PAI-1 and the Metabolic Syndrome: Links, Causes, and Consequences

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The metabolic syndrome

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The metabolic syndrome

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Increased oxidative stress in obesity and its impact on metabolic syndrome

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Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice

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The Metabolic Syndrome: Time for a Critical Appraisal

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Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis

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Impact of the Metabolic Syndrome on Mortality From Coronary Heart Disease, Cardiovascular Disease, and All Causes in United States Adults

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Hemostatic Factors and the Risk of Myocardial Infarction or Sudden Death in Patients with Angina Pectoris

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A transgenic model of visceral obesity and the metabolic syndrome

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Anti-inflammatory and antithrombotic effects of nicotine exposure in oral contraceptive-induced insulin resistance are glucocorticoid-independent

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A ketogenic diet containing medium-chain triglycerides reduces REM sleep duration without significant influence on mouse circadian phenotypes

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PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology

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Plasma fibrin clot properties and cardiovascular mortality in patients with type 2 diabetes: a long‐term follow‐up study

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Plasminogen Activator Inhibitor-1 Levels in Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

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Metabolically Healthy Obesity: Epidemiology, Criteria, and Implications in Chronic Kidney Disease

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Obesidad abdominal: un estandarte del riesgo cardiometabólico

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Visceral Adiposity, Insulin Resistance, and Type 2 Diabetes

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Plasminogen activator inhibitor type‐1 is an independent marker of metabolic disorders in young adults born small for gestational age

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Effect of Plasminogen Activator Inhibitor-1 and Tissue Plasminogen Activator Polymorphisms on Susceptibility to Type 2 Diabetes in Malaysian Subjects

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Plasminogen activator inhibitor-1 4G/5G polymorphism is associated with metabolic syndrome parameters in Malaysian subjects

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Hypofibrinolytic State in Subjects with Type 2 Diabetes Mellitus Aggravated by the Metabolic Syndrome before Clinical Manifestations of Atherothrombotic Disease

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Increased expression of plasminogen activator inhibitor type-1 (PAI-1) in HEPG2 cells induced by insulin mediated by the 3′-untranslated region of the PAI-1 gene and its pharmacologic implications

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CO-Induced TTP Activation Alleviates Cellular Senescence and Age-Dependent Hepatic Steatosis via Downregulation of PAI-1.

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A novel cholesterol absorption inhibitor, ezetimibe, decreases adipose-derived and vascular PAI-1 expression in vivo

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Dysregulation of monocyte biology in metabolic syndrome

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Serum C-Peptide, Visfatin, Resistin, and Ghrelin are Altered in Sporadic and GRN-Associated Frontotemporal Lobar Degeneration

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Sex-specific alteration to α2-antiplasmin incorporation in patients with type 2 diabetes

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Markers of remodeling in subcutaneous adipose tissue are strongly associated with overweight and insulin sensitivity in healthy non-obese men

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Plasma Plasminogen Activator Inhibitor-1 Levels and Nonalcoholic Fatty Liver in Individuals With Features of Metabolic Syndrome

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Multidimensional effects of metformin in patients with type 2 diabetes

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Coagulation Signaling through PAR1 as a Therapeutic Target in Pancreatic Ductal Adenocarcinoma

Kothari, A., & Flick, M. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105138 · Cited by 11

Plasminogen activator inhibitor-1, free fatty acids, and insulin resistance in patients with myocardial infarction

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Plasminogen activator inhibitor-1 concentrations and bone mineral density in postmenopausal women with type 2 diabetes mellitus

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Copper(II) Ions Increase Plasminogen Activator Inhibitor Type 1 Dynamics in Key Structural Regions That Govern Stability

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Cell adhesion molecules and plasminogen activator inhibitor type-1 (PAI-1) in patients with rheumatoid arthritis: influence of metabolic syndrome

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Association between plasminogen activator inhibitor‐1 in young adulthood and nonalcoholic fatty liver disease in midlife: CARDIA

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In vitro effects of detergent sclerosants on fibrinolytic enzymes and inhibitors

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Effect of daily ingestion of Bifidobacterium and dietary fiber on vascular endothelial function: a randomized, double-blind, placebo-controlled, parallel-group comparison study

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Sex Differences in Energy Balance, Body Composition, and Body Fat Distribution

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Fatty Acid-Induced Production of Plasminogen Activator Inhibitor-1 by Adipose Macrophages Is Greater in Middle-Aged Versus Younger Adult Participants

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Small Peptides as Modulators of Serine Proteases

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Increased plasminogen activator inhibitor-1 (PAI-1) and its associations with metabolic risk in healthy young adults with early life stress

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Dietary milk phospholipids increase body fat and modulate gut permeability, systemic inflammation, and lipid metabolism in mice

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Low-dose spironolactone ameliorates insulin resistance and suppresses elevated plasminogen activator inhibitor-1 during gestational testosterone exposure

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An antibody that targets cell-surface Glucose-regulated Protein-78 inhibits expression of inflammatory cytokines and plasminogen activator inhibitors by macrophages

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A Favorable Metabolic and Antiatherogenic Profile in Carriers of CYP21A2 Gene Mutations Supports the Theory of a Survival Advantage in This Population

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The Etiology of the Thrombotic Phenomena Involved in the Process of Coronary Artery Disease—What Is the Role of Thrombophilic Genes in the Development of This Pathology?

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The nutritional metabolic risk index as a predictor of all-cause and cardiovascular mortality: A national cohort study

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Impact of Obesity on Target Organ Damage in Patients with Metabolic Syndrome

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Soya protein hydrolysates modify the expression of various pro-inflammatory genes induced by fatty acids in ovine phagocytes

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Swimming, but not vitamin E, ameliorates prothrombotic state and hypofibrinolysis in a rat model of nonalcoholic fatty liver disease

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Significant Associations Among Hemostatic Parameters, Adipokines, and Components of the Metabolic Syndrome in Japanese Preschool Children

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Effect of palm-based tocotrienols and tocopherol mixture supplementation on platelet aggregation in subjects with metabolic syndrome: a randomised controlled trial

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Association of metabolic syndrome with atherothrombotic blood phenotypes in Asian Indian families with premature coronary artery disease

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Cardiovascular disease among professional drivers and subway staff in Stockholm

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Transgender Women With Suppressed Testosterone Display Lower Burden of Coronary Disease Than Matched Cisgender Men

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HOMA-IR as a Predictor of PAI-1 Levels in Women with Severe Obesity

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ABDOMINAL OBESITY, INSULIN RESISTANCE, AND ALTERATIONS IN HEMOSTASIS

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Venous Thromboembolic Disease and Hematologic Considerations in Obesity

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Interactions between CKD and MetS and the Development of CVD

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A metabolomics approach to identify factors influencing their activity relative to oleanolic acid contents in Korean mistletoe types

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Refining genomewide association for growth and fat deposition traits in an F2 pig population1

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Coagulation Signalling and Metabolic Disorders: Lessons Learned from Animal Models

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From obesity to cardiovascular disease: pathological basis and clinical implications

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Changes in mediators of inflammation and pro-thrombosis after 12 months of dietary modification in adults with metabolic syndrome

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The main pathogenetic mechanisms of hypercoagulation in diabetes and the possibility of its drug correction

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Increased peripheral of brain-derived neurotrophic factor levels in phenylketonuric patients treated with l-carnitine

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A Phytochemical-rich Multivitamin-multimineral Supplement is Bioavailable and Reduces Serum Oxidized Low-density Lipoprotein, Myeloperoxidase, and Plasminogen Activator Inhibitor-1 in a Four-week Pilot trial of Healthy Individuals

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Platelets and Fibrinolysis

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Resolving distinct molecular origins for copper effects on PAI-1

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Effects of lisinopril treatment on the pathophysiology of PCOS and plasminogen activator inhibitor-1 concentrations in rats

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Drug discovery in the metabolic syndrome: context and some recent developments

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Association among Fibrinolytic Proteins, Metabolic Syndrome Components, Insulin Secretion, and Resistance in Schoolchildren

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Plasminogen Activator Inhibitor-1 is Regulated Through Dietary Fat Intake and Heritability: Studies in Twins

Engstler, A. J., Frahnow, T., Kruse, M., Pfeiffer, A. F. H., & Bergheim, I. (2017) · Twin Research and Human Genetics · doi:10.1017/thg.2017.36 · Cited by 5

Estrogen and obesity synergistically suppress protein S via HIF1α, enhancing thrombosis potential

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Obesity paradox in acute myocardial infarction: Is plasminogen activator inhibitor 1 the culprit?

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Long-term effects of trans fatty acid intake during pregnancy and lactation: does it have deleterious consequences?

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Cardiovascular Risk Predictors High Sensitivity C-Reactive Protein and Plasminogen Activator Inhibitor-1 in Women with Lean Phenotype of Polycystic Ovarian Syndrome: A Prospective Case-Control Study

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SERPINE1 DNA Methylation Levels Quantified in Blood Cells at Five Years of Age Are Associated with Adiposity and Plasma PAI-1 Levels at Five Years of Age

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L’exposition humaine au bisphénol A : un facteur de risque environnemental des maladies métaboliques et cardiovasculaires

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Plasminogen activator inhibitor-1 4G/5G genotype and residual venous occlusion following acute unprovoked deep vein thrombosis of the lower limb: A prospective cohort study

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Genome-wide association study for circulating levels of plasminogen activator inhibitor-1 (PAI-1) provides novel insights into the regulation of PAI-1 Running title: HUANG et al., GENETIC LOCI ASSOCIATED WITH PAI-1

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When Heroes Fall: Reduced Expression of Heat-Resistant Obscure Proteins in Ischemic Stroke

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