorescent iron oxide nanoparticles prior to injury reveals that they are mobilized to infarcted myocardium

Montet-Abou, K., Daire, J., Hyacinthe, J., Jorge-Costa, M., Grosdemange, K., Mach, F., Petri‐Fink, A., Hofmann, H., Morel, D. R., Vallée, J., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp547 · Cited by 43 · see citing works

Imaging Tumor Necrosis with Ferumoxytol

Aghighi, M., Golovko, D. M., Ansari, C., Marina, N. M., Pisani, L. J., Kurlander, L., Klenk, C., Bhaumik, S., Wendland, M. F., & Daldrup-Link, H. E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142665 · Cited by 40 · see citing works

Dynamic magnetic resonance imaging assessment of vascular targeting agent effects in rat intracerebral tumor models

Muldoon, L. L., Gahramanov, S., Li, X., Marshall, D. J., Kraemer, D. F., & Neuwelt, E. A. (2010) · Neuro-Oncology · doi:10.1093/neuonc/noq150 · Cited by 38 · see citing works

Enhanced primary tumor delineation in pancreatic adenocarcinoma using ultrasmall super paramagnetic iron oxide nanoparticle-ferumoxytol: an initial experience with histopathologic correlation

Hedgire, S., Kenudson, M. M., Elmi, A., et al. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s59788 · Cited by 34 · see citing works

A Longitudinal Study of R2* and R2 Magnetic Resonance Imaging Relaxation Rate Measurements in Murine Liver After a Single Administration of 3 Different Iron Oxide-Based Contrast Agents

Kalber, T. L., Smith, C. J., Howe, F. A., Griffiths, J. R., Ryan, A. J., Waterton, J. C., & Robinson, S. P. (2005) · Investigative Radiology · doi:10.1097/01.rli.0000188025.66872.e4 · Cited by 34 · see citing works

Subtumoral analysis of PRINT nanoparticle distribution reveals targeting variation based on cellular and particle properties

Roode, L. E., Brighton, H. E., Bo, T., Perry, J. L., Parrott, M. C., Kersey, F. R., Luft, J. C., Bear, J. E., DeSimone, J. M., & Davis, I. J. (2016) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.12.382 · Cited by 34 · see citing works

Heat‐Induced Radiolabeling of Nanoparticles for Monocyte Tracking by PET

Normandin, M. D., Yuan, H., Wilks, M. Q., Chen, H. H., Kinsella, J. M., Cho, H., Guehl, N. J., Absi‐Halabi, N., Hosseini, S. M., Fakhri, G. E., et al. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201505525 · Cited by 31 · see citing works

Accurate Prediction of Nodal Status in Preoperative Patients with Pancreatic Ductal Adenocarcinoma Using Next-Gen Nanoparticle

McDermott, S., Thayer, S. P., Castillo, C. F.-D., Mino-Kenudson, M. A., Weissleder, R., & Harisinghani, M. G. (2013) · Translational Oncology · doi:10.1593/tlo.13400 · Cited by 29 · see citing works

Fluorescent Nanoparticle Imaging Allows Noninvasive Evaluation of Immune Cell Modulation in Esophageal Dysplasia

Habibollahi, P., Waldron, T. J., Heidari, P., et al. (2014) · Molecular Imaging · doi:10.2310/7290.2014.00003 · Cited by 20 · see citing works

Heat-induced-radiolabeling and click chemistry: A powerful combination for generating multifunctional nanomaterials

Yuan, H., Wilks, M. Q., Fakhri, G. E., Normandin, M. D., Kaittanis, C., & Josephson, L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172722 · Cited by 19 · see citing works

Clinical translation of ferumoxytol‐based vessel size imaging (VSI): Feasibility in a phase I oncology clinical trial population

Fredrickson, J. O., Serkova, N. J., Wyatt, S. K., Carano, R. A. D., Pirzkall, A., Rhee, I. P., Rosen, L. S., Bessudo, A., Weekes, C. D., & de Crespigny, A. J. (2016) · Magnetic Resonance in Medicine · doi:10.1002/mrm.26167 · Cited by 17 · see citing works

Ferumoxytol-enhanced MRI differentiation of meningioma from dural metastases: a pilot study with immunohistochemical observations

Hamilton, B. E., Woltjer, R. L., Netto, J. P., Nesbit, G. M., Gahramanov, S., Pham, T., Wagner, J., & Neuwelt, E. A. (2016) · Journal of Neuro-Oncology · doi:10.1007/s11060-016-2175-0 · Cited by 17 · see citing works

Clinical Translation of Nanomedicine

Min, Y., Caster, J. M., Wang, A. Z., et al. (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/ryn6-ns04 · Cited by 17 · see citing works

Simultaneous evaluation of vascular morphology, blood volume and transvascular permeability using SPION‐based, dual‐contrast MRI: imaging optimization and feasibility test

Kwon, H., Shim, W. H., Cho, G., Cho, H. J., Jung, H. S., Lee, C. K., Lee, Y. S., Baek, J. H., Kim, E. J., Suh, J., et al. (2015) · NMR in Biomedicine · doi:10.1002/nbm.3293 · Cited by 15 · see citing works

Analysis of Efficacy By Age for Patients Aged 60-75 with Untreated Secondary Acute Myeloid Leukemia (AML) Treated with CPX-351 Liposome Injection Versus Conventional Cytarabine and Daunorubicin in a Phase III Trial

Medeiros, B. C., Lancet, J. E., Cortes, J. E., et al. (2016) · Blood · doi:10.1182/blood.v128.22.902.902 · Cited by 9 · see citing works

Ultrasmall supraparamagnetic iron oxide-enhanced magnetic resonance imaging of antigen-induced arthritis: a comparative study between SHU 555 C, ferumoxtran-10, and ferumoxytol.

Simon, G. V.-F. (2006) · mediaTUM (Technical University of Munich) · Cited by 8 · see citing works

Evaluation of renal quantitative T2* changes on MRI following administration of ferumoxytol as a T2* contrast agent

Gaglia, J. L., Hedgire, S., McDermott, S., Wojtkiewicz, G. R., Abtahi, S. M., & Harisinghani, M. G. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s61460 · Cited by 6 · see citing works

Heat‐Induced Radiolabeling of Nanoparticles for Monocyte Tracking by PET

Normandin, M. D., Yuan, H., Wilks, M. Q., Chen, H. H., Kinsella, J. M., Cho, H., Guehl, N. J., Absi‐Halabi, N., Hosseini, S. M., Fakhri, G. E., et al. (2015) · Angewandte Chemie · doi:10.1002/ange.201505525 · Cited by 4 · see citing works

In vivo MRI using positive-contrast techniques in detection of cells labeled with superparamagnetic iron oxide nanoparticles

Liu, W., Dahnke, H., Jordan, E., et al. (2008) · Research Portal (King's College London) · Cited by 3 · see citing works

Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications

Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181 · see citing works

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

Rodell, C. B., Arlauckas, S. P., Cuccarese, M. F., Garris, C. S., Li, R., Ahmed, M. S., Kohler, R. H., Pittet, M. J., & Weissleder, R. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0236-8 · Cited by 1,099 · see citing works

The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors

Izci, M., Maksoudian, C., Manshian, B. B., & Soenen, S. J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00779 · Cited by 506 · see citing works

Non-invasive <i>In Vivo</i> Imaging of Cancer Using Surface-Enhanced Spatially Offset Raman Spectroscopy (SESORS)

Nicolson, F., Andreiuk, B., Andreou, C., Hsu, H.-T., Rudder, S., & Kircher, M. F. (2019) · Theranostics · doi:10.7150/thno.36321 · Cited by 152 · see citing works

Spatial heterogeneity of nanomedicine investigated by multiscale imaging of the drug, the nanoparticle and the tumour environment

de Maar, J. S., Sofias, A. M., Porta Siegel, T., Vreeken, R. J., Moonen, C., Bos, C., & Deckers, R. (2020) · Theranostics · doi:10.7150/thno.38625 · Cited by 71 · see citing works

Improving nanotherapy delivery and action through image-guided systems pharmacology

Ng, T. S. C., Garlin, M. A., Weissleder, R., & Miller, M. A. (2020) · Theranostics · doi:10.7150/thno.37215 · Cited by 60 · see citing works

Novel EPR-enhanced strategies for targeted drug delivery in pancreatic cancer: An update

Mohammadzadeh, V., Rahiman, N., Hosseinikhah, S. M., Barani, M., Rahdar, A., Jaafari, M. R., Sargazi, S., Zirak, M. R., Pandey, S., Bhattacharjee, R., et al. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103459 · Cited by 50 · see citing works

Safety and technique of ferumoxytol administration for MRI

Vasanawala, S. S., Nguyen, K., Hope, M. D., Bridges, M. D., Hope, T. A., Reeder, S. B., & Bashir, M. R. (2016) · Magnetic Resonance in Medicine · doi:10.1002/mrm.26151 · Cited by 210 · see citing works

Parenteral ferumoxytol interaction with magnetic resonance imaging: a case report, review of the literature and advisory warning

Schieda, N. (2013) · Insights into Imaging · doi:10.1007/s13244-013-0262-8 · Cited by 21 · see citing works

Ferumoxytol: an emerging therapeutic for iron deficiency anemia

Sakashita, M., & Nangaku, M. (2022) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2022.2150545 · Cited by 13 · see citing works

Ferumoxytol Use as an Intravenous Contrast Agent for Magnetic Resonance Angiography

Stabi, K. L., & Bendz, L. M. (2011) · Annals of Pharmacotherapy · doi:10.1345/aph.1q431 · Cited by 50 · see citing works

Emerging applications for ferumoxytol as a contrast agent in MRI

Bashir, M. R., Bhatti, L., Marin, D., & Nelson, R. C. (2014) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.24691 · Cited by 373 · see citing works